https://m2.mtmt.hu/ hun 2026-09-23 00:52 JournalArticle 35668946 VALIDATED true Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden Department of Physiology and Galway Neuroscience Centre, School of Medicine, University of Galway, Galway, Ireland CÚRAM–SFI Research Centre in Medical Devices, University of Galway, Galway, Ireland Institute of Biotechnology and Biomedicine, IBB, Autonomous University of Barcelona, Barcelona, Spain Department of Radiology, Section of Diagnostic and Interventional Neuroradiology, Sahlgrenska University Hospital, Gothenburg, Sweden Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden Department of Neurointerventions, National Institute of Clinical Neurosciences, Budapest, Hungary Second Department of Neurology, National & Kapodistrian University of Athens, “Attikon” University Hospital, Athens, Greece Stroke Unit, Metropolitan Hospital, Piraeus, Greece Export Date: 16 January 2025 CODEN: EJNEF Correspondence Address: Woock, M.; Department of Neurology, Blå stråket 7, Sweden; email: malin.woock@vgregion.se 0 false 2026-08-27T13:47:04.090+0000 2025-01-08T06:58:17.810+0000 2025-01-08T06:56:04.172+0000 true 10095366 Havas Petra Gabriella /api/admin/10095366 Admin true 2026-07-01T07:21:11.071+0000 2025-03-13T15:22:16.113+0000 true 521 Szuper Admin /api/admin/521 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Woock, Malin Clot signature in patients with large vessel occlusion stroke and concomitant active cancer. true true /api/journal/12149 REVIEWED true false 12149 false 12149 true 1351-5101 1468-1331 Journal FOREIGN 32 1 e70037 e70037 10 2025 Patients with active cancer face an increased risk of ischemic stroke. Also, stroke may be an initial indicator of cancer. In patients with large vessel occlusion (LVO) stroke treated with thrombectomy, analysis of the clot composition may contribute new insights into the pathological connections between these two conditions.We compared the content of 64 consecutively retrieved clots from LVO stroke patients with concomitant active cancer and 64 clots from matched-control LVO stroke patients without a history of cancer. Clots were analyzed with respect to histological composition by Martius Scarlet Blue, von Willebrand factor (vWF), citrullinated histone H3 (H3Cit, a biomarker of NETS), CD42b, and CD3 expression by immunohistochemistry. Orbit Image Analysis was used for quantification. Differences between groups were tested using the Mann-Whitney U-test and Chi-square Test.Clots from patients with concomitant cancer had a significantly higher content of vWF (median 26 [IQR13-38]% vs. 10 [4-18]%, p < 0.0001) and H3Cit (median 0.11 [IQR0.02-0.46]% vs. 0.05 [0.00-0.28]% p = 0.027) than controls. The presence of collagen >1% within the retrieved clots was highly indicative of cancer, occurring in 16/64 with active cancer and in 3/64 controls, p = 0.002. After correction for multiple comparisons, the statistical significance for H3Cit was lost. Red and white blood cells, platelets, fibrin, and expression of CD3 and CD42b did not differ between the groups.Clots from LVO patients with concomitant active cancer possess distinct characteristics, indicating an influence of cancer on the innate immune system, fibroblasts, and the vascular endothelium in the formation of LVO clots. true 2025 true true true false true false GOLD 2026-08-27 true https://doi.org/10.1111/ene.70037 5 0 5 5 0 5 5 5 5 5 5 5 5 5 0 0 5 5 5 5 0 7 7 Folyóiratcikk Journal Article 24 5 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 2 2 2 2 2026 0 3 3 3 3 Q1 false false false false 2025-04-08T05:56:09.984+0000 Országos Klinikai Idegtudományi Intézet 1 17 1 17 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 122620817 /api/authorship/122620817 1 0.059 true false true Woock Malin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122620818 /api/authorship/122620818 2 0.05882353 false false false Rossi Rosanna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122620819 /api/authorship/122620819 3 0.05882353 false false false Jabrah Duaa true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122620820 /api/authorship/122620820 4 0.05882353 false false false Douglas Andrew true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122620821 /api/authorship/122620821 5 0.05882353 false false false Redfors Petra true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122620822 /api/authorship/122620822 6 0.05882353 false false false Nordanstig Annika true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122620823 /api/authorship/122620823 7 0.05882353 false false false Tatlisumak Turgut true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122620824 /api/authorship/122620824 8 0.05882353 false false false Ceder Erik true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122620825 /api/authorship/122620825 9 0.05882353 false false false Dunker Dennis true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122620826 /api/authorship/122620826 10 0.05882353 false false false Carlqvist Jeanette true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122620827 /api/authorship/122620827 11 0.059 false false false Author 10014906 /api/author/10014906 Szikora István true 10014906 true Szikora István true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122620828 /api/authorship/122620828 12 0.05882353 false false false Tsivgoulis Georgios true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122620829 /api/authorship/122620829 13 0.05882353 false false false Psychogios Klearchos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122620830 /api/authorship/122620830 14 0.05882353 false false false Magoufis Georgios true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39760182&dopt=Abstract false true Keyword 11461 /api/keyword/11461 true 11461 true Keyword 1048602 /api/keyword/1048602 true 1048602 true Keyword 1142931 /api/keyword/1142931 true 1142931 true Keyword 1620369 /api/keyword/1620369 true true Keyword 3674268 /api/keyword/3674268 true true SjrRating 11607589 /api/sjrrating/11607589 54 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2728 /api/classificationexternal/2728 true 2728 true Q1 DIRECT true true /api/publication/35668946 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Woock Malin ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rossi Rosanna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jabrah Duaa </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Douglas Andrew </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Redfors Petra </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nordanstig Annika </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tatlisumak Turgut </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ceder Erik </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dunker Dennis </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Carlqvist Jeanette </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014906"><a href="/gui2/?type=authors&mode=browse&sel=10014906" target="_blank">Szikora István (<span class="authorship-author-name">Szikora István</span> <span class="authorAux-mtmt"> Intervenciós neuroradiológia</span>) </a> </span> <span class="author-affil">Országos Klinikai Idegtudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tsivgoulis Georgios </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Psychogios Klearchos </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Magoufis Georgios </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rentzos Alexandros </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Doyle Karen M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jood Katarina </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35668946" target="_blank">Clot signature in patients with large vessel occlusion stroke and concomitant active cancer.</a></div> <div> <span class="journal-title">EUROPEAN JOURNAL OF NEUROLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1351-5101">1351-5101</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1468-1331">1468-1331</a>)</span>: <span class="journal-volume">32</span> <span class="journal-issue">1</span> <span class="page"> Paper e70037. 10 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1111/ene.70037" target="_blank" href="https://doi.org/10.1111/ene.70037"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001390363100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001390363100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85214360524" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85214360524"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39760182" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39760182&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Neurology (clinical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Neurology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 5</span> | Független: 5 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 5 | Scopus jelölt:&nbsp;5 | WoS/Scopus jelölt:&nbsp;5 | DOI jelölt:&nbsp;5 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35668946&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35668946</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.01.08. 07:58 Havas Petra Gabriella (SE_KK_Idegsebeszet_Admin5_HP, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden Department of Physiology and Galway Neuroscience Centre, School of Medicine, University of Galway, Galway, Ireland ...</pre> </div></div>