https://m2.mtmt.hu/ hun 2026-09-22 16:46 JournalArticle 35744060 VALIDATED true 0 false 2026-08-27T13:46:32.016+0000 2026-05-14T07:38:50.337+0000 2025-02-07T07:47:01.430+0000 true 10074913 Sághi-Keszthelyi Anna /api/admin/10074913 Admin Sághi-Keszthelyi Anna (SE_KK_Admin5_SKA, admin) true 2026-05-14T09:30:38.189+0000 2026-05-14T09:30:38.189+0000 2025-10-09T08:04:01.232+0000 true 10069305 Kondor Zóra /api/admin/10069305 Admin Kondor Zóra (SE_KK_Admin5_KZ, admin) true Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin (MTMT Központi admin) Lévayné Deseő Katalin true 10025544 true 2026-06-09T18:52:05.519+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Takács, Tímea Tünde true true /api/journal/10071822 REVIEWED GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) 2509-2715 2509-2723 true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN 47 4 6005 6013 6005 9 2025 Current European Stroke Organisation (ESO) guidelines recommend extended time window reperfusion therapies (4.5–9 h for thrombolysis, 6–24 h for thrombectomy) based on advanced imaging. However, the workload and clinical benefit of this strategy on a population basis are not known. To determine the caseload, treatment rates, and outcomes in the extended as compared to the standard time windows. All consecutive ischaemic stroke patients within 24 h of last known well between 1st March 2021 and 28th February 2022 were included in a prospective single-centre study. Treatment eligibility in the extended time windows or wake-up strokes recognized within 4 h was based on current ESO guideline criteria using MRI DWI-PWI or DWI-FLAIR mismatch. MRI was only available during working hours (8–20 h); otherwise, CT/CTA was used. Clinical outcome in treated patients was assessed at three months. Among the 777 admitted patients, 252 (32.4%) had MRI. The thrombolysis rate was 119/304 (39.1%) in standard and 14/231 (6.1%) in the extended time window. The thrombectomy rate was 34/386 (8.8%) in standard and 15/391 (3.8%) in the extended time window. Independent clinical outcomes (mRS ≤ 2) were not statistically different in early and late-treated patients both for thrombolysis (48% vs. 28.6%, p = 0.25) and thrombectomy (38.4% vs. 33.3%, p = 0.99). Even with a limited availability of advanced imaging extending therapeutic time windows resulted in an 11.7% increase in thrombolysis and a 44% increase in thrombectomy with comparable clinical outcomes in early and late-treated patients at the price of a twofold burden in clinical and advanced imaging screening. 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(2025) GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) 2509-2715 2509-2723 47 4 6005-6013<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10070407"><a href="/gui2/?type=authors&mode=browse&sel=10070407" target="_blank">Takács Tímea Tünde ✉ (<span class="authorship-author-name">Takács Tímea</span> <span class="authorAux-mtmt"> neurológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Neurológiai Klinika; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10067272"><a href="/gui2/?type=authors&mode=browse&sel=10067272" target="_blank">Magyar-Stang Rita (<span class="authorship-author-name">Stang Rita</span> <span class="authorAux-mtmt"> Neurológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Neurológiai Klinika; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052181"><a href="/gui2/?type=authors&mode=browse&sel=10052181" target="_blank">Szatmári Szabolcs (<span class="authorship-author-name">Szatmári Szabolcs</span> <span class="authorAux-mtmt"> neurológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Neurológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024021"><a href="/gui2/?type=authors&mode=browse&sel=10024021" target="_blank">Sipos Ildikó (<span class="authorship-author-name">Sipos Ildikó</span> <span class="authorAux-mtmt"> Neuropathológia és liquordiagnosztika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Neurológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10099284"><a href="/gui2/?type=authors&mode=browse&sel=10099284" target="_blank">Saftics Katalin (<span class="authorship-author-name">Saftics Katalin</span> <span class="authorAux-mtmt"> neurológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Neurológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084426"><a href="/gui2/?type=authors&mode=browse&sel=10084426" target="_blank">Berki Ádám József (<span class="authorship-author-name">Berki Ádám József</span> <span class="authorAux-mtmt"> Neurológia, idegtudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Neurológiai Klinika; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Évin Sándor </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000800"><a href="/gui2/?type=authors&mode=browse&sel=10000800" target="_blank">Bereczki Dániel (<span class="authorship-author-name">Bereczki Dániel</span> <span class="authorAux-mtmt"> Stroke</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Neurológiai Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Neurológiai Klinika">NK</span>/HUN-REN-SE Neuroepidemiológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024884"><a href="/gui2/?type=authors&mode=browse&sel=10024884" target="_blank">Varga Csaba (<span class="authorship-author-name">Varga Csaba</span> <span class="authorAux-mtmt"> Sürgősségi ellátás</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Sürgősségi Orvostani Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10087897"><a href="/gui2/?type=authors&mode=browse&sel=10087897" target="_blank">Nyilas Nóra (<span class="authorship-author-name">Nyilas Nóra Luca</span> <span class="authorAux-mtmt"> radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Orvosi Képalkotó Klinika">OKK</span>/Neuroradiológia Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10102893"><a href="/gui2/?type=authors&mode=browse&sel=10102893" target="_blank">Bíró István (<span class="authorship-author-name">Biró István</span> <span class="authorAux-mtmt"> Radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Orvosi Képalkotó Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Orvosi Képalkotó Klinika">OKK</span>/Neuroradiológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10016418"><a href="/gui2/?type=authors&mode=browse&sel=10016418" target="_blank">Barsi Péter (<span class="authorship-author-name">Barsi Péter</span> <span class="authorAux-mtmt"> Neuroradiológia, neurológiai, pszichiátriai, id...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Orvosi Képalkotó Klinika">OKK</span>/Neuroradiológia Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10050367"><a href="/gui2/?type=authors&mode=browse&sel=10050367" target="_blank">Magyar Máté (<span class="authorship-author-name">Magyar Máté</span> <span class="authorAux-mtmt"> Neurológia; Radiológia; Neuroradiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Orvosi Képalkotó Klinika">OKK</span>/Neuroradiológia Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10019530"><a href="/gui2/?type=authors&mode=browse&sel=10019530" target="_blank">Maurovich-Horvat Pál (<span class="authorship-author-name">Maurovich-Horvat Pál</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Orvosi Képalkotó Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Orvosi Képalkotó Klinika">OKK</span>/Neuroradiológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10063551"><a href="/gui2/?type=authors&mode=browse&sel=10063551" target="_blank">Böjti Péter Pál (<span class="authorship-author-name">Böjti Péter Pál</span> <span class="authorAux-mtmt"> neurológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Idegsebészeti és Neurointervenciós Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10068848"><a href="/gui2/?type=authors&mode=browse&sel=10068848" target="_blank">Pásztor Máté (<span class="authorship-author-name">Pásztor Máté</span> <span class="authorAux-mtmt"> Neurológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Idegsebészeti és Neurointervenciós Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014906"><a href="/gui2/?type=authors&mode=browse&sel=10014906" target="_blank">Szikora István (<span class="authorship-author-name">Szikora István</span> <span class="authorAux-mtmt"> Intervenciós neuroradiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Idegsebészeti és Neurointervenciós Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026735"><a href="/gui2/?type=authors&mode=browse&sel=10026735" target="_blank">Nardai Sándor (<span class="authorship-author-name">Nardai Sándor</span> <span class="authorAux-mtmt"> orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Idegsebészeti és Neurointervenciós Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028242"><a href="/gui2/?type=authors&mode=browse&sel=10028242" target="_blank">Gunda Bence (<span class="authorship-author-name">Gunda Bence</span> <span class="authorAux-mtmt"> Neurológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Neurológiai Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35744060" target="_blank">Workload and clinical impact of MRI-based extension of reperfusion therapy time window in acute ischaemic stroke - a prospective single-centre study</a></div> <div> <span class="journal-title">GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>)</span>: <span class="journal-volume">47</span> <span class="journal-issue">4</span> <span class="page"> pp 6005-6013 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s11357-025-01549-1" target="_blank" href="https://doi.org/10.1007/s11357-025-01549-1"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001414818500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001414818500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85217641282" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85217641282"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39913034" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39913034&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Aging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 1 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35744060&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35744060</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (Open access funding provided by Semmelweis University) </div> <div class="lastModified">Utolsó módosítás: 2026.05.14. 09:38 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> <div class="lockedBy">Központi kezelésű 2026.06.09. 20:52 Lévayné Deseő Katalin (MTMT Központi admin) </div> </div></div>