https://m2.mtmt.hu/ eng 2026-10-23 06:53 JournalArticle 35685062 APPROVED true 0 false 2026-07-10T10:27:36.035+0000 2025-07-17T06:48:30.650+0000 2025-01-14T06:59:24.274+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2025-07-17T06:48:30.875+0000 2025-07-17T06:48:30.875+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Ismaylova, Elmira Brain serotonin, oxytocin, and their interaction: Relevance for eating disorders true true /api/journal/2815 REVIEWED true false 2815 false 2815 true 0269-8811 1461-7285 Journal FOREIGN 39 3 187 200 187 14 2025 Introduction: Eating disorders are characterized by maladaptive eating behaviors and preoccupations around body shape, weight, and eating. The serotonin system has been among the most widely studied neurobiological factors in relation to eating disorders. Recent research also highlighted the role of oxytocin.Aims and methods: This article aims to review animal and human studies on the involvement of central serotonin and oxytocin, and their interplay in eating disorders in particular. We synthesize results from studies using animal models of eating disorders and from research conducted in healthy individuals and clinical populations.Results/Outcomes: Altered serotonin neurotransmission and oxytocin levels in the brain-particularly in the hypothalamus, brainstem, and limbic regions-were associated with disturbances in eating behaviors and related maladaptive cognitions and emotions. These brain regions were found to constitute a typical neural network through which both central serotonin and oxytocin might operate in a bidirectional manner.Conclusions/Interpretation: Based on the preceding findings, we describe a developmental biopsychosocial model relevant to eating disorders, including the role of serotonin-oxytocin interactions in the brain. While it is clear that eating disorders are multifactorial in which many biopsychosocial pathways are involved, the current review highlights the importance of well-designed translational research when studying mechanisms of serotonin-oxytocin interactions in the brain. Such research would help to better understand the effects of joint central oxytocin and serotonin administration as a possible preventive or therapeutic intervention for eating disorders. 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<span class="author-name" mtid="10013858"><a href="/gui2/?type=authors&mode=browse&sel=10013858" target="_blank">Nemoda Zsofia (<span class="authorship-author-name">Nemoda Zsófia</span> <span class="authorAux-mtmt"> Molekuláris genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Booij Linda ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35685062" target="_blank">Brain serotonin, oxytocin, and their interaction: Relevance for eating disorders</a></div> <div> <span class="journal-title">JOURNAL OF PSYCHOPHARMACOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0269-8811">0269-8811</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1461-7285">1461-7285</a>)</span>: <span class="journal-volume">39</span> <span class="journal-issue">3</span> <span class="page"> pp 187-200 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1177/02698811241309617" target="_blank" href="https://doi.org/10.1177/02698811241309617"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001388166700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001388166700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85213861717" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85213861717"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39745000" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39745000&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Pharmacology (medical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Psychiatry and Mental Health&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 5</span> | Independent citation: 5 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 4 | Number of citations in Scopus:&nbsp;4 | WoS/Scopus assigned:&nbsp;5 | Number of citations with DOI:&nbsp;5 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35685062&sort=publishedYear,desc&sort=title"> Number of cited publications: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35685062</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> (2019-2.1.11-TÉT-2020-00242) </div> <div class="lastModified">Last Modified: 2025.07.17. 08:48 Márta Molnár-Taga (SE 4-es admin) </div> </div></div>