https://m2.mtmt.hu/ eng 2026-10-24 08:21 JournalArticle 36068866 VALIDATED true Journal Article; Systematic Review; Meta-Analysis 0 false 2026-10-15T07:25:05.329+0000 2025-10-15T12:04:47.774+0000 2025-04-01T04:59:11.758+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-09-07T08:58:07.204+0000 2025-04-10T08:56:37.657+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true Admin 10073918 /api/admin/10073918 Kovács Marcell true true 2025-10-07T15:13:22.424+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Szabó, A. Assessing the efficacy of varicocelectomy, antioxidants, FSH treatment, and lifestyle modifications on sperm DNA fragmentation: a systematic review and meta-analysis true true /api/journal/10019966 REVIEWED true false 10019966 false 10019966 true 2045-2322 Journal FOREIGN 15 1 10118 10118 9 2025 Infertility affects 15% of couples in developed countries, 50% accounting for male origin. In 2021, sperm DNA fragmentation (SDF) testing was incorporated into male fertility evaluations as an evidence-based functional test. We aimed to assess the effect of interventions that could potentially improve SDF. A random-effect meta-analysis was performed with a systematic search in three databases. Pooled mean differences (MD) with 95% confidence intervals (CI) were calculated. Initially, 36,531 articles were found, of which 86 papers with over 8,000 patients were included. Three months following varicocelectomy, the decrease in SDF was -6.74% (CI: -9.40, -4.08) compared to preoperative data of patients, whereas it was -12.39% (CI: -22.41, -2.36) after six months and -10.06% (CI: -22.69, + 2.56) at twelve months. A dose-dependent effect could also be observed in grade II and III varicoceles. The overall SDF decrease at three months was -4.27% (CI: -6.11, -2.43) for antioxidants, -4.51% (CI: -6.81, -2.20) for combined antioxidant therapy and -3.36% (CI: -4.44, -2.28) for monotherapy. In terms of follicle-stimulating hormone treatment (FSH) at three months, the change in SDF was -6.66% (CI: -9.64, -3.69). For lifestyle modifications, a change of -3.24% (CI: -5.33, -1.16) was observed at three months. Other interventions are narratively summarized in the systematic review. Of the interventions reviewed, varicocelectomy is the most effective in reducing SDF at six months, FSH treatment might be useful, antioxidants appear questionable, and lifestyle interventions require more studies of similar designs to draw firm conclusions. © The Author(s) 2025. 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(SE / AOK / K / SZSZNK); Transzlációs Medicina Intézet (PTE / ÁOK); Transzlációs Medicina Központ (SE / KSZE); Urológiai Klinika (SE / AOK / K) 10 65 7 10 0 true 10073918 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 126009268 /api/authorship/126009268 1 0.1 true false false Author 10086438 /api/author/10086438 Szabó Anett true true Szabó A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126009269 /api/authorship/126009269 2 0.1 false false false Author 10071961 /api/author/10071961 Váncsa Szilárd true true Váncsa S. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126009270 /api/authorship/126009270 3 0.1 false false false Author 10002629 /api/author/10002629 Hegyi Péter true 10002629 true Hegyi P. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126009271 /api/authorship/126009271 4 0.1 false false false 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Szarvas T. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126009276 /api/authorship/126009276 9 0.1 false false false Author 10013343 /api/author/10013343 Nyirády Péter true 10013343 true Nyirády P. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126009277 /api/authorship/126009277 10 0.1 false true true Author 10013889 /api/author/10013889 Kopa Zsolt true 10013889 true Kopa Z. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 29183595 /api/publicationidentifier/29183595 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1038/s41598-025-93267-z https://doi.org/10.1038/s41598-025-93267-z false true PublicationIdentifier 29273861 /api/publicationidentifier/29273861 PlainSource 1 /api/publicationsource/1 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40128318&dopt=Abstract false true PublicationIdentifier 31917822 /api/publicationidentifier/31917822 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true IDENTICAL https://www.nature.com/articles/s41598-025-93267-z https://www.nature.com/articles/s41598-025-93267-z false true Classification 12305 /api/classification/12305 true true Keyword 3375201 /api/keyword/3375201 true true MtaRating 519359 /api/mtarating/519359 RatingType 10007 /api/ratingtype/10007 SZTB Institute 14102 /api/institute/14102 0 false true false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true A nemzetközi true 19359 true MtaRating 11551161 /api/mtarating/11551161 RatingType 10010 /api/ratingtype/10010 RegTB Institute 14100 /api/institute/14100 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true B nemzetközi false true SjrRating 11736329 /api/sjrrating/11736329 24 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 true 1000 true Q1 DIRECT true true /api/publication/36068866 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10086438"><a href="/gui2/?type=authors&mode=browse&sel=10086438" target="_blank">Szabó A. (<span class="authorship-author-name">Szabó Anett</span> <span class="authorAux-mtmt"> urológia, andrológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Urology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071961"><a href="/gui2/?type=authors&mode=browse&sel=10071961" target="_blank">Váncsa S. (<span class="authorship-author-name">Váncsa Szilárd</span> <span class="authorAux-mtmt"> Orvostudomány, egészségtudomány</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Institute of Pancreatic Diseases; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi P. (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Institute of Pancreatic Diseases; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10042217"><a href="/gui2/?type=authors&mode=browse&sel=10042217" target="_blank">Kói T. (<span class="authorship-author-name">Kói Tamás</span> <span class="authorAux-mtmt"> információelmélet</span>) </a> </span> <span class="author-affil"><span title="Budapest University of Technology and Economics">BUTE</span>/<span title="Faculty of Natural Sciences">FNS</span>/<span title="Institute of Mathematics">IM</span>/Department of Stochastics; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10092650"><a href="/gui2/?type=authors&mode=browse&sel=10092650" target="_blank">Ács J. (<span class="authorship-author-name">Ács Júlia</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Urology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026960"><a href="/gui2/?type=authors&mode=browse&sel=10026960" target="_blank">Hermánné R.J. (<span class="authorship-author-name">Juhász Réka</span> <span class="authorAux-mtmt"> Élelmiszertudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Health Sciences">FHS</span>/Department of Dietetics and Nutrition Sciences; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013998"><a href="/gui2/?type=authors&mode=browse&sel=10013998" target="_blank">Ács N. (<span class="authorship-author-name">Ács Nándor</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052466"><a href="/gui2/?type=authors&mode=browse&sel=10052466" target="_blank">Szarvas T. (<span class="authorship-author-name">Szarvas Tibor</span> <span class="authorAux-mtmt"> urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Urology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013343"><a href="/gui2/?type=authors&mode=browse&sel=10013343" target="_blank">Nyirády P. (<span class="authorship-author-name">Nyirády Péter</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Urology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013889"><a href="/gui2/?type=authors&mode=browse&sel=10013889" target="_blank">Kopa Z. ✉ (<span class="authorship-author-name">Kopa Zsolt</span> <span class="authorAux-mtmt"> Andrológia, urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Urology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36068866" target="_blank">Assessing the efficacy of varicocelectomy, antioxidants, FSH treatment, and lifestyle modifications on sperm DNA fragmentation: a systematic review and meta-analysis</a></div> <div> <span class="journal-title">SCIENTIFIC REPORTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-2322">2045-2322</a>)</span>: <span class="journal-volume">15</span> <span class="journal-issue">1</span> <span class="page"> Paper 10118. 9 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41598-025-93267-z" target="_blank" href="https://doi.org/10.1038/s41598-025-93267-z"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001451257100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001451257100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105000757481" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105000757481"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40128318" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40128318&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://www.nature.com/articles/s41598-025-93267-z" target="_blank" href="https://www.nature.com/articles/s41598-025-93267-z"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 18</span> | Independent citation: 16 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 14 | Number of citations in Scopus:&nbsp;13 | WoS/Scopus assigned:&nbsp;18 | Number of citations with DOI:&nbsp;18 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36068866&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 36068866</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (Open access funding provided by Semmelweis University) </div> <div class="lastModified">Last Modified: 2025.10.15. 14:04 Marcell Kovács (MTMT Közp., admin) </div> <div class="lockedBy">Centrally managed 2025.10.07. 17:13 Marcell Kovács (MTMT Közp., admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Journal Article; Systematic Review; Meta-Analysis</pre> </div></div>