Splanchnic vein thrombosis (SVT) in pancreatic disease has a 20%–30% incidence rate,
leading to increased mortality and complication rates. Therefore, the aim of this
review is to summarize recent evidence about the incidence, risk factors, and management
of pancreatic cancer, pancreatic cystic neoplasm‐, and pancreatitis‐related SVT. Doppler
ultrasound should be the first imaging choice, followed by contrast‐enhanced computed
tomography or magnetic resonance imaging. Data regarding SVT treatment in acute pancreatitis
and pancreatic cancer are scarce; however, for venous thromboembolism treatment, direct
oral anticoagulants and low molecular weight heparin have been effective. Further
trials must investigate the length of anticoagulant treatment and the need for interventional
radiological procedures.
