https://m2.mtmt.hu/ hun 2026-07-27 21:04 JournalArticle 35830704 VALIDATED true Funding Agency and Grant Number: Hungarian Academy of Sciences [LP2022-5/2022]; European Research Council [ERC-CoG 724994, ERC-StGs 802305]; Hungarian Brain Research Program [NAP2022-I-1/2022]; German Research Foundation under Germany's Excellence Strategy [EXC 2145, FOR 2879, 405358801, TRR 274, 408885537]; Hungarian National Research, Development and Innovation Fund [OTKA K131844, 147109]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences; New National Excellence Program of the Ministry for Innovation and Technology [UNKP-23-5, UNKP-23-4-I]; Ministry of Culture and Innovation of Hungary from the National Research, Development and Innovation Fund [KDP-12-10/PALY-2022]; Gedeon Richter's Talentum Foundation, National Research, Development and Innovation Office grant, Hungary [NKFIH_SNN_132999]; New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund [UNKP-22-3]; National Academy of Scientist Education Program of the National Biomedical Foundation; [PC2022-4/2022] Funding text: We thank the Microscopy Center, the Cell Biology Center and the Human Brain Research Laboratory at the Institute of Experimental Medicine for kindly providing support in microscopy, measurement of inflammatory mediators and human brain samples, respectively. We are also grateful to M. Palkovits for his help in isolating medullary autonomic nuclei. This work was supported by the post-COVID program grant of the Hungarian Academy of Sciences (grant no. PC2022-4/2022), the 'Momentum' research grant from the Hungarian Academy of Sciences (grant no. LP2022-5/2022 to & Aacute;.D.), the European Research Council (grant nos. ERC-CoG 724994 to & Aacute;.D. and ERC-StGs 802305 to A.L.), the Hungarian Brain Research Program (grant no. NAP2022-I-1/2022 to & Aacute;.D.) and the German Research Foundation under Germany's Excellence Strategy (EXC 2145 SyNergy-ID), through FOR 2879 (ID 405358801) and TRR 274 (ID 408885537). Support was also received from the Hungarian National Research, Development and Innovation Fund (grant no. OTKA K131844 to S.B.). C.C. was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. C.C. (grant no. UNKP-23-5) and B.P. (grant no. UNKP-23-4-I) were supported by the New National Excellence Program of the Ministry for Innovation and Technology. Project no. KDP-12-10/PALY-2022 has been implemented with the support provided by the Ministry of Culture and Innovation of Hungary from the National Research, Development and Innovation Fund, financed under the KDP-2021 funding scheme (to A.D.S.). A.D.S. was supported by the Gedeon Richter's Talentum Foundation, National Research, Development and Innovation Office grant, Hungary (grant no. NKFIH_SNN_132999 to T.H.). E.B. (grant no. UNKP-22-3) was supported by the New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund. This research work was conducted with the support of the National Academy of Scientist Education Program of the National Biomedical Foundation under the sponsorship of the Hungarian Ministry of Culture and Innovation (S.V.). Support was also received from the Hungarian National Research, Development and Innovation Fund (grant nos. OTKA K131844 and 147109 to S.B.). 0 false 2026-07-23T14:36:18.045+0000 2026-05-04T09:09:42.989+0000 2025-03-09T08:11:21.865+0000 true 10040261 Vigyikánné Váradi Anikó /api/admin/10040261 Admin true 10040261 2026-05-19T12:28:51.824+0000 2026-05-19T12:28:51.824+0000 2025-07-14T11:52:24.851+0000 true 10097128 Sass Dávid /api/admin/10097128 Admin true Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2026-05-20T07:50:08.400+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Fekete, Rebeka Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19 true true /api/journal/19517 REVIEWED true false 19517 false 19517 true 1097-6256 1546-1726 Journal FOREIGN 28 3 558 576 558 19 2025 COVID-19 is associated with diverse neurological abnormalities, but the underlying mechanisms are unclear. We hypothesized that microglia, the resident immune cells of the brain, are centrally involved in this process. To study this, we developed an autopsy platform allowing the integration of molecular anatomy, protein and mRNA datasets in postmortem mirror blocks of brain and peripheral organ samples from cases of COVID-19. We observed focal loss of microglial P2Y12R, CX3CR1–CX3CL1 axis deficits and metabolic failure at sites of virus-associated vascular inflammation in severely affected medullary autonomic nuclei and other brain areas. Microglial dysfunction is linked to mitochondrial injury at sites of excessive synapse and myelin phagocytosis and loss of glutamatergic terminals, in line with proteomic changes of synapse assembly, metabolism and neuronal injury. Furthermore, regionally heterogeneous microglial changes are associated with viral load and central and systemic inflammation related to interleukin (IL)-1 or IL-6 via virus-sensing pattern recognition receptors and inflammasomes. Thus, SARS-CoV-2-induced inflammation might lead to a primarily gliovascular failure in the brain, which could be a common contributor to diverse COVID-19-related neuropathologies. Funding 2050591 /api/funding/2050591 false true Funding 2050593 /api/funding/2050593 false true Funding 2050590 /api/funding/2050590 false true Funding 2050592 /api/funding/2050592 false true Funding 2050594 /api/funding/2050594 false true Funding 2050595 /api/funding/2050595 false true Funding 2051146 /api/funding/2051146 false true Funding 2051147 /api/funding/2051147 false true true true 2025 true true true false true false GOLD 2026-07-23 true https://doi.org/10.1038/s41593-025-01871-z 35 0 35 34 4 34 34 35 34 35 35 34 34 34 1 0 35 34 35 34 0 11 11 Folyóiratcikk Journal Article 24 35 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 16 15 16 15 2026 0 19 19 19 19 D1 false 10061311,10003072,10061174 false false false 2025-03-20T08:46:37.461+0000 Anatómiai, Szövet- és Fejlődéstani Intézet (SE / AOK / I); Doktori Iskola (SE); HUN-REN Kísérleti Orvostudományi Kutatóintézet; Információs Technológiai és Bionikai Kar (PPKE); Neuroimmunológiai Kutatócsoport (HRN KOKI); Pathologiai Intézet (SZTE / SZAOK); Roska Tamás Műszaki és Természettudományi Dokto... (PPKE / ITK); Thalamus Kutatócsoport (HRN KOKI); Tüdőgyógyászati Klinika (SZTE / SZAOK); Élettani Intézet (DE / ÁOK) 21 89 10 24 0 true 10025544 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 123801901 /api/authorship/123801901 1 0.042 true false false Author 10049451 /api/author/10049451 Fekete Rebeka true 10049451 true Fekete Rebeka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801902 /api/authorship/123801902 2 0.041666668 false false false Simats Alba true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801903 /api/authorship/123801903 3 0.041666668 false false false Author 10078021 /api/author/10078021 Bíró Eduárd true true Bíró Eduárd true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801904 /api/authorship/123801904 4 0.042 false false false Author 10061174 /api/author/10061174 Pósfai Balázs true 10061174 true Pósfai Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801905 /api/authorship/123801905 5 0.042 false false false Author 172 /api/author/172 Cserép Csaba true 172 true Cserép Csaba true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801906 /api/authorship/123801906 6 0.042 false false false Author 10063826 /api/author/10063826 Schwarcz Dóra Anett true 10063826 true Schwarcz Anett D. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801907 /api/authorship/123801907 7 0.042 false false false Author 173 /api/author/173 Cserépné Szabadits Eszter true 173 true Szabadits Eszter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801908 /api/authorship/123801908 8 0.042 false false false Author 10011503 /api/author/10011503 Környei Zsuzsanna true 10011503 true Környei Zsuzsanna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801909 /api/authorship/123801909 9 0.042 false false false Author 10064506 /api/author/10064506 Tóth Krisztina true 10064506 true Tóth Krisztina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801910 /api/authorship/123801910 10 0.041666668 false false false Author 10061311 /api/author/10061311 Fichó Erzsébet true 10061311 true Fichó Erzsébet true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801911 /api/authorship/123801911 11 0.041666668 false false false Author 10091234 /api/author/10091234 Szalma János true true Szalma János true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801912 /api/authorship/123801912 12 0.041666668 false false false Author 10104526 /api/author/10104526 Vida Sára true true Vida Sára true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801913 /api/authorship/123801913 13 0.042 false false false Author 10085407 /api/author/10085407 Kellermayer Anna true true Kellermayer Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801914 /api/authorship/123801914 14 0.042 false false false Author 10018448 /api/author/10018448 Dávid Csaba true 10018448 true Dávid Csaba true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801915 /api/authorship/123801915 15 0.042 false false false Author 10009548 /api/author/10009548 Acsády László true 10009548 true Acsády László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801916 /api/authorship/123801916 16 0.042 false false false Author 10057362 /api/author/10057362 Kontra Levente true 10057362 true Kontra Levente true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801917 /api/authorship/123801917 17 0.041666668 false false false Silvestre-Roig Carlos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801918 /api/authorship/123801918 18 0.042 false false false Author 10003072 /api/author/10003072 Moldvay Judit true 10003072 true Moldvay Judit true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801919 /api/authorship/123801919 19 0.041666668 false false false Author 10023823 /api/author/10023823 Fillinger János true 10023823 true Fillinger János true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801920 /api/authorship/123801920 20 0.041666668 false false false Author 10012379 /api/author/10012379 Csikász-Nagy Attila true 10012379 true Csikász-Nagy Attila true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801921 /api/authorship/123801921 21 0.042 false false false Author 10017334 /api/author/10017334 Hortobágyi Tibor true 10017334 true Hortobágyi Tibor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801922 /api/authorship/123801922 22 0.041666668 false false false Liesz Arthur true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801923 /api/authorship/123801923 23 0.041666668 false false false Author 10020759 /api/author/10020759 Benkő Szilvia true 10020759 true Benkő Szilvia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123801924 /api/authorship/123801924 24 0.042 false true true Author 10012934 /api/author/10012934 Dénes Ádám true 10012934 true Dénes Ádám true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 28649664 /api/publicationidentifier/28649664 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1038/s41593-025-01871-z https://doi.org/10.1038/s41593-025-01871-z false true PublicationIdentifier 28929689 /api/publicationidentifier/28929689 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001438314000001 https://www.webofscience.com/wos/woscc/full-record/001438314000001 false true PublicationIdentifier 29871813 /api/publicationidentifier/29871813 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GOLD true 224630 https://real.mtak.hu/224630 false true PublicationIdentifier 29114115 /api/publicationidentifier/29114115 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 86000334207 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-86000334207 true true PublicationIdentifier 28649830 /api/publicationidentifier/28649830 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 40050441 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40050441&dopt=Abstract false true PublicationIdentifier 29859750 /api/publicationidentifier/29859750 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true NONE IDENTICAL https://www.scopus.com/inward/record.uri?eid=2-s2.0-86000334207&doi=10.1038%2Fs41593-025-01871-z&partnerID=40&md5=826c846545878f373832c91e970a030c https://www.scopus.com/inward/record.uri?eid=2-s2.0-86000334207&doi=10.1038%2Fs41593-025-01871-z&partnerID=40&md5=826c846545878f373832c91e970a030c false true Classification 12124 /api/classification/12124 true true Keyword 1069492 /api/keyword/1069492 true 1069492 true Keyword 3225075 /api/keyword/3225075 true true SjrRating 11607930 /api/sjrrating/11607930 1 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2801 /api/classificationexternal/2801 true 2801 true D1 DIRECT true true Reference 64755335 /api/reference/64755335 1 10.1016/S1474-4422(21)00252-0 false true Reference 64755336 /api/reference/64755336 2 10.1016/j.bbih.2021.100290 false true Reference 64755337 /api/reference/64755337 3 10.1111/bpa.13013 false true Reference 64755338 /api/reference/64755338 4 10.1038/s41577-022-00762-9 false true Reference 64755339 /api/reference/64755339 5 10.1016/S2352-3026(20)30216-7 false true Reference 64755340 /api/reference/64755340 6 10.1038/s41593-020-00758-5 false true Reference 64755341 /api/reference/64755341 7 10.1093/brain/awaa240 false true Reference 64755342 /api/reference/64755342 8 10.1038/s41586-022-04569-5 false true Reference 64755343 /api/reference/64755343 9 10.1126/science.abm2052 false true Reference 64755344 /api/reference/64755344 10 10.1038/s41579-022-00846-2 false true Reference 64755345 /api/reference/64755345 11 10.1038/s41584-021-00608-z false true Reference 64755346 /api/reference/64755346 12 10.1093/hmg/ddab324 false true Reference 64755347 /api/reference/64755347 13 10.1016/j.immuni.2021.06.002 false true Reference 64755348 /api/reference/64755348 14 10.1038/s41586-021-03710-0 false true Reference 64755349 /api/reference/64755349 15 10.1111/bpa.12997 false true Reference 64755350 /api/reference/64755350 16 10.1007/s00401-020-02213-y false true Reference 64755351 /api/reference/64755351 17 10.1093/brain/awab148 false true Reference 64755352 /api/reference/64755352 18 10.1016/S1474-4422(20)30308-2 false true Reference 64755353 /api/reference/64755353 19 10.1016/j.conb.2022.102608 false true Reference 64755354 /api/reference/64755354 20 10.1007/s00401-021-02314-2 false true Reference 64755355 /api/reference/64755355 21 10.1186/s12974-021-02339-0 false true Reference 64755356 /api/reference/64755356 22 10.1038/s41380-022-01831-0 false true Reference 64755357 /api/reference/64755357 23 10.17879/freeneuropathology-2020-2818 false true Reference 64755358 /api/reference/64755358 24 10.3389/fcell.2022.824851 false true Reference 64755359 /api/reference/64755359 25 10.1038/nn1805 false true Reference 64755360 /api/reference/64755360 26 10.1084/jem.20211071 false true Reference 64755361 /api/reference/64755361 27 10.1038/s41467-021-25590-8 false true Reference 64755362 /api/reference/64755362 28 10.1038/nn.2887 false true Reference 64755363 /api/reference/64755363 29 10.1111/j.1538-7836.2006.01995.x false true Reference 64755364 /api/reference/64755364 30 10.1111/jnc.13415 false true Reference 64755365 /api/reference/64755365 31 10.1016/j.bbi.2009.09.010 false true Reference 64755366 /api/reference/64755366 32 10.1182/blood.V77.8.1627.1627 false true Reference 64755367 /api/reference/64755367 33 10.1038/nri1664 false true Reference 64755368 /api/reference/64755368 34 10.1038/s41591-020-1051-9 false true Reference 64755369 /api/reference/64755369 35 10.1093/infdis/jiab604 false true Reference 64755370 /api/reference/64755370 36 10.7754/Clin.Lab.2022.211201 false true Reference 64755371 /api/reference/64755371 37 10.3389/fimmu.2021.746021 false true Reference 64755372 /api/reference/64755372 38 10.1038/nn1715 false true Reference 64755373 /api/reference/64755373 39 false true Reference 64755374 /api/reference/64755374 40 10.1038/nri.2016.58 false true Reference 64755375 /api/reference/64755375 41 10.1038/s41590-021-01091-0 false true Reference 64755376 /api/reference/64755376 42 10.1038/s41467-021-21246-9 false true Reference 64755377 /api/reference/64755377 43 10.1016/j.cell.2020.04.002 false true Reference 64755378 /api/reference/64755378 44 10.1038/s41591-023-02673-1 false true Reference 64755379 /api/reference/64755379 45 10.1038/nri.2016.70 false true Reference 64755380 /api/reference/64755380 46 10.1016/j.neuron.2020.11.007 false true Reference 64755381 /api/reference/64755381 47 10.1016/j.celrep.2020.107968 false true Reference 64755382 /api/reference/64755382 48 10.1152/physrev.00031.2018 false true Reference 64755383 /api/reference/64755383 49 10.1038/s41467-022-34068-0 false true Reference 64755384 /api/reference/64755384 50 10.1186/s40478-019-0795-2 false true Reference 64755385 /api/reference/64755385 51 10.1007/s13365-018-0695-4 false true Reference 64755386 /api/reference/64755386 52 10.1111/ene.15045 false true Reference 64755387 /api/reference/64755387 53 10.1128/jvi.01969-21 false true Reference 64755388 /api/reference/64755388 54 10.1002/glia.22423 false true Reference 64755389 /api/reference/64755389 55 10.1016/j.it.2019.02.001 false true Reference 64755390 /api/reference/64755390 56 10.1038/s41591-022-02156-9 false true Reference 64755391 /api/reference/64755391 57 10.1038/s41591-020-1038-6 false true Reference 64755392 /api/reference/64755392 58 10.1128/JCM.00958-20 false true Reference 64755393 /api/reference/64755393 59 10.1186/s12974-023-02711-2 false true Reference 64755394 /api/reference/64755394 60 10.1172/jci.insight.150542 false true Reference 64755395 /api/reference/64755395 61 10.1093/brain/awab302 false true Reference 64755396 /api/reference/64755396 62 10.1101/2023.01.25.524586 false true Reference 64755397 /api/reference/64755397 63 10.1007/s00401-018-1885-0 false true Reference 64755398 /api/reference/64755398 64 10.1172/JCI97229 false true Reference 64755399 /api/reference/64755399 65 10.1126/science.aax6752 false true Reference 64755400 /api/reference/64755400 66 10.1038/s41593-020-00773-6 false true Reference 64755401 /api/reference/64755401 67 10.1038/ncomms11499 false true Reference 64755402 /api/reference/64755402 68 10.1016/j.yebeh.2020.107682 false true Reference 64755403 /api/reference/64755403 69 10.1172/JCI147329 false true Reference 64755404 /api/reference/64755404 70 10.1038/jcbfm.2008.64 false true Reference 64755405 /api/reference/64755405 71 10.3389/fncel.2014.00229 false true Reference 64755406 /api/reference/64755406 72 10.3390/cells9102277 false true Reference 64755407 /api/reference/64755407 73 10.1038/s41380-022-01786-2 false true Reference 64755408 /api/reference/64755408 74 10.1073/pnas.2007814117 false true Reference 64755409 /api/reference/64755409 75 10.1038/s41593-024-01573-y false true Reference 64755410 /api/reference/64755410 76 10.1016/j.immuni.2011.02.006 false true Reference 64755411 /api/reference/64755411 77 10.1038/s41586-018-0119-x false true Reference 64755412 /api/reference/64755412 78 10.1016/j.exger.2020.110841 false true Reference 64755413 /api/reference/64755413 79 10.7554/eLife.19749 false true Reference 64755414 /api/reference/64755414 80 10.7554/eLife.71185 false true Reference 64755415 /api/reference/64755415 81 10.3389/fneur.2018.00181 false true Reference 64755416 /api/reference/64755416 82 10.1007/s11910-019-0951-x false true Reference 64755417 /api/reference/64755417 83 10.1001/jamapsychiatry.2023.1321 false true Reference 64755418 /api/reference/64755418 84 10.1038/s41593-024-01576-9 false true Reference 64755419 /api/reference/64755419 85 10.1016/S2665-9913(21)00216-2 false true Reference 64755420 /api/reference/64755420 86 10.1038/s41591-021-01499-z false true Reference 64755421 /api/reference/64755421 87 10.1093/nar/gkac1000 false true Reference 64755422 /api/reference/64755422 88 10.1111/j.1365-2559.2004.01794.x false true Reference 64755423 /api/reference/64755423 89 10.1016/0006-8993(73)90290-4 false true Reference 64755424 /api/reference/64755424 90 10.3389/fncel.2018.00106 false true Reference 64755425 /api/reference/64755425 91 10.1007/s00401-021-02393-1 false true Reference 64755426 /api/reference/64755426 92 10.1038/s41598-023-42275-y false true Reference 64755427 /api/reference/64755427 93 10.1016/j.jsb.2005.07.007 false true Reference 64755428 /api/reference/64755428 94 10.1006/jsbi.1996.0013 false true Reference 64755429 /api/reference/64755429 95 10.1002/jmv.26761 false true Reference 64755430 /api/reference/64755430 96 10.1038/nmeth.4463 false true Reference 64755431 /api/reference/64755431 97 10.1093/nar/gkz369 false true Reference 64755432 /api/reference/64755432 98 10.1371/journal.pone.0095192 false true Reference 64755433 /api/reference/64755433 99 10.12688/f1000research.24956.2 false true Reference 64755434 /api/reference/64755434 100 10.1111/j.2517-6161.1958.tb00292.x false true Reference 64755435 /api/reference/64755435 101 false true Reference 64755436 /api/reference/64755436 102 10.1038/nature13302 false true Reference 64755437 /api/reference/64755437 103 10.1371/journal.pcbi.1004424 false true Reference 64755438 /api/reference/64755438 104 10.1371/journal.pcbi.1009758 false true /api/publication/35830704 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10049451"><a href="/gui2/?type=authors&mode=browse&sel=10049451" target="_blank">Fekete Rebeka (<span class="authorship-author-name">Fekete Rebeka</span> <span class="authorAux-mtmt"> idegtudomány</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Kísérleti Orvostudományi Kutatóintézet">HRN KOKI</span>/Neuroimmunológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Simats Alba </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10078021"><a href="/gui2/?type=authors&mode=browse&sel=10078021" target="_blank">Bíró Eduárd (<span class="authorship-author-name">Bíró Eduárd</span> <span class="authorAux-mtmt"> immunológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061174"><a href="/gui2/?type=authors&mode=browse&sel=10061174" target="_blank">Pósfai Balázs (<span class="authorship-author-name">Pósfai Balázs</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Kísérleti Orvostudományi Kutatóintézet">HRN KOKI</span>/Neuroimmunológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="172"><a href="/gui2/?type=authors&mode=browse&sel=172" target="_blank">Cserép Csaba (<span class="authorship-author-name">Cserép Csaba</span> <span class="authorAux-mtmt"> Idegtudomány, Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Kísérleti Orvostudományi Kutatóintézet">HRN KOKI</span>/Neuroimmunológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10063826"><a href="/gui2/?type=authors&mode=browse&sel=10063826" target="_blank">Schwarcz Anett D. (<span class="authorship-author-name">Schwarcz Dóra Anett</span> <span class="authorAux-mtmt"> Neuroimmunológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Kísérleti Orvostudományi Kutatóintézet">HRN KOKI</span>/Neuroimmunológiai Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="173"><a href="/gui2/?type=authors&mode=browse&sel=173" target="_blank">Szabadits Eszter (<span class="authorship-author-name">Cserépné Szabadits Eszter</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Kísérleti Orvostudományi Kutatóintézet">HRN KOKI</span>/Neuroimmunológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011503"><a href="/gui2/?type=authors&mode=browse&sel=10011503" target="_blank">Környei Zsuzsanna (<span class="authorship-author-name">Környei Zsuzsanna</span> <span class="authorAux-mtmt"> Neuroimmunológia; Idegi sejt- és fejlődésbiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Kísérleti Orvostudományi Kutatóintézet">HRN KOKI</span>/Neuroimmunológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064506"><a href="/gui2/?type=authors&mode=browse&sel=10064506" target="_blank">Tóth Krisztina (<span class="authorship-author-name">Tóth Krisztina</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Kísérleti Orvostudományi Kutatóintézet">HRN KOKI</span>/Neuroimmunológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061311"><a href="/gui2/?type=authors&mode=browse&sel=10061311" target="_blank">Fichó Erzsébet (<span class="authorship-author-name">Fichó Erzsébet</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10091234"><a href="/gui2/?type=authors&mode=browse&sel=10091234" target="_blank">Szalma János (<span class="authorship-author-name">Szalma János</span> <span class="authorAux-mtmt"> informatika tudományág</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Katolikus Egyetem">PPKE</span>/<span title="Információs Technológiai és Bionikai Kar">ITK</span>/Roska Tamás Műszaki és Természettudományi Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10104526"><a href="/gui2/?type=authors&mode=browse&sel=10104526" target="_blank">Vida Sára (<span class="authorship-author-name">Vida Sára</span> <span class="authorAux-mtmt"> Neuroimmunológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10085407"><a href="/gui2/?type=authors&mode=browse&sel=10085407" target="_blank">Kellermayer Anna (<span class="authorship-author-name">Kellermayer Anna</span> <span class="authorAux-mtmt"> Neuroimmunológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Kísérleti Orvostudományi Kutatóintézet">HRN KOKI</span>/Neuroimmunológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018448"><a href="/gui2/?type=authors&mode=browse&sel=10018448" target="_blank">Dávid Csaba (<span class="authorship-author-name">Dávid Csaba</span> <span class="authorAux-mtmt"> idegrendszer</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009548"><a href="/gui2/?type=authors&mode=browse&sel=10009548" target="_blank">Acsády László (<span class="authorship-author-name">Acsády László</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Kísérleti Orvostudományi Kutatóintézet">HRN KOKI</span>/Thalamus Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057362"><a href="/gui2/?type=authors&mode=browse&sel=10057362" target="_blank">Kontra Levente (<span class="authorship-author-name">Kontra Levente</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil">HUN-REN Kísérleti Orvostudományi Kutatóintézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Silvestre-Roig Carlos </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003072"><a href="/gui2/?type=authors&mode=browse&sel=10003072" target="_blank">Moldvay Judit (<span class="authorship-author-name">Moldvay Judit</span> <span class="authorAux-mtmt"> Tüdõgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Tüdőgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023823"><a href="/gui2/?type=authors&mode=browse&sel=10023823" target="_blank">Fillinger János (<span class="authorship-author-name">Fillinger János</span> <span class="authorAux-mtmt"> patológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012379"><a href="/gui2/?type=authors&mode=browse&sel=10012379" target="_blank">Csikász-Nagy Attila (<span class="authorship-author-name">Csikász-Nagy Attila</span> <span class="authorAux-mtmt"> Rendszerbiológia</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Katolikus Egyetem">PPKE</span>/Információs Technológiai és Bionikai Kar</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017334"><a href="/gui2/?type=authors&mode=browse&sel=10017334" target="_blank">Hortobágyi Tibor (<span class="authorship-author-name">Hortobágyi Tibor</span> <span class="authorAux-mtmt"> Neuropathológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Pathologiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Liesz Arthur </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020759"><a href="/gui2/?type=authors&mode=browse&sel=10020759" target="_blank">Benkő Szilvia (<span class="authorship-author-name">Benkő Szilvia</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012934"><a href="/gui2/?type=authors&mode=browse&sel=10012934" target="_blank">Dénes Ádám ✉ (<span class="authorship-author-name">Dénes Ádám</span> <span class="authorAux-mtmt"> Neurobiológia, neuroimmunológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Kísérleti Orvostudományi Kutatóintézet">HRN KOKI</span>/Neuroimmunológiai Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35830704" target="_blank">Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19</a></div> <div> <span class="journal-title">NATURE NEUROSCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1097-6256">1097-6256</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1546-1726">1546-1726</a>)</span>: <span class="journal-volume">28</span> <span class="journal-issue">3</span> <span class="page"> pp 558-576 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41593-025-01871-z" target="_blank" href="https://doi.org/10.1038/s41593-025-01871-z"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001438314000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001438314000001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="224630" target="_blank" href="https://real.mtak.hu/224630"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="86000334207" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-86000334207"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40050441" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40050441&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/inward/record.uri?eid=2-s2.0-86000334207&doi=10.1038%2Fs41593-025-01871-z&partnerID=40&md5=826c846545878f373832c91e970a030c" target="_blank" href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-86000334207&doi=10.1038%2Fs41593-025-01871-z&partnerID=40&md5=826c846545878f373832c91e970a030c"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 35</span> | Független: 34 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 35 | Scopus jelölt:&nbsp;34 | WoS/Scopus jelölt:&nbsp;35 | DOI jelölt:&nbsp;34 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35830704&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 11 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35830704</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Bolyai+ Felsőoktatási Fiatal Oktatói, Kutatói Ösztöndíj(ÚNKP-23-5) Támogató: Bolyai+, (SNN 132999) Támogató: NKFIH, A mintázatfelismerő Nod-like receptorok, mint új, potenciális szabályozók a vázizom regeneráció m...(K131844) Támogató: OTKA, (ÚNKP-23-4-I), (ÚNKP-22-3), (K147109), Hungarian Brain Research Program(NAP2022-I-1/2022), (KDP-12-10/PALY-2022) </div> <div class="lastModified">Utolsó módosítás: 2026.05.04. 11:09 Vida Sára (Neuroimmunológia) </div> <div class="lockedBy">Központi kezelésű 2026.05.20. 09:50 Lévayné Deseő Katalin (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Hungarian Academy of Sciences [LP2022-5/2022]; European Research Council [ERC-CoG 724994, ERC-StGs 802305]; Hungarian Brain Research Program [NAP2022-I-1/2022]; German Research Foundation under Germany's Excellence Strategy [EXC 2145, FOR 2879, 405358801, TRR 274, 408885537]; Hungarian National Research, Development and Innovation Fund [OTKA K131844, 147109]; Ja...</pre> </div></div>