https://m2.mtmt.hu/ hun 2026-10-23 02:39 JournalArticle 35777220 VALIDATED true Funding Agency and Grant Number: This research was supported by the National Research, Development and Innovation Office (OTKA FK 138385 and OTKA PD 146424), as well as the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financ [138385, OTKA PD 146424]; National Research, Development and Innovation Office (OTKA FK) [TKP2021-EGA-25]; Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund Funding text: This research was supported by the National Research, Development and Innovation Office (OTKA FK 138385 and OTKA PD 146424), as well as the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA-25 funding scheme. 0 false 2026-10-14T06:58:00.601+0000 2026-04-09T10:47:02.023+0000 2025-02-21T07:20:56.970+0000 true 10053194 Farkas Kinga /api/author/10053194 Author Farkas Kinga (Pszichiátria) true 10053194 2026-09-24T11:45:08.743+0000 2025-11-25T14:49:41.310+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin Gere Tamásné (SE_KK_Admin5_GT, admin) true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Rácz, Frigyes Sámuel true true /api/journal/20108959 REVIEWED SCHIZOPHRENIA 2754-6993 true false false 20108959 true 2754-6993 Journal FOREIGN 11 1 20 20 10 2025 Altered neural excitation/inhibition (E/I) balance has long been suspected as a potential underlying cause for clinical symptoms in schizophrenia (SZ). Recent methodological advancements linking the spectral slope ( β ) of neurophysiological recordings – such as them electroencephalogram (EEG) – to E/I ratio provided much-needed tools to better understand this plausible relationship. Importantly, most approaches treat E/I ratio as a stationary feature in a single scaling range. On the other hand, previous research indicates that this property might change over time, as well as it can express different characteristics in low- and high-frequency regimes. In line, in this study we analyzed resting-state EEG recordings from 30 patients with SZ and 31 healthy controls (HC) and characterized E/I ratio via β separately for low- (1–4 Hz) and high- (20–45 Hz) frequency regimes in a time-resolved manner. Results from this analysis confirmed the bimodal nature of power spectra in both HC and SZ, with steeper spectral slopes in the high- compared to low-frequency ranges. We did not observe any between-group differences in stationary (i.e., time-averaged) neural signatures, however, the temporal variance of β in the 20–45 Hz regime was significantly reduced in SZ patients when compared to HC, predominantly over regions corresponding to the dorsal attention network. Furthermore, this alteration was found correlated to positive clinical symptom scores. Our study indicates that altered E/I ratio dynamics are a characteristic trait of SZ that reflect pathophysiological processes involving the parietal and occipital cortices, potentially responsible for some of the clinical features of the disorder. Funding 2050286 /api/funding/2050286 (FK 138385) false true Funding 2050287 /api/funding/2050287 (PD 146424) false true Funding 2050288 /api/funding/2050288 (TKP2021-EGA-25) false true Funding 2050289 /api/funding/2050289 (Open access funding provided by Semmelweis University) false true true true 2025 true true true false true false NONE 2026-10-14 false 4 0 4 2 2 4 4 4 4 4 4 2 2 2 2 0 4 2 4 2 0 17 17 Folyóiratcikk Journal Article 24 4 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 3 2 3 2 2026 0 1 0 1 0 false false false false 2025-03-02T08:35:59.910+0000 Megelőző Orvostani és Népegészségtani Intézet (SE / AOK / I); Pszichiátriai és Pszichoterápiás Klinika (SE / AOK / K); Élettani Intézet (SE / AOK / I) 7 24 3 7 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 123450586 /api/authorship/123450586 Rácz, Frigyes Sámuel [Rácz, Frigyes Sámuel (Élettan), szerző] Élettani Intézet (SE / AOK / I) 1 0.143 true false false Author 10059431 /api/author/10059431 Rácz Frigyes Sámuel (Élettan) Rácz Frigyes Sámuel true 10059431 true Rácz Frigyes Sámuel true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 123450587 /api/authorship/123450587 Farkas, Kinga [Farkas, Kinga (Pszichiátria), szerző] Pszichiátriai és Pszichoterápiás Klinika (SE / AOK / K) 2 0.143 false false false Author 10053194 /api/author/10053194 Farkas Kinga (Pszichiátria) Farkas Kinga true 10053194 true Farkas Kinga true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 123450588 /api/authorship/123450588 Becske, Melinda [Becske, Melinda (pszichológus), szerző] Pszichiátriai és Pszichoterápiás Klinika (SE / AOK / K) 3 0.143 false false false Author 10071582 /api/author/10071582 Becske Melinda (pszichológus) Becske Melinda true true Becske Melinda true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 123450589 /api/authorship/123450589 Molnár, Hajnalka [Molnár, Hajnalka (pszichiátria), szerző] Pszichiátriai és Pszichoterápiás Klinika (SE / AOK / K) 4 0.143 false false false Author 10080394 /api/author/10080394 Molnár Hajnalka (pszichiátria) Molnár Hajnalka true true Molnár Hajnalka true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 123450590 /api/authorship/123450590 Fodor, Zsuzsanna [Fodor, Zsuzsanna (Pszichiátria), szerző] Pszichiátriai és Pszichoterápiás Klinika (SE / AOK / K) 5 0.143 false false false Author 10055945 /api/author/10055945 Fodor Zsuzsanna (Pszichiátria) Fodor Zsuzsanna true 10055945 true Fodor Zsuzsanna true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 123450591 /api/authorship/123450591 Mukli, Péter [Mukli, Péter (Élettan, megelőző...), szerző] Élettani Intézet (SE / AOK / I); Megelőző Orvostani és Népegészségtani Intézet (SE / AOK / I) 6 0.143 false false false Author 10032249 /api/author/10032249 Mukli Péter (Élettan, megelőző orvostan és népegészségtan) Mukli Péter true 10032249 true Mukli Péter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 123450592 /api/authorship/123450592 Csukly, Gábor ✉ [Csukly, Gábor (Pszichiátria), szerző] Pszichiátriai és Pszichoterápiás Klinika (SE / AOK / K) 7 0.143 false true true Author 10023954 /api/author/10023954 Csukly Gábor (Pszichiátria) Csukly Gábor true 10023954 true Csukly Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 28449524 /api/publicationidentifier/28449524 DOI: 10.1038/s41537-025-00568-3 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1038/s41537-025-00568-3 https://doi.org/10.1038/s41537-025-00568-3 false true PublicationIdentifier 28568353 /api/publicationidentifier/28568353 WoS: 001424537600002 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001424537600002 https://www.webofscience.com/wos/woscc/full-record/001424537600002 true true PublicationIdentifier 28746258 /api/publicationidentifier/28746258 Scopus: 85219744945 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85219744945 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85219744945 false true PublicationIdentifier 28568354 /api/publicationidentifier/28568354 PubMed: 39966406 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39966406 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39966406&dopt=Abstract true true PublicationIdentifier 31810841 /api/publicationidentifier/31810841 Egyéb URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85219744945&doi=10.1038%2Fs41537-025-00568-3&partnerID=40&md5=65e44be7c6bd5d3020371726d6dd60b1 PlainSource 40 /api/publicationsource/40 Egyéb URL PublicationSourceType 10006 /api/publicationsourcetype/10006 Link true true true Egyéb URL Other URL @@@ true true 40 true NONE IDENTICAL https://www.scopus.com/inward/record.uri?eid=2-s2.0-85219744945&doi=10.1038%2Fs41537-025-00568-3&partnerID=40&md5=65e44be7c6bd5d3020371726d6dd60b1 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85219744945&doi=10.1038%2Fs41537-025-00568-3&partnerID=40&md5=65e44be7c6bd5d3020371726d6dd60b1 false true Classification 12318 /api/classification/12318 Pszichiátriai betegségek (pl. skizofrénia, autizmus, Tourette-szindróma, rögeszmés, kényszeres betegség, depresszió, bipoláris betegség, figyelemhiányos hiperaktivitás) true true Reference 63894811 /api/reference/63894811 1. 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(2025) SCHIZOPHRENIA 2754-6993 11 1<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10059431"><a href="/gui2/?type=authors&mode=browse&sel=10059431" target="_blank">Rácz Frigyes Sámuel (<span class="authorship-author-name">Rácz Frigyes Sámuel</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053194"><a href="/gui2/?type=authors&mode=browse&sel=10053194" target="_blank">Farkas Kinga (<span class="authorship-author-name">Farkas Kinga</span> <span class="authorAux-mtmt"> Pszichiátria</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pszichiátriai és Pszichoterápiás Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071582"><a href="/gui2/?type=authors&mode=browse&sel=10071582" target="_blank">Becske Melinda (<span class="authorship-author-name">Becske Melinda</span> <span class="authorAux-mtmt"> pszichológus</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pszichiátriai és Pszichoterápiás Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10080394"><a href="/gui2/?type=authors&mode=browse&sel=10080394" target="_blank">Molnár Hajnalka (<span class="authorship-author-name">Molnár Hajnalka</span> <span class="authorAux-mtmt"> pszichiátria</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pszichiátriai és Pszichoterápiás Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055945"><a href="/gui2/?type=authors&mode=browse&sel=10055945" target="_blank">Fodor Zsuzsanna (<span class="authorship-author-name">Fodor Zsuzsanna</span> <span class="authorAux-mtmt"> Pszichiátria</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pszichiátriai és Pszichoterápiás Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032249"><a href="/gui2/?type=authors&mode=browse&sel=10032249" target="_blank">Mukli Péter (<span class="authorship-author-name">Mukli Péter</span> <span class="authorAux-mtmt"> Élettan, megelőző orvostan és népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023954"><a href="/gui2/?type=authors&mode=browse&sel=10023954" target="_blank">Csukly Gábor ✉ (<span class="authorship-author-name">Csukly Gábor</span> <span class="authorAux-mtmt"> Pszichiátria</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pszichiátriai és Pszichoterápiás Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35777220" target="_blank">Reduced temporal variability of cortical excitation/inhibition ratio in schizophrenia</a></div> <div> <span class="journal-title">SCHIZOPHRENIA</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2754-6993">2754-6993</a>)</span>: <span class="journal-volume">11</span> <span class="journal-issue">1</span> <span class="page"> Paper 20. 10 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/s41537-025-00568-3" target="_blank" href="https://doi.org/10.1038/s41537-025-00568-3"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001424537600002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001424537600002"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85219744945" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85219744945"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39966406" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39966406&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85219744945&doi=10.1038%2Fs41537-025-00568-3&partnerID=40&md5=65e44be7c6bd5d3020371726d6dd60b1" target="_blank" href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85219744945&doi=10.1038%2Fs41537-025-00568-3&partnerID=40&md5=65e44be7c6bd5d3020371726d6dd60b1"> Egyéb URL </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 4</span> | Független: 2 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 4 | Scopus jelölt:&nbsp;4 | WoS/Scopus jelölt:&nbsp;4 | DOI jelölt:&nbsp;4 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35777220&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 17 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35777220</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (FK 138385), (PD 146424), (TKP2021-EGA-25), (Open access funding provided by Semmelweis University) </div> <div class="notDuplums"><a target="_blank" href="/api/publication/35777220/notduplums">8 Nem duplumnak jelölés</a> </div> <div class="lastModified">Utolsó módosítás: 2026.04.09. 12:47 Sonnevend Kinga (SE_AOK_Élettan_Admin5_SK, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: This research was supported by the National Research, Development and Innovation Office (OTKA FK 138385 and OTKA PD 146424), as well as the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financ [138385, OTKA PD 146424]; National Research, Development and Innovation Office (OTKA FK) [TKP2021-EGA-25]; ...</pre> </div></div>