https://m2.mtmt.hu/ eng 2026-06-25 09:34 JournalArticle 35667945 VALIDATED true 0 false 2026-05-28T10:29:33.977+0000 2026-02-17T10:02:39.431+0000 2025-01-07T13:06:16.452+0000 true 10030040 Ruzsits Ágnes /api/admin/10030040 Admin true 10030040 2026-02-17T10:02:39.019+0000 2025-06-25T07:39:40.641+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Nagy, Tamas Investigating the Role of TNF-Alpha through Blood-Brain Barrier Integrity in Stress-Induced Depression. A TNF-alfa szerepének vizsgálata a vér-agy gát integritásán keresztül stressz által kiváltott depresszióban true false /api/journal/2148638 REVIEWED true true 2148638 true 2148638 true 1419-8711 2064-2512 Journal FOREIGN_AND_HUNGARIAN 26 4 197 203 197 7 2024 Major depressive disorder (MDD) is a complex psychiatric condition significantly impacted by environmental stress and inflammation. Previous research suggests that stress-induced alterations in the blood-brain barrier (BBB) may allow pro-inflammatory cytokines like interleukin-6 (IL-6) to enter the brain, contributing to depression. Tumor necrosis factor-alpha (TNF-α) is another prominent cytokine implicated in depression, but its role in the context of BBB integrity and stress-mediated depression remains unclear.This study aimed to investigate whether TNF-α plays a similar role as IL-6 in the development of depression through interactions with environmental stress and BBB integrity. Specifically, we examined the interaction between environmental stress, genetic variants of CLDN5 (the gene of the Claudin-5, a protein critical for BBB integrity), and TNF (the gene encoding the TNF-α protein) genetic variants on depressive symptoms.We utilized data from the UK Biobank, comprising genetic, health, and lifestyle information from approximately 500,000 participants aged 40 to 69. Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9) and a composite Current Depressive Symptoms (CDS) score based on self-reported questionnaire items. Environmental stress was quantified through participants' reports of significant life events in the past two years. Genetic analysis focused on 15 single nucleotide polymorphisms (SNPs) within the TNF gene (after linkage disequilibrium pruning) and a functional polymorphism in CLDN5 (rs885985). Linear regression models were used to assess main effects, gene-gene interactions, gene-environment interactions, and three-way interactions on depressive symptoms, adjusting for covariates and applying Bonferroni correction for multiple testing.No significant associations were found between TNF genetic variants and depressive symptoms after correcting for multiple testing. While some TNF SNPs showed nominal significance in interaction models - most notably rs3093546, which showed nominal significance in both depressive phenotypes - the findings were not robust enough to confirm a significant role. Unlike previous findings with IL6, TNF did not exhibit significant interactions with environmental stress and CLDN5 variants affecting depression risk.The study does not support a significant role for TNF genetic variants interacting with environmental stress and BBB integrity in influencing depression risk. These findings suggest that IL-6 and BBB integrity may be more critical targets for understanding and treating stress-related depression, highlighting the complexity of depression's pathophysiology.(Neuropsychopharmacol Hung 2024; 26(4): 197-203) Funding 2049090 /api/funding/2049090 false true Funding 2049091 /api/funding/2049091 false true Funding 2049092 /api/funding/2049092 false true Funding 2049093 /api/funding/2049093 false true Funding 2049094 /api/funding/2049094 false true Funding 2049095 /api/funding/2049095 false true Funding 2049096 /api/funding/2049096 false true Funding 2049097 /api/funding/2049097 false true true true 2025 false true true false true false GOLD 2026-05-28 true https://mppt.hu/magazin/pdf/vol26issue4/v26i4p197.pdf 1 0 1 1 0 1 1 1 1 1 1 1 1 1 0 0 1 1 1 1 0 3 3 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 1 1 1 1 Q2 A false false false false 2025-01-23T07:37:31.448+0000 Gyógyszerhatástani Intézet (SE / GYTK); Klinikai Pszichológia Tanszék (SE / AOK / K / PPK); Mesterséges Intelligencia és Rendszertervezés T... (BME / VIK); NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport (SE / GYTK / GYHATAS); Pszichiátriai és Pszichoterápiás Klinika (SE / AOK / K); Személyiség- és Klinikai Pszichológia Tanszék (... 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MtaRating 10487089 /api/mtarating/10487089 RatingType 10026 /api/ratingtype/10026 PsziTB Institute 14108 /api/institute/14108 0 false true false Pszichológiai Tudományos Bizottság Committee on Psychology true 14108 true true true A true true SjrRating 11491875 /api/sjrrating/11491875 62 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3001 /api/classificationexternal/3001 true 3001 true Q2 DIRECT true true /api/publication/35667945 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10078334"><a href="/gui2/?type=authors&mode=browse&sel=10078334" target="_blank">Nagy Tamas (<span class="authorship-author-name">Nagy Tamás</span> <span class="authorAux-mtmt"> bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/NAP3.0-SE Neuropsychopharmacology Research Group; <span title="Budapest University of Technology and Economics">BUTE</span>/<span title="Faculty of Electrical Engineering and Informatics">FEEI</span>/ Department of Artificial Intelligence and Systems Engineering; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060155"><a href="/gui2/?type=authors&mode=browse&sel=10060155" target="_blank">Baksa Daniel (<span class="authorship-author-name">Baksa Dániel</span> <span class="authorAux-mtmt"> pszichológia, genetika, fMRI</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/NAP3.0-SE Neuropsychopharmacology Research Group; <span title="Pázmány Péter Catholic University">PPCU</span>/<span title="Faculty of Humanities and Social Sciences">FHSS (PPCU)</span>/<span title="Institute of Psychology">DPszich</span>/Department of Personality and Clinical Psychology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024138"><a href="/gui2/?type=authors&mode=browse&sel=10024138" target="_blank">Petschner Peter (<span class="authorship-author-name">Petschner Péter</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/NAP3.0-SE Neuropsychopharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003491"><a href="/gui2/?type=authors&mode=browse&sel=10003491" target="_blank">Gonda Xenia (<span class="authorship-author-name">Gonda Xénia</span> <span class="authorAux-mtmt"> Pszichiátria, pszichiátriai genetika, farmakoló...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Pszichiátriai és Pszichoterápiás Klinika">PPK</span>/Department of Clinical Psyhology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/NAP3.0-SE Neuropsychopharmacology Research Group; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Pszichiátriai és Pszichoterápiás Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10067900"><a href="/gui2/?type=authors&mode=browse&sel=10067900" target="_blank">Gal Zsofia (<span class="authorship-author-name">Gál Zsófia</span> <span class="authorAux-mtmt"> neurobiológia, pszichiátriai genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/NAP3.0-SE Neuropsychopharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017483"><a href="/gui2/?type=authors&mode=browse&sel=10017483" target="_blank">Juhasz Gabriella (<span class="authorship-author-name">Juhász Gabriella</span> <span class="authorAux-mtmt"> Neurológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/NAP3.0-SE Neuropsychopharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001318"><a href="/gui2/?type=authors&mode=browse&sel=10001318" target="_blank">Bagdy Gyorgy ✉ (<span class="authorship-author-name">Bagdy György</span> <span class="authorAux-mtmt"> Neuropszichofarmakológia, gyógyszertan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/NAP3.0-SE Neuropsychopharmacology Research Group</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35667945" target="_blank">Investigating the Role of TNF-Alpha through Blood-Brain Barrier Integrity in Stress-Induced Depression.</a></div> <div> <span class="journal-title">NEUROPSYCHOPHARMACOLOGIA HUNGARICA</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1419-8711">1419-8711</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2064-2512">2064-2512</a>)</span>: <span class="journal-volume">26</span> <span class="journal-issue">4</span> <span class="page"> pp 197-203 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85214772833" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85214772833"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39760673" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39760673&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="https://mppt.hu/magazin/pdf/vol26issue4/v26i4p197.pdf" target="_blank" href="https://mppt.hu/magazin/pdf/vol26issue4/v26i4p197.pdf"> Full text </a> </span> <span class="id identifier oa_NONE" title=" None "> <a style="color:blue" title="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85214772833&partnerID=40&md5=7da36ee886304a68baf19c8493a56b3c" target="_blank" href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85214772833&partnerID=40&md5=7da36ee886304a68baf19c8493a56b3c"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Pharmacology, Toxicology and Pharmaceutics (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Neurology (clinical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q4</div> <div class="journal-subject">Journal subject: Scopus - Neuropsychology and Physiological Psychology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q4</div> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q4</div> <div class="journal-subject">Committee on Psychology HASSPHSII PsziTB [1901-]&nbsp;&nbsp;&nbsp;A</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 1</span> | Independent citation: 1 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 1 | Number of citations in Scopus:&nbsp;1 | WoS/Scopus assigned:&nbsp;1 | Number of citations with DOI:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35667945&sort=publishedYear,desc&sort=title"> Number of cited publications: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35667945</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (KTIA_13_NAPA-II/14), KTIA _NAP(13-1-2013-0001), Hungarian Brain Research Program(KTIA_NAP_13-2-2015-0001), (2017 − 1.2.1-NKP-2017-00002), National Brain Programme(NAP2022-I-4/2022 3.0), (TKP2021-EGA-25), (K 143391), (2024-2.1.1.-EKÖP-2024-00004) </div> <div class="lastModified">Last Modified: 2026.02.17. 11:02 Ágnes Ruzsits (SE_GYTK_Gyhatástan_Admin5_RÁ, admin) </div> </div></div>