Background/Objectives: Zygomaticomaxillary complex (ZMC) fractures are the second
most common of all facial bone fractures, and conventional treatment represents a
challenge even for experienced surgeons. The aim of this systematic review and meta-analysis
was to compare Intraoperative Surgical Navigation (ISN) with conventional surgery
in the treatment of ZMC fractures. Methods: We reported our systematic review and
meta-analysis based on the recommendation of the PRISMA 2020 guideline. The electronic
search was conducted on 9 February 2025 in two search engines (PubMed and Web of Science)
and two databases (Embase and the Cochrane Library). Randomized controlled trials
and observational studies were included. The outcome variables were accuracy, operative
time, maximum mouth opening, postoperative stay, amount of bleeding, and cheek numbness.
The random-effects model was used for the analysis, and the results were given as
mean differences and odds ratios with 95% confidence intervals (CI). After duplicate
removal, 1961 articles were found. After the selection procedure, five studies were
found to be eligible for qualitative and quantitative analysis. Results: There were
no statistically significant differences between ISN and conventional surgery regarding
the outcomes investigated, except in postoperative average deviation of the zygomatic
bone. Our results showed an improvement of 0.64 mm [CI: 0.32, 0.92] zygomatic bone
deviation when ISN was used. Conclusions: The results suggest that ISN is as effective
as the conventional technique in the treatment of ZMC fractures. However, because
of the low number of eligible studies, further randomized controlled trials are necessary
to strengthen the level of evidence on this matter.
