https://m2.mtmt.hu/ hun 2026-09-23 12:57 JournalArticle 36054067 VALIDATED true 0 false 2026-09-10T12:39:29.001+0000 2025-05-09T09:54:18.205+0000 2025-03-24T13:24:22.365+0000 true 10090278 Maricza Katalin /api/author/10090278 Author true 2026-05-27T13:02:32.060+0000 2026-05-27T13:02:32.060+0000 2025-05-09T09:54:18.212+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Maricza, Katalin Co-Expression Analysis of the ZDHHC19 Palmitoyltransferase–miR-4733–miR-596 Putative Regulatory Axis in Sepsis true true /api/journal/10018335 REVIEWED true false 10018335 false 10018335 true 2073-4425 2073-4425 Journal FOREIGN 16 4 359 359 18 2025 Background: ZDHHC19—a protein acyltransferase—is known to be induced in sepsis, a dysregulated immune response to infection, but the underlying molecular mechanisms remain elusive. In this study, we aimed to explore whether upregulation of ZDHHC19 is modulated by single nucleotide polymorphisms (SNPs) affecting the binding of microRNA in the 3’ untranslated region of the gene. Methods: Inpatients with clinically verified severe infection (n = 83) or sepsis (n = 63) were recruited to the study. Genomic DNA and total RNA were prepared from buccal and peripheral blood samples, respectively. Genotyping of rs112579116 and rs2293161 SNPs was performed by TaqMan real-time PCR assays, while ZDHHC19 mRNA as well as miR-4733 and -596 microRNA levels were quantitated by reverse transcription qPCR. Correlations between genotypes, expression levels and clinical parameters were assessed by the Shapiro–Wilk, Mann–Whitney and t-tests. Results: Transcript levels of ZDHHC19 were significantly enhanced in septic blood samples (p = 0.0000709) and associated with clinical parameters such as procalcitonin levels, blood cell counts and clotting factors. Levels of both miRNAs showed an inverse but not significant correlation with those of ZDHHC19. Conclusions: Expression of ZDHHC19 should be considered a reliable molecular marker of sepsis, but further investigations are needed to shed light on regulatory mechanisms involved. Funding 2052631 /api/funding/2052631 false true Funding 2052632 /api/funding/2052632 false true true true 2025 true true true false true false GOLD 2026-09-10 false http://www.mdpi.com/journal/genes/ 2 0 2 2 0 2 2 2 2 2 2 2 2 2 0 0 2 2 2 2 0 2 2 Folyóiratcikk Journal Article 24 2 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 2 2 2 2 Q2 false 10001130 false false false 2025-05-08T09:54:18.013+0000 Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 7 16 1 9 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 125705937 /api/authorship/125705937 1 0.111 true false false Author 10090278 /api/author/10090278 Maricza Katalin true true Maricza Katalin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 125705938 /api/authorship/125705938 2 0.111 false false false Author 10048126 /api/author/10048126 Molnár Zsuzsanna true 10048126 true Elek Zsuzsanna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 125705939 /api/authorship/125705939 3 0.11111111 false false false Losoncz Eszter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 125705940 /api/authorship/125705940 4 0.111 false false false Author 10090148 /api/author/10090148 Molnár Krisztina true true Molnár Krisztina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 125705941 /api/authorship/125705941 5 0.11111111 false false false Fülep Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 125705942 /api/authorship/125705942 6 0.111 false false false Author 10032148 /api/author/10032148 Kovács-Nagy Réka true 10032148 true Kovács-Nagy Réka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 125705943 /api/authorship/125705943 7 0.111 false false false Author 10029333 /api/author/10029333 Bánlaki Zsófia true 10029333 true Bánlaki Zsófia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 125705944 /api/authorship/125705944 8 0.111 false false false Author 10023921 /api/author/10023921 Keszler Gergely true 10023921 true Keszler Gergely true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 125705945 /api/authorship/125705945 9 0.111 false true true Author 10001130 /api/author/10001130 Rónai Zsolt true 10001130 true Rónai Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 29148609 /api/publicationidentifier/29148609 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/genes16040359 https://doi.org/10.3390/genes16040359 false true PublicationIdentifier 29331906 /api/publicationidentifier/29331906 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001474489900001 https://www.webofscience.com/wos/woscc/full-record/001474489900001 false true PublicationIdentifier 29331907 /api/publicationidentifier/29331907 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105003592397 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105003592397 false true PublicationIdentifier 29331908 /api/publicationidentifier/29331908 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 40282319 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40282319&dopt=Abstract false true SjrRating 11584733 /api/sjrrating/11584733 47 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2716 /api/classificationexternal/2716 true 2716 true Q2 DIRECT true true /api/publication/36054067 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10090278"><a href="/gui2/?type=authors&mode=browse&sel=10090278" target="_blank">Maricza Katalin (<span class="authorship-author-name">Maricza Katalin</span> <span class="authorAux-mtmt"> Molekuláris genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048126"><a href="/gui2/?type=authors&mode=browse&sel=10048126" target="_blank">Elek Zsuzsanna (<span class="authorship-author-name">Molnár Zsuzsanna</span> <span class="authorAux-mtmt"> Molekuláris genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Losoncz Eszter </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10090148"><a href="/gui2/?type=authors&mode=browse&sel=10090148" target="_blank">Molnár Krisztina (<span class="authorship-author-name">Molnár Krisztina</span> <span class="authorAux-mtmt"> molekuláris genetika, biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Fülep Zoltán </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032148"><a href="/gui2/?type=authors&mode=browse&sel=10032148" target="_blank">Kovács-Nagy Réka (<span class="authorship-author-name">Kovács-Nagy Réka</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029333"><a href="/gui2/?type=authors&mode=browse&sel=10029333" target="_blank">Bánlaki Zsófia (<span class="authorship-author-name">Bánlaki Zsófia</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023921"><a href="/gui2/?type=authors&mode=browse&sel=10023921" target="_blank">Keszler Gergely (<span class="authorship-author-name">Keszler Gergely</span> <span class="authorAux-mtmt"> biokémia, molekuláris biológia, molekuláris gen...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001130"><a href="/gui2/?type=authors&mode=browse&sel=10001130" target="_blank">Rónai Zsolt ✉ (<span class="authorship-author-name">Rónai Zsolt</span> <span class="authorAux-mtmt"> Molekuláris genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36054067" target="_blank">Co-Expression Analysis of the ZDHHC19 Palmitoyltransferase–miR-4733–miR-596 Putative Regulatory Axis in Sepsis</a></div> <div> <span class="journal-title">GENES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2073-4425">2073-4425</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2073-4425">2073-4425</a>)</span>: <span class="journal-volume">16</span> <span class="journal-issue">4</span> <span class="page"> Paper 359. 18 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/genes16040359" target="_blank" href="https://doi.org/10.3390/genes16040359"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001474489900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001474489900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105003592397" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105003592397"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40282319" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40282319&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Genetics (clinical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Genetics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 2</span> | Független: 2 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 2 | Scopus jelölt:&nbsp;2 | WoS/Scopus jelölt:&nbsp;2 | DOI jelölt:&nbsp;2 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36054067&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36054067</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (K131680) Támogató: NKFIH, (STIA-18-KF/M) </div> <div class="lastModified">Utolsó módosítás: 2025.05.09. 11:54 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> </div></div>