https://m2.mtmt.hu/ hun 2026-09-23 01:38 JournalArticle 36052614 ADMIN_APPROVED true 0 false 2026-07-30T13:15:46.695+0000 2026-07-29T07:55:14.281+0000 2025-03-24T07:39:27.278+0000 true 10070075 Nádas Orsolya /api/admin/10070075 Admin Nádas Orsolya (OOI admin4) true 2026-07-29T07:51:44.186+0000 2026-07-29T07:51:44.186+0000 2026-07-29T07:55:14.433+0000 true 10103105 Mátics Bernadett /api/admin/10103105 Admin Mátics Bernadett (OOI admin5) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Major, Tibor true true /api/journal/31780 REVIEWED STRAHLENTHERAPIE UND ONKOLOGIE 0179-7158 1439-099X true false 31780 false 31780 true 0179-7158 1439-099X Journal FOREIGN 202 1 30 39 30 10 2026 Although a cornerstone of modern cancer treatment, radiotherapy (RT) is associated with a risk of secondary cancer due to irradiation of non-target tissues. Techniques such as intensity-modulated RT (IMRT), volumetric modulated RT (VMAT), and stereotactic body RT (SBRT) provide highly conformal target dose distributions and reduce doses to nearby organs at risk (OARs), albeit at the cost of larger normal tissue volumes being irradiated with lower doses. In brachytherapy (BT), the low-value isodoses cannot be changed: they are a consequence of the inverse-square law. This study evaluates and compares the normal tissue integral doses (NTIDs) delivered by BT and modern external-beam RT (EBRT) techniques in breast and head and neck (H&N) cancer patients.Included were the BT and IMRT plans of 34 women with early-stage breast cancer treated with interstitial high-dose-rate (HDR) BT and two groups of head and neck (H&N) patients: 38 patients with mobile tongue, floor of the mouth, and base of the tongue cancer treated definitively with interstitial HDR BT for whom VMAT treatment plans were also prepared and 20 patients with tongue and floor of the mouth tumors who received postoperative interstitial HDR BT for whom VMAT and stereotactic CyberKnife (CK, Accuray Inc., Sunnyvale, CA, USA) plans were also created. The NTIDs for three normal tissue volumes (NT_V10, NT_V5, NT_V2) and OARs were calculated and compared.Brachytherapy resulted in 39%, 32%, and 26% lower NTIDs compared to IMRT for NT_V10, NT_V5, and NT_V2, respectively, in patients with breast cancer. In H&N cancer, the NTIDs were always lower for BT compared to VMAT. The reductions in NTID achieved with BT were 45%, 36% and 27% with the same planning target volumes in BT and VMAT, and 56%, 48% and 37% with larger planning target volumes in VMAT. For CK, the NTID reductions were 54%, 49% and 41% compared to BT. In breast cases, BT resulted in a significant reduction in ipsilateral lung NTID, and in H&N cases, salivary glands NTIDs were always lower with BT than with VMAT.For patients with breast and head and neck cancer, interstitial BT results in lower integral dose to normal tissue and OARs compared to modern EBRT techniques. The clinical implications require further detailed investigation. Funding 2051191 /api/funding/2051191 (National Tumor Biology Laboratory project—2022-2.1.1-NL-2022-00010) false true Funding 2051192 /api/funding/2051192 (Tématerületi Kiválósági Program 2021 (TKP2021-EGA-44)) false true true NATIONAL 2025 true true true false true false NONE 2026-07-30 false 1 0 1 1 0 1 1 0 1 1 1 1 1 1 0 0 1 1 1 1 0 4 4 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 1 1 1 1 Q2 false false false false 2025-06-22T06:39:38.903+0000 Onkológiai Tanszék (SE / AOK / K); Országos Onkológiai Intézet 3 9 2 3 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 125697370 /api/authorship/125697370 Major, Tibor ✉ [Major, Tibor (klinikai sugárfizika), szerző] Országos Onkológiai Intézet; Onkológiai Tanszék (SE / AOK / K) 1 0.333 true false true Author 10044386 /api/author/10044386 Major Tibor (klinikai sugárfizika) Major Tibor true 10044386 true Major Tibor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 125697371 /api/authorship/125697371 Polgár, Csaba [Polgár, Csaba (Sugárterápia, kli...), szerző] Országos Onkológiai Intézet; Onkológiai Tanszék (SE / AOK / K) 2 0.333 false false false Author 10013383 /api/author/10013383 Polgár Csaba (Sugárterápia, klinikai onkológia) Polgár Csaba true 10013383 true Polgár Csaba true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 125697372 /api/authorship/125697372 Takácsi-Nagy, Zoltán [Takácsi-Nagy, Zoltán (Sugárterápia), szerző] Országos Onkológiai Intézet; Onkológiai Tanszék (SE / AOK / K) 3 0.333 false true false Author 10013883 /api/author/10013883 Takácsi-Nagy Zoltán (Sugárterápia) Takácsi-Nagy Zoltán true 10013883 true Takácsi-Nagy Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 29144360 /api/publicationidentifier/29144360 DOI: 10.1007/s00066-025-02382-3 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1007/s00066-025-02382-3 https://doi.org/10.1007/s00066-025-02382-3 false true PublicationIdentifier 29144361 /api/publicationidentifier/29144361 WoS: 001446056400001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001446056400001 https://www.webofscience.com/wos/woscc/full-record/001446056400001 false true PublicationIdentifier 29270205 /api/publicationidentifier/29270205 Scopus: 105000365581 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105000365581 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105000365581 false true PublicationIdentifier 29144359 /api/publicationidentifier/29144359 PubMed: 40094999 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 40094999 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40094999&dopt=Abstract false true Keyword 19760 /api/keyword/19760 Brachytherapy true 19760 true Keyword 20010 /api/keyword/20010 breast cancer true 20010 true Keyword 1033294 /api/keyword/1033294 Head and neck cancer true 1033294 true Keyword 1926267 /api/keyword/1926267 integral dose true true Keyword 1942112 /api/keyword/1942112 external beam therapy true true SjrRating 11708767 /api/sjrrating/11708767 sjr:Q2 (2026) Scopus - Oncology STRAHLENTHERAPIE UND ONKOLOGIE 0179-7158 1439-099X 203 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2730 /api/classificationexternal/2730 Scopus - Oncology true 2730 true Q2 FROM_LAST_YEAR true true /api/publication/36052614 Major Tibor et al. Comparison of integral doses to normal tissue and organs at risk between interstitial high-dose-rate brachytherapy and modern external-beam radiotherapy techniques in breast and head and neck cancer patients.. (2026) STRAHLENTHERAPIE UND ONKOLOGIE 0179-7158 1439-099X 202 1 30-39<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10044386"><a href="/gui2/?type=authors&mode=browse&sel=10044386" target="_blank">Major Tibor ✉ (<span class="authorship-author-name">Major Tibor</span> <span class="authorAux-mtmt"> klinikai sugárfizika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013383"><a href="/gui2/?type=authors&mode=browse&sel=10013383" target="_blank">Polgár Csaba (<span class="authorship-author-name">Polgár Csaba</span> <span class="authorAux-mtmt"> Sugárterápia, klinikai onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013883"><a href="/gui2/?type=authors&mode=browse&sel=10013883" target="_blank">Takácsi-Nagy Zoltán (<span class="authorship-author-name">Takácsi-Nagy Zoltán</span> <span class="authorAux-mtmt"> Sugárterápia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36052614" target="_blank">Comparison of integral doses to normal tissue and organs at risk between interstitial high-dose-rate brachytherapy and modern external-beam radiotherapy techniques in breast and head and neck cancer patients.</a></div> <div> <span class="journal-title">STRAHLENTHERAPIE UND ONKOLOGIE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0179-7158">0179-7158</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1439-099X">1439-099X</a>)</span>: <span class="journal-volume">202</span> <span class="journal-issue">1</span> <span class="page"> pp 30-39 </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s00066-025-02382-3" target="_blank" href="https://doi.org/10.1007/s00066-025-02382-3"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001446056400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001446056400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105000365581" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105000365581"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40094999" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40094999&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Radiology, Nuclear Medicine and Imaging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 1 | Függő: 0 | Nem jelölt: 0 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36052614&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36052614</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (National Tumor Biology Laboratory project—2022-2.1.1-NL-2022-00010), (Tématerületi Kiválósági Program 2021 (TKP2021-EGA-44)) </div> <div class="lastModified">Utolsó módosítás: 2026.07.29. 09:55 Mátics Bernadett (OOI admin5) </div> </div></div>