https://m2.mtmt.hu/ hun 2026-09-22 07:51 JournalArticle 35752875 VALIDATED true The TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States Anthos Therapeutics, Cambridge, MA, United States The Heart Rhythm Center, Taipei Veterans General Hospital and Cardiovascular Center, Taipei, Taiwan Taichung Veterans Hospital, Taichung, Taiwan National Yang Ming Chiao Tung University, Hsinchu, Taiwan National Chung Hsing University, Taichung, Taiwan St. Michael's Hospital, Unity Health Toronto, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Canada Canadian VIGOUR Centre, University of Alberta, Edmonton, Canada The Division of Cardiology, Severance Hospital, Yonsei University, College of Medicine, Seoul, South Korea The Department of Cardiology, Central Hospital of Northern Pest-Military Hospital, Budapest, Hungary The Heart and Vascular Center, Semmelweis University, Budapest, Hungary The Internal Cardiology Department, St. Ann University Hospital, Masaryk University, Brno, Czech Republic The Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland The Departments of Medicine and of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada The Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada Export Date: 17 April 2025; Cited By: 7; Correspondence Address: C.T. Ruff; Brigham and Women's Hospital, Boston, 60 Fenwood Rd., 02115, United States; email: cruff@bwh.harvard.edu; CODEN: NEJMA 0 false 2026-09-11T13:56:56.652+0000 2025-02-11T12:33:03.722+0000 2025-02-11T12:27:17.135+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2025-12-29T01:37:37.500+0000 2025-02-11T12:33:03.729+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Ruff, Christian T. Abelacimab versus Rivaroxaban in Patients with Atrial Fibrillation true true /api/journal/1394667 REVIEWED true false 1394667 false 1394667 true 0028-4793 1533-4406 Journal FOREIGN 392 4 361 371 361 11 2025 Background Abelacimab is a fully human monoclonal antibody that binds to the inactive form of factor XI and blocks its activation. The safety of abelacimab as compared with a direct oral anticoagulant in patients with atrial fibrillation is unknown. Methods Patients with atrial fibrillation and a moderate-to-high risk of stroke were randomly assigned, in a 1:1:1 ratio, to receive subcutaneous injection of abelacimab (150 mg or 90 mg once monthly) administered in a blinded fashion or oral rivaroxaban (20 mg once daily) administered in an open-label fashion. The primary end point was major or clinically relevant nonmajor bleeding. Download a PDF of the Plain Language Summary. Results A total of 1287 patients underwent randomization; the median age was 74 years, and 44% were women. At 3 months, the median reduction in free factor XI levels with abelacimab at a dose of 150 mg was 99% (interquartile range, 98 to 99) and with abelacimab at a dose of 90 mg was 97% (interquartile range, 51 to 99). The trial was stopped early on the recommendation of the independent data monitoring committee because of a greater-than-anticipated reduction in bleeding events with abelacimab. The incidence rate of major or clinically relevant nonmajor bleeding was 3.2 events per 100 person-years with 150-mg abelacimab and 2.6 events per 100 person-years with 90-mg abelacimab, as compared with 8.4 events per 100 person-years with rivaroxaban (hazard ratio for 150-mg abelacimab vs. rivaroxaban, 0.38 [95% confidence interval {CI}, 0.24 to 0.60]; hazard ratio for 90-mg abelacimab vs. rivaroxaban, 0.31 [95% CI, 0.19 to 0.51]; P<0.001 for both comparisons). The incidence and severity of adverse events appeared to be similar in the three groups. Conclusions Among patients with atrial fibrillation who were at moderate-to-high risk for stroke, treatment with abelacimab resulted in markedly lower levels of free factor XI and fewer bleeding events than treatment with rivaroxaban. true true 2025 true true true false true false NONE 2026-09-11 false 114 0 114 100 3 112 113 102 108 114 114 100 100 100 14 0 114 100 114 100 0 3 3 Folyóiratcikk Journal Article 24 114 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb 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10 0.05263158 false false false Joung Boyoung true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123250157 /api/authorship/123250157 11 0.053 false false false Author 10029771 /api/author/10029771 Kiss Róbert Gábor true 10029771 true Kiss Robert G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123250158 /api/authorship/123250158 12 0.05263158 false false false Spinar Jindrich true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123250159 /api/authorship/123250159 13 0.05263158 false false false Wojakowski Wojciech true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123250160 /api/authorship/123250160 14 0.05263158 false false false Weitz Jeffrey I. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123250161 /api/authorship/123250161 15 0.05263158 false false false Murphy Sabina A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123250162 /api/authorship/123250162 16 0.05263158 false false false Wiviott Stephen D. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123250163 /api/authorship/123250163 17 0.05263158 false false false Parkar Sanobar true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123250164 /api/authorship/123250164 18 0.05263158 false false false Bloomfield Daniel true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123250165 /api/authorship/123250165 19 0.05263158 false true false Sabatine Marc S. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true OrgAuthorship 123250166 /api/authorship/123250166 20 0.0 false false false true false false AuthorshipType 30 /api/authorshiptype/30 -29 true -29 true false 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title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Ruff Christian T. ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Patel Siddharth M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Giugliano Robert P. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Morrow David A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hug Bruce </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kuder Julia F. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Goodrich Erica L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chen Shih-Ann </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Goodman Shaun G. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Joung Boyoung </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029771"><a 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(<span class="authorship-author-name">Kiss Róbert Gábor</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Spinar Jindrich </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wojakowski Wojciech </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Weitz Jeffrey I. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Murphy Sabina A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wiviott Stephen D. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Parkar Sanobar </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bloomfield Daniel </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sabatine Marc S. </span> </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">AZALEA-TIMI 71 Investigators</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35752875" target="_blank">Abelacimab versus Rivaroxaban in Patients with Atrial Fibrillation</a></div> <div> <span class="journal-title">NEW ENGLAND JOURNAL OF MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-4793">0028-4793</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1533-4406">1533-4406</a>)</span>: <span class="journal-volume">392</span> <span class="journal-issue">4</span> <span class="page"> pp 361-371 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1056/NEJMoa2406674" target="_blank" href="https://doi.org/10.1056/NEJMoa2406674"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001405897400014" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001405897400014"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85216607693" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85216607693"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39842011" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39842011&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 114</span> | Független: 100 | Függő: 14 | Nem jelölt: 0 | WoS jelölt: 102 | Scopus jelölt:&nbsp;108 | WoS/Scopus jelölt:&nbsp;114 | DOI jelölt:&nbsp;113 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35752875&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35752875</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2025.02.11. 13:33 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: The TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States Anthos Therapeutics, Cambridge, MA, United States The Heart Rhythm Center, Taipei Veterans General Hospital and Cardiovascular Center, Taipei, Taiwan Taichung Veterans Hospital, Taichung, Ta...</pre> </div></div>