https://m2.mtmt.hu/ eng 2026-10-24 02:20 JournalArticle 35712785 VALIDATED true 0 false 2026-10-08T11:47:10.883+0000 2026-10-08T11:40:48.172+0000 2025-01-24T09:23:34.202+0000 true 10065463 Turek Márta /api/admin/10065463 Admin Márta Turek (KOKI admin 4) true 2026-10-08T11:28:08.212+0000 2026-10-08T11:28:08.212+0000 2026-03-13T08:21:41.032+0000 true 10071503 Szabó Regina /api/admin/10071503 Admin Regina Szabó (ELTE TTK admin 5) true Admin 10025544 /api/admin/10025544 Katalin Lévayné Deseő (MTMT Központi admin) Lévayné Deseő Katalin true 10025544 true 2026-05-20T07:50:04.747+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Jász, Anna true true /api/journal/10001349 REVIEWED PLOS BIOLOGY 1544-9173 1545-7885 true false 10001349 false 10001349 true 1544-9173 1545-7885 Journal FOREIGN 23 1 e3002962 e3002962 39 2025 A single exposure to a stressful event can result in enduring changes in behaviour. Long-term modifications in neuronal networks induced by stress are well explored but the initial steps leading to these alterations remain incompletely understood. In this study, we found that acute stress exposure triggers an immediate increase in the firing activity of calretinin-positive neurons in the paraventricular thalamic nucleus (PVT/CR+) that persists for several days in mice. This increase in activity had a causal role in stress-induced changes in spontaneous behaviour. Attenuating PVT/CR+ neuronal activity for only 1 h after the stress event rescued both the protracted increase in PVT/CR+ firing rate and the stress-induced behavioural alterations. Activation of the key forebrain targets (basolateral amygdala, prelimbic cortex, and nucleus accumbens) that mediate defensive behaviour has also been reduced by this post-stress inhibition. Reduction of PVT/CR+ cell activity 5 days later remained still effective in ameliorating stress-induced changes in spontaneous behaviour. The results demonstrate a critical role of the prolonged, post-stress changes in firing activity of PVT/CR+ neurons in shaping the behavioural changes associated with stress. Our data proposes a therapeutic window for intervention in acute stress-related disorders, offering potential avenues for targeted treatment strategies. Funding 2049270 /api/funding/2049270 MILAB(RRF-2.3.1-21-2022-00004) Funder: NRDIO false true Funding 2049271 /api/funding/2049271 (K135561) Funder: NRDIO false true Funding 2049272 /api/funding/2049272 (LP2023-2/2023) false true Funding 2049273 /api/funding/2049273 (TKP2021-EGA-25) false true true 2025 true true true false true false GOLD 2026-10-08 true https://doi.org/10.1371/journal.pbio.3002962 6 0 6 4 3 6 6 6 5 6 6 4 4 4 2 0 6 4 6 4 0 13 13 Folyóiratcikk Journal Article 24 6 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 2 0 2 0 2026 0 4 4 4 4 D1 false 10009548,10030200,10017954 false false false 2025-01-27T17:41:38.590+0000 Biológiai Fizika Tanszék (ELTE / TTK / FizCsill_I); Doktori Iskola (SE); Magatartástudományi Intézet (SE / AOK / I); Molekuláris Neuroendokrinológiai Kutatócsoport (HRN KOKI); Rendszer-Neurobiológia Kutatócsoport (HRN KOKI); Thalamus Kutatócsoport (HRN KOKI) 11 73 6 12 0 true 10025544 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 122942747 /api/authorship/122942747 Jász, Anna [Jász, Anna (Neurobiológia), author] Laboratory of Thalamus Research; School of PhD Studies (SU) 1 0.083 true false false Author 10077417 /api/author/10077417 Anna Jász (Neurobiológia) Jász Anna true true Jász Anna true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 122942748 /api/authorship/122942748 Biró, László* ✉ [Bíró, László (Magatartásélettan), author] Laboratory of Thalamus Research 2 0.083 true false true Author 10030200 /api/author/10030200 László Bíró (Magatartásélettan) Bíró László true 10030200 true Biró László true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 122942749 /api/authorship/122942749 Buday, Zsolt [Buday, Zsolt László (Neurobiológia), author] Laboratory of Thalamus Research; School of PhD Studies (SU) 3 0.083 false false false Author 10084476 /api/author/10084476 Zsolt László Buday (Neurobiológia) Buday Zsolt László true true Buday Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 122942750 /api/authorship/122942750 Király, Bálint [Király, Bálint (Biofizika, Idegtu...), author] Laboratory of System-Neurobiology; Department of Biological Physics (ELTE / ELU FoS) 4 0.083 false false false Author 10066230 /api/author/10066230 Bálint Király (Biofizika, Idegtudomány) Király Bálint true true Király Bálint true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 122942751 /api/authorship/122942751 Szalárdy, Orsolya [Szalárdy, Orsolya (Kognitív idegtudo...), author] Department of Behavioral Sciences (SU / FM / I) 5 0.083333336 false false false Author 10017954 /api/author/10017954 Orsolya Szalárdy (Kognitív idegtudomány) Szalárdy Orsolya true 10017954 true Szalárdy Orsolya true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 122942752 /api/authorship/122942752 Horváth, Krisztina [Horváth, Krisztina (Biológia), author] Laboratory of Molecular Neuroendocrinology 6 0.083 false false false Author 10061618 /api/author/10061618 Krisztina Horváth (Biológia) Horváth Krisztina true 10061618 true Horváth Krisztina true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 122942753 /api/authorship/122942753 Komlósi, Gergely [Komlósi, Gergely (idegtudomány), author] Laboratory of Thalamus Research 7 0.083 false false false Author 10033176 /api/author/10033176 Gergely Komlósi (idegtudomány) Komlósi Gergely true 10033176 true Komlósi Gergely true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 122942754 /api/authorship/122942754 Bódizs, Róbert [Bódizs, Róbert (Alváskutatás), author] Department of Behavioral Sciences (SU / FM / I) 8 0.083333336 false false false Author 10002059 /api/author/10002059 Róbert Bódizs (Alváskutatás) Bódizs Róbert true 10002059 true Bódizs Róbert true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 122942755 /api/authorship/122942755 Kovács, Krisztina J. [Kovács, Krisztina (Neuroendokrinológia), author] Laboratory of Molecular Neuroendocrinology 9 0.083 false false false Author 10009124 /api/author/10009124 Krisztina Kovács (Neuroendokrinológia) Kovács Krisztina true 10009124 true Kovács Krisztina J. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 122942756 /api/authorship/122942756 Diana, Marco A. 10 0.083333336 false false false Diana Marco A. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 122942757 /api/authorship/122942757 Hangya, Balázs [Hangya, Balázs (Neurobiológia), author] Laboratory of System-Neurobiology 11 0.083 false false false Author 220 /api/author/220 Balázs Hangya (Neurobiológia) Hangya Balázs true 220 true Hangya Balázs true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 122942758 /api/authorship/122942758 Acsády, László ✉ [Acsády, László (Neurobiológia), author] Laboratory of Thalamus Research 12 0.083 false true true Author 10009548 /api/author/10009548 László Acsády (Neurobiológia) Acsády László true 10009548 true Acsády László true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 28283120 /api/publicationidentifier/28283120 DOI: 10.1371/journal.pbio.3002962 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1371/journal.pbio.3002962 https://doi.org/10.1371/journal.pbio.3002962 false true PublicationIdentifier 28283141 /api/publicationidentifier/28283141 REAL: 214332 SwordSource 36 /api/publicationsource/36 REAL PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GOLD true IDENTICAL 214332 https://real.mtak.hu/214332 false true PublicationIdentifier 28373113 /api/publicationidentifier/28373113 WoS: 001408413300004 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001408413300004 https://www.webofscience.com/wos/woscc/full-record/001408413300004 true true PublicationIdentifier 28300983 /api/publicationidentifier/28300983 Scopus: 85215675532 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85215675532 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85215675532 false true PublicationIdentifier 28316918 /api/publicationidentifier/28316918 PubMed: 39836670 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39836670 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39836670&dopt=Abstract true true PublicationIdentifier 28283121 /api/publicationidentifier/28283121 Other URL: https://dx.plos.org/10.1371/journal.pbio.3002962 PlainSource 40 /api/publicationsource/40 Other URL PublicationSourceType 10006 /api/publicationsourcetype/10006 Link true true true Egyéb URL Other URL @@@ true true 40 true GOLD true IDENTICAL https://dx.plos.org/10.1371/journal.pbio.3002962 https://dx.plos.org/10.1371/journal.pbio.3002962 false true SjrRating 11552839 /api/sjrrating/11552839 sjr:D1 (2025) Scopus - Agricultural and Biological Sciences (miscellaneous) PLOS BIOLOGY 1544-9173 1545-7885 8 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1101 /api/classificationexternal/1101 Scopus - Agricultural and Biological Sciences (miscellaneous) true 1101 true D1 DIRECT true true Reference 62430690 /api/reference/62430690 1. 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(2025) PLOS BIOLOGY 1544-9173 1545-7885 23 1<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10077417"><a href="/gui2/?type=authors&mode=browse&sel=10077417" target="_blank">Jász Anna (<span class="authorship-author-name">Jász Anna</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Thalamus Research; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10030200"><a href="/gui2/?type=authors&mode=browse&sel=10030200" target="_blank">Biró László^* ✉ (<span class="authorship-author-name">Bíró László</span> <span class="authorAux-mtmt"> Magatartásélettan</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Thalamus Research</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084476"><a href="/gui2/?type=authors&mode=browse&sel=10084476" target="_blank">Buday Zsolt (<span class="authorship-author-name">Buday Zsolt László</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Thalamus Research; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10066230"><a href="/gui2/?type=authors&mode=browse&sel=10066230" target="_blank">Király Bálint (<span class="authorship-author-name">Király Bálint</span> <span class="authorAux-mtmt"> Biofizika, Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of System-Neurobiology; <span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Physics and Astronomy">InstPhysicsAstro</span>/Department of Biological Physics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017954"><a href="/gui2/?type=authors&mode=browse&sel=10017954" target="_blank">Szalárdy Orsolya (<span class="authorship-author-name">Szalárdy Orsolya</span> <span class="authorAux-mtmt"> Kognitív idegtudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Behavioral Sciences</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061618"><a href="/gui2/?type=authors&mode=browse&sel=10061618" target="_blank">Horváth Krisztina (<span class="authorship-author-name">Horváth Krisztina</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Molecular Neuroendocrinology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10033176"><a href="/gui2/?type=authors&mode=browse&sel=10033176" target="_blank">Komlósi Gergely (<span class="authorship-author-name">Komlósi Gergely</span> <span class="authorAux-mtmt"> idegtudomány</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Thalamus Research</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002059"><a href="/gui2/?type=authors&mode=browse&sel=10002059" target="_blank">Bódizs Róbert (<span class="authorship-author-name">Bódizs Róbert</span> <span class="authorAux-mtmt"> Alváskutatás</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Behavioral Sciences</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009124"><a href="/gui2/?type=authors&mode=browse&sel=10009124" target="_blank">Kovács Krisztina J. (<span class="authorship-author-name">Kovács Krisztina</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Molecular Neuroendocrinology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Diana Marco A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="220"><a href="/gui2/?type=authors&mode=browse&sel=220" target="_blank">Hangya Balázs (<span class="authorship-author-name">Hangya Balázs</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of System-Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009548"><a href="/gui2/?type=authors&mode=browse&sel=10009548" target="_blank">Acsády László ✉ (<span class="authorship-author-name">Acsády László</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Thalamus Research</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35712785" target="_blank">Persistently increased post-stress activity of paraventricular thalamic neurons is essential for the emergence of stress-induced alterations in behaviour</a></div> <div> <span class="journal-title">PLOS BIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1544-9173">1544-9173</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1545-7885">1545-7885</a>)</span>: <span class="journal-volume">23</span> <span class="journal-issue">1</span> <span class="page"> Paper e3002962. 39 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1371/journal.pbio.3002962" target="_blank" href="https://doi.org/10.1371/journal.pbio.3002962"> DOI </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="214332" target="_blank" href="https://real.mtak.hu/214332"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001408413300004" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001408413300004"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85215675532" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85215675532"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39836670" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39836670&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="https://dx.plos.org/10.1371/journal.pbio.3002962" target="_blank" href="https://dx.plos.org/10.1371/journal.pbio.3002962"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Agricultural and Biological Sciences (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Immunology and Microbiology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 6</span> | Independent citation: 4 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 6 | Number of citations in Scopus:&nbsp;5 | WoS/Scopus assigned:&nbsp;6 | Number of citations with DOI:&nbsp;6 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35712785&sort=publishedYear,desc&sort=title"> Number of cited publications: 13 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35712785</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> MILAB(RRF-2.3.1-21-2022-00004) Funder: NRDIO, (K135561) Funder: NRDIO, (LP2023-2/2023), (TKP2021-EGA-25) </div> <div class="lastModified">Last Modified: 2026.10.08. 13:40 Tamásné Gere (SE_KK_Admin5_GT, admin) </div> <div class="lockedBy">Centrally managed 2026.05.20. 09:50 Katalin Lévayné Deseő (MTMT Központi admin) </div> </div></div>