https://m2.mtmt.hu/ hun 2026-09-21 00:27 JournalArticle 35802820 VALIDATED true Department of Obstetrics and Gynecology, Semmelweis University, Budapest, 1088, Hungary Department of Medical Microbiology and Immunology, Medical School, University of Pecs, Pecs, 7624, Hungary Department of Anatomy, Medical School, University of Pecs, Pecs, 7624, Hungary Department of Gynecology-Center of Endometriosis St, John of God, Hospital St. John of God, Vienna, 1020, Austria Rudolfinerhaus Private Clinic and Campus, Vienna, 1190, Austria Export Date: 03 June 2026; Cited By: 2; Correspondence Address: R. Brubel; Department of Obstetrics and Gynecology, Semmelweis University, Budapest, 1088, Hungary; email: brubelreka@gmail.com 0 false 2026-09-15T07:30:09.279+0000 2026-06-03T02:54:44.462+0000 2025-03-03T16:33:25.500+0000 true 10052792 Balogh Dóra Bianka /api/author/10052792 Author true 10052792 2026-06-03T02:54:44.304+0000 2025-03-07T09:42:18.588+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Brubel, Reka Alteration of Serum Gal-3 Levels in Endometrium-Related Reproductive Disorders true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 26 4 1630 1630 12 2025 Endometriosis, a benign, chronic gynecological disorder characterized by the presence of endometrial-like tissue outside the uterine cavity, affects 15% of women of reproductive age. Galectins, a family of beta-galactoside-binding proteins, regulate inflammation and autoimmunity and are widely expressed in reproductive tissues. This study aimed to assess Galectin-3 (Gal-3) levels in the serum of patients with endometriosis compared to asymptomatic controls and investigate serum Gal-3 level changes over a one-year follow-up period of patients with endometriosis. To determine the levels of soluble Gal-3 in the serum of women with endometriosis or gynecological tumors as well as healthy controls, a human Gal-3-specific ELISA was used. Our findings revealed significantly elevated serum Gal-3 levels in patients with endometriosis compared with healthy controls. Furthermore, Gal-3 concentrations were markedly higher in patients with malignant gynecological transformation of the endometrium than in patients with or without endometriosis. During the one-year follow-up, patients with endometriosis exhibited a progressive increase in serum Gal-3 levels. These findings highlight the potential of Gal-3 as a biomarker for endometriosis and related gynecological conditions. However, further prospective studies with larger, more representative patient cohorts are needed to validate its clinical value. 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(SE / AOK / K / SZSZNK) 11 46 5 11 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 123599175 /api/authorship/123599175 1 0.091 true false true Author 10021063 /api/author/10021063 Brubel Réka true 10021063 true Brubel Reka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123599176 /api/authorship/123599176 2 0.091 false false false Author 10015900 /api/author/10015900 Polgár Beáta true 10015900 true Polgar Beata true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123599177 /api/authorship/123599177 3 0.091 false false false Author 10001373 /api/author/10001373 Szereday László true 10001373 true Szereday Laszlo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123599178 /api/authorship/123599178 4 0.091 false false false Author 10052792 /api/author/10052792 Balogh Dóra Bianka true 10052792 true Balogh Dora 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/api/reference/64485764 2 10.1016/S0015-0282(97)81391-X false true Reference 64485765 /api/reference/64485765 3 10.1517/13543784.2012.683783 false true Reference 64485766 /api/reference/64485766 4 false true Reference 64485767 /api/reference/64485767 5 10.1371/journal.pone.0114229 false true Reference 64485768 /api/reference/64485768 6 10.3390/biom10020230 false true Reference 64485769 /api/reference/64485769 7 10.1016/j.fertnstert.2017.09.008 false true Reference 64485770 /api/reference/64485770 8 10.1093/hropen/hoac009 false true Reference 64485771 /api/reference/64485771 9 10.1556/OH.2013.29699 false true Reference 64485772 /api/reference/64485772 10 10.1093/humrep/des073 false true Reference 64485773 /api/reference/64485773 11 10.1155/2012/869191 false true Reference 64485774 /api/reference/64485774 12 10.1097/GCO.0000000000000798 false true Reference 64485775 /api/reference/64485775 13 10.26650/experimed.1148905 false true Reference 64485776 /api/reference/64485776 14 10.1242/jcs.208884 false true Reference 64485777 /api/reference/64485777 15 false true Reference 64485778 /api/reference/64485778 16 10.1007/s40618-016-0435-7 false true Reference 64485779 /api/reference/64485779 17 10.3390/cancers15010111 false true Reference 64485780 /api/reference/64485780 18 10.1111/aogs.12255 false true Reference 64485781 /api/reference/64485781 19 10.1016/j.fertnstert.2015.02.013 false true Reference 64485782 /api/reference/64485782 20 10.1016/j.neubiorev.2019.12.004 false true Reference 64485783 /api/reference/64485783 21 10.1586/ern.09.20 false true /api/publication/35802820 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10021063"><a href="/gui2/?type=authors&mode=browse&sel=10021063" target="_blank">Brubel Reka ✉ (<span class="authorship-author-name">Brubel Réka</span> <span class="authorAux-mtmt"> szülészet-nőgyógyászat, Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Baross utcai részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015900"><a href="/gui2/?type=authors&mode=browse&sel=10015900" target="_blank">Polgar Beata (<span class="authorship-author-name">Polgár Beáta</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Mikrobiológiai és Immunitástani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001373"><a href="/gui2/?type=authors&mode=browse&sel=10001373" target="_blank">Szereday Laszlo (<span class="authorship-author-name">Szereday László</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Mikrobiológiai és Immunitástani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052792"><a href="/gui2/?type=authors&mode=browse&sel=10052792" target="_blank">Balogh Dora Bianka (<span class="authorship-author-name">Balogh Dóra Bianka</span> <span class="authorAux-mtmt"> Molekuláris biológia, Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szülészeti és Nőgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10089281"><a href="/gui2/?type=authors&mode=browse&sel=10089281" target="_blank">Toth Tunde (<span class="authorship-author-name">Tóth Tünde</span> <span class="authorAux-mtmt"> Hematológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Anatómiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026126"><a href="/gui2/?type=authors&mode=browse&sel=10026126" target="_blank">Mate Szabolcs (<span class="authorship-author-name">Máté Szabolcs</span> <span class="authorAux-mtmt"> onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Baross utcai részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10051999"><a href="/gui2/?type=authors&mode=browse&sel=10051999" target="_blank">Csibi Noemi (<span class="authorship-author-name">Csibi Noémi</span> <span class="authorAux-mtmt"> szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Baross utcai részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10066686"><a href="/gui2/?type=authors&mode=browse&sel=10066686" target="_blank">Dobo Noemi (<span class="authorship-author-name">Dobó Noémi</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Baross utcai részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10088759"><a href="/gui2/?type=authors&mode=browse&sel=10088759" target="_blank">Hudelist Gernot (<span class="authorship-author-name">Hudelist Gernot</span> <span class="authorAux-mtmt"> Obstetrician and Gynaecologist, Minimal invasiv...</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013998"><a href="/gui2/?type=authors&mode=browse&sel=10013998" target="_blank">Acs Nandor (<span class="authorship-author-name">Ács Nándor</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Üllői úti részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026013"><a href="/gui2/?type=authors&mode=browse&sel=10026013" target="_blank">Bokor Attila (<span class="authorship-author-name">Bokor Attila</span> <span class="authorAux-mtmt"> szülészet, nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Baross utcai részleg</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35802820" target="_blank">Alteration of Serum Gal-3 Levels in Endometrium-Related Reproductive Disorders</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">26</span> <span class="journal-issue">4</span> <span class="page"> Paper 1630. 12 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms26041630" target="_blank" href="https://doi.org/10.3390/ijms26041630"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001430240800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001430240800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85218850987" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85218850987"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40004091" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40004091&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://www.mdpi.com/1422-0067/26/4/1630" target="_blank" href="https://www.mdpi.com/1422-0067/26/4/1630"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 5</span> | Független: 4 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 3 | Scopus jelölt:&nbsp;3 | WoS/Scopus jelölt:&nbsp;3 | DOI jelölt:&nbsp;5 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35802820&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35802820</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (ÚNKP-19-4-SE-25) </div> <div class="lastModified">Utolsó módosítás: 2026.06.03. 04:54 Milánkovics Róbert (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Obstetrics and Gynecology, Semmelweis University, Budapest, 1088, Hungary Department of Medical Microbiology and Immunology, Medical School, University of Pecs, Pecs, 7624, Hungary Department of Anatomy, Medical School, University of Pecs, Pecs, 7624, Hungary Department of Gynecology-Center of Endometriosis St...</pre> </div></div>