Selective deletion of interleukin-1 alpha in microglia does not modify acute outcome but may regulate neurorepair processes after experimental ischemic stroke

https://m2.mtmt.hu/ eng 2026-10-23 17:47 JournalArticle 36068935 VALIDATED true 0 false 2026-09-07T14:02:46.390+0000 2026-02-10T14:09:28.672+0000 2025-04-01T06:43:21.515+0000 true 10065463 Turek Márta /api/admin/10065463 Admin Márta Turek (KOKI admin 4) true 2026-10-13T10:04:03.775+0000 2026-10-13T10:04:03.775+0000 2025-12-21T09:32:47.418+0000 true 521 Szuper Admin /api/admin/521 Admin Admin Szuper (admin) true Admin 10025544 /api/admin/10025544 Katalin Lévayné Deseő (MTMT Központi admin) Lévayné Deseő Katalin true 10025544 true 2026-05-20T07:50:11.181+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Lemarchand, Eloïse Selective deletion of interleukin-1 alpha in microglia does not modify acute outcome but may regulate neurorepair processes after experimental ischemic stroke true true /api/journal/2330 REVIEWED JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 0271-678X 1559-7016 true false 2330 false 2330 true 0271-678X 1559-7016 Journal FOREIGN 45 8 1479 1492 1479 14 2025 Inflammation is a key contributor to stroke pathogenesis and exacerbates brain damage leading to poor outcome. Interleukin-1 (IL-1) is an important regulator of post-stroke inflammation, and blocking its actions is beneficial in pre-clinical stroke models and safe in the clinical setting. However, the distinct roles of the two major IL-1 receptor type 1 agonists, IL-1α and IL-1β, and the specific role of IL-1α in ischemic stroke remain largely unknown. Here we show that IL-1α and IL-1β have different spatio-temporal expression profiles in the brain after experimental stroke, with early microglial IL-1α expression (4 h) and delayed IL-1β expression in infiltrated neutrophils and a small microglial subset (24–72 h). We examined for the first time the specific role of microglial-derived IL-1α in experimental permanent and transient ischemic stroke through microglial-specific tamoxifen-inducible Cre-loxP-mediated recombination. Microglial IL-1α deletion did not influence acute outcome after ischemic stroke. However, microglial IL-1α knock out (KO) mice showed reduced peri-infarct vessel density and reactive astrogliosis at 14 days post-stroke, alongside long-term impaired functional recovery. Our study identifies for the first time a critical role for microglial IL-1α on post-stroke neurorepair and recovery, highlighting the importance of targeting specific IL-1 mechanisms in brain injury to develop effective therapies. Funding 2051523 /api/funding/2051523 Medical Research Council(MR/T016515/1) false true Funding 2051524 /api/funding/2051524 Leducq Foundation Transatlantic Network of Excellence(Stroke- IMPaCT 19CVD01) false true Funding 2051525 /api/funding/2051525 R01(R01NS101752) false true Funding 2051526 /api/funding/2051526 British Heart Foundation(PG/21/10730) false true true 2025 true true true false true false GOLD 2026-09-07 true https://doi.org/10.1177/0271678X251323371 2 0 2 0 1 2 2 2 2 2 2 0 0 0 2 0 2 0 2 0 0 4 4 Folyóiratcikk Journal Article 24 2 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 1 0 1 0 2026 0 1 0 1 0 D1 false false false false 2025-06-30T06:43:25.970+0000 Neuroimmunológiai Kutatócsoport (HRN KOKI) 2 15 1 13 0 true 10025544 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 126009505 /api/authorship/126009505 Lemarchand, Eloïse 1 0.077 true false false Lemarchand Eloïse true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 126009506 /api/authorship/126009506 Grayston, Alba 2 0.07692308 false false false Grayston Alba true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 126009507 /api/authorship/126009507 Wong, Raymond 3 0.07692308 false false false Wong Raymond true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 126009508 /api/authorship/126009508 Rogers, Miyako 4 0.07692308 false false false Rogers Miyako true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 126009509 /api/authorship/126009509 Ouvrier, Blake 5 0.07692308 false false false Ouvrier Blake true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 126009510 /api/authorship/126009510 Llewellyn, Benjamin 6 0.07692308 false false false Llewellyn Benjamin true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 126009511 /api/authorship/126009511 Webb, Freddie 7 0.07692308 false false false Webb Freddie true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 126009512 /api/authorship/126009512 Lénárt, Nikolett [Lénárt, Nikolett (neurobiológia), author] Laboratory of Neuroimmunology 8 0.077 false false false Author 10030597 /api/author/10030597 Nikolett Lénárt (neurobiológia) Lénárt Nikolett true 10030597 true Lénárt Nikolett true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 126009513 /api/authorship/126009513 Dénes, Ádám [Dénes, Ádám (Neurobiológia, ne...), author] Laboratory of Neuroimmunology 9 0.077 false false false Author 10012934 /api/author/10012934 Ádám Dénes (Neurobiológia, neuroimmunológia) Dénes Ádám true 10012934 true Dénes Ádám true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 126009514 /api/authorship/126009514 Brough, David 10 0.07692308 false false false Brough David true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 126009515 /api/authorship/126009515 Allan, Stuart M 11 0.07692308 false false false Allan Stuart M true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 126009516 /api/authorship/126009516 Bix, Gregory J 12 0.07692308 false false false Bix Gregory J true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 126009517 /api/authorship/126009517 Pinteaux, Emmanuel 13 0.07692308 false true false Pinteaux Emmanuel true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 29183788 /api/publicationidentifier/29183788 DOI: 10.1177/0271678X251323371 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1177/0271678X251323371 https://doi.org/10.1177/0271678X251323371 false true PublicationIdentifier 29183790 /api/publicationidentifier/29183790 WoS: 001448194500001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 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(2025) JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 0271-678X 1559-7016 45 8 1479-1492<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Lemarchand Eloïse </span> ;    <span class="author-name" >Grayston Alba </span> ;    <span class="author-name" >Wong Raymond </span> ;    <span class="author-name" >Rogers Miyako </span> ;    <span class="author-name" >Ouvrier Blake </span> ;    <span class="author-name" >Llewellyn Benjamin </span> ;    <span class="author-name" >Webb Freddie </span> ;    <span class="author-name" mtid="10030597"><a href="/gui2/?type=authors&mode=browse&sel=10030597" target="_blank">Lénárt Nikolett (<span class="authorship-author-name">Lénárt Nikolett</span> <span class="authorAux-mtmt"> neurobiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Neuroimmunology</span> ;    <span class="author-name" mtid="10012934"><a href="/gui2/?type=authors&mode=browse&sel=10012934" target="_blank">Dénes Ádám (<span class="authorship-author-name">Dénes Ádám</span> <span class="authorAux-mtmt"> Neurobiológia, neuroimmunológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Neuroimmunology</span> ;    <span class="author-name" >Brough David </span> ;    <span class="author-name" >Allan Stuart M </span> ;    <span class="author-name" >Bix Gregory J </span> ;    <span class="author-name" >Pinteaux Emmanuel </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36068935" target="_blank">Selective deletion of interleukin-1 alpha in microglia does not modify acute outcome but may regulate neurorepair processes after experimental ischemic stroke</a></div> <div> <span class="journal-title">JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0271-678X">0271-678X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1559-7016">1559-7016</a>)</span>: <span class="journal-volume">45</span> <span class="journal-issue">8</span> <span class="page"> pp 1479-1492 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1177/0271678X251323371" target="_blank" href="https://doi.org/10.1177/0271678X251323371"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001448194500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001448194500001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="243208" target="_blank" href="https://real.mtak.hu/243208"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105000466671" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105000466671"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40110693" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40110693&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://journals.sagepub.com/doi/10.1177/0271678X251323371" target="_blank" href="https://journals.sagepub.com/doi/10.1177/0271678X251323371"> Other URL </a> </span> <span class="id identifier oa_NONE" title=" None "> <a style="color:blue" title="https://www.scopus.com/inward/record.uri?eid=2-s2.0-105000466671&doi=10.1177%2F0271678X251323371&partnerID=40&md5=c85ce92af72fbee6b3c2dcd86f36f97c" target="_blank" href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-105000466671&doi=10.1177%2F0271678X251323371&partnerID=40&md5=c85ce92af72fbee6b3c2dcd86f36f97c"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cardiology and Cardiovascular Medicine   Rank: D1</div> <div class="journal-subject">Journal subject: Scopus - Neurology (clinical)   Rank: D1</div> <div class="journal-subject">Journal subject: Scopus - Neurology   Rank: D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 2</span> | Independent citation: 0 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 2 | Number of citations in Scopus: 2 | WoS/Scopus assigned: 2 | Number of citations with DOI: 2 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36068935&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 36068935</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Medical Research Council(MR/T016515/1), Leducq Foundation Transatlantic Network of Excellence(Stroke- IMPaCT 19CVD01), R01(R01NS101752), British Heart Foundation(PG/21/10730) </div> <div class="lastModified">Last Modified: 2026.02.10. 15:09 Márta Turek (KOKI admin 4) </div> <div class="lockedBy">Centrally managed 2026.05.20. 09:50 Katalin Lévayné Deseő (MTMT Központi admin) </div> </div></div>