https://m2.mtmt.hu/ hun 2026-07-28 04:47 JournalArticle 35724858 APPROVED true Cancer Biology and Epigenetics Group, Research Center of IPO Porto (CI-IPOP)/CI-IPOP@RISE (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal Doctoral Program in Biomedical Sciences, ICBAS — School of Medicine & Biomedical Sciences, University of Porto (ICBAS-UP), Porto, Portugal Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC), Porto, Portugal Department of Pathology and Molecular Immunology, ICBAS — School of Medicine & Biomedical Sciences, University of Porto, Porto, Portugal Export Date: 23 March 2025; Cited By: 1; Correspondence Address: C. Jerónimo; Cancer Biology and Epigenetics Group, Research Center of IPO Porto (CI-IPOP)/CI-IPOP@RISE (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal; email: carmenjeronimo@ipoporto.min-saude.pt 0 false 2025-06-26T12:57:47.469+0000 2025-06-26T12:56:25.016+0000 2025-01-29T18:47:48.794+0000 true 10071338 Molnár-Taga Márta /api/admin/10071338 Admin true 2025-07-15T13:01:20.170+0000 false false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Constancio, Vera Prostate cancer epigenetics - from pathophysiology to clinical application true true /api/journal/10011748 REVIEWED true false 10011748 false 10011748 true 1759-4812 1759-4820 Journal FOREIGN 22 447 469 447 23 2025 Prostate cancer is a multifactorial disease influenced by various molecular features. Over the past decades, epigenetics, which is the study of changes in gene expression without altering the DNA sequence, has been recognized as a major driver of this disease. In the past 50 years, advancements in technological tools to characterize the epigenome have highlighted crucial roles of epigenetic mechanisms throughout the entire spectrum of prostate cancer, from initiation to progression, including localized disease, metastatic dissemination, castration resistance and neuroendocrine transdifferentiation. Substantial advances in the understanding of epigenetic mechanisms in the pathophysiology of prostate cancer have been carried out, but translating preclinical achievements into clinical practice remains challenging. Ongoing research and biomarker-oriented clinical trials are expected to increase the likelihood of successfully integrating epigenetics into prostate cancer clinical management. true true 2025 true true true false false false NONE 2025-06-26 false 0 0 0 0 0 0 0 0 0 0 0 0 2 2 D1 false false false false 2025-04-29T17:48:17.161+0000 6 36 0 5 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 123010929 /api/authorship/123010929 1 0.2 true false false Constancio Vera true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123010930 /api/authorship/123010930 2 0.2 false false false Lobo Joao true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123010931 /api/authorship/123010931 3 0.2 false false false Sequeira Jose Pedro true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 123010932 /api/authorship/123010932 4 0.2 false false 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src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Constancio Vera </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lobo Joao </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sequeira Jose Pedro </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Henrique Rui </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jeronimo Carmen </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35724858" target="_blank">Prostate cancer epigenetics - from pathophysiology to clinical application</a></div> <div> <span class="journal-title">NATURE REVIEWS UROLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1759-4812">1759-4812</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1759-4820">1759-4820</a>)</span>: <span class="journal-volume">22</span> <span class="page"> pp 447-469 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/s41585-024-00991-8" target="_blank" href="https://doi.org/10.1038/s41585-024-00991-8"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001397062400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001397062400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85217260403" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85217260403"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="39820138" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39820138&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35724858&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35724858</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2025.06.26. 14:56 Molnár-Taga Márta (SE 4-es admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Cancer Biology and Epigenetics Group, Research Center of IPO Porto (CI-IPOP)/CI-IPOP@RISE (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal Doctoral Program in Biomedical Sciences, ICBAS — School of Medicine & Biomedical Sciences, University of Porto (IC...</pre> </div></div>