https://m2.mtmt.hu/ eng 2026-10-24 11:05 JournalArticle 35739679 VALIDATED true 0 false 2026-09-17T07:52:55.574+0000 2026-04-13T10:05:29.259+0000 2025-02-05T09:55:38.487+0000 true 10065463 Turek Márta /api/admin/10065463 Admin true 2026-09-16T11:03:34.889+0000 2025-12-18T15:43:06.127+0000 true 521 Szuper Admin /api/admin/521 Admin true Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2026-05-20T07:50:06.812+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Sinkó, Richárd Variable transduction of thyroid hormone signaling in structures of the mouse brain true true /api/journal/3547 REVIEWED true false 3547 false 3547 true 0027-8424 1091-6490 Journal FOREIGN 122 6 e2415970122 e2415970122 10 2025 L-thyroxine (L-T4) monotherapy is the standard treatment for hypothyroidism, administered daily to normalize TSH levels. Once absorbed, T4 is converted to T3 to alleviate most symptoms. However, this treatment abnormally elevates plasma T4 levels in over 50% of patients. Using L-T4-treated Thyroid Hormone (TH) Action Indicator mice, which express a T3-regulated luciferase (Luc) reporter, we examined whether these T4 elevations disrupt TH signaling. Hypothyroid mice exhibited reduced Luc expression across brain regions, and L-T4 treatment failed to restore T3 signaling uniformly. There was also variability in the activity of type 2 deiodinase (D2), the enzyme that generates most brain T3. Intracerebroventricular T4 administration achieved higher elevation of Luc expression in the mediobasal hypothalamus compared to the cortex, and studies on cultured cortical astrocytes and hypothalamic tanycytes revealed cell-type-specific responses to T4. In tanycytes, exposure to T4 sustained D2 activity, leading to progressive T3 signaling, whereas in astrocytes, T4 exposure triggered a drop in D2 activity, limiting T3 production through a ubiquitin-dependent, self-limiting mechanism. The sustained D2 activity in tanycytes was linked to rapid deubiquitination by USP33, as confirmed using a ubiquitin-specific protease (USP) pan-inhibitor and USP33 knockout mice. In conclusion, the brain’s response to L-T4 treatment is heterogeneous, influenced by cell-specific regulation of D2-mediated T3 production. While cortical astrocytes exhibit limited T3 signaling due to D2 ubiquitination, tanycytes coexpressing USP33 amplify T3 signaling by rescuing ubiquitinated D2 from proteasomal degradation. These findings provide mechanistic insights into the limitations of L-T4 therapy and highlight the need for tailored approaches to managing hypothyroidism. Funding 2050085 /api/funding/2050085 false true Funding 2050086 /api/funding/2050086 false true Funding 2050087 /api/funding/2050087 false true Funding 2050088 /api/funding/2050088 false true true true 2025 true true true false true false GREEN 2026-09-17 true https://doi.org/10.1073/pnas.2415970122 10 0 10 7 2 10 10 10 10 10 10 7 7 7 3 0 10 7 10 7 0 27 27 Folyóiratcikk Journal Article 24 10 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 6 5 6 5 2026 0 4 2 4 2 D1 A false 10052876,10011473 false false false 2025-05-06T09:04:23.344+0000 Doktori Iskola (SE); Integratív Neuroendokrinológiai Kutatócsoport (HRN KOKI); Molekuláris Sejt Metabolizmus Kutatócsoport (HRN KOKI) 7 24 3 12 0 true 10025544 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 123132460 /api/authorship/123132460 1 0.083 true false false Author 10052876 /api/author/10052876 Sinkó Richárd true 10052876 true Sinkó Richárd true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123132461 /api/authorship/123132461 2 0.083 true false false Salas-Lucia Federico true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123132462 /api/authorship/123132462 3 0.083 false false false Author 10023404 /api/author/10023404 Mohácsik Petra true 10023404 true Mohácsik Petra true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123132463 /api/authorship/123132463 4 0.083 false false false Author 10083912 /api/author/10083912 Halmos Emese true true Halmos Emese true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123132464 /api/authorship/123132464 5 0.083 false false false Author 136 /api/author/136 Wittmann Gábor true 136 true Wittmann Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123132465 /api/authorship/123132465 6 0.083 false false false Author 206 /api/author/206 Egri Péter true 206 true Egri Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123132466 /api/authorship/123132466 7 0.083333336 false false false Bocco Barbara M. L. C. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123132467 /api/authorship/123132467 8 0.083333336 false false false Batistuzzo Alice true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123132468 /api/authorship/123132468 9 0.083333336 false false false Fonseca Tatiana L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123132469 /api/authorship/123132469 10 0.083 false false false Author 10012354 /api/author/10012354 Fekete Csaba true 10012354 true Fekete Csaba true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123132470 /api/authorship/123132470 11 0.083 false false true Bianco Antonio C. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123132471 /api/authorship/123132471 12 0.083 false true true Author 10011473 /api/author/10011473 Gereben Balázs true 10011473 true Gereben Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 28349636 /api/publicationidentifier/28349636 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GREEN true IDENTICAL 10.1073/pnas.2415970122 https://doi.org/10.1073/pnas.2415970122 false true PublicationIdentifier 28349752 /api/publicationidentifier/28349752 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GREEN true IDENTICAL 215199 https://real.mtak.hu/215199 false true PublicationIdentifier 29252700 /api/publicationidentifier/29252700 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001459599300012 https://www.webofscience.com/wos/woscc/full-record/001459599300012 false true PublicationIdentifier 28467689 /api/publicationidentifier/28467689 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85218066949 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85218066949 false true PublicationIdentifier 30061819 /api/publicationidentifier/30061819 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39903117 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39903117&dopt=Abstract false true PublicationIdentifier 28349637 /api/publicationidentifier/28349637 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true GREEN true IDENTICAL https://pnas.org/doi/10.1073/pnas.2415970122 https://pnas.org/doi/10.1073/pnas.2415970122 false true Keyword 1 /api/keyword/1 true 1 true Keyword 19390 /api/keyword/19390 true 19390 true Keyword 1519104 /api/keyword/1519104 true true Keyword 1952217 /api/keyword/1952217 true true MtaRating 11435140 /api/mtarating/11435140 RatingType 10031 /api/ratingtype/10031 X. FTO Institute 70 /api/institute/70 0 false false false X. Földtudományok Osztálya HAS Section of Earth Sciences (X.) true 70 true true true A true true MtaRating 11551102 /api/mtarating/11551102 RatingType 10010 /api/ratingtype/10010 RegTB Institute 14100 /api/institute/14100 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true A nemzetközi false true MtaRating 519088 /api/mtarating/519088 RatingType 10007 /api/ratingtype/10007 SZTB Institute 14102 /api/institute/14102 0 false true false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true A nemzetközi true 19088 true SjrRating 11736298 /api/sjrrating/11736298 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 true 1000 true D1 DIRECT true true Reference 63018637 /api/reference/63018637 1 10.1016/S0140-6736(17)30703-1 false true Reference 63018638 /api/reference/63018638 2 10.1038/s41574-021-00625-8 false true Reference 63018639 /api/reference/63018639 3 10.1016/j.eprac.2021.12.003 false true Reference 63018640 /api/reference/63018640 4 10.1016/j.eprac.2023.04.003 false true Reference 63018641 /api/reference/63018641 5 10.1210/jendso/bvaa136 false true Reference 63018642 /api/reference/63018642 6 10.1016/S0083-6729(05)71004-9 false true Reference 63018643 /api/reference/63018643 7 10.1210/er.2018-00275 false true Reference 63018644 /api/reference/63018644 8 10.1089/thy.2024.0120 false true Reference 63018645 /api/reference/63018645 9 10.1210/er.2008-0019 false true Reference 63018646 /api/reference/63018646 10 10.7554/eLife.82683 false true Reference 63018647 /api/reference/63018647 11 10.3389/fendo.2014.00082 false true Reference 63018648 /api/reference/63018648 12 10.1038/nrendo.2015.186 false true Reference 63018649 /api/reference/63018649 13 10.1210/endo-110-2-367 false true Reference 63018650 /api/reference/63018650 14 10.4061/2011/215718 false true Reference 63018651 /api/reference/63018651 15 10.1172/JCI41977 false true Reference 63018652 /api/reference/63018652 16 10.1210/en.2016-1272 false true Reference 63018653 /api/reference/63018653 17 10.1089/thy.2022.0404 false true Reference 63018654 /api/reference/63018654 18 10.1210/jc.2014-4092 false true Reference 63018655 /api/reference/63018655 19 10.1210/en.2008-1616 false true Reference 63018656 /api/reference/63018656 20 10.1210/mend.14.11.0558 false true Reference 63018657 /api/reference/63018657 21 10.1210/jcem-40-2-326 false true Reference 63018658 /api/reference/63018658 22 false true Reference 63018659 /api/reference/63018659 23 10.1210/endocr/bqad155 false true Reference 63018660 /api/reference/63018660 24 10.1210/clinem/dgae139 false true Reference 63018661 /api/reference/63018661 25 10.1210/en.2017-00582 false true Reference 63018662 /api/reference/63018662 26 10.1089/thy.2014.0028 false true Reference 63018663 /api/reference/63018663 27 10.1210/en.2011-1905 false true Reference 63018664 /api/reference/63018664 28 10.1172/jci.insight.174645 false true Reference 63018665 /api/reference/63018665 29 10.1016/S0006-8993(00)02105-3 false true Reference 63018666 /api/reference/63018666 30 10.1172/JCI61231 false true Reference 63018667 /api/reference/63018667 31 10.1073/pnas.94.19.10391 false true Reference 63018668 /api/reference/63018668 32 10.1038/ncb1272 false true Reference 63018669 /api/reference/63018669 33 10.1371/journal.pone.0090381 false true Reference 63018670 /api/reference/63018670 34 10.1016/j.jbc.2024.107477 false true Reference 63018671 /api/reference/63018671 35 10.1172/JCI77588 false true Reference 63018672 /api/reference/63018672 36 10.1128/MCB.01498-08 false true Reference 63018673 /api/reference/63018673 37 10.1210/en.2007-0448 false true Reference 63018674 /api/reference/63018674 38 10.1016/j.chembiol.2011.08.018 false true Reference 63018675 /api/reference/63018675 39 10.1038/nrendo.2015.155 false true Reference 63018676 /api/reference/63018676 40 10.1046/j.1365-2265.2002.01654.x false true Reference 63018677 /api/reference/63018677 41 10.3389/fendo.2019.00446 false true Reference 63018678 /api/reference/63018678 42 10.1089/thy.2017.0681 false true Reference 63018679 /api/reference/63018679 43 10.1371/journal.pone.0022552 false true Reference 63018680 /api/reference/63018680 44 10.1016/0026-0495(84)90203-8 false true Reference 63018681 /api/reference/63018681 45 10.1152/ajpendo.2001.281.1.E54 false true Reference 63018682 /api/reference/63018682 46 10.1128/MCB.00283-07 false true Reference 63018683 /api/reference/63018683 47 10.1210/me.2013-1281 false true Reference 63018684 /api/reference/63018684 48 10.1172/JCI18348 false true Reference 63018685 /api/reference/63018685 49 10.1038/s41598-024-66044-7 false true Reference 63018686 /api/reference/63018686 50 10.1126/science.aay5947 false true Reference 63018687 /api/reference/63018687 51 10.1210/en.2005-1300 false true Reference 63018688 /api/reference/63018688 52 10.1210/clinem/dgac725 false true Reference 63018689 /api/reference/63018689 53 10.1089/thy.2013.0109 false true Reference 63018690 /api/reference/63018690 54 10.1210/clinem/dgad243 false true Reference 63018691 /api/reference/63018691 55 10.1007/s00441-017-2608-x false true Reference 63018692 /api/reference/63018692 56 10.1530/JME-14-0156 false true /api/publication/35739679 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10052876"><a href="/gui2/?type=authors&mode=browse&sel=10052876" target="_blank">Sinkó Richárd (<span class="authorship-author-name">Sinkó Richárd</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Molecular Cell Metabolism</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Salas-Lucia Federico<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023404"><a href="/gui2/?type=authors&mode=browse&sel=10023404" target="_blank">Mohácsik Petra (<span class="authorship-author-name">Mohácsik Petra</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Molecular Cell Metabolism</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10083912"><a href="/gui2/?type=authors&mode=browse&sel=10083912" target="_blank">Halmos Emese (<span class="authorship-author-name">Halmos Emese</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Molecular Cell Metabolism; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="136"><a href="/gui2/?type=authors&mode=browse&sel=136" target="_blank">Wittmann Gábor (<span class="authorship-author-name">Wittmann Gábor</span> <span class="authorAux-mtmt"> Endokrin neurobiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Integratív Neuroendokrinológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="206"><a href="/gui2/?type=authors&mode=browse&sel=206" target="_blank">Egri Péter (<span class="authorship-author-name">Egri Péter</span> <span class="authorAux-mtmt"> Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Molecular Cell Metabolism</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bocco Barbara M. L. C. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Batistuzzo Alice </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Fonseca Tatiana L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012354"><a href="/gui2/?type=authors&mode=browse&sel=10012354" target="_blank">Fekete Csaba (<span class="authorship-author-name">Fekete Csaba</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Integratív Neuroendokrinológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bianco Antonio C. ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011473"><a href="/gui2/?type=authors&mode=browse&sel=10011473" target="_blank">Gereben Balázs ✉ (<span class="authorship-author-name">Gereben Balázs</span> <span class="authorAux-mtmt"> Pajzsmirigy endokrinológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Molecular Cell Metabolism</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35739679" target="_blank">Variable transduction of thyroid hormone signaling in structures of the mouse brain</a></div> <div> <span class="journal-title">PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0027-8424">0027-8424</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1091-6490">1091-6490</a>)</span>: <span class="journal-volume">122</span> <span class="journal-issue">6</span> <span class="page"> Paper e2415970122. 10 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="10.1073/pnas.2415970122" target="_blank" href="https://doi.org/10.1073/pnas.2415970122"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="215199" target="_blank" href="https://real.mtak.hu/215199"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001459599300012" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001459599300012"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85218066949" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85218066949"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39903117" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39903117&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="https://pnas.org/doi/10.1073/pnas.2415970122" target="_blank" href="https://pnas.org/doi/10.1073/pnas.2415970122"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">HAS Section of Earth Sciences (X.) HASSESX&nbsp;&nbsp;&nbsp;A</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 10</span> | Independent citation: 7 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 10 | Number of citations in Scopus:&nbsp;10 | WoS/Scopus assigned:&nbsp;10 | Number of citations with DOI:&nbsp;10 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35739679&sort=publishedYear,desc&sort=title"> Number of cited publications: 27 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35739679</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> National Laboratory of Translational Neuroscience (TINL)(RRF-2.3.1-21-2022-00011), (Recovery and Resilience Facility of the European Union within the framework of Programme Széchenyi Plan Plus grant number RRF-2.3.1-21-2022-00011), (RRF-2.3.1-21-2022-00011), National Institute of Diabetes and Digestive and Kidney Diseases(DK58538) </div> <div class="lastModified">Last Modified: 2026.04.13. 12:05 Márta Turek (KOKI admin 4) </div> <div class="lockedBy">Centrally managed 2026.05.20. 09:50 Katalin Lévayné Deseő (MTMT Központi admin) </div> </div></div>