https://m2.mtmt.hu/ hun 2026-10-25 10:50 JournalArticle 36051983 VALIDATED true 0 false 2026-09-24T14:46:37.999+0000 2026-01-13T13:46:35.568+0000 2025-03-23T10:48:32.737+0000 true 10044851 Szilágyi Botond /api/author/10044851 Author Szilágyi Botond (Folyamatmérnök, vegyészmérnök) true 10044851 2026-01-13T11:46:12.447+0000 2026-01-13T11:46:12.447+0000 2025-04-14T12:47:05.839+0000 true 10072271 Andódy Katalin /api/admin/10072271 Admin Andódy Katalin (BME admin4) true 2026-01-01T03:36:50.006+0000 true 521 Szuper Admin /api/admin/521 Admin Szuper Admin (admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Orosz, Álmos true true /api/journal/3746 REVIEWED POWDER TECHNOLOGY 0032-5910 1873-328X true false 3746 false 3746 true 0032-5910 1873-328X Journal FOREIGN 458 120934 120934 10 2025 Our paper presents a simple method that bridges computational fluid dynamics (CFD) simulations with systematic experimentation using multivariable statistics, which was developed in the spirit of rapid applicability, quick transferability, and practical simplicity in the process development and scale-up stage. This applies to technologies that have already been developed on a small scale, and it applies when the focal point of scale-up is the stirring conditions, rather than heat transfer or other issues. We propose identifying the predictive CFD variables on the measured CQAs and then training a predictive model that allows us to estimate the CQAs from the simulated flow fields in a technology transfer. The case study of cooling crystallization of L-glutamic acid demonstrates the workflow. Small-scale experiments (0.5 L) are performed with varied active volume and agitation rates, and the particle size distributions (PSD) of the products are measured. The corresponding quasi-steady-state CFD simulations were executed to obtain the flow field using the k−ɛ turbulence model. A partial least squares (PLS)–based recursive feature selection identified the predictive mixing parameters from the plethora of available CFD variables and simultaneously built a predictive model for the product CQA-s. Five critical CFD variables were identified in this case study, all related to the shear-rate distributions. The calibrated optimal PLS model had two components, and allowed the prediction of the mean sizes of the product, that is, Dv10, Dv50, and Dv90 on a 5 L scale with 0.2, 16.4, and 1.2μm deviation from the measured values. This data-driven method simplifies and accelerates the CFD-based scale-up under certain conditions (moderate nonlinearities, flow-centric problem) but does not aim to replace the meticulously identified nonlinear first-principles models. © 2025 The Authors true true 2025 true true true false true false GOLD 2026-09-24 true https://doi.org/10.1016/j.powtec.2025.120934 4 0 4 4 0 4 3 3 3 3 3 3 3 4 0 0 4 4 4 4 0 3 3 Folyóiratcikk Journal Article 24 3 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 1 1 1 1 2026 0 3 3 3 3 Q1 false false false false 2025-04-13T12:47:05.560+0000 Hidrodinamikai Rendszerek Tanszék (BME / GPK); Kémiai és Környezeti Folyamatmérnöki Tanszék (BME / VBK); Vegyészmérnöki és Biomérnöki Kar (BME) 6 8 3 6 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 125689013 /api/authorship/125689013 Orosz, Álmos [Orosz, Álmos (kristályosítás, p...), szerző] Kémiai és Környezeti Folyamatmérnöki Tanszék (BME / VBK) 1 0.167 true false false Author 10083600 /api/author/10083600 Orosz Álmos (kristályosítás, populációmérleg modellezés) Orosz Álmos true true Orosz Álmos true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 125689014 /api/authorship/125689014 Sandor, Levente [Sándor, Levente (áramlástan), szerző] Hidrodinamikai Rendszerek Tanszék (BME / GPK) 2 0.167 false false false Author 10079796 /api/author/10079796 Sándor Levente (áramlástan) Sándor Levente true true Sandor Levente true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 125689015 /api/authorship/125689015 Firoozirad, Khadijeh [Firoozirad, Khadijeh (crystallization &...), szerző] Kémiai és Környezeti Folyamatmérnöki Tanszék (BME / VBK) 3 0.167 false false false Author 10085580 /api/author/10085580 Firoozirad Khadijeh (crystallization & process engineering) Firoozirad Khadijeh true true Firoozirad Khadijeh true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 125689016 /api/authorship/125689016 Pusztai, Eva [Pusztai, Éva (ipari statisztika), szerző] Kémiai és Környezeti Folyamatmérnöki Tanszék (BME / VBK) 4 0.167 false false false Author 10061361 /api/author/10061361 Pusztai Éva (ipari statisztika) Pusztai Éva true 10061361 true Pusztai Eva true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 125689017 /api/authorship/125689017 Nagy-Gyorgy, Peter ✉ [Nagy-György, Péter (gépészeti tudományok), szerző] Hidrodinamikai Rendszerek Tanszék (BME / GPK) 5 0.167 false false true Author 10061331 /api/author/10061331 Nagy-György Péter (gépészeti tudományok) Nagy-György Péter true 10061331 true Nagy-Gyorgy Peter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 125689018 /api/authorship/125689018 Szilagyi, Botond ✉ [Szilágyi, Botond (Folyamatmérnök, v...), szerző] Vegyészmérnöki és Biomérnöki Kar (BME) 6 0.167 false true true Author 10044851 /api/author/10044851 Szilágyi Botond (Folyamatmérnök, vegyészmérnök) Szilágyi Botond true 10044851 true Szilagyi Botond true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 29142704 /api/publicationidentifier/29142704 DOI: 10.1016/j.powtec.2025.120934 PlainSource 6 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(2025) POWDER TECHNOLOGY 0032-5910 1873-328X 458<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10083600"><a href="/gui2/?type=authors&mode=browse&sel=10083600" target="_blank">Orosz Álmos (<span class="authorship-author-name">Orosz Álmos</span> <span class="authorAux-mtmt"> kristályosítás, populációmérleg modellezés</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Kémiai és Környezeti Folyamatmérnöki Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10079796"><a href="/gui2/?type=authors&mode=browse&sel=10079796" target="_blank">Sandor Levente (<span class="authorship-author-name">Sándor Levente</span> <span class="authorAux-mtmt"> áramlástan</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Gépészmérnöki Kar">GPK</span>/Hidrodinamikai Rendszerek Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10085580"><a href="/gui2/?type=authors&mode=browse&sel=10085580" target="_blank">Firoozirad Khadijeh (<span class="authorship-author-name">Firoozirad Khadijeh</span> <span class="authorAux-mtmt"> crystallization & process engineering</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Kémiai és Környezeti Folyamatmérnöki Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061361"><a href="/gui2/?type=authors&mode=browse&sel=10061361" target="_blank">Pusztai Eva (<span class="authorship-author-name">Pusztai Éva</span> <span class="authorAux-mtmt"> ipari statisztika</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Kémiai és Környezeti Folyamatmérnöki Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061331"><a href="/gui2/?type=authors&mode=browse&sel=10061331" target="_blank">Nagy-Gyorgy Peter ✉ (<span class="authorship-author-name">Nagy-György Péter</span> <span class="authorAux-mtmt"> gépészeti tudományok</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Gépészmérnöki Kar">GPK</span>/Hidrodinamikai Rendszerek Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044851"><a href="/gui2/?type=authors&mode=browse&sel=10044851" target="_blank">Szilagyi Botond ✉ (<span class="authorship-author-name">Szilágyi Botond</span> <span class="authorAux-mtmt"> Folyamatmérnök, vegyészmérnök</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/Vegyészmérnöki és Biomérnöki Kar</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36051983" target="_blank">Streamlining crystallization process scale-up using statistical modeling of experiments and complementary CFD flow fields</a></div> <div> <span class="journal-title">POWDER TECHNOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0032-5910">0032-5910</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1873-328X">1873-328X</a>)</span>: <span class="journal-volume">458</span> <span class="page"> Paper 120934. 10 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1016/j.powtec.2025.120934" target="_blank" href="https://doi.org/10.1016/j.powtec.2025.120934"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001461794400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001461794400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105001403235" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105001403235"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://linkinghub.elsevier.com/retrieve/pii/S0032591025003298" target="_blank" href="https://linkinghub.elsevier.com/retrieve/pii/S0032591025003298"> Teljes dokumentum </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://phd.gpk.bme.hu/pub/s/j/l9/t2?11617246" target="_blank" href="https://phd.gpk.bme.hu/pub/s/j/l9/t2?11617246"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Chemical Engineering (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 4</span> | Független: 4 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 3 | Scopus jelölt:&nbsp;3 | WoS/Scopus jelölt:&nbsp;3 | DOI jelölt:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36051983&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36051983</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2026.01.13. 14:46 Pécsi Éva (MTMT Közp 2,3, admin) </div> </div></div>