https://m2.mtmt.hu/ hun 2026-10-23 04:04 JournalArticle 35958975 APPROVED true 0 false 2026-10-12T08:54:10.702+0000 2025-06-27T10:44:00.085+0000 2025-03-17T09:50:17.301+0000 true 10069641 Csűry-Bagaméry Beáta /api/admin/10069641 Admin false 2026-01-23T08:21:15.739+0000 2026-01-23T08:21:15.739+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Hajdu, Endre A Modified Viscoelastic Point-of-Care Method for Rapid Quantitative Detection of Enoxaparin: A Single-Centre Observational Study. true true /api/journal/10017543 REVIEWED true false 10017543 false 10017543 true 2077-0383 Journal FOREIGN 14 4 1328 1328 2025 Background: Laboratory monitoring of the effect of low-molecular-weight heparins (LMWHs) is generally not necessary. However, prompt evaluation of heparin inhibitory effects (i.e., anti-Xa activity) is important in cases of life-threatening bleeding, need for urgent surgery or acute thromboembolism under LMWH treatment. We aimed to establish a simple and reliable point-of-care method for the detection of enoxaparin. Methods: Eighty patients under enoxaparin therapy and ten healthy volunteers without any anticoagulant treatment were enrolled. Simultaneous measurements of anti-Xa activity using the chromogenic method and clotting times in the absence and presence of polybrene using viscoelastometric assays containing Russell's viper venom (RVV-test) were performed on the ClotPro device. Results: Among the measured and derived RVV-test parameters, the ratio of the RVV clotting times (RVV CT) detected in the absence and presence of polybrene showed the best statistically significant correlation with anti-Xa activity (r = 0.774, p < 0.001). Based on ROC analysis, we designated RVV CT ratios of 1.02, 1.23 and 1.6 as the best cut-off values for separating anti-Xa ranges below and above 0.3 and 0.6 IU/mL, respectively. If the RVV CT ratio is below or above 1.23, the anti-Xa activity is suggested to be below 0.6 IU/mL or above 0.3 IU/mL with high certainty, respectively. Further differentiation is possible if the RVV CT ratio is measured below 1.02 or above 1.6. In these cases, the measured anti-Xa values are below 0.3 IU/mL or above 0.6 IU/mL, respectively, with high probability and good predictive values. Conclusions: Our method can provide semiquantitative information on the effect of enoxaparin and the expected anti-Xa activity within 10 min in real clinical situations. 2025 true true true false true false GOLD 2026-10-12 false http://www.mdpi.com/journal/jcm 1 0 1 1 0 1 1 1 1 1 1 1 1 1 0 0 1 1 1 1 0 1 1 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 1 1 1 1 Q2 false 10038165,10022095 false false false 2025-04-09T11:38:15.256+0000 Aneszteziológiai és Intenzív Terápiás Tanszék (DE / ÁOK); Hematológiai Tanszék (DE / ÁOK / BelgyI); Klinikai Laboratóriumi Kutató Tanszék (DE / ÁOK / LMI); Onkológiai Tanszék (DE / ÁOK) 8 30 4 9 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 124708799 /api/authorship/124708799 1 0.111 true false true Author 10096495 /api/author/10096495 Hajdu Endre true true Hajdu Endre true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 124708800 /api/authorship/124708800 2 0.111 false false false Author 10078222 /api/author/10078222 Molnár Éva true true Molnar Eva true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 124708801 /api/authorship/124708801 3 0.111 false false false Author 10052973 /api/author/10052973 Rázsó Katalin true 10052973 true Razso Katalin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 124708802 /api/authorship/124708802 4 0.111 false false false Author 10075247 /api/author/10075247 Schlammadinger Ágota true true Schlammadinger Agota true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 124708803 /api/authorship/124708803 5 0.111 false false false Author 10060606 /api/author/10060606 Árokszállási Anita true 10060606 true Arokszallasi Anita true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 124708804 /api/authorship/124708804 6 0.11111111 false false false Lukacs Csenge Greta true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 124708805 /api/authorship/124708805 7 0.111 false false false Author 10013888 /api/author/10013888 Fülesdi Béla true 10013888 true Fulesdi Bela true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 124708806 /api/authorship/124708806 8 0.111 false false true Author 10022095 /api/author/10022095 Bereczky Zsuzsanna true 10022095 true Bereczky Zsuzsanna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 124708807 /api/authorship/124708807 9 0.111 false true true Author 10038165 /api/author/10038165 Oláh Zsolt true 10038165 true Olah Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 28929268 /api/publicationidentifier/28929268 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/jcm14041328 https://doi.org/10.3390/jcm14041328 false true PublicationIdentifier 28929269 /api/publicationidentifier/28929269 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001430752800001 https://www.webofscience.com/wos/woscc/full-record/001430752800001 false true PublicationIdentifier 29223694 /api/publicationidentifier/29223694 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85218852567 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85218852567 false true PublicationIdentifier 28929267 /api/publicationidentifier/28929267 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true 40004857 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40004857&dopt=Abstract false true Keyword 539 /api/keyword/539 true 539 true Keyword 1016421 /api/keyword/1016421 true 1016421 true Keyword 1496976 /api/keyword/1496976 true true Keyword 3796828 /api/keyword/3796828 true true Keyword 3796829 /api/keyword/3796829 true true SjrRating 11603514 /api/sjrrating/11603514 638 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true Q2 DIRECT true true /api/publication/35958975 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10096495"><a href="/gui2/?type=authors&mode=browse&sel=10096495" target="_blank">Hajdu Endre ✉ (<span class="authorship-author-name">Hajdu Endre</span> <span class="authorAux-mtmt"> Aneszteziológia és intenzív terápia, hemosztázis</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Aneszteziológiai és Intenzív Terápiás Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10078222"><a href="/gui2/?type=authors&mode=browse&sel=10078222" target="_blank">Molnar Eva (<span class="authorship-author-name">Molnár Éva</span> <span class="authorAux-mtmt"> hemosztázis</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Laboratóriumi Medicina Intézet">LMI</span>/Klinikai Laboratóriumi Kutató Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052973"><a href="/gui2/?type=authors&mode=browse&sel=10052973" target="_blank">Razso Katalin (<span class="authorship-author-name">Rázsó Katalin</span> <span class="authorAux-mtmt"> belgyógyászat, kardiológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Belgyógyászati Intézet">BelgyI</span>/Hematológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075247"><a href="/gui2/?type=authors&mode=browse&sel=10075247" target="_blank">Schlammadinger Agota (<span class="authorship-author-name">Schlammadinger Ágota</span> <span class="authorAux-mtmt"> hemosztázis</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Belgyógyászati Intézet">BelgyI</span>/Hematológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060606"><a href="/gui2/?type=authors&mode=browse&sel=10060606" target="_blank">Arokszallasi Anita (<span class="authorship-author-name">Árokszállási Anita</span> <span class="authorAux-mtmt"> Onkológia, belgyógyászat, általános orvos</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lukacs Csenge Greta </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013888"><a href="/gui2/?type=authors&mode=browse&sel=10013888" target="_blank">Fulesdi Bela (<span class="authorship-author-name">Fülesdi Béla</span> <span class="authorAux-mtmt"> Aneszteziológia és intenzív terápia; neurológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Aneszteziológiai és Intenzív Terápiás Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10022095"><a href="/gui2/?type=authors&mode=browse&sel=10022095" target="_blank">Bereczky Zsuzsanna ✉ (<span class="authorship-author-name">Bereczky Zsuzsanna</span> <span class="authorAux-mtmt"> véralvadás</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Laboratóriumi Medicina Intézet">LMI</span>/Klinikai Laboratóriumi Kutató Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038165"><a href="/gui2/?type=authors&mode=browse&sel=10038165" target="_blank">Olah Zsolt ✉ (<span class="authorship-author-name">Oláh Zsolt</span> <span class="authorAux-mtmt"> belgyógyászat; aneszteziológia és intenzív terápia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Aneszteziológiai és Intenzív Terápiás Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35958975" target="_blank">A Modified Viscoelastic Point-of-Care Method for Rapid Quantitative Detection of Enoxaparin: A Single-Centre Observational Study.</a></div> <div> <span class="journal-title">JOURNAL OF CLINICAL MEDICINE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2077-0383">2077-0383</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">4</span> <span class="page"> Paper 1328. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/jcm14041328" target="_blank" href="https://doi.org/10.3390/jcm14041328"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001430752800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001430752800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85218852567" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85218852567"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="40004857" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40004857&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 1 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35958975&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35958975</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.06.27. 12:44 Pécsi Éva (MTMT Közp 2,3, admin) </div> </div></div>