https://m2.mtmt.hu/ hun 2026-09-22 03:52 JournalArticle 35764352 VALIDATED true This study was funded by a National Research, Development, and Innovation Office Jedlik Ányos grant to Anxiofit Ltd., which was represented at that time by J.H. and T.F.F. 0 false 2026-08-04T13:58:53.915+0000 2026-03-07T00:27:58.730+0000 2025-02-17T09:39:21.488+0000 true 10019979 Somorjai Noémi /api/admin/10019979 Admin true 10019979 2026-03-25T17:19:03.981+0000 2026-03-25T17:19:03.981+0000 2025-04-30T12:44:53.125+0000 true 10058509 Margit István /api/admin/10058509 Admin true 10058509 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Haller, József The Effects of Echinacea (EP107TM) on Anxiety: A Comparison of Anxiety Measures in a Randomized, Double Blind, Placebo-Controlled Study true true /api/journal/10024432 REVIEWED true false 10024432 false 10024432 true 1424-8247 Journal FOREIGN 18 2 264 264 15 2025 Background/Objectives: Echinacea extracts with unique alkamide profiles (EP107™) have been shown to affect upper respiratory tract infections and reduce anxiety in both animals and humans. However, a recent study found that a similar extract did not reduce anxiety more than a placebo, although it did enhance well-being and produced antidepressant-like effects. We hypothesized that the discrepancy arose from the differences in the anxiety assessment methods used. The study that observed no effects used the Clinically Useful Anxiety Outcome Scale, which focuses on physical symptoms, while earlier studies used the State-Trait Anxiety Inventory, which focuses on psychic symptoms. Methods: To investigate the influence of the anxiety measure on the detectability of anxiolytic effects, we examined the effects of Echinacea EP107TM using the Hospital Anxiety and Depression Scale–anxiety subscale (HADS-A), which focuses on psychic symptoms, and the Hamilton Anxiety Rating Scale (HAM-A), most items of which involve physical symptoms. The study was placebo-controlled, double-blind, and multicenter. Results: The extract significantly alleviated anxiety compared to placebo when measured with HADS-A. HAM-A total scores did not show significant treatment effects. However, Echinacea was superior to placebo in three psychic anxiety items on the HAM-A. Conclusions: These findings suggest that Echinacea EP107TM reduces psychic anxiety without affecting somatic symptoms. This indicates that the extract may be useful in mild or early-phase anxiety when somatic symptoms are not prominent. 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<span class="author-name" mtid="10005313"><a href="/gui2/?type=authors&mode=browse&sel=10005313" target="_blank">Faludi Gábor (<span class="authorship-author-name">Faludi Gábor</span> <span class="authorAux-mtmt"> Psychiatria</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pszichiátriai és Pszichoterápiás Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kovacs Gábor </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023077"><a href="/gui2/?type=authors&mode=browse&sel=10023077" target="_blank">Purebl György (<span class="authorship-author-name">Purebl György</span> <span class="authorAux-mtmt"> Pszichiátria, alvásmedicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Magatartástudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Füzesi Zoltán </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >F. Freund Tamás </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35764352" target="_blank">The Effects of Echinacea (EP107TM) on Anxiety: A Comparison of Anxiety Measures in a Randomized, Double Blind, Placebo-Controlled Study</a></div> <div> <span class="journal-title">PHARMACEUTICALS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1424-8247">1424-8247</a>)</span>: <span class="journal-volume">18</span> <span class="journal-issue">2</span> <span class="page"> Paper 264. 15 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ph18020264" target="_blank" href="https://doi.org/10.3390/ph18020264"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="102229" target="_blank" href="https://tudasportal.uni-nke.hu/xmlui/handle/20.500.12944/102229"> NKE Közszolgálati Tudásportál </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="10040" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/10040"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001431898200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001431898200001"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="218407" target="_blank" href="https://real.mtak.hu/218407"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85218958414" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85218958414"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40006076" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40006076&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Drug Discovery&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmaceutical Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 2</span> | Független: 2 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;2 | WoS/Scopus jelölt:&nbsp;2 | DOI jelölt:&nbsp;2 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35764352&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35764352</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (National Research, Development, and Innovation Office Jedlik Ányos grant) </div> <div class="lastModified">Utolsó módosítás: 2026.03.07. 01:27 Pécsi Éva (MTMT Közp 2,3, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: This study was funded by a National Research, Development, and Innovation Office Jedlik Ányos grant to Anxiofit Ltd., which was represented at that time by J.H. and T.F.F.</pre> </div></div>