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      <comment>The Hong Kong University of Science and Technology, Hong Kong            
            Beihang University, China            
            Conference code: 200372            
            Cited By :6            
            Export Date: 21 February 2025            
            Correspondence Address: Xie, F.; Beihang UniversityChina; email: xfy_73@buaa.edu.cn            
            Correspondence Address: Chen, H.; The Hong Kong University of Science and TechnologyHong Kong; email: jhc@cse.ust.hk            
            Funding details: National Natural Science Foundation of China, NSFC, 62202403            
            Funding details: National Natural Science Foundation of China, NSFC            
            Funding details: Science, Technology and Innovation Commission of Shenzhen Municipality, SGDX20210823103201011            
            Funding details: Science, Technology and Innovation Commission of Shenzhen Municipality            
            Funding details: Research Grants Council, University Grants Committee, 研究資助局, R6003-22            
            Funding details: Research Grants Council, University Grants Committee, 研究資助局            
            Funding text 1: This work was supported by National Natural Science Foundation of China (No. 62202403), Shenzhen Science and Technology Innovation Committee Funding (Project No. SGDX20210823103201011), the Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. R6003-22 and C4024-22GF).</comment>
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      <title>PROTOTYPICAL INFORMATION BOTTLENECKING AND DISENTANGLING FOR MULTIMODAL CANCER SURVIVAL PREDICTION</title>
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      <abstractText>Multimodal learning significantly benefits cancer survival prediction, especially the integration of pathological images and genomic data. Despite advantages of multimodal learning for cancer survival prediction, massive redundancy in multimodal data prevents it from extracting discriminative and compact information: (1) An extensive amount of intra-modal task-unrelated information blurs discriminability, especially for gigapixel whole slide images (WSIs) with many patches in pathology and thousands of pathways in genomic data, leading to an “intra-modal redundancy” issue. (2) Duplicated information among modalities dominates the representation of multimodal data, which makes modality-specific information prone to being ignored, resulting in an “inter-modal redundancy” issue. To address these, we propose a new framework, Prototypical Information Bottlenecking and Disentangling (PIBD), consisting of Prototypical Information Bottleneck (PIB) module for intra-modal redundancy and Prototypical Information Disentanglement (PID) module for inter-modal redundancy. Specifically, a variant of information bottleneck, PIB, is proposed to model prototypes approximating a bunch of instances for different risk levels, which can be used for selection of discriminative instances within modality. PID module decouples entangled multimodal data into compact distinct components: modality-common and modality-specific knowledge, under the guidance of the joint prototypical distribution. Extensive experiments on five cancer benchmark datasets demonstrated our superiority over other methods. The code is released. © 2024 12th International Conference on Learning Representations, ICLR 2024. All rights reserved.</abstractText>
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          <label>64. Yao, Jiawen, Zhu, Xinliang, Jonnagaddala, Jitendra, Hawkins, Nicholas, Huang, Junzhou, Whole slide images based cancer survival prediction using attention guided deep multiple instance learning networks (2020) Medical Image Analysis, 65, p. 101789</label>
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          <label>67. Zhang, Chao, Yang, Zichao, He, Xiaodong, Deng, Li, Multimodal intelligence: Representation learning, information fusion, and applications (2020) IEEE Journal of Selected Topics in Signal Processing, 14 (3), pp. 478-493</label>
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      <label>Zhang Y. et al. PROTOTYPICAL INFORMATION BOTTLENECKING AND DISENTANGLING FOR MULTIMODAL CANCER SURVIVAL PREDICTION. (2024) Megjelent: 12th International Conference on Learning Representations, ICLR 2024</label><template>&lt;div class=&quot;BookChapter Publication short-list&quot;&gt; &lt;div class=&quot;authors&quot;&gt; &lt;span class=&quot;author-name&quot; &gt; Zhang, Y. &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Xu, Y. &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Chen, J. &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Xie, F. ✉ &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Chen, H. ✉ &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; &lt;/div &gt;&lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;35778536&quot; mtid=&quot;35778536&quot; target=&quot;_blank&quot;&gt;PROTOTYPICAL INFORMATION BOTTLENECKING AND DISENTANGLING FOR MULTIMODAL CANCER SURVIVAL PREDICTION&lt;/a&gt;&lt;/div&gt; &lt;div class=&quot;InBook&quot;&gt;In: &lt;span class=&quot;booktitle&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;35178194&quot; target=&quot;_blank&quot;&gt;12th International Conference on Learning Representations, ICLR 2024 &lt;/a&gt;&lt;/span &gt; &lt;/div&gt;&lt;div class=&quot;pub-info&quot;&gt; &lt;span class=&quot;publisher&quot;&gt;International Conference on Learning Representations, ICLR&lt;/span&gt; &lt;span class=&quot;year&quot;&gt;(2024)&lt;/span&gt; &lt;span class=&quot;page&quot;&gt; Paper: Code 200372 &lt;/span&gt; &lt;/div&gt; &lt;div class=&quot;pub-end&quot;&gt;&lt;div class=&quot;identifier-list&quot;&gt; &lt;span class=&quot;identifiers&quot;&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:black&quot; title=&quot;85199363043&quot; target=&quot;_blank&quot; href=&quot;http://www.scopus.com/record/display.url?origin=inward&amp;eid=2-s2.0-85199363043&quot;&gt; Scopus &lt;/a&gt; &lt;/span&gt; &lt;/span&gt; &lt;/div&gt; &lt;div class=&quot;short-pub-prop-list&quot;&gt; &lt;span class=&quot;short-pub-mtid&quot;&gt; Közlemény:35778536 &lt;/span&gt; &lt;span class=&quot;status-holder&quot;&gt;&lt;span class=&quot;status-data status-APPROVED&quot;&gt; Nyilvános &lt;/span&gt;&lt;/span&gt; &lt;span class=&quot;pub-core&quot;&gt; Idéző Duplumgyanú &lt;/span&gt; &lt;span class=&quot;pub-type&quot;&gt;Egyéb konferenciaközlemény (Konferenciaközlemény ) &lt;/span&gt; &lt;!-- &amp;&amp; !record.category.scientific --&gt; &lt;span class=&quot;pub-category&quot;&gt;Tudományos&lt;/span&gt; &lt;/div&gt; &lt;/div&gt; &lt;/div&gt;</template><template2>&lt;div class=&quot;BookChapter Publication long-list&quot;&gt;
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        &lt;div class=&quot;duplumMark&quot;&gt;Duplumjelölés:
            
            2025.02.21. 14:49
            	(Győrffy Balázs (Onkológia))
        &lt;/div&gt;
&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2025.02.21. 14:49 Sonnevend Kinga (SE_AOK_Adm5_Élet_kutcsop, admin)
&lt;/div&gt;




	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: The Hong Kong University of Science and Technology, Hong Kong            
            Beihang University, China            
            Conference code: 200372            
            Cited By :6            
            Export Date: 21 February 2025            
            Correspondence Address: Xie, F.; Beihang UniversityChina; email: xfy_73@buaa.edu.cn            
            Correspondence ...&lt;/pre&gt;
&lt;/div&gt;
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