https://m2.mtmt.hu/ hun 2026-09-23 05:33 JournalArticle 35801227 VALIDATED true Funding Agency and Grant Number: Hungarian National Research, Development and Innovation Office (NKFIH) [137563]; Thematic Institutional Excellence funding scheme of the Ministry of Innovation and Technology in Hungary for the Molecular Biology thematic program of Semmelweis University [TKP2021-EGA-24]; Central Europe Leuven Strategic Alliance CELSA research fund [CELSA/22/024] Funding text: This work was supported by the Hungarian National Research, Development and Innovation Office (NKFIH) (#137563), Thematic Institutional Excellence funding scheme of the Ministry of Innovation and Technology in Hungary for the Molecular Biology thematic program of Semmelweis University (TKP2021-EGA-24), Central Europe Leuven Strategic Alliance CELSA research fund (CELSA/22/024). 0 false 2026-09-21T21:07:55.613+0000 2026-09-09T12:48:45.976+0000 2025-03-03T09:49:32.421+0000 true 10000059 Kolev Kraszimir Nikolaev /api/author/10000059 Author true 10000059 2026-06-23T11:47:35.830+0000 2026-09-09T12:48:46.247+0000 true 10082922 Csajbók Edit /api/admin/10082922 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Varju, Imre Neutrophil extracellular traps: at the interface of thrombosis and co-morbidities true true /api/journal/4063 REVIEWED true false 4063 false 4063 true 0094-6176 1098-9064 Journal FOREIGN 51 07 724 735 724 12 2025 Since their discovery in 2004, neutrophil extracellular traps (NETs) have been in the center of multidisciplinary attention. While a key tool in neutrophil-mediated immunity, these filamentous, enzyme-enriched DNA-histone complexes can be detrimental to tissues and have been identified as an underlying factor in a range of pathological conditions. Building on more than 20 years of research into NETs, this review places thrombosis, the pathological formation of blood clots, in the spotlight. From this point of view, we discuss the structure and formation of NETs, as well as the interaction of their components with the hemostatic system, dissecting the pathways through which NETs exert their marked effect on formation and the dissolution of thrombi. We pay distinct attention to the latest developments in the research of a key player in NET-formation, peptidyl-arginine-deiminase (PAD) enzymes: their types, sources, and potential cross-play with the hemostatic machinery. Besides these molecular details, we elaborate on the link between pathological thrombosis, NETs, and widespread conditions that represent a debilitating public health burden worldwide, such as sepsis and neoplasms. Finally, future implications on the treatment of thrombosis-related conditions will be discussed. Funding 2051847 /api/funding/2051847 false true Funding 2051848 /api/funding/2051848 false true true true 2025 true true true false true false NONE 2026-09-21 false 13 0 13 13 0 13 13 10 6 10 10 10 10 13 0 0 13 13 13 13 0 11 11 Folyóiratcikk Journal Article 24 13 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 6 6 6 6 2026 0 7 7 7 7 Q1 false false false false 2025-06-01T08:51:16.860+0000 Biokémiai Tanszék (SE / AOK / I / BMBI) 3 9 1 3 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 123591908 /api/authorship/123591908 1 0.333 true false true Author 10022755 /api/author/10022755 Varjú Imre true 10022755 true Varju Imre true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123591909 /api/authorship/123591909 2 0.333 true false false Author 10021854 /api/author/10021854 Tanka-Salamon Anna true 10021854 true Tanka-Salamon Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123591910 /api/authorship/123591910 3 0.333 false true false Author 10000059 /api/author/10000059 Kolev Kraszimir Nikolaev true 10000059 true Kolev Krasimir true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 28569702 /api/publicationidentifier/28569702 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1055/a-2548-0805 https://doi.org/10.1055/a-2548-0805 false true PublicationIdentifier 29215952 /api/publicationidentifier/29215952 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001455584000001 https://www.webofscience.com/wos/woscc/full-record/001455584000001 true true PublicationIdentifier 29227889 /api/publicationidentifier/29227889 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105001845003 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105001845003 true true PublicationIdentifier 28569714 /api/publicationidentifier/28569714 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 40020757 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40020757&dopt=Abstract false true PublicationIdentifier 31617756 /api/publicationidentifier/31617756 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true IDENTICAL http://www.thieme-connect.de/DOI/DOI?10.1055/a-2548-0805 http://www.thieme-connect.de/DOI/DOI?10.1055/a-2548-0805 false true SjrRating 11563317 /api/sjrrating/11563317 87 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 true 2705 true Q1 DIRECT true true /api/publication/35801227 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10022755"><a href="/gui2/?type=authors&mode=browse&sel=10022755" target="_blank">Varju Imre ✉ (<span class="authorship-author-name">Varjú Imre</span> <span class="authorAux-mtmt"> orvosi biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Biokémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021854"><a href="/gui2/?type=authors&mode=browse&sel=10021854" target="_blank">Tanka-Salamon Anna<sup>*</sup> (<span class="authorship-author-name">Tanka-Salamon Anna</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Biokémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000059"><a href="/gui2/?type=authors&mode=browse&sel=10000059" target="_blank">Kolev Krasimir (<span class="authorship-author-name">Kolev Kraszimir Nikolaev</span> <span class="authorAux-mtmt"> Orvosi biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Biokémiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35801227" target="_blank">Neutrophil extracellular traps: at the interface of thrombosis and co-morbidities</a></div> <div> <span class="journal-title">SEMINARS IN THROMBOSIS AND HEMOSTASIS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0094-6176">0094-6176</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1098-9064">1098-9064</a>)</span>: <span class="journal-volume">51</span> <span class="journal-issue">07</span> <span class="page"> pp 724-735 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1055/a-2548-0805" target="_blank" href="https://doi.org/10.1055/a-2548-0805"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001455584000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001455584000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105001845003" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105001845003"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40020757" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40020757&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="http://www.thieme-connect.de/DOI/DOI?10.1055/a-2548-0805" target="_blank" href="http://www.thieme-connect.de/DOI/DOI?10.1055/a-2548-0805"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Hematology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 13</span> | Független: 13 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 10 | Scopus jelölt:&nbsp;6 | WoS/Scopus jelölt:&nbsp;10 | DOI jelölt:&nbsp;13 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35801227&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 11 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35801227</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (K137563), (TKP2021-EGA-24) </div> <div class="lastModified">Utolsó módosítás: 2026.09.09. 14:48 Csajbók Edit (SE admin4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Hungarian National Research, Development and Innovation Office (NKFIH) [137563]; Thematic Institutional Excellence funding scheme of the Ministry of Innovation and Technology in Hungary for the Molecular Biology thematic program of Semmelweis University [TKP2021-EGA-24]; Central Europe Leuven Strategic Alliance CELSA research fund [CELSA/22/024] Fund...</pre> </div></div>