https://m2.mtmt.hu/ hun 2026-09-23 04:45 JournalArticle 35697594 VALIDATED true 0 false 2026-09-17T08:37:19.135+0000 2026-05-15T09:21:09.829+0000 2025-01-17T07:41:31.922+0000 true 10012997 Székvölgyi Lóránt /api/author/10012997 Author Székvölgyi Lóránt (Kromatin szerkezet) true 10012997 2026-08-14T12:13:13.871+0000 2025-02-17T08:52:46.810+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin (MTMT Központi admin) Lévayné Deseő Katalin true 10025544 true 2026-05-28T10:32:19.080+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Összefoglaló cikk (Folyóiratcikk) 102 true 1134514 true 1 /api/category/1 Category Tudományos true 1 Tóth, Dániel Márton true true /api/journal/10015686 REVIEWED EPIGENETICS & CHROMATIN 1756-8935 1756-8935 true false 10015686 false 10015686 true 1756-8935 1756-8935 Journal FOREIGN 18 1 5 5 16 2025 DNA methylation, catalyzed by DNA methyltransferases (DNMT), plays pivotal role in regulating embryonic development, gene expression, adaption to environmental stress, and maintaining genome integrity. DNMT family consists of DNMT1, DNMT3A, DNMT3B, and the enzymatically inactive DNMT3L. DNMT3A and DNMT3B establish novel methylation patterns maintained by DNMT1 during replication. Genetic variants of DNMT3A and DNMT3B cause rare diseases such as Tatton-Brown-Rahman and ICF syndromes. Additionally, somatic mutations cause common conditions such as osteoarthritis, osteoporosis, clonal hematopoiesis of indeterminate potential (CHIP), hematologic malignancies, and cancer. While DNMTs have been extensively studied in vitro, in early development and in disease, their detailed physiologic roles remain less understood as in vivo investigations are hindered by the embryonic or perinatal lethality of the knockout mice. To circumvent this problem, tissue-specific Dnmt3a and Dnmt3b knockouts were engineered. This review explores their diverse molecular roles across various organs and cell types and characterizes the phenotype of the knockout mice. We provide a comprehensive collection of over forty tissue-specific knockout models generated by cre recombinase. We highlight the distinct functions of DNMT3A and DNMT3B in germ cells, early development, uterus, hematopoietic differentiation, musculoskeletal development, visceral organs, and nervous system. Our findings indicate that DNMT3A primarily regulates hematopoietic differentiation, while DNMT3B is crucial for cartilage homeostasis and ossification. We emphasize the context-dependent roles of DNMT3A and DNMT3B and demonstrate that they also complement DNMT1 maintenance methyltransferase activity. Overall, the expression patterns of DNMTs across tissues provide insights into potential therapeutic applications for treating neurologic diseases, cancer, and osteoporosis. Funding 2049535 /api/funding/2049535 (K-142137) false true Funding 2049536 /api/funding/2049536 (TKP2021-EGA-18) Támogató: NKFIH false true Funding 2049537 /api/funding/2049537 (K-132695) false true Funding 2049538 /api/funding/2049538 (FK131946) Támogató: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal false true true true 2025 true true true false true false GOLD 2026-09-17 false http://www.epigeneticsandchromatin.com/home 34 0 34 32 1 32 34 32 33 34 34 32 32 32 2 0 34 32 34 32 0 6 6 Folyóiratcikk Journal Article 24 34 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 18 16 18 16 2026 0 16 16 16 16 Q1 false 10012997,10012617 false false false 2025-02-04T09:06:49.356+0000 MTA-DE Lendület Genom Szerkezet és Rekombináció... (DE / ÁOK); Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI); Molekuláris Élettudományi Intézet (HRN TTK); Molekuláris és Nanogyógyszerészeti Tanszék (DE / GYTK) 6 59 4 6 0 true 10025544 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 122818975 /api/authorship/122818975 Tóth, Dániel Márton ✉ [Tóth, Dániel Márton (Gyógyszertudomány), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 1 0.167 true false true Author 10025949 /api/author/10025949 Tóth Dániel Márton (Gyógyszertudomány) Tóth Dániel Márton true 10025949 true Tóth Dániel Márton true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 122818976 /api/authorship/122818976 Szeri, Flóra* ✉ [Szeri, Flóra (Biológiai tudományok), szerző] Molekuláris Élettudományi Intézet (HRN TTK) 2 0.167 true false true Author 10017348 /api/author/10017348 Szeri Flóra (Biológiai tudományok) Szeri Flóra true 10017348 true Szeri Flóra true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 122818977 /api/authorship/122818977 Ashaber, Mária [Ashaber, Mária (Magatartásélettan), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 3 0.167 false false false Author 214 /api/author/214 Ashaber Mária (Magatartásélettan) Ashaber Mária true 214 true Ashaber Mária true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 122818978 /api/authorship/122818978 Muazu, Muhyiddeen [Muhyiddeen, Muazu (Epigenetika), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 4 0.167 false false false Author 10094341 /api/author/10094341 Muhyiddeen Muazu (Epigenetika) Muhyiddeen Muazu true true Muazu Muhyiddeen true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 122818979 /api/authorship/122818979 Székvölgyi, Lóránt** ✉ [Székvölgyi, Lóránt (Kromatin szerkezet), szerző] Molekuláris és Nanogyógyszerészeti Tanszék (DE / GYTK); MTA-DE Lendület Genom Szerkezet és Rekombináció... (DE / ÁOK) 5 0.167 false true true Author 10012997 /api/author/10012997 Székvölgyi Lóránt (Kromatin szerkezet) Székvölgyi Lóránt true 10012997 true Székvölgyi Lóránt true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 122818980 /api/authorship/122818980 Arányi, Tamás ✉ [Arányi, Tamás (Génexpresszió sza...), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI); Molekuláris Élettudományi Intézet (HRN TTK) 6 0.167 false true true Author 10012617 /api/author/10012617 Arányi Tamás (Génexpresszió szabályozás) Arányi Tamás true 10012617 true Arányi Tamás true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 28246643 /api/publicationidentifier/28246643 DOI: 10.1186/s13072-024-00566-2 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1186/s13072-024-00566-2 https://doi.org/10.1186/s13072-024-00566-2 false true PublicationIdentifier 28372118 /api/publicationidentifier/28372118 WoS: 001409729300001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001409729300001 https://www.webofscience.com/wos/woscc/full-record/001409729300001 false true PublicationIdentifier 28372117 /api/publicationidentifier/28372117 Scopus: 85216044397 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85216044397 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85216044397 false true PublicationIdentifier 28372122 /api/publicationidentifier/28372122 PubMed: 39819598 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39819598 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39819598&dopt=Abstract true true SjrRating 11584383 /api/sjrrating/11584383 sjr:Q1 (2025) Scopus - Genetics EPIGENETICS & CHROMATIN 1756-8935 1756-8935 57 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1311 /api/classificationexternal/1311 Scopus - Genetics true 1311 true Q1 DIRECT true true Reference 62092703 /api/reference/62092703 1. 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(2025) EPIGENETICS & CHROMATIN 1756-8935 1756-8935 18 1<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10025949"><a href="/gui2/?type=authors&mode=browse&sel=10025949" target="_blank">Tóth Dániel Márton ✉ (<span class="authorship-author-name">Tóth Dániel Márton</span> <span class="authorAux-mtmt"> Gyógyszertudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017348"><a href="/gui2/?type=authors&mode=browse&sel=10017348" target="_blank">Szeri Flóra^* ✉ (<span class="authorship-author-name">Szeri Flóra</span> <span class="authorAux-mtmt"> Biológiai tudományok</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="214"><a href="/gui2/?type=authors&mode=browse&sel=214" target="_blank">Ashaber Mária (<span class="authorship-author-name">Ashaber Mária</span> <span class="authorAux-mtmt"> Magatartásélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10094341"><a href="/gui2/?type=authors&mode=browse&sel=10094341" target="_blank">Muazu Muhyiddeen (<span class="authorship-author-name">Muhyiddeen Muazu</span> <span class="authorAux-mtmt"> Epigenetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012997"><a href="/gui2/?type=authors&mode=browse&sel=10012997" target="_blank">Székvölgyi Lóránt^** ✉ (<span class="authorship-author-name">Székvölgyi Lóránt</span> <span class="authorAux-mtmt"> Kromatin szerkezet</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Molekuláris és Nanogyógyszerészeti Tanszék; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/MTA-DE Lendület Genom Szerkezet és Rekombináció Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012617"><a href="/gui2/?type=authors&mode=browse&sel=10012617" target="_blank">Arányi Tamás ✉ (<span class="authorship-author-name">Arányi Tamás</span> <span class="authorAux-mtmt"> Génexpresszió szabályozás</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35697594" target="_blank">Tissue-specific roles of de novo DNA methyltransferases</a></div> <div> <span class="journal-title">EPIGENETICS & CHROMATIN</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1756-8935">1756-8935</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1756-8935">1756-8935</a>)</span>: <span class="journal-volume">18</span> <span class="journal-issue">1</span> <span class="page"> Paper 5. 16 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1186/s13072-024-00566-2" target="_blank" href="https://doi.org/10.1186/s13072-024-00566-2"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001409729300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001409729300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85216044397" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85216044397"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39819598" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39819598&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Genetics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 34</span> | Független: 32 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 32 | Scopus jelölt:&nbsp;33 | WoS/Scopus jelölt:&nbsp;34 | DOI jelölt:&nbsp;34 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35697594&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35697594</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (K-142137), (TKP2021-EGA-18) Támogató: NKFIH, (K-132695), (FK131946) Támogató: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal </div> <div class="lastModified">Utolsó módosítás: 2026.05.15. 11:21 Szendrei László (DE/BTK admin5) </div> <div class="lockedBy">Központi kezelésű 2026.05.28. 12:32 Lévayné Deseő Katalin (MTMT Központi admin) </div> </div></div>