Workload and clinical impact of MRI-based extension of reperfusion therapy time window in acute ischaemic stroke

https://m2.mtmt.hu/ eng 2026-10-23 19:36 JournalArticle 35744060 VALIDATED true 0 false 2026-10-13T12:49:40.882+0000 2026-05-14T07:38:50.337+0000 2025-02-07T07:47:01.430+0000 true 10074913 Sághi-Keszthelyi Anna /api/admin/10074913 Admin Anna Sághi-Keszthelyi (SE_KK_Admin5_SKA, admin) true 2026-10-13T12:46:20.648+0000 2025-10-09T08:04:01.232+0000 true 10069305 Kondor Zóra /api/admin/10069305 Admin Zóra Kondor (SE_KK_Admin5_KZ, admin) true Admin 10025544 /api/admin/10025544 Katalin Lévayné Deseő (MTMT Központi admin) Lévayné Deseő Katalin true 10025544 true 2026-06-09T18:52:05.519+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Takács, Tímea Tünde Workload and clinical impact of MRI-based extension of reperfusion therapy time window in acute ischaemic stroke - a prospective single-centre study true true /api/journal/10071822 REVIEWED GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) 2509-2715 2509-2723 true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN 47 4 6005 6013 6005 9 2025 Current European Stroke Organisation (ESO) guidelines recommend extended time window reperfusion therapies (4.5–9 h for thrombolysis, 6–24 h for thrombectomy) based on advanced imaging. However, the workload and clinical benefit of this strategy on a population basis are not known. To determine the caseload, treatment rates, and outcomes in the extended as compared to the standard time windows. All consecutive ischaemic stroke patients within 24 h of last known well between 1st March 2021 and 28th February 2022 were included in a prospective single-centre study. Treatment eligibility in the extended time windows or wake-up strokes recognized within 4 h was based on current ESO guideline criteria using MRI DWI-PWI or DWI-FLAIR mismatch. MRI was only available during working hours (8–20 h); otherwise, CT/CTA was used. Clinical outcome in treated patients was assessed at three months. Among the 777 admitted patients, 252 (32.4%) had MRI. The thrombolysis rate was 119/304 (39.1%) in standard and 14/231 (6.1%) in the extended time window. The thrombectomy rate was 34/386 (8.8%) in standard and 15/391 (3.8%) in the extended time window. Independent clinical outcomes (mRS ≤ 2) were not statistically different in early and late-treated patients both for thrombolysis (48% vs. 28.6%, p = 0.25) and thrombectomy (38.4% vs. 33.3%, p = 0.99). Even with a limited availability of advanced imaging extending therapeutic time windows resulted in an 11.7% increase in thrombolysis and a 44% increase in thrombectomy with comparable clinical outcomes in early and late-treated patients at the price of a twofold burden in clinical and advanced imaging screening. Funding 2049455 /api/funding/2049455 (Open access funding provided by Semmelweis University) false true true 2025 true true true false true false NONE 2026-10-13 false 2 0 2 2 1 2 2 2 2 2 2 2 2 2 0 0 2 2 2 2 0 5 5 Folyóiratcikk Journal Article 24 2 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 2 2 2 2 D1 false false false false 2025-02-27T11:33:08.436+0000 Doktori Iskola (SE); HUN-REN-SE Neuroepidemiológiai Kutatócsoport (SE / AOK / K / NK); Idegsebészeti és Neurointervenciós Klinika (SE / AOK / K); Neurológiai Klinika (SE / AOK / K); Neuroradiológia Tanszék (SE / AOK / K / OKK); Orvosi Képalkotó Klinika (SE / AOK / K); Sürgősségi Orvostani Klinika (SE / AOK / K) 18 60 7 19 0 true 10025544 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 123170122 /api/authorship/123170122 Takács, Tímea Tünde ✉ [Takács, Tímea (neurológia), author] Department of Neurology (SU / FM / C); School of PhD Studies (SU) 1 0.053 true false true Author 10070407 /api/author/10070407 Tímea Takács (neurológia) Takács Tímea true true Takács Tímea Tünde true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 123170123 /api/authorship/123170123 Magyar-Stang, Rita [Stang, Rita (Neurológia), author] Department of Neurology (SU / FM / C); School of PhD Studies (SU) 2 0.053 false false false Author 10067272 /api/author/10067272 Rita Stang (Neurológia) Stang Rita true true Magyar-Stang Rita true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 123170124 /api/authorship/123170124 Szatmári, Szabolcs [Szatmári, Szabolcs (neurológia), author] Department of Neurology (SU / FM / C) 3 0.053 false false false Author 10052181 /api/author/10052181 Szabolcs Szatmári (neurológia) Szatmári Szabolcs true 10052181 true Szatmári Szabolcs true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 123170125 /api/authorship/123170125 Sipos, Ildikó [Sipos, Ildikó (Neuropathológia é...), author] Department of Neurology (SU / FM / C) 4 0.053 false false false Author 10024021 /api/author/10024021 Ildikó Sipos (Neuropathológia és liquordiagnosztika) Sipos Ildikó true 10024021 true Sipos Ildikó true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 123170126 /api/authorship/123170126 Saftics, Katalin [Saftics, Katalin (neurológia), author] Department of Neurology (SU / FM / C) 5 0.053 false false false Author 10099284 /api/author/10099284 Katalin Saftics (neurológia) Saftics Katalin true true Saftics Katalin true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 123170127 /api/authorship/123170127 Berki, Ádám József [Berki, Ádám József (Neurológia, idegt...), author] Department of Neurology (SU / FM / C); 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Orvosi Képalkotó Klinika (SU / FM / C) 10 0.053 false false false Author 10087897 /api/author/10087897 Nóra Luca Nyilas (radiológia) Nyilas Nóra Luca true true Nyilas Nóra true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 123170132 /api/authorship/123170132 Bíró, István [Biró, István (Radiológia), author] Orvosi Képalkotó Klinika (SU / FM / C); Neuroradiológia Tanszék (SU / FM / C / OKK) 11 0.05263158 false false false Author 10102893 /api/author/10102893 István Biró (Radiológia) Biró István true true Bíró István true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 123170133 /api/authorship/123170133 Barsi, Péter [Barsi, Péter (Neuroradiológia, ...), author] Neuroradiológia Tanszék (SU / FM / C / OKK); Orvosi Képalkotó Klinika (SU / FM / C) 12 0.053 false false false Author 10016418 /api/author/10016418 Péter Barsi (Neuroradiológia, neurológiai, pszichiátriai, idegsebészeti betegségek) Barsi Péter true 10016418 true Barsi Péter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 123170134 /api/authorship/123170134 Magyar, Máté [Magyar, Máté (Neurológia; 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(2025) GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) 2509-2715 2509-2723 47 4 6005-6013<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <a href="/gui2/?type=authors&mode=browse&sel=10070407" target="_blank">Takács Tímea Tünde ✉ (Takács Tímea neurológia) </a> SU/FM/C/Department of Neurology; SU/School of PhD Studies ;    <a href="/gui2/?type=authors&mode=browse&sel=10067272" target="_blank">Magyar-Stang Rita (Stang Rita Neurológia) </a> SU/FM/C/Department of Neurology; SU/School of PhD Studies ;    <a href="/gui2/?type=authors&mode=browse&sel=10052181" target="_blank">Szatmári Szabolcs (Szatmári Szabolcs neurológia) </a> SU/FM/C/Department of Neurology ;    <a href="/gui2/?type=authors&mode=browse&sel=10024021" target="_blank">Sipos Ildikó (Sipos Ildikó Neuropathológia és liquordiagnosztika) </a> SU/FM/C/Department of Neurology ;    <a href="/gui2/?type=authors&mode=browse&sel=10099284" target="_blank">Saftics Katalin (Saftics Katalin neurológia) </a> SU/FM/C/Department of Neurology ;    <a href="/gui2/?type=authors&mode=browse&sel=10084426" target="_blank">Berki Ádám József (Berki Ádám József Neurológia, idegtudományok) </a> SU/FM/C/Department of Neurology; SU/School of PhD Studies ;    Évin Sándor ;    <a href="/gui2/?type=authors&mode=browse&sel=10000800" target="_blank">Bereczki Dániel (Bereczki Dániel Stroke) </a> SU/FM/C/Department of Neurology; SU/FM/C/DN/HUN-REN-SE Neuroepidemiológiai Kutatócsoport ;    <a href="/gui2/?type=authors&mode=browse&sel=10024884" target="_blank">Varga Csaba (Varga Csaba Sürgősségi ellátás) </a> SU/FM/C/Sürgősségi Orvostani Klinika ;    <a href="/gui2/?type=authors&mode=browse&sel=10087897" target="_blank">Nyilas Nóra (Nyilas Nóra Luca radiológia) </a> SU/FM/C/OKK/Neuroradiológia Tanszék; SU/FM/C/Orvosi Képalkotó Klinika ;    <a href="/gui2/?type=authors&mode=browse&sel=10102893" target="_blank">Bíró István (Biró István Radiológia) </a> SU/FM/C/Orvosi Képalkotó Klinika; SU/FM/C/OKK/Neuroradiológia Tanszék ;    <a href="/gui2/?type=authors&mode=browse&sel=10016418" target="_blank">Barsi Péter (Barsi Péter Neuroradiológia, neurológiai, pszichiátriai, id...) </a> SU/FM/C/OKK/Neuroradiológia Tanszék; SU/FM/C/Orvosi Képalkotó Klinika ;    <a href="/gui2/?type=authors&mode=browse&sel=10050367" target="_blank">Magyar Máté (Magyar Máté Neurológia; Radiológia; Neuroradiológia) </a> SU/FM/C/OKK/Neuroradiológia Tanszék; SU/FM/C/Orvosi Képalkotó Klinika ;    <a href="/gui2/?type=authors&mode=browse&sel=10019530" target="_blank">Maurovich-Horvat Pál (Maurovich-Horvat Pál kardiológia) </a> SU/FM/C/Orvosi Képalkotó Klinika; SU/FM/C/OKK/Neuroradiológia Tanszék ;    <a href="/gui2/?type=authors&mode=browse&sel=10063551" target="_blank">Böjti Péter Pál (Böjti Péter Pál neurológia) </a> SU/FM/C/Neurosurgery and Neurointerventional Department ;    <a href="/gui2/?type=authors&mode=browse&sel=10068848" target="_blank">Pásztor Máté (Pásztor Máté Neurológia) </a> SU/FM/C/Neurosurgery and Neurointerventional Department ;    <a href="/gui2/?type=authors&mode=browse&sel=10014906" target="_blank">Szikora István (Szikora István Intervenciós neuroradiológia) </a> SU/FM/C/Neurosurgery and Neurointerventional Department ;    <a href="/gui2/?type=authors&mode=browse&sel=10026735" target="_blank">Nardai Sándor (Nardai Sándor orvostudományok) </a> SU/FM/C/Neurosurgery and Neurointerventional Department ;    <a href="/gui2/?type=authors&mode=browse&sel=10028242" target="_blank">Gunda Bence (Gunda Bence Neurológia) </a> SU/FM/C/Department of Neurology </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35744060" target="_blank">Workload and clinical impact of MRI-based extension of reperfusion therapy time window in acute ischaemic stroke - a prospective single-centre study</a></div> <div> GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) (<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>): 47 4 pp 6005-6013 (2025) </div> <div class="pub-footer"> Language: English | <a style="color:blue" title="10.1007/s11357-025-01549-1" target="_blank" href="https://doi.org/10.1007/s11357-025-01549-1"> DOI </a> <a style="color:blue" title="001414818500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001414818500001"> WoS </a> <a style="color:blue" title="85217641282" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85217641282"> Scopus </a> <a style="color:blue" title="39913034" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39913034&dopt=Abstract"> PubMed </a> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Complementary and Alternative Medicine   Rank: D1</div> <div class="journal-subject">Journal subject: Scopus - Geriatrics and Gerontology   Rank: D1</div> <div class="journal-subject">Journal subject: Scopus - Veterinary (miscellaneous)   Rank: D1</div> <div class="journal-subject">Journal subject: Scopus - Aging   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Cardiology and Cardiovascular Medicine   Rank: Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> Citing papers: 2 | Independent citation: 2 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 2 | Number of citations in Scopus: 2 | WoS/Scopus assigned: 2 | Number of citations with DOI: 2 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35744060&sort=publishedYear,desc&sort=title"> Number of cited publications: 5 </a> </div> <div class="mtid">Publication: 35744060 | Validated Core Citing | Journal Article ( Article ) | Scientific | kézi felvitel </div> <div class="funder"> (Open access funding provided by Semmelweis University) </div> <div class="lastModified">Last Modified: 2026.05.14. 09:38 Tamásné Gere (SE_KK_Admin5_GT, admin) </div> <div class="lockedBy">Centrally managed 2026.06.09. 20:52 Katalin Lévayné Deseő (MTMT Központi admin) </div> </div></div>