https://m2.mtmt.hu/ hun 2026-09-21 02:13 JournalArticle 35658607 VALIDATED true Megosztott első szerzőség 0 false 2026-09-15T07:33:50.337+0000 2025-12-03T07:56:48.316+0000 2025-01-03T07:20:14.165+0000 true 10028537 Baczkó Gabriella /api/admin/10028537 Admin true 10028537 2026-09-15T07:32:43.144+0000 2025-07-29T12:20:25.767+0000 true 10028537 Baczkó Gabriella /api/admin/10028537 Admin true 10028537 Admin 10099440 /api/admin/10099440 Csernyik Rita true true 2025-12-03T07:12:49.555+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Bánfi-Bacsárdi, Fanni Therapeutic Consequences and Prognostic Impact of Multimorbidity in Heart Failure: Time to Act true true /api/journal/10017543 REVIEWED true false 10017543 false 10017543 true 2077-0383 Journal FOREIGN 14 1 139 139 21 2025 Background/Objectives: In heart failure (HF) with reduced ejection fraction (HFrEF), the early diagnosis and proper treatment of comorbidities (CMs) are of fundamental relevance. Our aim was to assess the prevalence of CMs among real-world patients requiring hospitalisation for HFrEF and to investigate the effect of CMs on the implementation of guideline-directed medical therapy (GDMT) and on all-cause mortality (ACM). Methods: The data of a consecutive HFrEF patient cohort hospitalised for HF between 2021 and 2024 were analysed retrospectively. Sixteen CMs (6 CV and 10 non-CV) were considered. Patients were divided into three categories: 0–3 vs. 4–6 vs. ≥7 CMs. GDMT at discharge and ACM were compared among CM categories. The predictors of 1-year ACM were also evaluated. Results: From the 388 patients (male: 76%, age: 61 [50–70] years; NT-proBNP: 5286 [2570–9923] pg/mL; ≥2 cardiovascular–kidney–metabolic disease overlap: 46%), a large proportion received GDMT (RASi: 91%; βB: 85%; MRA: 95%; SGLT2i: 59%; triple therapy [TT: RASi+βB+MRA]: 82%; quadruple therapy [QT: TT + SGLT2i]: 54%) at discharge. Multimorbidity was accompanied with a (p < 0.05) lower application ratio of RASi (96% vs. 92% vs. 85%; 0–3 vs. 4–6 vs. ≥7 CMs) and βB therapy (94% vs. 85% vs. 78%), while MRA (99% vs. 94% vs. 94%) and SGTL2i use (61% vs. 59% vs. 57%) did not differ (p > 0.05). Patients with multimorbidity were less likely to be treated with TT (93% vs. 82% vs. 73%, p = 0.001), while no difference was detected in the implementation of QT (56% vs. 54% vs. 50%, p = 0.685). The 1-year ACM of patients with an increased burden of CMs was higher (9% vs. 13% vs. 25%, p = 0.003). The risk of 1-year ACM was favourably affected by the use of TT/QT and less severe left ventricular systolic dysfunction, while having ≥5 CMs had an unfavourable impact on prognosis. Conclusions: According to our real-world analysis, HFrEF patients with an increased burden of CMs can expect a less favourable outcome. However, modern GDMT can even be applied in this patient population, resulting in a significantly improved prognosis. Thus, clinicians should insist on the early, conscious implementation of a prognosis-modifying drug regime in multimorbid HF patients as well. true true 2025 true true true false true false GOLD 2026-09-15 true http://publicatio.bibl.u-szeged.hu/35444 10 0 10 4 7 6 10 7 10 10 10 4 4 4 6 0 10 4 10 4 0 23 23 Folyóiratcikk Journal Article 24 10 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 6 2 6 2 2026 0 4 2 4 2 Q2 false false false false 2025-01-02T07:20:22.879+0000 Belgyógyászati Klinika (SZTE / SZAOK); Doktori Iskola (SE); Gottsegen György Országos Kardiovaszkuláris Int...; Klinikai Orvostudományi Doktori Iskola (SZTE / DI) 11 38 4 15 0 true 10099440 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 122546491 /api/authorship/122546491 1 0.067 true false false Author 10091214 /api/author/10091214 Bánfi-Bacsárdi Fanni true true Bánfi-Bacsárdi Fanni true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122546492 /api/authorship/122546492 2 0.067 true false false Kazay Ádám true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122546493 /api/authorship/122546493 3 0.067 false false false Author 10074629 /api/author/10074629 Gergely Tamás G true true Gergely Tamás G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122546494 /api/authorship/122546494 4 0.067 false false false Author 10100832 /api/author/10100832 Forrai Zsolt true true Forrai Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122546495 /api/authorship/122546495 5 0.067 false false false Author 10096939 /api/author/10096939 Füzesi Tamás Péter true true Füzesi Tamás Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122546496 /api/authorship/122546496 6 0.067 false false false Hanuska Laura Fanni true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122546497 /api/authorship/122546497 7 0.067 false false false Schäffer Pál Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122546498 /api/authorship/122546498 8 0.067 false false false Author 10084293 /api/author/10084293 Pilecky Dávid true true Pilecky Dávid true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122546499 /api/authorship/122546499 9 0.067 false false false Author 10059739 /api/author/10059739 Vámos Máté true 10059739 true Vámos Máté true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122546500 /api/authorship/122546500 10 0.067 false false false Author 10072413 /api/author/10072413 Vértes Vivien true true Vértes Vivien true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122546501 /api/authorship/122546501 11 0.06666667 false false false Dékány Miklós true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122546502 /api/authorship/122546502 12 0.067 false false false Author 10049457 /api/author/10049457 Andréka Péter true 10049457 true Andréka Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122546503 /api/authorship/122546503 13 0.067 false false false Author 10060550 /api/author/10060550 Piróth Zsolt true 10060550 true Piróth Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122546504 /api/authorship/122546504 14 0.067 false false false Author 10054440 /api/author/10054440 Nyolczas Noémi true 10054440 true Nyolczas Noémi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 122546505 /api/authorship/122546505 15 0.067 false true true Author 10078593 /api/author/10078593 Muk Balázs true true Muk Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 28144156 /api/publicationidentifier/28144156 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/jcm14010139 https://doi.org/10.3390/jcm14010139 false 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class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10091214"><a href="/gui2/?type=authors&mode=browse&sel=10091214" target="_blank">Bánfi-Bacsárdi Fanni (<span class="authorship-author-name">Bánfi-Bacsárdi Fanni</span> <span class="authorAux-mtmt"> kardiológia, szívelégtelenség</span>) </a> </span> <span class="author-affil">Gottsegen György Országos Kardiovaszkuláris Intézet; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Doktori Iskolák">DI</span>/Klinikai Orvostudományi Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kazay Ádám<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074629"><a href="/gui2/?type=authors&mode=browse&sel=10074629" target="_blank">Gergely Tamás G. (<span class="authorship-author-name">Gergely Tamás G</span> <span class="authorAux-mtmt"> kardiovaszkuláris farmakológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10100832"><a href="/gui2/?type=authors&mode=browse&sel=10100832" target="_blank">Forrai Zsolt (<span class="authorship-author-name">Forrai Zsolt</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil">Gottsegen György Országos Kardiovaszkuláris Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10096939"><a href="/gui2/?type=authors&mode=browse&sel=10096939" target="_blank">Füzesi Tamás Péter (<span class="authorship-author-name">Füzesi Tamás Péter</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hanuska Laura Fanni </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schäffer Pál Péter </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084293"><a href="/gui2/?type=authors&mode=browse&sel=10084293" target="_blank">Pilecky Dávid (<span class="authorship-author-name">Pilecky Dávid</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil">Gottsegen György Országos Kardiovaszkuláris Intézet; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Doktori Iskolák">DI</span>/Klinikai Orvostudományi Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10059739"><a href="/gui2/?type=authors&mode=browse&sel=10059739" target="_blank">Vámos Máté (<span class="authorship-author-name">Vámos Máté</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10072413"><a href="/gui2/?type=authors&mode=browse&sel=10072413" target="_blank">Vértes Vivien (<span class="authorship-author-name">Vértes Vivien</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dékány Miklós </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10049457"><a href="/gui2/?type=authors&mode=browse&sel=10049457" target="_blank">Andréka Péter (<span class="authorship-author-name">Andréka Péter</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil">Gottsegen György Országos Kardiovaszkuláris Intézet; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060550"><a href="/gui2/?type=authors&mode=browse&sel=10060550" target="_blank">Piróth Zsolt (<span class="authorship-author-name">Piróth Zsolt</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil">Gottsegen György Országos Kardiovaszkuláris Intézet; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054440"><a href="/gui2/?type=authors&mode=browse&sel=10054440" target="_blank">Nyolczas Noémi (<span class="authorship-author-name">Nyolczas Noémi</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Doktori Iskolák">DI</span>/Klinikai Orvostudományi Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10078593"><a href="/gui2/?type=authors&mode=browse&sel=10078593" target="_blank">Muk Balázs ✉ (<span class="authorship-author-name">Muk Balázs</span> <span class="authorAux-mtmt"> kardiológia, szívelégtelenség</span>) </a> </span> <span class="author-affil">Gottsegen György Országos Kardiovaszkuláris Intézet; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Doktori Iskolák">DI</span>/Klinikai Orvostudományi Doktori Iskola; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35658607" target="_blank">Therapeutic Consequences and Prognostic Impact of Multimorbidity in Heart Failure: Time to Act</a></div> <div> <span class="journal-title">JOURNAL OF CLINICAL MEDICINE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2077-0383">2077-0383</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">1</span> <span class="page"> Paper 139. 21 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/jcm14010139" target="_blank" href="https://doi.org/10.3390/jcm14010139"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001395081700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001395081700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85214522868" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85214522868"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39797222" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39797222&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://www.mdpi.com/2077-0383/14/1/139" target="_blank" href="https://www.mdpi.com/2077-0383/14/1/139"> Egyéb URL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="35444" target="_blank" href="http://publicatio.bibl.u-szeged.hu/35444"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 10</span> | Független: 4 | Függő: 6 | Nem jelölt: 0 | WoS jelölt: 7 | Scopus jelölt:&nbsp;10 | WoS/Scopus jelölt:&nbsp;10 | DOI jelölt:&nbsp;10 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35658607&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 23 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35658607</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.12.03. 08:56 Csernyik Rita (MTMT központi admin) </div> <div class="lockedBy">Központi kezelésű 2025.12.03. 08:12 Csernyik Rita (MTMT központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Megosztott első szerzőség</pre> </div></div>