https://m2.mtmt.hu/ hun 2026-06-27 11:56 JournalArticle 35949386 VALIDATED true 0 false 2026-05-24T17:41:14.679+0000 2025-04-10T09:02:53.356+0000 2025-03-16T19:11:08.046+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 2025-07-07T12:53:05.817+0000 2025-07-07T12:53:05.817+0000 2025-04-10T09:02:53.362+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Schneider, Luca Catecholaminergic Polymorphic Ventricular Tachycardia: Advancing From Molecular Insights to Preclinical Models true true /api/journal/10024761 REVIEWED true false 10024761 false 10024761 true 2047-9980 2047-9980 Journal FOREIGN 14 6 e038308 e038308 14 2025 Inherited cardiac channelopathies are linked to a heightened risk of sudden cardiac death. Despite evolving knowledge on different genes for these inherited conditions, for certain subtypes, such as catecholaminergic polymorphic ventricular tachycardia syndrome, the specific genetic causes remain unidentified. The research of the pathophysiological mechanisms underlying catecholaminergic polymorphic ventricular tachycardia syndrome has been conducted through different in vitro and in vivo models, including genetically modified animal models, cardiac‐specific transgenic models, pharmacological interventions in animal models, human‐induced pluripotent stem cell–derived cardiomyocytes in 2‐ and 3‐dimensional cardiac models. Recent research predominantly utilizes human‐induced pluripotent stem cell–derived cardiomyocytes, focusing on genotype–phenotype correlations and pharmacological screening. The integration of cutting‐edge techniques such as clustered regularly interspaced short palindromic repeats/Cas9 genome editing and 3‐dimensional–engineered heart tissues has shed new light on the pathophysiological mechanisms of catecholaminergic polymorphic ventricular tachycardia, potentially enhancing drug therapies as part of personalized medicine approaches. This review emphasizes the diverse insights gained from both in vivo and in vitro studies of catecholaminergic polymorphic ventricular tachycardia, along with the application of these models in various research contexts. true 2025 true true true false true false GOLD 2026-05-24 false http://jaha.ahajournals.org 4 0 4 4 0 4 4 4 1 4 4 4 4 4 0 0 4 4 4 4 0 0 0 Folyóiratcikk Journal Article 24 4 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 2 2 2 2 2026 0 2 2 2 2 D1 false false false false 2025-04-09T09:01:31.390+0000 Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); Farmakológiai és Gyógyszerkutatás-fejlesztési K... (SE / KSZE); HCEMM- SE Kardiovaszkuláris Komorbiditások Kuta... (SE / AOK / I / FFI) 1 8 3 6 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 124643019 /api/authorship/124643019 1 0.16666667 true false false Schneider Luca true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 124643020 /api/authorship/124643020 2 0.16666667 false false false Begovic Merima true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 124643021 /api/authorship/124643021 3 0.16666667 false false false Zhou Xiaobo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 124643022 /api/authorship/124643022 4 0.167 false false false Author 10086357 /api/author/10086357 Hamdani Nazha true true Hamdani Nazha true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 124643023 /api/authorship/124643023 5 0.16666667 false false false Akin Ibrahim true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 124643024 /api/authorship/124643024 6 0.167 false true true El‐Battrawy Ibrahim true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 28909139 /api/publicationidentifier/28909139 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1161/JAHA.124.038308 https://doi.org/10.1161/JAHA.124.038308 false true PublicationIdentifier 29222984 /api/publicationidentifier/29222984 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001446634500001 https://www.webofscience.com/wos/woscc/full-record/001446634500001 false true PublicationIdentifier 29222985 /api/publicationidentifier/29222985 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105001223883 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105001223883 false true PublicationIdentifier 28909140 /api/publicationidentifier/28909140 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 40079282 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40079282&dopt=Abstract false true Classification 12139 /api/classification/12139 true true SjrRating 11563288 /api/sjrrating/11563288 37 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 true 2705 true D1 DIRECT true true Reference 64910120 /api/reference/64910120 1 10.1016/j.hrcr.2018.04.003 false true Reference 64910121 /api/reference/64910121 2 10.3390/ijms22179293 false true Reference 64910122 /api/reference/64910122 3 10.1038/s10038-020-0738-6 false true Reference 64910123 /api/reference/64910123 4 10.1136/jmg.2004.028993 false true Reference 64910124 /api/reference/64910124 5 10.15420/aer.2022.09 false true Reference 64910125 /api/reference/64910125 6 10.1016/j.pcad.2019.05.006 false true Reference 64910126 /api/reference/64910126 7 10.3238/arztebl.m2024.0130 false true Reference 64910127 /api/reference/64910127 8 10.1016/j.hrthm.2006.08.018 false true Reference 64910128 /api/reference/64910128 9 10.1002/ejhf.541 false true Reference 64910129 /api/reference/64910129 10 10.1001/jamacardio.2017.1320 false true Reference 64910130 /api/reference/64910130 11 10.1016/j.ccep.2023.04.002 false true Reference 64910131 /api/reference/64910131 12 10.1007/s00399-023-00937-4 false true Reference 64910132 /api/reference/64910132 13 10.1093/europace/euad091 false true Reference 64910133 /api/reference/64910133 14 10.1186/2044-5040-1-18 false true Reference 64910134 /api/reference/64910134 15 10.1016/j.jacc.2020.12.073 false true Reference 64910135 /api/reference/64910135 16 10.1016/j.genrep.2019.100439 false true Reference 64910136 /api/reference/64910136 17 10.1016/j.yjmcc.2016.08.020 false true Reference 64910137 /api/reference/64910137 18 10.1073/pnas.1419795112 false true Reference 64910138 /api/reference/64910138 19 10.1007/s00431-010-1154-2 false true Reference 64910139 /api/reference/64910139 20 10.1093/eurheartj/ehab687 false true Reference 64910140 /api/reference/64910140 21 10.15252/emmm.201505719 false true Reference 64910141 /api/reference/64910141 22 10.3390/cells12020204 false true Reference 64910142 /api/reference/64910142 23 10.1080/19336950.2017.1344799 false true Reference 64910143 /api/reference/64910143 24 10.1073/pnas.0402388101 false true Reference 64910144 /api/reference/64910144 25 10.1016/j.joa.2015.09.008 false true Reference 64910145 /api/reference/64910145 26 10.1093/eurheartj/suab104 false true Reference 64910146 /api/reference/64910146 27 10.1016/j.tcm.2020.04.011 false true Reference 64910147 /api/reference/64910147 28 10.1161/CIRCRESAHA.111.243956 false true Reference 64910148 /api/reference/64910148 29 10.1161/CIRCRESAHA.118.313406 false true Reference 64910149 /api/reference/64910149 30 10.1161/JAHA.117.008155 false true Reference 64910150 /api/reference/64910150 31 10.1016/j.bpj.2022.11.2769 false true Reference 64910151 /api/reference/64910151 32 10.1016/j.bpj.2023.11.2781 false true Reference 64910152 /api/reference/64910152 33 10.1038/s41598-023-27503-9 false true Reference 64910153 /api/reference/64910153 34 10.3390/cells7060048 false true Reference 64910154 /api/reference/64910154 35 10.1161/CIRCULATIONAHA.119.039711 false true Reference 64910155 /api/reference/64910155 36 10.1016/j.yjmcc.2020.04.017 false true Reference 64910156 /api/reference/64910156 37 10.1111/j.1540-8167.2007.00766.x false true Reference 64910157 /api/reference/64910157 38 10.1016/j.bpj.2023.11.2782 false true Reference 64910158 /api/reference/64910158 39 10.1016/j.bpj.2023.11.2776 false true Reference 64910159 /api/reference/64910159 40 10.1515/med-2023-0880 false true Reference 64910160 /api/reference/64910160 41 10.1161/res.133.suppl_1.P3135 false true Reference 64910161 /api/reference/64910161 42 10.1161/CIRCULATIONAHA.111.075382 false true Reference 64910162 /api/reference/64910162 43 10.3390/jcm9040903 false true Reference 64910163 /api/reference/64910163 44 10.1161/CIRCRESAHA.121.319094 false true Reference 64910164 /api/reference/64910164 45 10.1172/jci.insight.151893 false true Reference 64910165 /api/reference/64910165 46 10.20517/jca.2023.42 false true Reference 64910166 /api/reference/64910166 47 10.1161/CIRCULATIONAHA.113.006901 false true Reference 64910167 /api/reference/64910167 48 10.1093/eurheartj/ehad655.3135 false true Reference 64910168 /api/reference/64910168 49 10.1016/j.bpj.2023.11.3228 false true Reference 64910169 /api/reference/64910169 50 10.1146/annurev-pharmtox-051421-111814 false true Reference 64910170 /api/reference/64910170 51 10.1126/scitranslmed.abq7839 false true Reference 64910171 /api/reference/64910171 52 10.1161/CIRCEP.110.959916 false true Reference 64910172 /api/reference/64910172 53 10.1038/nm.1942 false true Reference 64910173 /api/reference/64910173 54 10.1161/CIRCRESAHA.120.316819 false true Reference 64910174 /api/reference/64910174 55 10.3389/fphar.2019.01566 false true Reference 64910175 /api/reference/64910175 56 10.1038/cddis.2013.369 false true Reference 64910176 /api/reference/64910176 57 10.1124/jpet.122.001455 false true Reference 64910177 /api/reference/64910177 58 10.1152/physrev.00041.2017 false true Reference 64910178 /api/reference/64910178 59 10.1017/CBO9781139344319 false true Reference 64910179 /api/reference/64910179 60 10.3390/bioengineering9040168 false true Reference 64910180 /api/reference/64910180 61 10.1016/j.scr.2021.102259 false true Reference 64910181 /api/reference/64910181 62 10.1002/emmm.201100194 false true Reference 64910182 /api/reference/64910182 63 10.1007/s11033-019-05201-y false true Reference 64910183 /api/reference/64910183 64 10.1016/j.jacc.2012.02.066 false true Reference 64910184 /api/reference/64910184 65 10.1242/dmm.026823 false true Reference 64910185 /api/reference/64910185 66 10.3390/ijms22062825 false true Reference 64910186 /api/reference/64910186 67 10.1111/jcmm.12581 false true Reference 64910187 /api/reference/64910187 68 10.1161/CIRCEP.116.004725 false true Reference 64910188 /api/reference/64910188 69 10.1161/CIRCEP.122.011387 false true Reference 64910189 /api/reference/64910189 70 10.3389/fcell.2020.00178 false true Reference 64910190 /api/reference/64910190 71 10.1038/s41586-020-2797-4 false true Reference 64910191 /api/reference/64910191 72 10.1161/CIRCRESAHA.115.307778 false true Reference 64910192 /api/reference/64910192 73 10.1038/s41598-022-22225-w false true Reference 64910193 /api/reference/64910193 74 10.3791/61962 false true Reference 64910194 /api/reference/64910194 75 10.1016/j.stem.2020.05.004 false true Reference 64910195 /api/reference/64910195 76 10.1002/jbm.a.37428 false true Reference 64910196 /api/reference/64910196 77 10.1089/ten.tea.2016.0027 false true Reference 64910197 /api/reference/64910197 78 10.1007/978-3-031-23965-6_7 false true Reference 64910198 /api/reference/64910198 79 10.3389/fbioe.2023.1155052 false true Reference 64910199 /api/reference/64910199 80 10.1016/j.bios.2022.114840 false true Reference 64910200 /api/reference/64910200 81 10.3389/fcvm.2022.967659 false true Reference 64910201 /api/reference/64910201 82 10.1097/FJC.0000000000000972 false true Reference 64910202 /api/reference/64910202 83 10.1016/j.ymeth.2021.06.009 false true Reference 64910203 /api/reference/64910203 84 10.1089/ten.teb.2021.0088 false true Reference 64910204 /api/reference/64910204 85 10.1016/j.ppedcard.2017.07.001 false true Reference 64910205 /api/reference/64910205 86 10.3390/ijms21176388 false true Reference 64910206 /api/reference/64910206 87 10.3390/ijms21124354 false true Reference 64910207 /api/reference/64910207 88 10.1016/j.hlc.2019.10.013 false true Reference 64910208 /api/reference/64910208 89 10.1113/JP284739 false true Reference 64910209 /api/reference/64910209 90 10.1016/j.hrthm.2018.08.025 false true Reference 64910210 /api/reference/64910210 91 10.1093/cvr/cvae009 false true Reference 64910211 /api/reference/64910211 92 10.4103/apc.apc_96_23 false true Reference 64910212 /api/reference/64910212 93 10.3390/jpm12040536 false true Reference 64910213 /api/reference/64910213 94 10.3390/jcm13061781 false true Reference 64910214 /api/reference/64910214 95 10.1016/j.jelectrocard.2024.03.013 false true /api/publication/35949386 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" >Schneider Luca </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Begovic Merima </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zhou Xiaobo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10086357"><a href="/gui2/?type=authors&mode=browse&sel=10086357" target="_blank">Hamdani Nazha (<span class="authorship-author-name">Hamdani Nazha</span> <span class="authorAux-mtmt"> Medicine</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/HCEMM- SE Kardiovaszkuláris Komorbiditások Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Akin Ibrahim </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >El‐Battrawy Ibrahim ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35949386" target="_blank">Catecholaminergic Polymorphic Ventricular Tachycardia: Advancing From Molecular Insights to Preclinical Models</a></div> <div> <span class="journal-title">JOURNAL OF THE AMERICAN HEART ASSOCIATION</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2047-9980">2047-9980</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2047-9980">2047-9980</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">6</span> <span class="page"> Paper e038308. 14 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1161/JAHA.124.038308" target="_blank" href="https://doi.org/10.1161/JAHA.124.038308"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001446634500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001446634500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105001223883" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105001223883"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40079282" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40079282&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 4</span> | Független: 4 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 4 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;4 | DOI jelölt:&nbsp;4 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35949386</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.04.10. 11:02 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> </div></div>