https://m2.mtmt.hu/ eng 2026-10-25 00:19 JournalArticle 35737873 VALIDATED true 0 false 2026-08-12T13:22:19.457+0000 2026-05-20T08:51:51.479+0000 2025-02-04T13:54:12.133+0000 true 10065463 Turek Márta /api/admin/10065463 Admin true 2026-05-20T08:51:51.962+0000 2026-05-20T08:51:51.962+0000 2025-12-18T16:46:57.266+0000 true 521 Szuper Admin /api/admin/521 Admin true Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2026-05-20T07:50:06.352+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Edwards, Alexander Ghrelin recruits the endocannabinoid system to modulate food reward. true true /api/journal/2707 REVIEWED true false 2707 false 2707 true 0270-6474 1529-2401 Journal FOREIGN 45 9 e1620242024 e1620242024 15 2025 Ghrelin enhances feeding by activating the growth hormone secretagogue receptor (GHSR). In the brain, GHSRs are expressed in regions responsible for regulating food motivation including the ventral tegmental area (VTA). Endogenous cannabinoids also promote food seeking behaviors through the cannabinoid receptor 1 type (CB-1Rs) in brain regions including the VTA. It is not known, however, if ghrelin and endocannabinoids interact in the VTA to produce these effects. We therefore examined if GHSR and CB-1R interact within the VTA to enhance food motivation. Results show that GHSR and CB-1R mRNA are expressed in the VTA cells in male and female rats and mice, with the GHSR being expressed in dopamine cells, and the CB-1R being expressed primarily in non-dopaminergic cells with no obvious sex differences. Ghrelin directly activated and increased excitatory tone onto dopamine cells of male and female mice. Male rats lacking fully functional GHSR signalling showed disrupted gene expression of transcripts important for regulating the synthesis, release, and degradation of endocannabinoids and lowered the levels of 2-arachidonoylglycerol (2-AG) within the VTA. Moreover, pharmacological antagonism of VTA CB-1Rs attenuates the orexigenic and appetitive effects of intra-VTA ghrelin in rats and blocks the ability of ghrelin to promote excitatory drive to VTA dopamine neurons. Finally, blocking the breakdown of cannabinoids in the VTA enhances the effects of ghrelin on food motivation. Together, our data show that ghrelin stimulates VTA dopamine cells and ultimately food motivation in part through a mechanism that involves endocannabinoid signalling at the CB-1R. 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true 0 true false true PersonAuthorship 123119484 /api/authorship/123119484 10 0.09090909 false false false Chee Melissa J. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123119485 /api/authorship/123119485 11 0.09090909 false true false Abizaid Alfonso true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 28344737 /api/publicationidentifier/28344737 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GREEN true IDENTICAL 10.1523/JNEUROSCI.1620-24.2024 https://doi.org/10.1523/JNEUROSCI.1620-24.2024 false true PublicationIdentifier 28674832 /api/publicationidentifier/28674832 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GREEN true 216619 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10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2801 /api/classificationexternal/2801 true 2801 true Q1 DIRECT true true /api/publication/35737873 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Edwards Alexander </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >DeSante Stephanie </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Spencer Carl Duncan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hyland Lindsay </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Smith Andrea </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sankhe Aditi S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055055"><a href="/gui2/?type=authors&mode=browse&sel=10055055" target="_blank">Szilvásy-Szabó Anett (<span class="authorship-author-name">Stiftné Szilvásy-Szabó Anett</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Integratív Neuroendokrinológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012354"><a href="/gui2/?type=authors&mode=browse&sel=10012354" target="_blank">Fekete Csaba (<span class="authorship-author-name">Fekete Csaba</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Integratív Neuroendokrinológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hill Matthew N. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chee Melissa J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Abizaid Alfonso </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35737873" target="_blank">Ghrelin recruits the endocannabinoid system to modulate food reward.</a></div> <div> <span class="journal-title">JOURNAL OF NEUROSCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0270-6474">0270-6474</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1529-2401">1529-2401</a>)</span>: <span class="journal-volume">45</span> <span class="journal-issue">9</span> <span class="page"> Paper e1620242024. 15 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="10.1523/JNEUROSCI.1620-24.2024" target="_blank" href="https://doi.org/10.1523/JNEUROSCI.1620-24.2024"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="216619" target="_blank" href="https://real.mtak.hu/216619"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001437281800002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001437281800002"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85219245156" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85219245156"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39779372" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39779372&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.1620-24.2024" target="_blank" href="https://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.1620-24.2024"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 7</span> | Independent citation: 7 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 6 | Number of citations in Scopus:&nbsp;7 | WoS/Scopus assigned:&nbsp;7 | Number of citations with DOI:&nbsp;7 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35737873&sort=publishedYear,desc&sort=title"> Number of cited publications: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35737873</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Nemzeti Agykutatási Program(NAP2022-I-10/2022) Funder: HAS, Discovery Grant(06248), National Brain Research Program of the Hungarian Academy of Sciences(NAP 3.0) </div> <div class="lastModified">Last Modified: 2026.05.20. 10:51 Katalin Lévayné Deseő (MTMT Központi admin) </div> <div class="lockedBy">Centrally managed 2026.05.20. 09:50 Katalin Lévayné Deseő (MTMT Központi admin) </div> </div></div>