https://m2.mtmt.hu/ hun 2026-10-23 02:22 JournalArticle 35681869 VALIDATED true 0 false 2026-09-03T07:37:54.984+0000 2026-02-04T23:01:11.388+0000 2025-01-13T09:07:14.925+0000 true 10070075 Nádas Orsolya /api/admin/10070075 Admin true 2026-02-04T23:01:11.399+0000 2026-02-04T23:01:11.399+0000 2025-01-20T10:55:55.320+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true Admin 10065569 /api/admin/10065569 Pécsi Éva true true 2026-02-06T10:56:21.970+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Sándor, Gyöngyvér Orsolya Assessment of the predictive power the radiation-induced lymphocyte apoptosis method in prostate cancer patients true true /api/journal/10019966 REVIEWED true false 10019966 false 10019966 true 2045-2322 Journal FOREIGN 15 1 1516 1516 9 2025 Due to the better survival of patients with tumorous diseases, it is increasingly important to predict the side effects of radiotherapy, for which the Radiation-Induced Lymphocyte Apoptosis (RILA) method is proving to be effective in multicentric studies. Prostate cancer is the leading cause of cancer-related deaths among men worldwide, which is usually treated with radiotherapy. We recruited 49 patients with localized prostate cancer and performed RILA measurements before radiotherapy. Patients were treated with CyberKnife (35-40 Gy) or high-dose-rate brachytherapy (1 × 21 Gy). We performed chromosome aberration test for five years and graded side effects, IPSS and QoL questionnaire scores were recorded. We found that RILA% correlated with the IPSS increase (p = 0.0016, r=-0.44), which was confirmed with negative binomial regression (p = 0.0013). The negative predictive value for severe urinary side effects according to the IPSS questionnaire was 87.9% at the lower tertile of RILA values. Chromosome aberrations also correlated with side effects, but when we built models including variables of baseline and treatment characteristics of the patients, RILA, and chromosome aberrations, only RILA predicted a late increase in IPSS score (p < 0.0001, adjusted R2 = 68%). The RILA method was shown to be predictive of urinary side effects especially of patient-reported outcomes. Funding 2048756 /api/funding/2048756 false true Funding 2048757 /api/funding/2048757 false true Funding 2048758 /api/funding/2048758 false true true 2025 true true true false true false GOLD 2026-09-03 true https://doi.org/10.1038/s41598-024-81450-7 3 0 3 3 0 3 3 1 1 1 1 1 1 3 0 0 3 3 3 3 0 0 0 Folyóiratcikk Journal Article 24 3 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 1 1 1 1 2026 0 2 2 2 2 Q1 A nemzetközi false 10020433,10010426 false false false 2025-01-12T14:15:35.395+0000 Biológiai Fizika Tanszék (ELTE / TTK / FizCsill_I); Onkológiai Tanszék (SE / AOK / K); Országos Onkológiai Intézet 16 38 3 16 0 true 10065569 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 122709386 /api/authorship/122709386 1 0.063 true false false Author 10070301 /api/author/10070301 Sándor Gyöngyvér Orsolya true true Sándor Gyöngyvér Orsolya true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122709387 /api/authorship/122709387 2 0.063 false false false Author 10011699 /api/author/10011699 Farkas Gyöngyi true 10011699 true Farkas Gyöngyi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122709388 /api/authorship/122709388 3 0.063 false false false Author 10032265 /api/author/10032265 Székely Gábor true 10032265 true Székely Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122709389 /api/authorship/122709389 4 0.063 false false false Author 10030572 /api/author/10030572 Ágoston Péter Zoltán true 10030572 true Ágoston Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122709390 /api/authorship/122709390 5 0.063 false false false Author 10064469 /api/author/10064469 Jorgo Kliton true 10064469 true Jorgo Kliton true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122709391 /api/authorship/122709391 6 0.063 false false false Author 10058289 /api/author/10058289 Gesztesi László true 10058289 true Gesztesi László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122709392 /api/authorship/122709392 7 0.063 false false false Author 10044386 /api/author/10044386 Major Tibor true 10044386 true Major Tibor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122709393 /api/authorship/122709393 8 0.063 false false false Author 10018107 /api/author/10018107 Pesznyák Csilla true 10018107 true Pesznyák Csilla true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122709394 /api/authorship/122709394 9 0.063 false false false Author 10042833 /api/author/10042833 Herein András true 10042833 true Herein András true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122709395 /api/authorship/122709395 10 0.063 false false false Author 10042823 /api/author/10042823 Stelczer Gábor true 10042823 true Stelczer Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122709396 /api/authorship/122709396 11 0.063 false false false Author 10065843 /api/author/10065843 Mihály Dalma true true Mihály Dalma true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122709397 /api/authorship/122709397 12 0.063 false false false Author 10016868 /api/author/10016868 Fröhlich Georgina true 10016868 true Fröhlich Georgina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122709398 /api/authorship/122709398 13 0.063 false false true Author 10010426 /api/author/10010426 Jurányi Zsolt true 10010426 true Jurányi Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122709399 /api/authorship/122709399 14 0.063 false false false Author 10013883 /api/author/10013883 Takácsi-Nagy Zoltán true 10013883 true Takácsi-Nagy Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122709400 /api/authorship/122709400 15 0.063 false false false Author 10013383 /api/author/10013383 Polgár Csaba true 10013383 true Polgár Csaba true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122709401 /api/authorship/122709401 16 0.063 false true false Author 10020433 /api/author/10020433 Kocsis Zsuzsa true 10020433 true Kocsis Zsuzsa S true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 28200849 /api/publicationidentifier/28200849 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1038/s41598-024-81450-7 https://doi.org/10.1038/s41598-024-81450-7 false true PublicationIdentifier 28256192 /api/publicationidentifier/28256192 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001394989600029 https://www.webofscience.com/wos/woscc/full-record/001394989600029 false true PublicationIdentifier 28255924 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false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true A nemzetközi true 19359 true MtaRating 11551161 /api/mtarating/11551161 RatingType 10010 /api/ratingtype/10010 RegTB Institute 14100 /api/institute/14100 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true B nemzetközi false true SjrRating 11736329 /api/sjrrating/11736329 24 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 true 1000 true Q1 DIRECT true true /api/publication/35681869 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10070301"><a href="/gui2/?type=authors&mode=browse&sel=10070301" target="_blank">Sándor Gyöngyvér Orsolya (<span class="authorship-author-name">Sándor Gyöngyvér Orsolya</span> <span class="authorAux-mtmt"> GO Sandor</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011699"><a href="/gui2/?type=authors&mode=browse&sel=10011699" target="_blank">Farkas Gyöngyi (<span class="authorship-author-name">Farkas Gyöngyi</span> <span class="authorAux-mtmt"> Környezeti mikrobiológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032265"><a href="/gui2/?type=authors&mode=browse&sel=10032265" target="_blank">Székely Gábor (<span class="authorship-author-name">Székely Gábor</span> <span class="authorAux-mtmt"> genetika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10030572"><a href="/gui2/?type=authors&mode=browse&sel=10030572" target="_blank">Ágoston Péter (<span class="authorship-author-name">Ágoston Péter Zoltán</span> <span class="authorAux-mtmt"> Sugárterápia, onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064469"><a href="/gui2/?type=authors&mode=browse&sel=10064469" target="_blank">Jorgo Kliton (<span class="authorship-author-name">Jorgo Kliton</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058289"><a href="/gui2/?type=authors&mode=browse&sel=10058289" target="_blank">Gesztesi László (<span class="authorship-author-name">Gesztesi László</span> <span class="authorAux-mtmt"> Sugárterápia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044386"><a href="/gui2/?type=authors&mode=browse&sel=10044386" target="_blank">Major Tibor (<span class="authorship-author-name">Major Tibor</span> <span class="authorAux-mtmt"> klinikai sugárfizika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018107"><a href="/gui2/?type=authors&mode=browse&sel=10018107" target="_blank">Pesznyák Csilla (<span class="authorship-author-name">Pesznyák Csilla</span> <span class="authorAux-mtmt"> Orvosfizika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10042833"><a href="/gui2/?type=authors&mode=browse&sel=10042833" target="_blank">Herein András (<span class="authorship-author-name">Herein András</span> <span class="authorAux-mtmt"> Fizikai</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10042823"><a href="/gui2/?type=authors&mode=browse&sel=10042823" target="_blank">Stelczer Gábor (<span class="authorship-author-name">Stelczer Gábor</span> <span class="authorAux-mtmt"> Orvosfizika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10065843"><a href="/gui2/?type=authors&mode=browse&sel=10065843" target="_blank">Mihály Dalma (<span class="authorship-author-name">Mihály Dalma</span> <span class="authorAux-mtmt"> Klinikai sugárfizika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10016868"><a href="/gui2/?type=authors&mode=browse&sel=10016868" target="_blank">Fröhlich Georgina (<span class="authorship-author-name">Fröhlich Georgina</span> <span class="authorAux-mtmt"> Sugárfizika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Fizikai és Csillagászati Intézet">FizCsill_I</span>/Biológiai Fizika Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010426"><a href="/gui2/?type=authors&mode=browse&sel=10010426" target="_blank">Jurányi Zsolt ✉ (<span class="authorship-author-name">Jurányi Zsolt</span> <span class="authorAux-mtmt"> Onkológiai kutatás, sugárterápia, sugárbiológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013883"><a href="/gui2/?type=authors&mode=browse&sel=10013883" target="_blank">Takácsi-Nagy Zoltán (<span class="authorship-author-name">Takácsi-Nagy Zoltán</span> <span class="authorAux-mtmt"> Sugárterápia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013383"><a href="/gui2/?type=authors&mode=browse&sel=10013383" target="_blank">Polgár Csaba (<span class="authorship-author-name">Polgár Csaba</span> <span class="authorAux-mtmt"> Sugárterápia, klinikai onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020433"><a href="/gui2/?type=authors&mode=browse&sel=10020433" target="_blank">Kocsis Zsuzsa S (<span class="authorship-author-name">Kocsis Zsuzsa</span> <span class="authorAux-mtmt"> sugárbiológia, onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35681869" target="_blank">Assessment of the predictive power the radiation-induced lymphocyte apoptosis method in prostate cancer patients</a></div> <div> <span class="journal-title">SCIENTIFIC REPORTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-2322">2045-2322</a>)</span>: <span class="journal-volume">15</span> <span class="journal-issue">1</span> <span class="page"> Paper 1516. 9 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41598-024-81450-7" target="_blank" href="https://doi.org/10.1038/s41598-024-81450-7"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001394989600029" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001394989600029"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85214912117" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85214912117"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39789068" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39789068&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Regionális Tudományok Bizottsága IXGJO RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 3</span> | Független: 3 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;3 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35681869</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (National Tumor Biology Laboratory (2022–2.1.1-NL-2022-00010))), Hungarian Thematic Excellence Program((TKP2021-EGA-44)), (2020-1.1.6-JÖVŐ-2021-00008) </div> <div class="lastModified">Utolsó módosítás: 2026.02.05. 00:01 Pécsi Éva (MTMT Közp 2,3, admin) </div> <div class="lockedBy">Központi kezelésű 2026.02.06. 11:56 Pécsi Éva (MTMT Közp 2,3, admin) </div> </div></div>