https://m2.mtmt.hu/ eng 2026-10-23 16:52 JournalArticle 35770092 VALIDATED true 0 false 2026-08-05T10:52:17.266+0000 2026-01-21T12:50:29.435+0000 2025-02-19T08:09:20.991+0000 true 10065463 Turek Márta /api/admin/10065463 Admin true 2026-05-19T12:28:47.347+0000 2026-05-19T12:28:47.347+0000 2025-09-25T11:33:01.490+0000 true 10069305 Kondor Zóra /api/admin/10069305 Admin true Admin 10003141 /api/admin/10003141 Aggod Zsuzsa true 10003141 true 2026-04-22T08:11:27.347+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Zichó, Krisztián Identification of the subventricular tegmental nucleus as brainstem reward center true true /api/journal/4028 REVIEWED true false 4028 false 4028 true 0036-8075 1095-9203 Journal FOREIGN 387 6732 eadr2191 eadr2191 16 2025 Rewards are essential for motivation, decision-making, memory, and mental health. We identified the subventricular tegmental nucleus (SVTg) as a brainstem reward center. In mice, reward and its prediction activate the SVTg, and SVTg stimulation leads to place preference, reduced anxiety, and accumbal dopamine release. Mice self-stimulate the SVTg, which can also be activated directly by the neocortex, resulting in effective inhibition of the lateral habenula, a region associated with depression. This mechanism may also explain why SVTg suppression induces aversion and increases fear. The translational relevance of these findings is supported by evidence in the rat, monkey, and human brainstem, establishing SVTg as a key hub for reward processing, emotional valence, and motivation. Funding 2049887 /api/funding/2049887 false true Funding 2049888 /api/funding/2049888 false true Funding 2049889 /api/funding/2049889 false true Funding 2049890 /api/funding/2049890 false true Funding 2049891 /api/funding/2049891 false true Funding 2049892 /api/funding/2049892 false true Funding 2049893 /api/funding/2049893 false true Funding 2049894 /api/funding/2049894 false true Funding 2049895 /api/funding/2049895 false true Funding 2049896 /api/funding/2049896 false true Funding 2049897 /api/funding/2049897 false true Funding 2049898 /api/funding/2049898 false true Funding 2049899 /api/funding/2049899 false true Funding 2049900 /api/funding/2049900 false true Funding 2049901 /api/funding/2049901 false true true 2025 true true true false true false GOLD 2026-08-05 true https://doi.org/10.1126/science.adr2191 7 0 7 7 0 7 7 6 7 7 7 7 7 7 0 0 7 7 7 7 0 5 5 Folyóiratcikk Journal Article 24 7 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 4 4 4 4 2026 0 3 3 3 3 D1 A false 215,10012277,10012928 false false false 2025-03-25T09:50:33.296+0000 Agykéreg Kutatócsoport (HRN KOKI); Celluláris Neurofarmakológia Kutatócsoport (HRN KOKI); Doktori Iskola (SE); Roska Tamás Műszaki és Természettudományi Dokto... (PPKE / ITK); Transzlációs Magatartás Idegtudomány Kutatócsoport (HRN KOKI) 12 33 5 14 0 true 10003141 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 123391906 /api/authorship/123391906 1 0.071 true false false Author 10076796 /api/author/10076796 Zichó Krisztián true true Zichó Krisztián true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123391907 /api/authorship/123391907 2 0.071 false false false Author 10076779 /api/author/10076779 Balog Boldizsár Zsolt true true Balog Boldizsár Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123391908 /api/authorship/123391908 3 0.071 false false false Author 10099006 /api/author/10099006 Sebestény Réka Zsófia true true Sebestény Réka Z true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123391909 /api/authorship/123391909 4 0.071 false false false Author 10014148 /api/author/10014148 Brunner János true 10014148 true Brunner János true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123391910 /api/authorship/123391910 5 0.071 false false false Author 223 /api/author/223 Tresóné Takács Virág true 223 true Takács Virág true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123391911 /api/authorship/123391911 6 0.071 false false false Author 10054351 /api/author/10054351 Barth Albert true 10054351 true Barth Albert M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123391912 /api/authorship/123391912 7 0.071428575 false false false Seng Charlotte true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123391913 /api/authorship/123391913 8 0.071 false false false Author 10088816 /api/author/10088816 Orosz Áron true true Orosz Áron true false false AuthorshipType 1 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false false false Author 215 /api/author/215 Szabadics János true 215 true Szabadics János true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123391919 /api/authorship/123391919 14 0.071 false true true Author 10012277 /api/author/10012277 Nyiri Gábor true 10012277 true Nyiri Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 28426881 /api/publicationidentifier/28426881 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1126/science.adr2191 https://doi.org/10.1126/science.adr2191 false true PublicationIdentifier 28427837 /api/publicationidentifier/28427837 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GOLD true IDENTICAL 215752 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Földtudományok Osztálya HAS Section of Earth Sciences (X.) true 70 true true true A true true MtaRating 11551103 /api/mtarating/11551103 RatingType 10010 /api/ratingtype/10010 RegTB Institute 14100 /api/institute/14100 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true A nemzetközi false true MtaRating 519101 /api/mtarating/519101 RatingType 10007 /api/ratingtype/10007 SZTB Institute 14102 /api/institute/14102 0 false true false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true A nemzetközi true 19101 true SjrRating 11590759 /api/sjrrating/11590759 1 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1207 /api/classificationexternal/1207 true 1207 true D1 DIRECT true true /api/publication/35770092 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10076796"><a href="/gui2/?type=authors&mode=browse&sel=10076796" target="_blank">Zichó Krisztián (<span class="authorship-author-name">Zichó Krisztián</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Cerebral Cortex Research; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10076779"><a href="/gui2/?type=authors&mode=browse&sel=10076779" target="_blank">Balog Boldizsár Zsolt (<span class="authorship-author-name">Balog Boldizsár Zsolt</span> <span class="authorAux-mtmt"> </span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Cerebral Cortex Research; <span title="Pázmány Péter Catholic University">PPCU</span>/<span title="Információs Technológiai és Bionikai Kar">ITK</span>/Roska Tamás Műszaki és Természettudományi Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10099006"><a href="/gui2/?type=authors&mode=browse&sel=10099006" target="_blank">Sebestény Réka Z (<span class="authorship-author-name">Sebestény Réka Zsófia</span> <span class="authorAux-mtmt"> Neurobiólógia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Cerebral Cortex Research</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014148"><a href="/gui2/?type=authors&mode=browse&sel=10014148" target="_blank">Brunner János (<span class="authorship-author-name">Brunner János</span> <span class="authorAux-mtmt"> Neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Cellular Neuropharmacology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="223"><a href="/gui2/?type=authors&mode=browse&sel=223" target="_blank">Takács Virág (<span class="authorship-author-name">Tresóné Takács Virág</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Cerebral Cortex Research</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054351"><a href="/gui2/?type=authors&mode=browse&sel=10054351" target="_blank">Barth Albert M (<span class="authorship-author-name">Barth Albert</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Cerebral Cortex Research</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Seng Charlotte </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10088816"><a href="/gui2/?type=authors&mode=browse&sel=10088816" target="_blank">Orosz Áron (<span class="authorship-author-name">Orosz Áron</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Cerebral Cortex Research; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020826"><a href="/gui2/?type=authors&mode=browse&sel=10020826" target="_blank">Aliczki Manó (<span class="authorship-author-name">Aliczki Manó</span> <span class="authorAux-mtmt"> Magatartásélettan</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Translational Behavioural Neuroscience Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10088897"><a href="/gui2/?type=authors&mode=browse&sel=10088897" target="_blank">Sebők Hunor (<span class="authorship-author-name">Sebők Hunor</span> <span class="authorAux-mtmt"> neurobiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Cerebral Cortex Research</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012928"><a href="/gui2/?type=authors&mode=browse&sel=10012928" target="_blank">Mikics Eva (<span class="authorship-author-name">Mikics Éva</span> <span class="authorAux-mtmt"> Neuroendokrinológia, viselkedésbiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Translational Behavioural Neuroscience Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Földy Csaba </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="215"><a href="/gui2/?type=authors&mode=browse&sel=215" target="_blank">Szabadics János (<span class="authorship-author-name">Szabadics János</span> <span class="authorAux-mtmt"> Celluláris neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Cellular Neuropharmacology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012277"><a href="/gui2/?type=authors&mode=browse&sel=10012277" target="_blank">Nyiri Gábor ✉ (<span class="authorship-author-name">Nyiri Gábor</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Cerebral Cortex Research</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35770092" target="_blank">Identification of the subventricular tegmental nucleus as brainstem reward center</a></div> <div> <span class="journal-title">SCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0036-8075">0036-8075</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1095-9203">1095-9203</a>)</span>: <span class="journal-volume">387</span> <span class="journal-issue">6732</span> <span class="page"> Paper eadr2191. 16 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1126/science.adr2191" target="_blank" href="https://doi.org/10.1126/science.adr2191"> DOI </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="215752" target="_blank" href="https://real.mtak.hu/215752"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001496574700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001496574700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85216717665" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85216717665"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39847621" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39847621&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - History and Philosophy of Science&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">HAS Section of Earth Sciences (X.) HASSESX&nbsp;&nbsp;&nbsp;A</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 7</span> | Independent citation: 7 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 6 | Number of citations in Scopus:&nbsp;7 | WoS/Scopus assigned:&nbsp;7 | Number of citations with DOI:&nbsp;7 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35770092&sort=publishedYear,desc&sort=title"> Number of cited publications: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35770092</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Hungarian National Research, Development and Innovation Office (NRDI Fund)(133837), Hungarian Brain Research Program (NAP 2.0)(2017–1.2.1-NKP-2017-00002), Hungarian Brain Research Program(NAP2022-I-1/2022), MILAB(RRF-2.3.1-21-2022-00004) Funder: NRDIO, MILAB(RRF-2.3.1-21-2022-00004) Funder: NRDIO, National Laboratory of Translational Neuroscience (TINL)(RRF-2.3.1-21-2022-00011), (Recovery and Resilience Facility of the European Union within the framework of Programme Széchenyi Plan Plus grant number RRF-2.3.1-21-2022-00011), (RRF-2.3.1-21-2022-00011), Funding details: European Research Council, ERC(ERC-CoG 772452), (FEIF/646-4/2021-ITM_SZERZ), (ÚNKP-23-3-I-SE-48), ÚNKP(22-3-II-SE-7), ÚNKP(23-3-II-SE-24), ÚNKP(23-2-II-SE-25), (EFOP-3.6.3.-VEKOP-16-2017-00009) </div> <div class="lastModified">Last Modified: 2026.01.21. 13:50 András Balázs (MTMT Központ, admin) </div> <div class="lockedBy">Centrally managed 2026.04.22. 10:11 Zsuzsa Aggod (MTMT 2-3, admin) </div> </div></div>