https://m2.mtmt.hu/ hun 2026-09-21 05:43 JournalArticle 35714647 VALIDATED true 0 false 2026-08-06T05:13:35.088+0000 2025-08-26T09:45:59.812+0000 2025-01-24T19:25:23.016+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-04-24T05:55:42.033+0000 2026-04-24T05:55:42.033+0000 2025-08-26T09:46:00.085+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2026-06-09T18:51:57.569+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Sziva, Réka Eszter Increased Oxidative and Nitrative Stress and Decreased Sex Steroid Relaxation in a Vitamin D-Deficient Hyperandrogenic Rodent Model—And a Validation of the Polycystic Ovary Syndrome Model true true /api/journal/10016563 REVIEWED true false 10016563 false 10016563 true 2072-6643 Journal FOREIGN 17 2 201 201 21 2025 Background/Objectives: Both hyperandrogenism (HA) and vitamin D deficiency (VDD) can separately lead to impaired vascular reactivity and ovulatory dysfunction in fertile females. The aim was to examine the early interactions of these states in a rat model of PCOS. Methods: Four-week-old adolescent female rats were divided into four groups: vitamin D (VD)-supplemented (n = 12); VD-supplemented and testosterone-treated (n = 12); VDD- (n = 11) and VDD-and-testosterone-treated (n = 11). Animals underwent transdermal testosterone treatment for 8 weeks. Target VD levels were achieved with oral VD supplementation and a VD-free diet. Estrous cycles were followed by vaginal smear, and quantitative histomorphometric measurements of the ovaries were also taken. In the 8th week, testosterone- and estrogen-induced relaxation of coronary arterioles was examined with pressure angiography. Estrogen receptor (ER) density and oxidative and nitrative stress parameters (Poly-(ADP-Ribose)-Polymerase and 3-nitrotyrosine) in the vessel wall were investigated with immunohistochemistry. Results: VDD caused impaired estrous cycles, and testosterone caused anovulatory cycles (the cycles were stopped at the diestrous phase). VDD combined with testosterone treatment resulted in reduced testosterone and estrogen vasorelaxation, lower ER density, and higher oxidative and nitrative stress in the vessel wall. Conclusions: PCOS with vitamin D deficiency may be associated with increased oxidative–nitrative stress in coronary arterioles. This oxidative and nitrative stress, potentially caused by hyperandrogenism and/or vitamin D deficiency, could impair estrogen-induced relaxation of the coronary arterioles, possibly by decreasing NO bioavailability and disrupting the estrogen-induced relaxation pathway. Funding 2049126 /api/funding/2049126 false true Funding 2049127 /api/funding/2049127 false true Funding 2049128 /api/funding/2049128 false true true true 2025 true true true false true false GOLD 2026-08-06 false http://www.mdpi.com/journal/nutrients/ 5 0 5 5 0 5 5 4 4 4 4 4 4 5 0 0 5 5 5 5 0 9 9 Folyóiratcikk Journal Article 24 5 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 3 3 3 3 2026 0 2 2 2 2 D1 false 10056835 false false false 2025-02-06T09:02:09.359+0000 Doktori Iskola (SE); HUN-REN-SE Cerebrovaszkuláris és Neurokognitív ... (SE / AOK / I / KKI); Orvosi Képalkotó Klinika (SE / AOK / K); Szülészeti és Nőgyógyászati Klinika (SZTE / SZAOK); Szülészeti és Nőgyógyászati Klinika Üllői úti r... (SE / AOK / K / SZSZNK); Transzlációs Medicina Intézet (SE / AOK / I); Élettani Intézet (SE / AOK / I) 13 35 7 13 0 true 10025544 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 122952102 /api/authorship/122952102 1 0.077 true false false Author 10065600 /api/author/10065600 Sziva Réka Eszter true true Sziva Réka Eszter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122952103 /api/authorship/122952103 2 0.077 true false true Author 10095641 /api/author/10095641 Kollarics Réka true true Kollarics Réka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122952104 /api/authorship/122952104 3 0.077 false false false Author 10056835 /api/author/10056835 Pál Éva true 10056835 true Pál Éva true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122952105 /api/authorship/122952105 4 0.077 false false false Author 10075180 /api/author/10075180 Bányai Bálint Péter true true Bányai Bálint true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122952106 /api/authorship/122952106 5 0.07692308 false false false Author 10081348 /api/author/10081348 Korsós-Novák Ágnes true true Korsós-Novák Ágnes true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122952107 /api/authorship/122952107 6 0.077 false false false Author 10023889 /api/author/10023889 Fontányi Zoltán true 10023889 true Fontányi Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122952108 /api/authorship/122952108 7 0.077 false false false Author 10023698 /api/author/10023698 Magyar Péter true 10023698 true Magyar Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122952109 /api/authorship/122952109 8 0.077 false false false Author 10068368 /api/author/10068368 Süli Anita true true Süli Anita true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122952110 /api/authorship/122952110 9 0.077 false false false Author 10023262 /api/author/10023262 Nádasy György László true 10023262 true Nádasy György L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122952111 /api/authorship/122952111 10 0.077 false false false Author 10013998 /api/author/10013998 Ács Nándor true 10013998 true Ács Nándor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122952112 /api/authorship/122952112 11 0.077 false false false Author 10020503 /api/author/10020503 Horvath Eszter Mária true 10020503 true Horváth Eszter Mária true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122952113 /api/authorship/122952113 12 0.077 false true false Author 10027020 /api/author/10027020 Hadjadj Leila true 10027020 true Hadjadj Leila true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122952114 /api/authorship/122952114 13 0.077 false true false Author 10011316 /api/author/10011316 Várbíró Szabolcs true 10011316 true Várbíró Szabolcs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 28287640 /api/publicationidentifier/28287640 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/nu17020201 https://doi.org/10.3390/nu17020201 false true PublicationIdentifier 28361357 /api/publicationidentifier/28361357 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001404150000001 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mtid="10065600"><a href="/gui2/?type=authors&mode=browse&sel=10065600" target="_blank">Sziva Réka Eszter (<span class="authorship-author-name">Sziva Réka Eszter</span> <span class="authorAux-mtmt"> Szülészet-Nőgyógyászat, Nőgyógyászati endokrino...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/Doktori Iskola; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Üllői úti részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10095641"><a href="/gui2/?type=authors&mode=browse&sel=10095641" target="_blank">Kollarics Réka<sup>*</sup> ✉ (<span class="authorship-author-name">Kollarics Réka</span> <span class="authorAux-mtmt"> szülészet-nőgyógyászat, nőgyógyászati endokrino...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Szülészeti és Nőgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10056835"><a href="/gui2/?type=authors&mode=browse&sel=10056835" target="_blank">Pál Éva (<span class="authorship-author-name">Pál Éva</span> <span class="authorAux-mtmt"> élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Klinikai Kórélettani Intézet">KKI</span>/HUN-REN-SE Cerebrovaszkuláris és Neurokognitív Betegségek Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075180"><a href="/gui2/?type=authors&mode=browse&sel=10075180" target="_blank">Bányai Bálint (<span class="authorship-author-name">Bányai Bálint Péter</span> <span class="authorAux-mtmt"> Élettan, Transzlációs medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10081348"><a href="/gui2/?type=authors&mode=browse&sel=10081348" target="_blank">Korsós-Novák Ágnes (<span class="authorship-author-name">Korsós-Novák Ágnes</span> <span class="authorAux-mtmt"> patológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023889"><a href="/gui2/?type=authors&mode=browse&sel=10023889" target="_blank">Fontányi Zoltán (<span class="authorship-author-name">Fontányi Zoltán</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Üllői úti részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023698"><a href="/gui2/?type=authors&mode=browse&sel=10023698" target="_blank">Magyar Péter (<span class="authorship-author-name">Magyar Péter</span> <span class="authorAux-mtmt"> radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10068368"><a href="/gui2/?type=authors&mode=browse&sel=10068368" target="_blank">Süli Anita (<span class="authorship-author-name">Süli Anita</span> <span class="authorAux-mtmt"> Szülészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Üllői úti részleg; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023262"><a href="/gui2/?type=authors&mode=browse&sel=10023262" target="_blank">Nádasy György L. (<span class="authorship-author-name">Nádasy György László</span> <span class="authorAux-mtmt"> Keringésélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013998"><a href="/gui2/?type=authors&mode=browse&sel=10013998" target="_blank">Ács Nándor (<span class="authorship-author-name">Ács Nándor</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Üllői úti részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020503"><a href="/gui2/?type=authors&mode=browse&sel=10020503" target="_blank">Horváth Eszter Mária (<span class="authorship-author-name">Horvath Eszter Mária</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027020"><a href="/gui2/?type=authors&mode=browse&sel=10027020" target="_blank">Hadjadj Leila<sup>**</sup> (<span class="authorship-author-name">Hadjadj Leila</span> <span class="authorAux-mtmt"> Aneszteziológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011316"><a href="/gui2/?type=authors&mode=browse&sel=10011316" target="_blank">Várbíró Szabolcs (<span class="authorship-author-name">Várbíró Szabolcs</span> <span class="authorAux-mtmt"> Keringésélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/Doktori Iskola; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Üllői úti részleg; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Szülészeti és Nőgyógyászati Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35714647" target="_blank">Increased Oxidative and Nitrative Stress and Decreased Sex Steroid Relaxation in a Vitamin D-Deficient Hyperandrogenic Rodent Model—And a Validation of the Polycystic Ovary Syndrome Model</a></div> <div> <span class="journal-title">NUTRIENTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2072-6643">2072-6643</a>)</span>: <span class="journal-volume">17</span> <span class="journal-issue">2</span> <span class="page"> Paper 201. 21 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/nu17020201" target="_blank" href="https://doi.org/10.3390/nu17020201"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001404150000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001404150000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85216238869" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85216238869"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39861332" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39861332&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Food Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Nutrition and Dietetics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 5</span> | Független: 5 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 4 | Scopus jelölt:&nbsp;4 | WoS/Scopus jelölt:&nbsp;4 | DOI jelölt:&nbsp;5 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35714647&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 9 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35714647</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (STIA-OTKA-2021), (FK129206), (PD-143327) </div> <div class="lastModified">Utolsó módosítás: 2025.08.26. 11:45 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> <div class="lockedBy">Központi kezelésű 2026.06.09. 20:51 Lévayné Deseő Katalin (MTMT Központi admin) </div> </div></div>