https://m2.mtmt.hu/ eng 2026-05-31 06:12 JournalArticle 35807395 VALIDATED true This research was also funded by 2023-1.1.1-PIACI_FÓKUSZ-2024-00036, 2020-1.1.6-JÖVŐ-2021-00003 and 2022-1.2.6-TÉT-IPARI-TR-2022-00023 grants from the National Research, Development and Innovation Office (NKFI), Hungary. 0 false 2026-05-29T17:20:57.499+0000 2025-12-10T08:34:03.516+0000 2025-03-05T12:26:29.244+0000 true 10062334 Gáspár Renáta /api/admin/10062334 Admin Renáta Gáspár (SZTE admin5 (SZTE ÁOK Biokémiai Intézet)) true 10062334 2025-12-30T07:31:22.951+0000 2025-04-01T07:35:07.282+0000 true 10045852 Patkósné Hanesz Andrea /api/admin/10045852 Admin Andrea Patkósné Hanesz (SZBK-4-es admin) true 10045852 2025-07-23T07:19:28.819+0000 true 10058176 Nagyné Tari Emese /api/admin/10058176 Admin Emese Nagyné Tari (SZTE admin5) true 10058176 Admin 10013962 /api/admin/10013962 Lilian Vasvari (MTMT Központ, admin) Vasvari Lilian true 10013962 true 2026-05-29T17:19:40.979+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Pipicz, Márton true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 26 5 2247 2247 20 2025 Obesity-related cardiac dysfunction is a significant global health challenge. High-fat diets (HFDs) are well-established models of obesity. HFD has been reported to induce cardiac dysfunction and alter cardiac miRNA expression, DNA methylation and histone modifications. Nevertheless, it remains unclear whether cardiac miRNAs altered due to HFD target epigenetic regulator enzymes and function as epigenetic regulator miRNAs (epi-miRNAs), thereby contributing to HFD-induced epigenetic changes and cardiac dysfunction. To address this gap in our knowledge, this study aimed to identify putative cardiac epi-miRNAs and their potential epigenetic targets through an in silico analysis of a previously published miRNA dataset from Sprague Dawley rats subjected to HFD. Using two independent databases, miRDB and miRWalk, predicted miRNA-mRNA interactions were analyzed. A total of 71 miRNAs were identified in our present study as putative epi-miRNAs. A total of 34 epi-miRNAs were upregulated (e.g., miR-92b-3p, let-7c-5p, miR-132-3p), and 37 were downregulated (e.g., miR-21-3p, miR-29c-3p, miR-199a-3p) in response to HFD. Epi-miRNAs targeted 81 individual epigenetic regulators (e.g., Dnmt3a, Ezh2, Hdac4, Kdm3a) with 202 possible miRNA–target interactions. Most of the targeted epigenetic regulators were involved in histone modification. An epi-miRNA–target analysis indicated increased DNA methylation and histone acetylation and decreased histone methylation in the hearts of HFD-fed rats. These findings suggest the importance of epi-miRNA-induced epigenetic changes in HFD-related cardiac dysfunction. Funding 2050489 /api/funding/2050489 Hiperlipidémia-indukálta szülői epigenetikai változások hatásai a szív funkciójára és kondícinálh...(K143889) Funder: NRDIO false true Funding 2050490 /api/funding/2050490 (TKP2021-EGA-32) Funder: NRDIO false true Funding 2050491 /api/funding/2050491 (2020-1.1.6-JÖVŐ-2021-00003) Funder: NRDIO false true Funding 2050492 /api/funding/2050492 (2022-1.2.6-TÉT-IPARI-TR-2022-00023) false true true 2025 true true true false true false GOLD 2026-05-29 true http://real.mtak.hu/235769 2 0 2 2 0 2 2 2 1 2 2 2 2 2 0 0 2 2 2 2 0 2 2 Folyóiratcikk Journal Article 24 2 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 2 2 2 2 D1 false 10028282 false false false 2025-03-30T10:27:19.313+0000 Biokémiai Intézet (SZTE / SZAOK); Központi Laboratóriumok (HRN SZBK) 5 15 2 5 0 true 10013962 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 123621686 /api/authorship/123621686 Pipicz, Márton [Pipicz, Márton (experimentális ka...), author] Department of Biochemistry (SZTE / ASZMS) 1 0.2 true false false Author 10034993 /api/author/10034993 Márton Pipicz (experimentális kardiológia) Pipicz Márton true 10034993 true Pipicz Márton true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 123621687 /api/authorship/123621687 Biró, Gergő Zalán* [Biró, Gergő Zalán (elméleti orvostud...), author] Department of Biochemistry (SZTE / ASZMS) 2 0.2 true false false Author 10103071 /api/author/10103071 Gergő Zalán Biró (elméleti orvostudományok) Biró Gergő Zalán true true Biró Gergő Zalán true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 123621688 /api/authorship/123621688 Szabó, Márton Richárd [Szabó, Márton Richárd (biokémia), author] Department of Biochemistry (SZTE / ASZMS) 3 0.2 false false false Author 10052821 /api/author/10052821 Márton Richárd Szabó (biokémia) Szabó Márton Richárd true 10052821 true Szabó Márton Richárd true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 123621689 /api/authorship/123621689 Zvara, Ágnes [Zvara, Ágnes (Molekuláris biológia), author] Központi Laboratóriumok 4 0.2 false false false Author 10000637 /api/author/10000637 Ágnes Zvara (Molekuláris biológia) Zvara Ágnes true 10000637 true Zvara Ágnes true false 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(2025) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 26 5<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10034993"><a href="/gui2/?type=authors&mode=browse&sel=10034993" target="_blank">Pipicz Márton (<span class="authorship-author-name">Pipicz Márton</span> <span class="authorAux-mtmt"> experimentális kardiológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Albert Szent-Györgyi Medical School">ASZMS</span>/Department of Biochemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10103071"><a href="/gui2/?type=authors&mode=browse&sel=10103071" target="_blank">Biró Gergő Zalán^* (<span class="authorship-author-name">Biró Gergő Zalán</span> <span class="authorAux-mtmt"> elméleti orvostudományok</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Albert Szent-Györgyi Medical School">ASZMS</span>/Department of Biochemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052821"><a href="/gui2/?type=authors&mode=browse&sel=10052821" target="_blank">Szabó Márton Richárd (<span class="authorship-author-name">Szabó Márton Richárd</span> <span class="authorAux-mtmt"> biokémia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Albert Szent-Györgyi Medical School">ASZMS</span>/Department of Biochemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000637"><a href="/gui2/?type=authors&mode=browse&sel=10000637" target="_blank">Zvara Ágnes (<span class="authorship-author-name">Zvara Ágnes</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Biological Research Centre, Szeged">HUN-REN BRC</span>/Központi Laboratóriumok</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028282"><a href="/gui2/?type=authors&mode=browse&sel=10028282" target="_blank">Csont Tamás ✉ (<span class="authorship-author-name">Csont Tamás Bálint</span> <span class="authorAux-mtmt"> Kísérletes kardiológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Albert Szent-Györgyi Medical School">ASZMS</span>/Department of Biochemistry</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35807395" target="_blank">Putative Epigenetic Regulator microRNAs (epi-miRNAs) and Their Predicted Targets in High-Fat Diet-Induced Cardiac Dysfunction: An In Silico Analysis in Obese Rats</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">26</span> <span class="journal-issue">5</span> <span class="page"> Paper 2247. 20 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/ijms26052247" target="_blank" href="https://doi.org/10.3390/ijms26052247"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001442621500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001442621500001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="235769" target="_blank" href="http://real.mtak.hu/235769"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="86000717081" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-86000717081"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40076868" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40076868&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://www.mdpi.com/1422-0067/26/5/2247" target="_blank" href="https://www.mdpi.com/1422-0067/26/5/2247"> Other URL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="37293" target="_blank" href="http://publicatio.bibl.u-szeged.hu/37293"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Catalysis&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 2</span> | Independent citation: 2 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 2 | Number of citations in Scopus:&nbsp;1 | WoS/Scopus assigned:&nbsp;2 | Number of citations with DOI:&nbsp;2 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35807395&sort=publishedYear,desc&sort=title"> Number of cited publications: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35807395</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Hiperlipidémia-indukálta szülői epigenetikai változások hatásai a szív funkciójára és kondícinálh...(K143889) Funder: NRDIO, (TKP2021-EGA-32) Funder: NRDIO, (2020-1.1.6-JÖVŐ-2021-00003) Funder: NRDIO, (2022-1.2.6-TÉT-IPARI-TR-2022-00023) </div> <div class="lastModified">Last Modified: 2025.12.10. 09:34 Renáta Gáspár (SZTE admin5 (SZTE ÁOK Biokémiai Intézet)) </div> <div class="lockedBy">Centrally managed 2026.05.29. 19:19 Lilian Vasvari (MTMT Központ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: This research was also funded by 2023-1.1.1-PIACI_FÓKUSZ-2024-00036, 2020-1.1.6-JÖVŐ-2021-00003 and 2022-1.2.6-TÉT-IPARI-TR-2022-00023 grants from the National Research, Development and Innovation Office (NKFI), Hungary.</pre> </div></div>