Endokrinológia és anyagcserebetegségek (benne cukorbetegség, hormonok)
Orvos- és egészségtudomány
The present study was conducted in type 1 diabetic (T1DM) patients to evaluate the
metabolic and glycemic control as well as the manifestations of neuropathy. The impact
of continuous glucose monitoring (CGM) on the measured parameters was also analyzed.
A total of 61 T1DM patients (age: 42.5 ± 1.8 years, DM duration: 22.8 ± 1.6 years,
mean ± SE) participated in the study. In total, 24 patients had CGM sensors and 37
did not. Cardiovascular autonomic neuropathy was assessed using cardiovascular reflex
tests. Peripheral sensory function was evaluated by a Neurometer and calibrated tuning
fork on the upper and lower limbs. Metabolic status was characterized by the determination
of triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), total
cholesterol, and glycated haemoglobin (HBA1c). A positive correlation was found between
HbA1c and triglyceride levels (r = 0.28, p < 0.05). CGM users and non-users differed
in triglyceride (0.9 ± 0.1 vs. 1.24 ± 0.12 mmol/L, p < 0.05), HDL cholesterol (1.7
± 0.1 vs. 1.4 ± 0.1 p < 0.05 mmol/L), and HbA1C (7.5 ± 0.2 vs. 8.3 ± 0.3%, p < 0.05)
levels as well. Significant differences were found for the Valsalva ratio, Neurometer,
and calibrated tuning fork results between CGM users and non-users. This study found
a significant correlation between HbA1c and triglyceride levels in T1DM. CGM use resulted
in improved metabolic parameters and less autonomic and sensory nerve damage. As a
novel finding, CGM is presumed to prevent both micro-, and macrovascular complications
and, by this way, potentially reducing mortality rates.
