https://m2.mtmt.hu/ hun 2026-09-22 12:49 JournalArticle 35756771 VALIDATED true Funding Agency and Grant Number: European Union [RRF-2.3.1-21-2022-00015]; Agency for Credits and Study Grants by the Romanian Ministry of National Education [118/2023]; New National Excellence Program of the Ministry for Culture and Innovation from the source of the National, Research, Development and Innovation Fund [EKOP-24-3-BME-103]; National Research Development and Innovation Fund of the Ministry of Culture and Innovation; Budapest University of Technology and Economics; National Research, Development and Innovation Office Funding text: Project no. RRF-2.3.1-21-2022-00015 has been implemented with the support provided by the European Union. The research was supported by the Agency for Credits and Study Grants coordinated by the Romanian Ministry of National Education from the source of the research grant established through the Government Decision no. 118/2023. The research was supported by the EKOP-24-3-BME-103 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National, Research, Development and Innovation Fund. The project supported by the Doctoral Excellence Fellowship Programme (DCEP) is funded by the National Research Development and Innovation Fund of the Ministry of Culture and Innovation and the Budapest University of Technology and Economics, under a grant agreement with the National Research, Development and Innovation Office. 0 false 2026-09-18T10:34:25.553+0000 2026-04-29T06:32:23.844+0000 2025-02-12T20:21:53.659+0000 true 10079154 Péterfi Orsolya /api/author/10079154 Author Péterfi Orsolya (gyógyszerészet) true 2026-09-18T10:31:45.240+0000 2025-08-26T10:42:05.815+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Péterfi, Orsolya true true /api/journal/10037972 REVIEWED JOURNAL OF PHARMACEUTICAL ANALYSIS 2095-1779 2214-0883 true false 10037972 false 10037972 true 2095-1779 2214-0883 Journal FOREIGN 15 8 101227 101227 12 2025 In this study, an artificial intelligence-based machine vision system was developed for in-line particle size analysis during the pellet layering process. Drug-layered pellets were produced by coating microcrystalline cellulose cores with an ibuprofen-containing layering liquid until the target drug content was achieved. Drug content increases with pellet size; therefore, particle size monitoring can ensure product safety and quality. The direct imaging system, consisting of a rigid endoscope, a light source, and a high-speed camera, provides real-time information about pellet size and layer uniformity, enabling timely intervention in the case of out-of-spec products. A convolutional neural network-based instance segmentation algorithm was employed to detect particles in focus, ensuring that pellet size could be accurately determined despite the dense flow of the particles. After training the model, the performance of the developed system was assessed by analysing the particle size distribution of pellet cores with variable sizes within the 250–850 μm size range. The endoscopic system was tested in-line at a larger scale during the drug layering of inert pellet cores. The particle size data acquired in real time with the endoscopic imaging system corresponded with the reference methods, demonstrating the feasibility of the proposed machine vision-based method as a process analytical technology tool for in-line process monitoring. Funding 2049685 /api/funding/2049685 Nemzeti Gyógyszerkutatási és Fejlesztési Laboratórium (PharmaLab)(RRF-2.3.1-21-2022-00015) Támogató: NKFIH false true true true 2025 true true true false true false GOLD 2026-09-18 true https://doi.org/10.1016/j.jpha.2025.101227 7 0 7 5 1 7 7 6 7 7 7 5 5 5 2 0 7 5 7 5 0 7 7 Folyóiratcikk Journal Article 24 7 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 2 1 2 1 2026 0 5 4 5 4 D1 false false false false 2025-02-16T09:01:53.216+0000 Farmakológiai és Gyógyszerkutatás-fejlesztési K... 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(2025) JOURNAL OF PHARMACEUTICAL ANALYSIS 2095-1779 2214-0883 15 8<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10079154"><a href="/gui2/?type=authors&mode=browse&sel=10079154" target="_blank">Péterfi Orsolya (<span class="authorship-author-name">Péterfi Orsolya</span> <span class="authorAux-mtmt"> gyógyszerészet</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Szerves Kémia és Technológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020629"><a href="/gui2/?type=authors&mode=browse&sel=10020629" target="_blank">Kállai-Szabó Nikolett ✉ (<span class="authorship-author-name">Kállai-Szabó Nikolett</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Demeter Kincső Renáta </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071340"><a href="/gui2/?type=authors&mode=browse&sel=10071340" target="_blank">Barna Ádám Tibor (<span class="authorship-author-name">Barna Ádám Tibor</span> <span class="authorAux-mtmt"> gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020626"><a href="/gui2/?type=authors&mode=browse&sel=10020626" target="_blank">Antal István (<span class="authorship-author-name">Antal István</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10062688"><a href="/gui2/?type=authors&mode=browse&sel=10062688" target="_blank">Szabó Edina (<span class="authorship-author-name">Szabó Edina</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Szerves Kémia és Technológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10051433"><a href="/gui2/?type=authors&mode=browse&sel=10051433" target="_blank">Sipos Emese (<span class="authorship-author-name">Sipos Emese</span> <span class="authorAux-mtmt"> Gyógyszerészet</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10039089"><a href="/gui2/?type=authors&mode=browse&sel=10039089" target="_blank">Nagy Zsombor Kristóf ✉ (<span class="authorship-author-name">Nagy Zsombor Kristóf</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Szerves Kémia és Technológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10062618"><a href="/gui2/?type=authors&mode=browse&sel=10062618" target="_blank">Galata Dorián László (<span class="authorship-author-name">Galata Dorián László</span> <span class="authorAux-mtmt"> szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Szerves Kémia és Technológia Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35756771" target="_blank">Artificial intelligence-aided endoscopic in-line particle size analysis during the pellet layering process</a></div> <div> <span class="journal-title">JOURNAL OF PHARMACEUTICAL ANALYSIS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2095-1779">2095-1779</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2214-0883">2214-0883</a>)</span>: <span class="journal-volume">15</span> <span class="journal-issue">8</span> <span class="page"> Paper 101227. 12 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1016/j.jpha.2025.101227" target="_blank" href="https://doi.org/10.1016/j.jpha.2025.101227"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="224990" target="_blank" href="https://real.mtak.hu/224990"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001594966100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001594966100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105013567722" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105013567722"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41050111" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41050111&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://linkinghub.elsevier.com/retrieve/pii/S2095177925000449" target="_blank" href="https://linkinghub.elsevier.com/retrieve/pii/S2095177925000449"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Analytical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Drug Discovery&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmaceutical Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Electrochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 7</span> | Független: 5 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 6 | Scopus jelölt:&nbsp;7 | WoS/Scopus jelölt:&nbsp;7 | DOI jelölt:&nbsp;7 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35756771&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35756771</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Nemzeti Gyógyszerkutatási és Fejlesztési Laboratórium (PharmaLab)(RRF-2.3.1-21-2022-00015) Támogató: NKFIH </div> <div class="lastModified">Utolsó módosítás: 2026.04.29. 08:32 Sipos Emese (Gyógyszerészet) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: European Union [RRF-2.3.1-21-2022-00015]; Agency for Credits and Study Grants by the Romanian Ministry of National Education [118/2023]; New National Excellence Program of the Ministry for Culture and Innovation from the source of the National, Research, Development and Innovation Fund [EKOP-24-3-BME-103]; National Research Development and Innovation Fund of the...</pre> </div></div>