https://m2.mtmt.hu/ hun 2026-09-22 20:17 JournalArticle 35696199 VALIDATED true 0 false 2026-07-25T10:54:03.666+0000 2025-01-25T20:10:40.937+0000 2025-01-16T12:52:54.603+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin Gere Tamásné (SE_KK_Admin5_GT, admin) true 10062062 2025-02-20T14:42:42.605+0000 2025-02-20T14:42:42.605+0000 2025-01-25T20:08:25.012+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Oláh, Csilla true true /api/journal/10062888 REVIEWED JOURNAL OF PATHOLOGY: CLINICAL RESEARCH 2056-4538 true false 10062888 false 10062888 true 2056-4538 Journal FOREIGN 11 1 e70017 e70017 10 2025 Distinct molecular subtypes of muscle‐invasive bladder cancer (MIBC) may show different platinum sensitivities. Currently available data were mostly generated at transcriptome level and have limited comparability to each other. We aimed to determine the platinum sensitivity of molecular subtypes by using the protein expression‐based Lund Taxonomy. In addition, we assessed the tumor heterogeneity within the primary tumor and between the primary and lymph node (LN) metastatic sites. Thirteen immunohistochemical markers were stained in a tissue microarray with an overall number of 1,508 cores. Statistical evaluation was performed in 199 patients divided into three chemo‐naïve MIBC cohorts: (1) pT3/4 and/or LN+ patients who received radical cystectomy without platinum treatment, (2) patients who received adjuvant chemotherapy (AC), and (3) patients who underwent palliative platinum treatment for metastatic disease or postoperative progression. Overall survival (OS) was used as the primary endpoint. Patients with the genomically unstable (GU) subtype had significantly better OS in the AC group compared to the radical cystectomy group (HR: 0.395, 95% CI: 0.205–0.795, p = 0.005). In contrast, no such association was observed for the basal/squamous (Ba/Sq) subtype. Intratumor heterogeneity was present in 19% of cases, with the lowest level in the Ba/Sq and GU tumors (14% each) and the highest level of 43% in small‐cell/neuroendocrine‐like tumors. There was greater subtype heterogeneity between primary tumors and LN metastases. In conclusion, immunohistochemistry‐based Lund Taxonomy subtypes remain stable within the same primary tumor, with the GU subtype deriving the greatest OS benefit from AC. However, high tumor heterogeneity between the primary tumor and metastatic sites can impact the effectiveness of therapies. Funding 2049136 /api/funding/2049136 (K139059) false true Funding 2049137 /api/funding/2049137 (Open access funding provided by Semmelweis University) false true true true 2025 true true true false true false GOLD 2026-07-25 false 4 0 4 3 1 4 4 4 4 4 4 3 3 3 1 0 4 3 4 3 0 1 1 Folyóiratcikk Journal Article 24 4 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 3 3 3 3 2026 0 1 0 1 0 Q1 false false false false 2025-01-24T20:08:24.768+0000 Patológiai, Igazságügyi és Biztosítási Orvostan... (SE / AOK / I); Urológiai Klinika (SE / AOK / K) 6 19 2 15 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 122813043 /api/authorship/122813043 Oláh, Csilla [Oláh, Csilla (Urológia), szerző] 1 0.067 true false false Author 10051826 /api/author/10051826 Oláh Csilla (Urológia) Oláh Csilla true 10051826 true Oláh Csilla true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 122813044 /api/authorship/122813044 Shmorhun, Oleksandr 2 0.06666667 false false false Shmorhun Oleksandr true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 122813045 /api/authorship/122813045 Klamminger, Gilbert Georg 3 0.06666667 false false false Klamminger Gilbert Georg true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 122813046 /api/authorship/122813046 Rawitzer, Josefine 4 0.06666667 false false false Rawitzer Josefine true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 122813047 /api/authorship/122813047 Sichward, Lara 5 0.06666667 false false false Sichward Lara true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 122813048 /api/authorship/122813048 Hadaschik, Boris 6 0.06666667 false false false Hadaschik Boris true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 122813049 /api/authorship/122813049 Al‐Nader, Mulham 7 0.06666667 false false false Al‐Nader Mulham true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 122813050 /api/authorship/122813050 Krafft, Ulrich 8 0.06666667 false false false Krafft Ulrich true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 122813051 /api/authorship/122813051 Niedworok, Christian 9 0.06666667 false false false Niedworok Christian true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 122813052 /api/authorship/122813052 Váradi, Melinda [Váradi, Melinda (Urológia), szerző] Urológiai Klinika (SE / AOK / K) 10 0.067 false false false Author 10074880 /api/author/10074880 Váradi Melinda (Urológia) Váradi Melinda true true Váradi Melinda true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 122813053 /api/authorship/122813053 Nyirady, Peter [Nyirády, Péter (Urológia), szerző] Urológiai Klinika (SE / AOK / K) 11 0.067 false false false Author 10013343 /api/author/10013343 Nyirády Péter (Urológia) Nyirády Péter true 10013343 true Nyirady Peter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 122813054 /api/authorship/122813054 Kiss, András [Kiss, András (Pathológia, hepat...), szerző] Patológiai, Igazságügyi és Biztosítási Orvostan... (SE / AOK / I) 12 0.067 false false false Author 10000554 /api/author/10000554 Kiss András (Pathológia, hepatocarcinogenesis) Kiss András true 10000554 true Kiss András true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 122813055 /api/authorship/122813055 Székely, Eszter [Székely, Eszter (patologia), szerző] Patológiai, Igazságügyi és Biztosítási Orvostan... (SE / AOK / I) 13 0.067 false false false Author 10023805 /api/author/10023805 Székely Eszter (patologia) Székely Eszter DUPLUM true 10023805 true Székely Eszter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 122813056 /api/authorship/122813056 Reis, Henning** 14 0.067 false true false Reis Henning true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 122813057 /api/authorship/122813057 Szarvas, Tibor ✉ [Szarvas, Tibor (urológia), szerző] Urológiai Klinika (SE / AOK / K) 15 0.067 false true true Author 10052466 /api/author/10052466 Szarvas Tibor (urológia) Szarvas Tibor true 10052466 true Szarvas Tibor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 28243035 /api/publicationidentifier/28243035 DOI: 10.1002/2056-4538.70017 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1002/2056-4538.70017 https://doi.org/10.1002/2056-4538.70017 false true PublicationIdentifier 28290129 /api/publicationidentifier/28290129 WoS: 001396484600001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001396484600001 https://www.webofscience.com/wos/woscc/full-record/001396484600001 false true PublicationIdentifier 28290130 /api/publicationidentifier/28290130 Scopus: 85215008487 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85215008487 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85215008487 false true PublicationIdentifier 28243077 /api/publicationidentifier/28243077 PubMed: 39817402 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39817402 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39817402&dopt=Abstract true true Classification 12305 /api/classification/12305 Urológia true true SjrRating 11611164 /api/sjrrating/11611164 sjr:Q1 (2025) Scopus - Pathology and Forensic Medicine JOURNAL OF PATHOLOGY: CLINICAL RESEARCH 2056-4538 24 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2734 /api/classificationexternal/2734 Scopus - Pathology and Forensic Medicine true 2734 true Q1 DIRECT true true Reference 62056550 /api/reference/62056550 1. 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(2025) JOURNAL OF PATHOLOGY: CLINICAL RESEARCH 2056-4538 11 1<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10051826"><a href="/gui2/?type=authors&mode=browse&sel=10051826" target="_blank">Oláh Csilla (<span class="authorship-author-name">Oláh Csilla</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Shmorhun Oleksandr </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Klamminger Gilbert Georg </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rawitzer Josefine </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sichward Lara </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hadaschik Boris </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Al‐Nader Mulham </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Krafft Ulrich </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Niedworok Christian </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074880"><a href="/gui2/?type=authors&mode=browse&sel=10074880" target="_blank">Váradi Melinda (<span class="authorship-author-name">Váradi Melinda</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013343"><a href="/gui2/?type=authors&mode=browse&sel=10013343" target="_blank">Nyirady Peter (<span class="authorship-author-name">Nyirády Péter</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000554"><a href="/gui2/?type=authors&mode=browse&sel=10000554" target="_blank">Kiss András (<span class="authorship-author-name">Kiss András</span> <span class="authorAux-mtmt"> Pathológia, hepatocarcinogenesis</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023805"><a href="/gui2/?type=authors&mode=browse&sel=10023805" target="_blank">Székely Eszter (<span class="authorship-author-name">Székely Eszter</span> <span class="authorAux-mtmt"> patologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Reis Henning^** </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052466"><a href="/gui2/?type=authors&mode=browse&sel=10052466" target="_blank">Szarvas Tibor ✉ (<span class="authorship-author-name">Szarvas Tibor</span> <span class="authorAux-mtmt"> urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35696199" target="_blank">Immunohistochemistry‐based molecular subtypes of urothelial carcinoma derive different survival benefit from platinum chemotherapy</a></div> <div> <span class="journal-title">JOURNAL OF PATHOLOGY: CLINICAL RESEARCH</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2056-4538">2056-4538</a>)</span>: <span class="journal-volume">11</span> <span class="journal-issue">1</span> <span class="page"> Paper e70017. 10 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1002/2056-4538.70017" target="_blank" href="https://doi.org/10.1002/2056-4538.70017"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001396484600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001396484600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85215008487" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85215008487"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39817402" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39817402&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pathology and Forensic Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 4</span> | Független: 3 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 4 | Scopus jelölt:&nbsp;4 | WoS/Scopus jelölt:&nbsp;4 | DOI jelölt:&nbsp;4 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35696199&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35696199</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (K139059), (Open access funding provided by Semmelweis University) </div> <div class="lastModified">Utolsó módosítás: 2025.01.25. 21:10 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> </div></div>