https://m2.mtmt.hu/ hun 2026-10-23 19:33 JournalArticle 36067289 VALIDATED true The University of Texas MD Anderson Cancer Center, Houston, TX, United States Mayo Clinic, Rochester, MN, United States ECOG, University of Pennsylvania, Philadelphia, PA, United States The University of Newcastle, Callaghan, NSW, Australia Centre Hospitalier Universitaire de Québec-Université Laval, Quebec, Canada Memorial Sloan Kettering Cancer Center, New York, NY, United States Helios University Clinic Wuppertal, University Witten/Herdecke Germany, Wuppertal, Germany Medical University of Graz, Graz, Austria Ohio State University/Alliance, Columbus, OH, United States Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria University of British Columbia, Vancouver, BC, Canada Vanderbilt University Medical Center, Nashville, TN, United States Medical University of Innsbruck, Innsbruck, Austria Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC), Policlinico San Martino IRCCS, University of Genoa, Genoa, Italy GEICAM, Hospital General Universitario Gregorio Marañón, Universidad Complutense, Madrid, Spain A Coruña University Hospital, A Coruna, Spain Breast Cancer Research Centre, Nedlands, WA, Australia The Royal Marsden Hospital, NHS Foundation Trust, East Sussex, United Kingdom Johns Hopkins University/ECOG, Baltimore, MD, United States Oncology Department, Dr. Balmis General University Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain Lakeside Specialist Breast Clinic, Nepean Cancer Care Centre, Norwest, NSW, Australia Dana-Farber Cancer Institute, Boston, MA, United States The Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland University of Pittsburgh Cancer Institute UPMC Hillman Cancer Center, Pittsburgh, PA, United States Vall d’Hebron Institute of Oncology, Barcelona, Spain Karolinska Institute and University Hospital, Solna, Sweden New York University, New York, NY, United States National Institute of Oncology, Budapest, Hungary Breast International Group, Brussels, Belgium Pfizer, Chicago, IL, United States University of North Carolina/Alliance, Chapel Hill, NC, United States Austrian Breast and Colorectal Cancer Study Group AT, Vienna, Austria Medical University of Vienna AT, Vienna, Austria Export Date: 21 July 2025; Cited By: 0; Correspondence Address: E. Shinn; The University of Texas MD Anderson Cancer Center, Houston, United States; email: eshinn@mdanderson.org; CODEN: BCTRD 0 false 2026-06-17T08:41:05.274+0000 2026-01-16T07:29:21.848+0000 2025-03-31T06:48:48.140+0000 true 10081340 Pirmann Tamás /api/admin/10081340 Admin true 2026-02-19T09:56:14.500+0000 2025-05-23T10:52:37.967+0000 true 10065569 Pécsi Éva /api/admin/10065569 Admin true 2025-12-23T23:37:02.310+0000 true 521 Szuper Admin /api/admin/521 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Shinn, Eileen Impact of adding palbociclib on treatment adherence to ongoing adjuvant endocrine treatment in the global randomized PALLAS randomized trial in patients with early breast cancer. true true /api/journal/799 REVIEWED true false 799 false 799 true 0167-6806 1573-7217 Journal FOREIGN 211 2 385 397 385 13 2025 Using patient-reported outcomes (PROs) and more objective measures, we evaluated adherence to adjuvant palbociclib and ET in the PALLAS trial, and the impact of palbociclib on ET adherence.The open-label, global, phase 3 PALLAS trial randomized patients with hormone receptor-positive (HR+), HER2-negative stage II-III breast cancer (1:1) to either 26 cycles of palbociclib (125 mg/day for 21 days and then 7 days off) plus adjuvant ET, versus ET alone. After 23.7 months median follow-up, palbociclib was stopped due to futility of the intervention and patients were moved to follow-up. For each cycle, daily adherence to ET was measured with study diaries; for palbociclib, study diaries and pill counts. At cycles 2, 3, 6, 12, 18 and 24, patients completed the Morisky Medication Adherence Scale-4 plus an additional item and the McHorney Adherence Questionnaire. Mean persistence was defined in months from treatment initiation to cessation.Four thousand six hundred eighty-eight of 5796 total PALLAS participants were included. Across all cycles, mean daily ET adherence values measured by study diary were > 98.0% and did not differ between treatment arms. Mean persistence to ET was similar between arms (19.2 months for palbociclib + ET vs. 19.6 months for ET alone). However, patient-reported maximal ET adherence was higher across time for palbociclib + ET compared to ET alone (p ≤ 0.0001, modified MMAS-4; p = 0.05, McHorney).In the PALLAS trial, addition of palbociclib did not decrease adherence to adjuvant ET. 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title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Shinn Eileen </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060070"><a href="/gui2/?type=authors&mode=browse&sel=10060070" target="_blank">Rubovszky Gabor (<span class="authorship-author-name">Rubovszky Gábor</span> <span class="authorAux-mtmt"> klinikai onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; et al. (43) </div> <div><a target="_blank" href="/api/publication/36067289?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36067289" target="_blank">Impact of adding palbociclib on treatment adherence to ongoing adjuvant endocrine treatment in the global randomized PALLAS randomized trial in patients with early breast cancer.</a></div> <div> <span class="journal-title">BREAST CANCER RESEARCH AND TREATMENT</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0167-6806">0167-6806</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1573-7217">1573-7217</a>)</span>: <span class="journal-volume">211</span> <span class="journal-issue">2</span> <span class="page"> pp 385-397 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s10549-025-07653-2" target="_blank" href="https://doi.org/10.1007/s10549-025-07653-2"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001454235300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001454235300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105001496212" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105001496212"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40140172" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40140172&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 0 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36067289&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36067289</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2026.01.16. 08:29 Mátics Bernadett (OOI admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: The University of Texas MD Anderson Cancer Center, Houston, TX, United States Mayo Clinic, Rochester, MN, United States ECOG, University of Pennsylvania, Philadelphia, PA, United States The University of Newcastle, Callaghan, NSW, Australia Centre Hospitalier Universitaire de Québec-Université Laval,...</pre> </div></div>