https://m2.mtmt.hu/ hun 2026-09-22 19:02 JournalArticle 35761180 VALIDATED true Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, 8380453, Chile Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, 7830490, Chile Center for Prevention and Diagnosis of Celiac Disease, Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, 20122, Italy Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, 20122, Italy Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, 20122, Italy Export Date: 6 March 2025 Correspondence Address: Valenzuela, R.; Department of Nutrition, Chile; email: rvalenzuelab@uchile.cl 0 false 2026-06-29T05:25:35.095+0000 2025-10-31T10:40:05.940+0000 2025-02-14T13:04:07.264+0000 true 10073702 Heronyányi Zsolt /api/admin/10073702 Admin Heronyányi Zsolt (PTE ÁOK admin 5) true 2026-06-29T05:24:08.129+0000 2025-03-06T13:55:54.056+0000 true 10065569 Pécsi Éva /api/admin/10065569 Admin Pécsi Éva (MTMT Közp 2,3, admin) true 2025-03-08T03:17:01.609+0000 true 521 Szuper Admin /api/admin/521 Admin Szuper Admin (admin) true false false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Összefoglaló cikk (Folyóiratcikk) 102 true 1134514 true 1 /api/category/1 Category Tudományos true 1 Bascuñán, Karla A. true true /api/journal/10016563 REVIEWED NUTRIENTS 2072-6643 true false 10016563 false 10016563 true 2072-6643 Journal FOREIGN 17 4 621 621 2025 Celiac disease (CD) is a chronic autoimmune disorder driven by both genetic and environmental factors, with the HLA DQ2/DQ8 genotypes playing a central role in its development. Despite the genetic predisposition, only a small percentage of individuals carrying these genotypes develop the disease. Gluten, a protein found in wheat, rye, and barley, is the primary environmental trigger, but other factors, such as the intestinal microbiota, may also contribute to disease progression. While the gluten-free diet (GFD) remains the cornerstone of treatment, many CD patients experience persistent inflammation and gut dysbiosis, leading to ongoing symptoms and complications. This chronic inflammation, which impairs nutrient absorption, increases the risk of malnutrition, anemia, and other autoimmune disorders. Recent studies have identified an altered gut microbiota in CD patients, both on and off the GFD, highlighting the potential role of the microbiota in disease pathogenesis. An emerging area of interest is the supplementation of n-3 polyunsaturated fatty acids (PUFAs), known for their anti-inflammatory properties, as a potential therapeutic strategy. n-3 PUFAs, found in fish oil and certain plant oils, modulate the immune cell function and cytokine production, making them a promising intervention for controlling chronic inflammation in CD. This review explores the current understanding of n-3 PUFAs’ effects on the gut microbiota’s composition and inflammation in CD, with the goal of identifying new avenues for complementary treatments to improve disease management. true 2025 true true true false false GOLD 2026-06-29 false http://www.mdpi.com/journal/nutrients/ 0 0 0 0 0 0 0 0 0 0 0 0 3 3 D1 false false false false 2025-03-05T13:55:53.581+0000 22 59 0 7 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 123335823 /api/authorship/123335823 Bascuñán, Karla A. 1 0.14285715 true false false Bascuñán Karla A. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 123335824 /api/authorship/123335824 Araya, Magdalena 2 0.14285715 false false false Araya Magdalena true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 123335825 /api/authorship/123335825 Rodríguez, Juan Manuel 3 0.14285715 false false false Rodríguez Juan Manuel true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 123335826 /api/authorship/123335826 Roncoroni, Leda 4 0.14285715 false false false Roncoroni Leda true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 123335827 /api/authorship/123335827 Elli, Luca 5 0.14285715 false false false Elli Luca true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 123335828 /api/authorship/123335828 Alvarez, Josefina Del Pilar López 6 0.14285715 false false false Alvarez Josefina Del Pilar López true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 123335829 /api/authorship/123335829 Valenzuela, Rodrigo 7 0.14285715 false true false Valenzuela Rodrigo true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 28403923 /api/publicationidentifier/28403923 DOI: 10.3390/nu17040621 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/nu17040621 https://doi.org/10.3390/nu17040621 false true PublicationIdentifier 28596346 /api/publicationidentifier/28596346 WoS: 001429774300001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001429774300001 https://www.webofscience.com/wos/woscc/full-record/001429774300001 true true PublicationIdentifier 28596334 /api/publicationidentifier/28596334 Scopus: 85218456369 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85218456369 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85218456369 true true SjrRating 11583198 /api/sjrrating/11583198 sjr:D1 (2025) Scopus - Food Science NUTRIENTS 2072-6643 25 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1106 /api/classificationexternal/1106 Scopus - Food Science true 1106 true D1 DIRECT true true Reference 63485877 /api/reference/63485877 1. Brown 2019: A Clinician’s Guide to Celiac Disease HLA Genetics., Am. J. Gastroenterol., 114, p. 1587, DOI: 10.14309/ajg.0000000000000310 1 10.14309/ajg.0000000000000310 false true Reference 63485878 /api/reference/63485878 2. Lebwohl 2017: Coeliac Disease., Lancet, 391, p. 70, DOI: 10.1016/S0140-6736(17)31796-8 2 10.1016/S0140-6736(17)31796-8 false true Reference 63485879 /api/reference/63485879 3. Kang 2013: Systematic Review: Worldwide Variation in the Frequency of Coeliac Disease and Changes over Time., Aliment. Pharmacol. Ther., 38, p. 226, DOI: 10.1111/apt.12373 3 10.1111/apt.12373 false true Reference 63485880 /api/reference/63485880 4. Singh 2018: Global Prevalence of Celiac Disease: Systematic Review and Meta-Analysis., Clin. Gastroenterol. Hepatol., 16, p. 823, DOI: 10.1016/j.cgh.2017.06.037 4 10.1016/j.cgh.2017.06.037 false true Reference 63485881 /api/reference/63485881 5. King 2020: Incidence of Celiac Disease Is Increasing Over Time: A Systematic Review and Meta-Analysis., Am. J. Gastroenterol., 115, p. 507, DOI: 10.14309/ajg.0000000000000523 5 10.14309/ajg.0000000000000523 false true Reference 63485882 /api/reference/63485882 6. Ferretti 2017: Coping with Celiac Disease: How Heavy Is the Burden for Caregivers?., Rev. Esp. Enfermedades Dig., 109, p. 250, DOI: 10.17235/reed.2017.4518/2016 6 10.17235/reed.2017.4518/2016 false true Reference 63485883 /api/reference/63485883 7. Nachman 2009: Quality of Life in Celiac Disease Patients: Prospective Analysis on the Importance of Clinical Severity at Diagnosis and the Impact of Treatment., Dig. Liver Dis., 41, p. 15, DOI: 10.1016/j.dld.2008.05.011 7 10.1016/j.dld.2008.05.011 false true Reference 63485884 /api/reference/63485884 8. White 2016: Coeliac Disease and the Gluten-Free Diet: A Review of the Burdens; Factors Associated with Adherence and Impact on Health-Related Quality of Life, with Specific Focus on Adolescence., J. Hum. Nutr. Diet., 29, p. 593, DOI: 10.1111/jhn.12375 8 10.1111/jhn.12375 false true Reference 63485885 /api/reference/63485885 9. Dakó, E., Dakó, S., Papp, V., Juhász, M., Takács, J., Csobod, É.C., and Pálfi, E. (2024). Monitoring the Quality of Life and the Relationship between Quality of Life, Dietary Intervention, and Dietary Adherence in Patients with Coeliac Disease. Nutrients, 16., DOI: 10.3390/nu16172964 9 10.3390/nu16172964 false true Reference 63485886 /api/reference/63485886 10. Sciurti 2018: Genetic Susceptibilty and Celiac Disease: What Role Do HLA Haplotypes Play?., Acta Bio-Medica, 89, p. 17 10 false true Reference 63485887 /api/reference/63485887 11. Megiorni 2009: HLA-DQ and Risk Gradient for Celiac Disease., Human. Immunol., 70, p. 55, DOI: 10.1016/j.humimm.2008.10.018 11 10.1016/j.humimm.2008.10.018 false true Reference 63485888 /api/reference/63485888 12. Franke 2007: A Genome-Wide Association Study for Celiac Disease Identifies Risk Variants in the Region Harboring IL2 and IL21., Nat. Genet., 39, p. 827, DOI: 10.1038/ng2058 12 10.1038/ng2058 false true Reference 63485889 /api/reference/63485889 13. Trynka 2011: Dense Genotyping Identifies and Localizes Multiple Common and Rare Variant Association Signals in Celiac Disease., Nat. Genet., 43, p. 1193, DOI: 10.1038/ng.998 13 10.1038/ng.998 false true Reference 63485890 /api/reference/63485890 14. Zhernakova 2015: Fine Mapping in the MHC Region Accounts for 18% Additional Genetic Risk for Celiac Disease., Nat. Genet., 47, p. 577, DOI: 10.1038/ng.3268 14 10.1038/ng.3268 false true Reference 63485891 /api/reference/63485891 15. Bilbao 2021: Celiac Disease Susceptibility: The Genome and Beyond., Int. Rev. Cell Mol. Biol., 358, p. 1, DOI: 10.1016/bs.ircmb.2020.10.002 15 10.1016/bs.ircmb.2020.10.002 false true Reference 63485892 /api/reference/63485892 16. Vespa 2017: Celiac Disease: Understanding the Gluten-Free Diet., Eur. J. Nutr., 56, p. 449, DOI: 10.1007/s00394-016-1238-5 16 10.1007/s00394-016-1238-5 false true Reference 63485893 /api/reference/63485893 17. Lanzini 2009: Complete Recovery of Intestinal Mucosa Occurs Very Rarely in Adult Coeliac Patients despite Adherence to Gluten-Free Diet., Aliment. Pharmacol. Ther., 29, p. 1299, DOI: 10.1111/j.1365-2036.2009.03992.x 17 10.1111/j.1365-2036.2009.03992.x false true Reference 63485894 /api/reference/63485894 18. Newnham 2016: Adherence to the Gluten-Free Diet Can Achieve the Therapeutic Goals in Almost All Patients with Coeliac Disease: A 5-Year Longitudinal Study from Diagnosis., J. Gastroenterol. Hepatol., 31, p. 342, DOI: 10.1111/jgh.13060 18 10.1111/jgh.13060 false true Reference 63485895 /api/reference/63485895 19. Barone, M.V., Auricchio, R., Nanayakkara, M., Greco, L., Troncone, R., and Auricchio, S. (2022). Pivotal Role of Inflammation in Celiac Disease. Int. J. Mol. Sci., 23., DOI: 10.3390/ijms23137177 19 10.3390/ijms23137177 false true Reference 63485896 /api/reference/63485896 20. Meresse 2008: Celiac Disease: From Oral Tolerance to Intestinal Inflammation, Autoimmunity and Lymphomagenesis., Mucosal Immunol., 2, p. 8, DOI: 10.1038/mi.2008.75 20 10.1038/mi.2008.75 false true Reference 63485897 /api/reference/63485897 21. Vici 2016: Gluten Free Diet and Nutrient Deficiencies: A Review., Clin. Nutr., 35, p. 1236, DOI: 10.1016/j.clnu.2016.05.002 21 10.1016/j.clnu.2016.05.002 false true Reference 63485898 /api/reference/63485898 22. Gege 2024: New Developments in Celiac Disease Treatments., Drug Discov. Today, 29, p. 104113, DOI: 10.1016/j.drudis.2024.104113 22 10.1016/j.drudis.2024.104113 false true Reference 63485899 /api/reference/63485899 23. Araya 2020: Dietary Gluten as a Conditioning Factor of the Gut Microbiota in Celiac Disease., Adv. Nutr., 11, p. 160, DOI: 10.1093/advances/nmz080 23 10.1093/advances/nmz080 false true Reference 63485900 /api/reference/63485900 24. Bakhtiari, S., Asri, N., Nikzamir, A., Ahmadipour, S., Rostami-Nejad, M., and Ciacci, C. (2024). Exploring Fatty Acid Effects in Celiac Disease: Potential Therapeutic Avenues. Tissue Barriers, 2435552., DOI: 10.1080/21688370.2024.2435552 24 10.1080/21688370.2024.2435552 false true Reference 63485901 /api/reference/63485901 25. Calder 2010: Omega-3 Fatty Acids and Inflammatory Processes., Nutrients, 2, p. 355, DOI: 10.3390/nu2030355 25 10.3390/nu2030355 false true Reference 63485902 /api/reference/63485902 26. Calder 2017: Omega-3 Fatty Acids and Inflammatory Processes: From Molecules to Man., Biochem. Soc. Trans., 45, p. 1105, DOI: 10.1042/BST20160474 26 10.1042/BST20160474 false true Reference 63485903 /api/reference/63485903 27. Simopoulos 2002: Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases., J. Am. Coll. Nutr., 21, p. 495, DOI: 10.1080/07315724.2002.10719248 27 10.1080/07315724.2002.10719248 false true Reference 63485904 /api/reference/63485904 28. Schuppan 2009: Celiac Disease: From Pathogenesis to Novel Therapies., Gastroenterology, 137, p. 1912, DOI: 10.1053/j.gastro.2009.09.008 28 10.1053/j.gastro.2009.09.008 false true Reference 63485905 /api/reference/63485905 29. Catassi 2022: Coeliac Disease., Lancet, 399, p. 2413, DOI: 10.1016/S0140-6736(22)00794-2 29 10.1016/S0140-6736(22)00794-2 false true Reference 63485906 /api/reference/63485906 30. Sollid 2002: Coeliac Disease: Dissecting a Complex Inflammatory Disorder., Nat. Rev. Immunol., 2, p. 647, DOI: 10.1038/nri885 30 10.1038/nri885 false true Reference 63485907 /api/reference/63485907 31. Fasano 2001: Current Approaches to Diagnosis and Treatment of Celiac Disease: An Evolving Spectrum., Gastroenterology, 120, p. 636, DOI: 10.1053/gast.2001.22123 31 10.1053/gast.2001.22123 false true Reference 63485908 /api/reference/63485908 32. Nilsen 1995: Gluten Specific, HLA-DQ Restricted T Cells from Coeliac Mucosa Produce Cytokines with Th1 or Th0 Profile Dominated by Interferon Gamma., Gut, 37, p. 766, DOI: 10.1136/gut.37.6.766 32 10.1136/gut.37.6.766 false true Reference 63485909 /api/reference/63485909 33. Santin 2009: TH17 (and TH1) Signatures of Intestinal Biopsies of CD Patients in Response to Gliadin., Autoimmunity, 42, p. 69, DOI: 10.1080/08916930802350789 33 10.1080/08916930802350789 false true Reference 63485910 /api/reference/63485910 34. Anderson 2020: Innate and Adaptive Immunity in Celiac Disease., Curr. Opin. Gastroenterol., 36, p. 470, DOI: 10.1097/MOG.0000000000000672 34 10.1097/MOG.0000000000000672 false true Reference 63485911 /api/reference/63485911 35. Wapenaar 2004: The Interferon Gamma Gene in Celiac Disease: Augmented Expression Correlates with Tissue Damage but No Evidence for Genetic Susceptibility., J. Autoimmun., 23, p. 183, DOI: 10.1016/j.jaut.2004.05.004 35 10.1016/j.jaut.2004.05.004 false true Reference 63485912 /api/reference/63485912 36. Drijfhout 2005: Natural Variation in Toxicity of Wheat: Potential for Selection of Nontoxic Varieties for Celiac Disease Patients., Gastroenterology, 129, p. 797, DOI: 10.1053/j.gastro.2005.06.017 36 10.1053/j.gastro.2005.06.017 false true Reference 63485913 /api/reference/63485913 37. Serena, G., Huynh, D., Lima, R.S., Vise, L.M., Freire, R., Ingano, L., Leonard, M.M., Senger, S., and Fasano, A. (2019). Intestinal Epithelium Modulates Macrophage Response to Gliadin in Celiac Disease. Front. Nutr., 6., DOI: 10.3389/fnut.2019.00167 37 10.3389/fnut.2019.00167 false true Reference 63485914 /api/reference/63485914 38. Meresse 2009: Innate T Cell Responses in Human Gut., Semin. Immunol., 21, p. 121, DOI: 10.1016/j.smim.2009.01.002 38 10.1016/j.smim.2009.01.002 false true Reference 63485915 /api/reference/63485915 39. Londei 2005: Gliadin as a Stimulator of Innate Responses in Celiac Disease., Mol. Immunol., 42, p. 913, DOI: 10.1016/j.molimm.2004.12.005 39 10.1016/j.molimm.2004.12.005 false true Reference 63485916 /api/reference/63485916 40. Szebeni 2007: Increased Mucosal Expression of Toll-like Receptor (TLR)2 and TLR4 in Coeliac Disease., J. Pediatr. Gastroenterol. Nutr., 45, p. 187, DOI: 10.1097/MPG.0b013e318064514a 40 10.1097/MPG.0b013e318064514a false true Reference 63485917 /api/reference/63485917 41. Mittal 2014: Reactive Oxygen Species in Inflammation and Tissue Injury., Antioxid. Redox Signal., 20, p. 1126, DOI: 10.1089/ars.2012.5149 41 10.1089/ars.2012.5149 false true Reference 63485918 /api/reference/63485918 42. Teskey 2018: Glutathione as a Marker for Human Disease., Adv. Clin. Chem., 87, p. 141, DOI: 10.1016/bs.acc.2018.07.004 42 10.1016/bs.acc.2018.07.004 false true Reference 63485919 /api/reference/63485919 43. Blokhina 2003: Antioxidants, Oxidative Damage and Oxygen Deprivation Stress: A Review., Ann. Bot., 91, p. 179, DOI: 10.1093/aob/mcf118 43 10.1093/aob/mcf118 false true Reference 63485920 /api/reference/63485920 44. He 2008: Free Radicals, Antioxidants in Disease and Health., Int. J. Biomed. Sci. IJBS, 4, p. 89, DOI: 10.59566/IJBS.2008.4089 44 10.59566/IJBS.2008.4089 false true Reference 63485921 /api/reference/63485921 45. Burton 2011: Oxidative Stress., Best Pract. Res. Clin. Obstet. Gynaecol., 25, p. 287, DOI: 10.1016/j.bpobgyn.2010.10.016 45 10.1016/j.bpobgyn.2010.10.016 false true Reference 63485922 /api/reference/63485922 46. Ambrożewicz, E., Wójcik, P., Wroński, A., Łuczaj, W., Jastrząb, A., Žarković, N., and Skrzydlewska, E. (2018). Pathophysiological Alterations of Redox Signaling and Endocannabinoid System in Granulocytes and Plasma of Psoriatic Patients. Cells, 7., DOI: 10.3390/cells7100159 46 10.3390/cells7100159 false true Reference 63485923 /api/reference/63485923 47. 2012: Glutathione Redox Cycle in Small Intestinal Mucosa and Peripheral Blood of Pediatric Celiac Disease Patients., An. Acad. Bras. Cienc., 84, p. 175, DOI: 10.1590/S0001-37652012000100018 47 10.1590/S0001-37652012000100018 false true Reference 63485924 /api/reference/63485924 48. Ferretti 2012: Celiac Disease, Inflammation and Oxidative Damage: A Nutrigenetic Approach., Nutrients, 4, p. 243, DOI: 10.3390/nu4040243 48 10.3390/nu4040243 false true Reference 63485925 /api/reference/63485925 49. Li, X., Bi, X., Wang, S., Zhang, Z., Li, F., and Zhao, A.Z. (2019). Therapeutic Potential of ω-3 Polyunsaturated Fatty Acids in Human Autoimmune Diseases. Front. Immunol., 10., DOI: 10.3389/fimmu.2019.02241 49 10.3389/fimmu.2019.02241 false true Reference 63485926 /api/reference/63485926 50. Galipeau 2015: Intestinal Microbiota Modulates Gluten-Induced Immunopathology in Humanized Mice., Am. J. Pathol., 185, p. 2969, DOI: 10.1016/j.ajpath.2015.07.018 50 10.1016/j.ajpath.2015.07.018 false true Reference 63485927 /api/reference/63485927 51. Behnsen 2016: Mucosal Immunity to Pathogenic Intestinal Bacteria., Nat. Rev. Immunol., 16, p. 135, DOI: 10.1038/nri.2015.17 51 10.1038/nri.2015.17 false true Reference 63485928 /api/reference/63485928 52. Girbovan 2017: Dysbiosis a Risk Factor for Celiac Disease., Med. Microbiol. Immunol., 206, p. 83, DOI: 10.1007/s00430-017-0496-z 52 10.1007/s00430-017-0496-z false true Reference 63485929 /api/reference/63485929 53. Nistal 2012: Differences in Faecal Bacteria Populations and Faecal Bacteria Metabolism in Healthy Adults and Celiac Disease Patients., Biochimie, 94, p. 1724, DOI: 10.1016/j.biochi.2012.03.025 53 10.1016/j.biochi.2012.03.025 false true Reference 63485930 /api/reference/63485930 54. Cenit 2015: Intestinal Microbiota and Celiac Disease: Cause, Consequence or Co-Evolution?., Nutrients, 17, p. 6900, DOI: 10.3390/nu7085314 54 10.3390/nu7085314 false true Reference 63485931 /api/reference/63485931 55. Zmora 2019: You Are What You Eat: Diet, Health and the Gut Microbiota., Nat. Rev. Gastroenterol. Hepatol., 16, p. 35, DOI: 10.1038/s41575-018-0061-2 55 10.1038/s41575-018-0061-2 false true Reference 63485932 /api/reference/63485932 56. Litvak 2018: Colonocyte Metabolism Shapes the Gut Microbiota., Science, 362, p. eaat9076, DOI: 10.1126/science.aat9076 56 10.1126/science.aat9076 false true Reference 63485933 /api/reference/63485933 57. Bevilacqua, A., Costabile, A., Bergillos-Meca, T., Gonzalez, I., Landriscina, L., Ciuffreda, E., D’Agnello, P., Corbo, M.R., Sinigaglia, M., and Lamacchia, C. (2016). Impact of Gluten-Friendly Bread on the Metabolism and Function of In Vitro Gut Microbiota in Healthy Human and Coeliac Subjects. PLoS ONE, 11., DOI: 10.1371/journal.pone.0162770 57 10.1371/journal.pone.0162770 false true Reference 63485934 /api/reference/63485934 58. Nylund, L., Hakkola, S., Lahti, L., Salminen, S., Kalliomäki, M., Yang, B., and Linderborg, K.M. (2020). Diet, Perceived Intestinal Well-Being and Compositions of Fecal Microbiota and Short Chain Fatty Acids in Oat-Using Subjects with Celiac Disease or Gluten Sensitivity. Nutrients, 12., DOI: 10.3390/nu12092570 58 10.3390/nu12092570 false true Reference 63485935 /api/reference/63485935 59. Mercado 2024: Impact of Polyunsaturated Fatty Acids during and Pregnancy and Lactation: A Comprehensive Review., Prostaglandins Leukot. Essent. Fat. Acids, 203, p. 102656, DOI: 10.1016/j.plefa.2024.102656 59 10.1016/j.plefa.2024.102656 false true Reference 63485936 /api/reference/63485936 60. Sambra, V., Echeverria, F., Valenzuela, A., Chouinard-Watkins, R., and Valenzuela, R. (2021). Docosahexaenoic and Arachidonic Acids as Neuroprotective Nutrients throughout the Life Cycle. Nutrients, 13., DOI: 10.3390/nu13030986 60 10.3390/nu13030986 false true Reference 63485937 /api/reference/63485937 61. Serhan 2018: Resolvins in Inflammation: Emergence of the pro-Resolving Superfamily of Mediators., J. Clin. Investig., 128, p. 2657, DOI: 10.1172/JCI97943 61 10.1172/JCI97943 false true Reference 63485938 /api/reference/63485938 62. Valenzuela 2024: Protein Concentrations and Activities of Fatty Acid Desaturase and Elongase Enzymes in Liver, Brain, Testicle, and Kidney from Mice: Substrate Dependency., Biofactors, 50, p. 89, DOI: 10.1002/biof.1992 62 10.1002/biof.1992 false true Reference 63485939 /api/reference/63485939 63. Serhan 2014: Pro-Resolving Lipid Mediators Are Leads for Resolution Physiology., Nature, 510, p. 92, DOI: 10.1038/nature13479 63 10.1038/nature13479 false true Reference 63485940 /api/reference/63485940 64. Endres 1989: The Effect of Dietary Supplementation with N-3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells., N. Engl. J. Med., 320, p. 265, DOI: 10.1056/NEJM198902023200501 64 10.1056/NEJM198902023200501 false true Reference 63485941 /api/reference/63485941 65. Meydani 1991: Oral (n-3) Fatty Acid Supplementation Suppresses Cytokine Production and Lymphocyte Proliferation: Comparison between Young and Older Women., J. Nutr., 121, p. 547, DOI: 10.1093/jn/121.4.547 65 10.1093/jn/121.4.547 false true Reference 63485942 /api/reference/63485942 66. Trebble 2003: Prostaglandin E2 Production and T Cell Function after Fish-Oil Supplementation: Response to Antioxidant Cosupplementation., Am. J. Clin. Nutr., 78, p. 376, DOI: 10.1093/ajcn/78.3.376 66 10.1093/ajcn/78.3.376 false true Reference 63485943 /api/reference/63485943 67. Lee 1985: Effect of Dietary Enrichment with Eicosapentaenoic and Docosahexaenoic Acids on In Vitro Neutrophil and Monocyte Leukotriene Generation and Neutrophil Function., N. Engl. J. Med., 312, p. 1217, DOI: 10.1056/NEJM198505093121903 67 10.1056/NEJM198505093121903 false true Reference 63485944 /api/reference/63485944 68. Rees 2006: Dose-Related Effects of Eicosapentaenoic Acid on Innate Immune Function in Healthy Humans: A Comparison of Young and Older Men., Am. J. Clin. Nutr., 83, p. 331, DOI: 10.1093/ajcn/83.2.331 68 10.1093/ajcn/83.2.331 false true Reference 63485945 /api/reference/63485945 69. Sperling 1993: Dietary ω-3 Polyunsaturated Fatty Acids Inhibit Phosphoinositide Formation and Chemotaxis in Neutrophils., J. Clin. Investig., 91, p. 651, DOI: 10.1172/JCI116245 69 10.1172/JCI116245 false true Reference 63485946 /api/reference/63485946 70. Yaqoob 1995: Influence of Cell Culture Conditions on Diet-Induced Changes in Lymphocyte Fatty Acid Composition., Biochim. Et Biophys. Acta (BBA)/Lipids Lipid Metab., 1255, p. 333, DOI: 10.1016/0005-2760(94)00251-S 70 10.1016/0005-2760(94)00251-S false true Reference 63485947 /api/reference/63485947 71. Lokesh 1986: Peritoneal Macrophages from Mice Fed Dietary (n-3) Polyunsaturated Fatty Acids Secrete Low Levels of Prostaglandins., J. Nutr., 116, p. 2547, DOI: 10.1093/jn/116.12.2547 71 10.1093/jn/116.12.2547 false true Reference 63485948 /api/reference/63485948 72. Brouard 1990: Effects of Moderate Dietary Supplementations with n − 3 Fatty Acids on Macrophage and Lymphocyte Phospholipids and Macrophage Eicosanoid Synthesis in the Rat., Biochim. Et Biophys. Acta (BBA)/Lipids Lipid Metab., 1047, p. 19, DOI: 10.1016/0005-2760(90)90255-V 72 10.1016/0005-2760(90)90255-V false true Reference 63485949 /api/reference/63485949 73. Fritsche 1993: Maternally-Supplied Fish Oil Alters Piglet Immune Cell Fatty Acid Profile and Eicosanoid Production., Lipids, 28, p. 677, DOI: 10.1007/BF02535986 73 10.1007/BF02535986 false true Reference 63485950 /api/reference/63485950 74. Sprecher 1989: Effect of a Fish Oil Diet on the Composition of Rat Neutrophil Lipids and the Molecular Species of Choline and Ethanolamine Glycerophospholipids., J. Lipid Res., 30, p. 77, DOI: 10.1016/S0022-2275(20)38400-5 74 10.1016/S0022-2275(20)38400-5 false true Reference 63485951 /api/reference/63485951 75. 2004: Effects of Different Dietary Oils on Inflammatory Mediator Generation and Fatty Acid Composition in Rat Neutrophils., Metab. Clin. Exp., 53, p. 59, DOI: 10.1016/j.metabol.2003.08.010 75 10.1016/j.metabol.2003.08.010 false true Reference 63485952 /api/reference/63485952 76. Nathan 2002: Points of Control in Inflammation., Nature, 420, p. 846, DOI: 10.1038/nature01320 76 10.1038/nature01320 false true Reference 63485953 /api/reference/63485953 77. Savoye 2013: Polyunsaturated Fatty Acids in Inflammatory Bowel Diseases: A Reappraisal of Effects and Therapeutic Approaches., Inflamm. Bowel Dis., 19, p. 650, DOI: 10.1097/MIB.0b013e3182810122 77 10.1097/MIB.0b013e3182810122 false true Reference 63485954 /api/reference/63485954 78. Trebble 2004: Peripheral Blood Mononuclear Cell Fatty Acid Composition and Inflammatory Mediator Production in Adult Crohn’s Disease., Clin. Nutr., 23, p. 647, DOI: 10.1016/j.clnu.2003.10.017 78 10.1016/j.clnu.2003.10.017 false true Reference 63485955 /api/reference/63485955 79. Levy 2001: Lipid Mediator Class Switching During Acute Inflammation: Signals in Resolution., Nat. Immunol., 2, p. 612, DOI: 10.1038/89759 79 10.1038/89759 false true Reference 63485956 /api/reference/63485956 80. Curtis 2000: N-3 Fatty Acids Specifically Modulate Catabolic Factors Involved in Articular Cartilage Degradation., J. Biol. Chem., 275, p. 721, DOI: 10.1074/jbc.275.2.721 80 10.1074/jbc.275.2.721 false true Reference 63485957 /api/reference/63485957 81. Calder 2013: Omega-3 Polyunsaturated Fatty Acids and Inflammatory Processes: Nutrition or Pharmacology?., Br. J. Clin. Pharmacol., 75, p. 645, DOI: 10.1111/j.1365-2125.2012.04374.x 81 10.1111/j.1365-2125.2012.04374.x false true Reference 63485958 /api/reference/63485958 82. Kumar 2004: Nuclear Factor-kappaB: Its Role in Health and Disease., J. Mol. Med., 82, p. 434, DOI: 10.1007/s00109-004-0555-y 82 10.1007/s00109-004-0555-y false true Reference 63485959 /api/reference/63485959 83. Perkins 2007: Integrating Cell-Signalling Pathways with NF-kappaB and IKK Function., Nat. Rev. Mol. Cell Biol., 8, p. 49, DOI: 10.1038/nrm2083 83 10.1038/nrm2083 false true Reference 63485960 /api/reference/63485960 84. Wei 2021: The Effects of Low-Ratio n-6/n-3 PUFA on Biomarkers of Inflammation: A Systematic Review and Meta-Analysis., Food Funct., 12, p. 30, DOI: 10.1039/D0FO01976C 84 10.1039/D0FO01976C false true Reference 63485961 /api/reference/63485961 85. Shi 2022: Docosahexaenoic Acid-Acylated Curcumin Diester Alleviates Cisplatin-Induced Acute Kidney Injury by Regulating the Effect of Gut Microbiota on the Lipopolysaccharide- and Trimethylamine-N-Oxide-Mediated PI3K/Akt/NF-κB Signaling Pathway in Mice., Food Funct., 13, p. 6103, DOI: 10.1039/D1FO04178A 85 10.1039/D1FO04178A false true Reference 63485962 /api/reference/63485962 86. Rasouli-Saravani, A., Jahankhani, K., Moradi, S., Gorgani, M., Shafaghat, Z., Mirsanei, Z., Mehmandar, A., and Mirzaei, R. (2023). Role of Microbiota Short-Chain Fatty Acids in the Pathogenesis of Autoimmune Diseases. Biomed. Pharmacother., 162., DOI: 10.1016/j.biopha.2023.114620 86 10.1016/j.biopha.2023.114620 false true Reference 63485963 /api/reference/63485963 87. Watson 2018: A Randomised Trial of the Effect of Omega-3 Polyunsaturated Fatty Acid Supplements on the Human Intestinal Microbiota., Gut, 67, p. 1974, DOI: 10.1136/gutjnl-2017-314968 87 10.1136/gutjnl-2017-314968 false true Reference 63485964 /api/reference/63485964 88. Costantini, L., Molinari, R., Farinon, B., and Merendino, N. (2017). Impact of Omega-3 Fatty Acids on the Gut Microbiota. Int. J. Mol. Sci., 18., DOI: 10.3390/ijms18122645 88 10.3390/ijms18122645 false true Reference 63485965 /api/reference/63485965 89. Zhao 2006: Rapid Determination of Short-Chain Fatty Acids in Colonic Contents and Faeces of Humans and Rats by Acidified Water-Extraction and Direct-Injection Gas Chromatography., Biomed. Chromatogr. BMC, 20, p. 674, DOI: 10.1002/bmc.580 89 10.1002/bmc.580 false true Reference 63485966 /api/reference/63485966 90. Zhang 2019: Potential of Omega-3 Polyunsaturated Fatty Acids in Managing Chemotherapy- or Radiotherapy-Related Intestinal Microbial Dysbiosis., Adv. Nutr., 10, p. 133, DOI: 10.1093/advances/nmy076 90 10.1093/advances/nmy076 false true Reference 63485967 /api/reference/63485967 91. Fu 2021: Associations among Dietary Omega-3 Polyunsaturated Fatty Acids, the Gut Microbiota, and Intestinal Immunity., Mediat. Inflamm., 2021, p. 8879227, DOI: 10.1155/2021/8879227 91 10.1155/2021/8879227 false true Reference 63485968 /api/reference/63485968 92. Wall 2010: Impact of Administered Bifidobacterium on Murine Host Fatty Acid Composition., Lipids, 45, p. 429, DOI: 10.1007/s11745-010-3410-7 92 10.1007/s11745-010-3410-7 false true Reference 63485969 /api/reference/63485969 93. Blanchard 2013: Comparative Effects of Well-Balanced Diets Enriched in α-Linolenic or Linoleic Acids on LC-PUFA Metabolism in Rat Tissues., Prostaglandins Leukot. Essent. Fat. Acids, 88, p. 383, DOI: 10.1016/j.plefa.2013.03.006 93 10.1016/j.plefa.2013.03.006 false true Reference 63485970 /api/reference/63485970 94. Van Hees, N.J.M., Giltay, E.J., Geleijnse, J.M., Janssen, N., and Van Der Does, W. (2014). DHA Serum Levels Were Significantly Higher in Celiac Disease Patients Compared to Healthy Controls and Were Unrelated to Depression. PLoS ONE, 9., DOI: 10.1371/journal.pone.0097778 94 10.1371/journal.pone.0097778 false true Reference 63485971 /api/reference/63485971 95. Steel 2006: Abnormal Fatty Acid Pattern in Intestinal Mucosa of Children with Celiac Disease Is Not Reflected in Serum Phospholipids., J. Pediatr. Gastroenterol. Nutr., 43, p. 318, DOI: 10.1097/01.mpg.0000228107.98863.45 95 10.1097/01.mpg.0000228107.98863.45 false true Reference 63485972 /api/reference/63485972 96. Auricchio, R., Galatola, M., Cielo, D., Amoresano, A., Caterino, M., De Vita, E., Illiano, A., Troncone, R., Greco, L., and Ruoppolo, M. (2019). A Phospholipid Profile at 4 Months Predicts the Onset of Celiac Disease in At-Risk Infants. Sci. Rep., 9., DOI: 10.1038/s41598-019-50735-7 96 10.1038/s41598-019-50735-7 false true Reference 63485973 /api/reference/63485973 97. Solakivi 2009: Serum Fatty Acid Profile in Celiac Disease Patients before and after a Gluten-Free Diet., Scand. J. Gastroenterol., 44, p. 826, DOI: 10.1080/00365520902912589 97 10.1080/00365520902912589 false true Reference 63485974 /api/reference/63485974 98. Krilis 1986: Small Bowel Mucosa from Celiac Patients Generates 15-Hydroxyeicosatetraenoic Acid (15-HETE) after in Vitro Challenge with Gluten., J. Immunol., 137, p. 3768, DOI: 10.4049/jimmunol.137.12.3768 98 10.4049/jimmunol.137.12.3768 false true Reference 63485975 /api/reference/63485975 99. Riezzo 2014: Lipidomic Analysis of Fatty Acids in Erythrocytes of Coeliac Patients before and after a Gluten-Free Diet Intervention: A Comparison with Healthy Subjects., Br. J. Nutr., 112, p. 1787, DOI: 10.1017/S0007114514002815 99 10.1017/S0007114514002815 false true Reference 63485976 /api/reference/63485976 100. Vincentini 2011: Docosahexaenoic Acid Modulates in Vitro the Inflammation of Celiac Disease in Intestinal Epithelial Cells via the Inhibition of cPLA 2., Clin. Nutr., 30, p. 541, DOI: 10.1016/j.clnu.2011.02.007 100 10.1016/j.clnu.2011.02.007 false true Reference 63485977 /api/reference/63485977 101. Bai 2024: Association of Dietary Intake and Serum Concentration of Omega-3 Fatty Acids on Celiac Disease: Evidence from Observational Study and Mendelian Randomization., Eur. J. Gastroenterol. Hepatol., 36, p. 1101, DOI: 10.1097/MEG.0000000000002814 101 10.1097/MEG.0000000000002814 false true Reference 63485978 /api/reference/63485978 102. Decsi 2015: Low N-3 Long-Chain Polyunsaturated Fatty Acids in Newly Diagnosed Celiac Disease in Children with Preexisting Type 1 Diabetes Mellitus., J. Pediatr. Gastroenterol. Nutr., 60, p. 255, DOI: 10.1097/MPG.0000000000000561 102 10.1097/MPG.0000000000000561 false true Reference 63485979 /api/reference/63485979 103. Serhan 2007: Resolution of Inflammation: State of the Art, Definitions and Terms., FASEB J., 21, p. 325, DOI: 10.1096/fj.06-7227rev 103 10.1096/fj.06-7227rev false true Reference 63485980 /api/reference/63485980 104. Wawrzyniak 2021: Nutritional Lipids and Mucosal Inflammation., Mol. Nutr. Food Res., 65, p. e1901269, DOI: 10.1002/mnfr.201901269 104 10.1002/mnfr.201901269 false true /api/publication/35761180 Bascuñán Karla A. et al. Interplay of n-3 Polyunsaturated Fatty Acids, Intestinal Inflammation, and Gut Microbiota in Celiac Disease Pathogenesis. (2025) NUTRIENTS 2072-6643 17 4<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Bascuñán Karla A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Araya Magdalena </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rodríguez Juan Manuel </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Roncoroni Leda </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Elli Luca </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Alvarez Josefina Del Pilar López </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Valenzuela Rodrigo </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35761180" target="_blank">Interplay of n-3 Polyunsaturated Fatty Acids, Intestinal Inflammation, and Gut Microbiota in Celiac Disease Pathogenesis</a></div> <div> <span class="journal-title">NUTRIENTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2072-6643">2072-6643</a>)</span>: <span class="journal-volume">17</span> <span class="journal-issue">4</span> <span class="page"> Paper 621. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/nu17040621" target="_blank" href="https://doi.org/10.3390/nu17040621"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001429774300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001429774300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85218456369" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85218456369"> Scopus </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35761180&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35761180</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.10.31. 11:40 Hegedűs Andrea (SE_ETK_Admin5_HA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, 8380453, Chile Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, 7830490, Chile Center for Prevention and Diagnosis of Celiac Disease, Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, 20...</pre> </div></div>