https://m2.mtmt.hu/ hun 2026-10-24 17:07 JournalArticle 35662459 ADMIN_APPROVED true Institut Jules Bordet and l'Université Libre de Bruxelles (U.L.B.), Hôpital Universitaire de Bruxelles (H.U.B.), Brussels, Belgium Department of Gynecology and Gynecological Oncology, Medical University of Vienna, Vienna, Austria Austrian Breast and Colorectal Cancer Study Group (ABCSG), Vienna, Austria Dana-Farber Cancer Institute, Boston, United States Department of Medical Oncology, Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genoa, Italy Department of Internal Medicine and Medical Specialties (DIMI), School of Medicine, University of Genova, Genoa, Italy Vall d'Hebron Institute of Oncology, Barcelona, Spain Winship Cancer Institute, Emory University, Atlanta, United States National Institute of Oncology, Budapest, Hungary University of Newcastle, Newcastle, Australia New York University, New York, United States Hospital Universitario Virgen del Rocío, Seville, Spain GEICAM, Spanish Breast Cancer Group, Madrid, Spain BC Cancer, Vancouver, Canada AdventHealth Cancer Institute, Orlando, United States Nagoya City University, Nagoya, Japan Pfizer, NY, United States Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States Export Date: 4 February 2025 Correspondence Address: Agostinetto, E.; Academic Trials Promoting Team, Rue Meylemeersch 90, 1070 Anderlecht, Belgium; email: elisa.agostinetto@hubruxelles.be Chemicals/CAS: omeprazole, 73590-58-6, 95510-70-6; palbociclib, 571190-30-2, 827022-33-3; tamoxifen, 10540-29-1 0 false 2026-08-22T12:32:05.629+0000 2025-02-03T14:35:30.397+0000 2025-01-06T07:19:28.978+0000 true 10070075 Nádas Orsolya /api/admin/10070075 Admin true 2025-07-21T13:12:05.657+0000 2025-02-03T14:35:30.401+0000 true 10081340 Pirmann Tamás /api/admin/10081340 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Agostinetto, E Drug-drug interactions between palbociclib and proton pump inhibitors in early breast cancer an exploratory analysis of PALLAS (ABCSG-42/AFT-05/BIG-14-13/PrE0109). true true /api/journal/10082274 REVIEWED true false 10082274 false 10082274 true 2059-7029 2059-7029 Journal FOREIGN 10 1 104096 104096 8 2025 Concomitant intake of proton pump inhibitors (PPIs) may create drug-drug interactions, potentially impacting efficacy of anticancer agents. In the phase III PALLAS trial, the addition of palbociclib capsules to standard adjuvant endocrine therapy in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative early breast cancer did not improve invasive disease-free survival (iDFS). We explored whether concomitant use of PPIs affected survival outcomes in patients treated with palbociclib in PALLAS.This is an exploratory analysis of PALLAS including patients who received at least one dose of palbociclib capsules. We aimed to determine the association of concomitant PPI use with iDFS, distant relapse-free survival and overall survival. Uni- and multivariable Cox models with time-dependent PPI were used. The association between PPI use and neutropenia was also investigated.Of 2840 patients treated with palbociclib + endocrine therapy, 525 (18.5%) had concomitant PPI and palbociclib intake. PPI intake was significantly associated with older age, post-menopausal status, use of aromatase inhibitors, higher body mass index, and worse Eastern Cooperative Oncology Group status (all P < 0.001). Concomitant PPI intake was not significantly associated with survival outcomes (iDFS, distant relapse-free survival, overall survival). All-grade neutropenia rates were numerically lower in patients who initiated a PPI before study start compared with patients never initiating PPIs (adjusted odds ratio 0.81, 95% confidence interval 0.60-1.09).Our exploratory analysis did not demonstrate worse survival outcomes in patients receiving concomitant palbociclib and PPIs in PALLAS. 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class="autype autype0"> <span class="author-name" >Agostinetto E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pfeiler G </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hlauschek D </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mayer E L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lambertini M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >de Azambuja E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bellet-Ezquerra M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Meisel J L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060070"><a href="/gui2/?type=authors&mode=browse&sel=10060070" target="_blank">Rubovszky G (<span class="authorship-author-name">Rubovszky Gábor</span> <span class="authorAux-mtmt"> klinikai onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zdenkowski N </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Novik Y </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ruiz-Borrego M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gelmon K A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mamounas E P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Iwata H </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lu D R </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Soelkner L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Fesl C </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gnant M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >DeMichele A </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35662459" target="_blank">Drug-drug interactions between palbociclib and proton pump inhibitors in early breast cancer : an exploratory analysis of PALLAS (ABCSG-42/AFT-05/BIG-14-13/PrE0109)..</a></div> <div> <span class="journal-title">ESMO OPEN</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2059-7029">2059-7029</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2059-7029">2059-7029</a>)</span>: <span class="journal-volume">10</span> <span class="journal-issue">1</span> <span class="page"> Paper 104096. 8 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.esmoop.2024.104096" target="_blank" href="https://doi.org/10.1016/j.esmoop.2024.104096"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001404175300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001404175300001"> 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Függő: 0 | Nem jelölt: 0 | WoS jelölt: 5 | Scopus jelölt:&nbsp;3 | WoS/Scopus jelölt:&nbsp;5 | DOI jelölt:&nbsp;5 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35662459&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35662459</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.02.03. 15:35 Pirmann Tamás (OOI addmin5, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Institut Jules Bordet and l'Université Libre de Bruxelles (U.L.B.), Hôpital Universitaire de Bruxelles (H.U.B.), Brussels, Belgium Department of Gynecology and Gynecological Oncology, Medical University of Vienna, Vienna, Austria Austrian Breast and Colorectal Cancer Study Group (ABCSG), Vienna, Austria Dana-Farber Cancer I...</pre> </div></div>