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      <abstractText>Risk-adapted treatment protocols conferred remarkable improvement in the survival rates of pediatric acute lymphoblastic leukemia/lymphoma (ALL/LBL). Nevertheless, clinical management is still challenging in certain molecular subgroups and in the presence of alterations associated with an increased rate of relapse. In this study, disease-relevant genomic and transcriptomic profiles were established in a prospective, multicenter, real-world cohort involving 192 children diagnosed with ALL/LBL. Gene fusions were detected in 34.9% of B-ALL and 46.4% of T-ALL patients, with novel chimeric genes involving JAK2, KMT2A, PAX5, RUNX1 and NOTCH1, and with KMT2A-rearranged patients displaying the worst 3-year event-free survival (p=0.019). Non-synonymous mutations were uncovered in 74.9% of the analyzed patients, and a pairwise scrutiny of genetic lesions revealed recurrent clonal selection mechanisms commonly converging on the same pathway (e.g. Ras, JAK/STAT and Notch) in individual patients. Investigation of matched diagnostic and relapse samples unraveled complex subclonal variegation, and mutations affecting the NT5C2, TP53, CDKN2A, and PIK3R1 genes, emerging at the time of relapse. TP53 and CREBBP mutations, even as subclonal aberrations, were associated with shorter 3-year event-free survival among all patients with B-ALL (TP53 mutant vs wild-type: p=0.008, CREBBP mutant vs wild-type: p=0.010); and notably, B-ALL patients showing no measurable residual disease on day 33 could be further stratified based on TP53 mutational status (p&lt;0.001). Our in-depth molecular characterization performed across all risk groups identified novel opportunities for molecularly targeted therapy in 55.9% of high-risk and in 31.6% of standard/intermediate-risk patients.</abstractText>
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																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10077542&quot; target=&quot;_blank&quot;&gt;Péterffy Borbála
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Péterffy Borbála&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Élettan&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/&lt;span title=&quot;Patológiai és Kísérleti Rákkutató Intézet&quot;&gt;PKRI&lt;/span&gt;/HCEMM-SE Molekuláris Onkohematológiai Kutatócsoport; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/Patológiai és Kísérleti Rákkutató Intézet; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/&lt;span title=&quot;I. Sz. Patológiai és Kísérleti Rákkutató Intézet&quot;&gt;ISZPKRI&lt;/span&gt;/MTA-SE Lendület Molekuláris Onkohematológia Kutatócsoport&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10065846&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10065846&quot; target=&quot;_blank&quot;&gt;Krizsán Szilvia
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Krizsán Szilvia&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Gyermekgyógyászat, hematológia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/&lt;span title=&quot;Patológiai és Kísérleti Rákkutató Intézet&quot;&gt;PKRI&lt;/span&gt;/HCEMM-SE Molekuláris Onkohematológiai Kutatócsoport; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/Patológiai és Kísérleti Rákkutató Intézet; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/&lt;span title=&quot;I. Sz. Patológiai és Kísérleti Rákkutató Intézet&quot;&gt;ISZPKRI&lt;/span&gt;/MTA-SE Lendület Molekuláris Onkohematológia Kutatócsoport; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/Gyermekgyógyászati Klinika&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10072921&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10072921&quot; target=&quot;_blank&quot;&gt;Egyed Bálint
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Egyed Bálint&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Gyermekgyógyászat, hematológia, onkogenetika&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/&lt;span title=&quot;Patológiai és Kísérleti Rákkutató Intézet&quot;&gt;PKRI&lt;/span&gt;/HCEMM-SE Molekuláris Onkohematológiai Kutatócsoport; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/Patológiai és Kísérleti Rákkutató Intézet; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/Gyermekgyógyászati Klinika; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/&lt;span title=&quot;I. Sz. Patológiai és Kísérleti Rákkutató Intézet&quot;&gt;ISZPKRI&lt;/span&gt;/MTA-SE Lendület Molekuláris Onkohematológia Kutatócsoport&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10069185&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10069185&quot; target=&quot;_blank&quot;&gt;Bedics Gábor
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Bedics Gábor&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Patológia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/&lt;span title=&quot;Patológiai és Kísérleti Rákkutató Intézet&quot;&gt;PKRI&lt;/span&gt;/HCEMM-SE Molekuláris Onkohematológiai Kutatócsoport; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/Patológiai és Kísérleti Rákkutató Intézet; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/&lt;span title=&quot;I. Sz. Patológiai és Kísérleti Rákkutató Intézet&quot;&gt;ISZPKRI&lt;/span&gt;/MTA-SE Lendület Molekuláris Onkohematológia Kutatócsoport&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
													&lt;span class=&quot;author-name&quot; mtid=&quot;10023613&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10023613&quot; target=&quot;_blank&quot;&gt;Erdélyi Dániel János
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Erdélyi Dániel&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Gyermekgyógyászat&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/Gyermekgyógyászati Klinika&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10023438&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10023438&quot; target=&quot;_blank&quot;&gt;Müller Judit
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Müller Judit&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Csecsemő- és gyermekgyógyászat, Gyermek hemato-...&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/Gyermekgyógyászati Klinika&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10035070&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10035070&quot; target=&quot;_blank&quot;&gt;Nagy Tibor
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Nagy Tibor&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Bioinformatika&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Debreceni Egyetem&quot;&gt;DE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/Biokémiai és Molekuláris Biológiai Intézet&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10092627&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10092627&quot; target=&quot;_blank&quot;&gt;Hegyi Lajos László
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Hegyi Lajos&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Molekuláris biológia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/&lt;span title=&quot;Patológiai és Kísérleti Rákkutató Intézet&quot;&gt;PKRI&lt;/span&gt;/HCEMM-SE Molekuláris Onkohematológiai Kutatócsoport; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/Patológiai és Kísérleti Rákkutató Intézet; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/&lt;span title=&quot;I. Sz. Patológiai és Kísérleti Rákkutató Intézet&quot;&gt;ISZPKRI&lt;/span&gt;/MTA-SE Lendület Molekuláris Onkohematológia Kutatócsoport&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10084490&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10084490&quot; target=&quot;_blank&quot;&gt;Bekő Anna
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Bekő Anna&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Molekuláris onkohematológia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/&lt;span title=&quot;Patológiai és Kísérleti Rákkutató Intézet&quot;&gt;PKRI&lt;/span&gt;/HCEMM-SE Molekuláris Onkohematológiai Kutatócsoport; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/Patológiai és Kísérleti Rákkutató Intézet; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/&lt;span title=&quot;I. Sz. Patológiai és Kísérleti Rákkutató Intézet&quot;&gt;ISZPKRI&lt;/span&gt;/MTA-SE Lendület Molekuláris Onkohematológia Kutatócsoport&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10068648&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10068648&quot; target=&quot;_blank&quot;&gt;Kenéz Lili Anna
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Kenéz Lili Anna&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; sejtbiológia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/Patológiai és Kísérleti Rákkutató Intézet; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/&lt;span title=&quot;Patológiai és Kísérleti Rákkutató Intézet&quot;&gt;PKRI&lt;/span&gt;/HCEMM-SE Molekuláris Onkohematológiai Kutatócsoport; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/&lt;span title=&quot;I. Sz. Patológiai és Kísérleti Rákkutató Intézet&quot;&gt;ISZPKRI&lt;/span&gt;/MTA-SE Lendület Molekuláris Onkohematológia Kutatócsoport&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10025328&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10025328&quot; target=&quot;_blank&quot;&gt;Jakab Zsuzsanna
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Jakab Zsuzsanna&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Gyermekgyógyászat onkológia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
													&lt;span class=&quot;author-name&quot; mtid=&quot;10083949&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10083949&quot; target=&quot;_blank&quot;&gt;Csanádi Krisztina
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Csanádi Krisztina&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; gyermekgyógyászat, gyermek hemato-onkológia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;Heim Pál Országos Gyermekgyógyászati Intézet&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10020332&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10020332&quot; target=&quot;_blank&quot;&gt;Ottóffy Gábor
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Ottóffy Gábor&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Gyermekonkológia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Pécsi Tudományegyetem&quot;&gt;PTE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/Gyermekgyógyászati Klinika&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10016444&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10016444&quot; target=&quot;_blank&quot;&gt;Csernus Katalin
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Csernus Katalin&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Gyermekgyógyászat&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Pécsi Tudományegyetem&quot;&gt;PTE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/Gyermekgyógyászati Klinika&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10021149&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10021149&quot; target=&quot;_blank&quot;&gt;Vojcek Ágnes
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Vojcek Ágnes&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Orvostudomány&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Pécsi Tudományegyetem&quot;&gt;PTE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/Gyermekgyógyászati Klinika&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10076698&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10076698&quot; target=&quot;_blank&quot;&gt;Tiszlavicz Lilla Györgyi
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Tiszlavicz Lilla Györgyi&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; gyermekgyógyászat&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Szegedi Tudományegyetem&quot;&gt;SZTE&lt;/span&gt;/&lt;span title=&quot;Szent-Györgyi Albert Orvostudományi Kar&quot;&gt;SZAOK&lt;/span&gt;/Gyermekgyógyászati Klinika és Gyermek Egészségügyi Központ&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10030588&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10030588&quot; target=&quot;_blank&quot;&gt;Gábor Krisztina Mita
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Gábor Krisztina&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; gyermekgyógyászat, onkológia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Szegedi Tudományegyetem&quot;&gt;SZTE&lt;/span&gt;/&lt;span title=&quot;Szent-Györgyi Albert Orvostudományi Kar&quot;&gt;SZAOK&lt;/span&gt;/Gyermekgyógyászati Klinika és Gyermek Egészségügyi Központ&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
										&lt;span class=&quot;author-name&quot; mtid=&quot;10012832&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10012832&quot; target=&quot;_blank&quot;&gt;Hauser Péter
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Hauser Péter&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Gyermekkori központi idegrendszeri daganatok&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10065552&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10065552&quot; target=&quot;_blank&quot;&gt;Kállay Krisztián
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Kállay Krisztián Miklós&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; gyermekhematológia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
										&lt;span class=&quot;author-name&quot; mtid=&quot;10045405&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10045405&quot; target=&quot;_blank&quot;&gt;Gaál Zsuzsanna
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Gaál Zsuzsanna&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; orvostudományok&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Debreceni Egyetem&quot;&gt;DE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/&lt;span title=&quot;Gyermekgyógyászati Intézet&quot;&gt;GygyI&lt;/span&gt;/Gyermekhematológiai-Onkológiai Nem Önálló Tanszék&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10028502&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10028502&quot; target=&quot;_blank&quot;&gt;Szegedi István
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Szegedi István&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Gyermekgyógyászat&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Debreceni Egyetem&quot;&gt;DE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/&lt;span title=&quot;Gyermekgyógyászati Intézet&quot;&gt;GygyI&lt;/span&gt;/Gyermekhematológiai-Onkológiai Nem Önálló Tanszék&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10023553&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10023553&quot; target=&quot;_blank&quot;&gt;Barna Gábor
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Barna Gábor&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Hematologia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/&lt;span title=&quot;Patológiai és Kísérleti Rákkutató Intézet&quot;&gt;PKRI&lt;/span&gt;/HCEMM-SE Molekuláris Onkohematológiai Kutatócsoport; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/Patológiai és Kísérleti Rákkutató Intézet; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/&lt;span title=&quot;I. Sz. Patológiai és Kísérleti Rákkutató Intézet&quot;&gt;ISZPKRI&lt;/span&gt;/MTA-SE Lendület Molekuláris Onkohematológia Kutatócsoport&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10035394&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10035394&quot; target=&quot;_blank&quot;&gt;Márk Ágnes
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Márk Ágnes&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Hematopatológia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/&lt;span title=&quot;Patológiai és Kísérleti Rákkutató Intézet&quot;&gt;PKRI&lt;/span&gt;/HCEMM-SE Molekuláris Onkohematológiai Kutatócsoport; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/Patológiai és Kísérleti Rákkutató Intézet; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/&lt;span title=&quot;I. Sz. Patológiai és Kísérleti Rákkutató Intézet&quot;&gt;ISZPKRI&lt;/span&gt;/MTA-SE Lendület Molekuláris Onkohematológia Kutatócsoport&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10023751&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10023751&quot; target=&quot;_blank&quot;&gt;Haltrich Irén
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Haltrich Irén&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Biológia, genetika&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/Gyermekgyógyászati Klinika&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10002236&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10002236&quot; target=&quot;_blank&quot;&gt;Hevessy Zsuzsanna
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Hevessy Zsuzsanna Dóra&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Véralvadás XIII-as faktora&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Debreceni Egyetem&quot;&gt;DE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/Laboratóriumi Medicina Intézet&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10029147&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10029147&quot; target=&quot;_blank&quot;&gt;Ujfalusi Anikó
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Ujfalusi Anikó&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Genetika&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Debreceni Egyetem&quot;&gt;DE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/Laboratóriumi Medicina Intézet&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10016503&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10016503&quot; target=&quot;_blank&quot;&gt;Kajtár Béla
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Kajtár Béla&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Patológia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Pécsi Tudományegyetem&quot;&gt;PTE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/Pathologiai Intézet&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10023574&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10023574&quot; target=&quot;_blank&quot;&gt;Timár Botond
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Timár Botond&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Hematopatológia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/&lt;span title=&quot;Patológiai és Kísérleti Rákkutató Intézet&quot;&gt;PKRI&lt;/span&gt;/HCEMM-SE Molekuláris Onkohematológiai Kutatócsoport; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/Patológiai és Kísérleti Rákkutató Intézet; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/&lt;span title=&quot;I. Sz. Patológiai és Kísérleti Rákkutató Intézet&quot;&gt;ISZPKRI&lt;/span&gt;/MTA-SE Lendület Molekuláris Onkohematológia Kutatócsoport&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10009363&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10009363&quot; target=&quot;_blank&quot;&gt;Kiss Csongor
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Kiss Csongor&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Gyermekgyógyászat&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Debreceni Egyetem&quot;&gt;DE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/Gyermekgyógyászati Intézet&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10027992&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10027992&quot; target=&quot;_blank&quot;&gt;Kriván Gergely
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Kriván Gergely&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Gyermekgyógyászat&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
			 et al. (41)
	    &lt;/div&gt;
    &lt;div&gt;&lt;a target=&quot;_blank&quot; href=&quot;/api/publication/35798493?labelLang=hun&quot;&gt;Összes szerző&lt;/a&gt;&lt;/div&gt;
&lt;/div&gt;
&lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;35798493&quot; target=&quot;_blank&quot;&gt;Molecular profiling reveals novel gene fusions and genetic markers for refined patient stratification in pediatric acute lymphoblastic leukemia&lt;/a&gt;&lt;/div&gt;    &lt;div&gt;		&lt;span class=&quot;journal-title&quot;&gt;MODERN PATHOLOGY&lt;/span&gt;

        &lt;span class=&quot;journal-issn&quot;&gt;(&lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/0893-3952&quot;&gt;0893-3952&lt;/a&gt; &lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/1530-0285&quot;&gt;1530-0285&lt;/a&gt;)&lt;/span&gt;:
		&lt;span class=&quot;journal-volume&quot;&gt;38&lt;/span&gt; &lt;span class=&quot;journal-issue&quot;&gt;6&lt;/span&gt;
&lt;span class=&quot;page&quot;&gt;
	p. 100741.
	Paper 100741.
	 14 p. 
&lt;/span&gt;		 &lt;span class=&quot;year&quot;&gt;(2025)&lt;/span&gt;  
    &lt;/div&gt;
&lt;div class=&quot;pub-footer&quot;&gt;
    

	&lt;span class=&quot;language&quot; xmlns=&quot;http://www.w3.org/1999/html&quot;&gt;Nyelv:
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&quot;&gt;
							
							&lt;a style=&quot;color:blue&quot; title=&quot;10.1016/j.modpat.2025.100741&quot; target=&quot;_blank&quot; href=&quot;https://doi.org/10.1016/j.modpat.2025.100741&quot;&gt;
									DOI
							&lt;/a&gt;
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							&lt;a style=&quot;color:blue&quot; title=&quot;001453335900001&quot; target=&quot;_blank&quot; href=&quot;https://www.webofscience.com/wos/woscc/full-record/001453335900001&quot;&gt;
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				&lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Pathology and Forensic Medicine&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;D1&lt;/div&gt;
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	&lt;div class=&quot;publication-citation&quot; style=&quot;margin-left: 0.5cm;&quot;&gt;
		&lt;span title=&quot;Nyilvános idézőközlemények összesen, említések nélkül&quot; class=&quot;citingPub-count&quot;&gt;Nyilvános idéző összesen: 9&lt;/span&gt;
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		| WoS jelölt: 8 
		|  Scopus jelölt:&amp;nbsp;7 
		|  WoS/Scopus jelölt:&amp;nbsp;9 
		|  DOI jelölt:&amp;nbsp;9 
		
	&lt;/div&gt;
    
    
	&lt;div class=&quot;publication-citation&quot;&gt;
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    &lt;div class=&quot;mtid&quot;&gt;&lt;span class=&quot;long-pub-mtid&quot;&gt;Közlemény: 35798493&lt;/span&gt;
    | &lt;span class=&quot;status-data status-APPROVED&quot;&gt; 	Nyilvános
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Forrás	 Idéző
	
	
    | &lt;span class=&quot;type-subtype&quot;&gt;Folyóiratcikk
			( Sokszerzős vagy csoportos szerzőségű szakcikk
			
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	| &lt;span class=&quot;publication-sourceOfData&quot;&gt;kézi felvitel&lt;/span&gt;
&lt;/div&gt;

&lt;div class=&quot;funder&quot;&gt; (FK20_134253),    (K21_137948),    (K22_143021),    HCEMM(739593) Támogató: Horizon 2020,    (KDP-2020-1008491),    (2023-2.1.2-KDP-2023-00016) Támogató: Kulturális és Innovációs Minisztérium Nemzeti Kutatási Fejlesztési és Innovációs Alap,    (BO/00125/22),    (LP2024-3),    Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Támogató: EFOP-VEKOP,    (ÚNKP-22-5-SE-7),    (TKP2021-EGA-24),    (TKP2021-NVA-15),    Richter Gedeon Talentum Foundation   &lt;/div&gt;
&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2026.09.04. 13:58 Törőné Bíró Edina (DE/GYTK admin5)
&lt;/div&gt;




	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: * Megosztott szerzőség&lt;/pre&gt;

&lt;/div&gt;&lt;/div&gt;</template2>
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