https://m2.mtmt.hu/ eng 2026-04-29 03:36 BookChapter 35675487 APPROVED true 0 false 2025-05-15T11:52:17.287+0000 2025-01-09T13:43:22.776+0000 2025-01-09T13:33:35.197+0000 true 10086016 Blazsek Martin János /api/author/10086016 Author true 2026-03-23T11:18:08.354+0000 2026-03-23T11:18:08.354+0000 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2025-05-15T11:49:02.300+0000 true false true 31 31 /api/publicationtype/31 PublicationType 4 true 31 BookChapter true 10000175 Abstract true 31 31 /api/publicationtype/31 PublicationType 4 true 31 BookChapter /api/subtype/10000175 Absztrakt / Kivonat SubType 453 true 10000175 true 1 /api/category/1 Category true 1 Blazsek, Martin Characteristics of place field formation in the hippocampal CA1 and CA3 regions PS01-26AM-034 PS01-26AM-034 2024 Hippocampal pyramidal cells (PCs) express spatially tuned activity (i.e., ‘place cells’ exhibiting ‘place fields’, PF) to support navigation. However, the cellular mechanisms of novel PF formation are elusive. Behavioral time scale synaptic plasticity (BTSP), recently described in mouse CA1PCs, is a putative mechanism of PF formation (Bittner et al., 2015). It starts with a silent PC exhibiting a large Ca2+ plateau in dendrites accompanied by somatic bursting, which initiates the emergence of tuning near the location of induction. Consequently, activity is strongest during formation and lower during subsequent visits. BTSP in CA1PCs has an asymmetric, seconds-long kernel giving rise to a backward shift in tuning after PF formation. The properties of BTSP-formed PFs in CA1 are still incompletely understood, with even less known about BTSP in CA3. Here we recorded CA1PCs and CA3PCs using two-photon Ca2+ imaging in head-fixed Thy1-GCaMP6s mice navigating in two randomly alternating virtual environments, and classified PFs as either newly formed or established. Inspired by recent work (Priestley et al., 2022), we calculated PF formation gain (i.e., relatively strong formation activity) and initial shift (i.e., backward shift in tuning) that capture the proposed properties of BTSP-formed PFs in CA1. We show that newly formed PFs in CA1PCs exhibit higher gain and larger shift than established PFs. In contrast, newly formed PFs in CA3 do not differ from established PFs in terms of shifting. This suggests that BTSP is either less prevalent in CA3, or it manifests differently. 2025 true true false true false NONE 2025-05-15 false 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 false false false false 2025-04-09T12:43:22.509+0000 Biológiai Számítások Laboratórium (HRN KOKI); Celluláris Idegélettani Kutatócsoport (HRN KOKI); HUN-REN Kísérleti Orvostudományi Kutatóintézet; Idegi Jelátvitel Kutatócsoport (HRN KOKI); Roska Tamás Műszaki és Természettudományi Dokto... (PPKE / ITK) 7 44 5 8 0 true true 10002 English /api/language/10002 Angol Language true 2 false /api/publication/35079159 true true 32 32 /api/publicationtype/32 PublicationType 6 true 32 Book FENS Forum 2024 false 35079159 false true true true false Book 2024 true 1 /api/category/1 Category true 1 false 10014568 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 122662562 /api/authorship/122662562 1 1.0 true false Author 10086016 /api/author/10086016 Blazsek Martin János true true Blazsek Martin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122663168 /api/authorship/122663168 2 0.0 false false Szamosfalvi Kata true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122663169 /api/authorship/122663169 3 0.0 false false Author 10053230 /api/author/10053230 Raus Balind Snezana true 10053230 true Snezana Raus Balind true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122663170 /api/authorship/122663170 4 0.0 false false Author 10078036 /api/author/10078036 Lükő Balázs true true Balázs Lükő true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122663171 /api/authorship/122663171 5 0.0 false false Author 10040852 /api/author/10040852 Oláh Gáspár true 10040852 true Gáspár Oláh true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122663172 /api/authorship/122663172 6 0.0 false false Author 10012933 /api/author/10012933 Sümegi Máté true 10012933 true Máté Sümegi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122663173 /api/authorship/122663173 7 0.0 false false Author 10017153 /api/author/10017153 Ujfalussy Balázs Benedek true 10017153 true Balázs Ujfalussy true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122663174 /api/authorship/122663174 8 0.0 false true Author 146 /api/author/146 Makara Judit true 146 true Judit Makara true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true /api/publication/35675487 <div class="BookChapter Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10086016"><a href="/gui2/?type=authors&mode=browse&sel=10086016" target="_blank">Blazsek Martin (<span class="authorship-author-name">Blazsek Martin János</span> <span class="authorAux-mtmt"> Elméleti neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Catholic University">PPCU</span>/<span title="Információs Technológiai és Bionikai Kar">ITK</span>/Roska Tamás Műszaki és Természettudományi Doktori Iskola; HUN-REN Institute of Experimental Medicine; <span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Neuronal Signaling</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szamosfalvi Kata </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053230"><a href="/gui2/?type=authors&mode=browse&sel=10053230" target="_blank">Snezana Raus Balind (<span class="authorship-author-name">Raus Balind Snezana</span> <span class="authorAux-mtmt"> Neurophysiology. Neurobiology</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Neuronal Signaling</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10078036"><a href="/gui2/?type=authors&mode=browse&sel=10078036" target="_blank">Balázs Lükő (<span class="authorship-author-name">Lükő Balázs</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil">HUN-REN Institute of Experimental Medicine; <span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Neuronal Signaling</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040852"><a href="/gui2/?type=authors&mode=browse&sel=10040852" target="_blank">Gáspár Oláh (<span class="authorship-author-name">Oláh Gáspár</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil">HUN-REN Institute of Experimental Medicine; <span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012933"><a href="/gui2/?type=authors&mode=browse&sel=10012933" target="_blank">Máté Sümegi (<span class="authorship-author-name">Sümegi Máté</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017153"><a href="/gui2/?type=authors&mode=browse&sel=10017153" target="_blank">Balázs Ujfalussy (<span class="authorship-author-name">Ujfalussy Balázs Benedek</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil">HUN-REN Institute of Experimental Medicine; <span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/ Laboratory of Biological Computatio</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="146"><a href="/gui2/?type=authors&mode=browse&sel=146" target="_blank">Judit Makara (<span class="authorship-author-name">Makara Judit</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil">HUN-REN Institute of Experimental Medicine; <span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Neuronal Signaling</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35675487" target="_blank">Characteristics of place field formation in the hippocampal CA1 and CA3 regions</a></div> <div class="InBook"><div class="chapter-in">In:</div> <div class="authors"> </div> <div class="booktitle"><a href="/gui2/?mode=browse&params=publication;35079159" target="_blank">FENS Forum 2024 </a></div> <div class="conference"> Conference: <span class="location">Wien, Vienna, Austria <span class="conference-date">2024.06.25. - 2024.06.29.</span> </div> : <span class="page"> p. PS01-26AM-034. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English </span> <span class="identifiers"> </span> <div class="mtid"><span class="long-pub-mtid">Publication: 35675487</span> | <span class="status-data status-APPROVED"> Published </span> <span class="long-book-mtid">Book: 35079159</span> Core | <span class="type-subtype">Conference paper ( Abstract ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Last Modified: 2025.01.09. 14:43 Martin János Blazsek (Elméleti neurobiológia) </div> <div class="lockedBy">Centrally managed 2025.05.15. 13:49 Andrea Vándor (VA, admin) </div> </div> </div>