https://m2.mtmt.hu/ hun 2026-09-20 17:24 JournalArticle 35639578 VALIDATED true 0 false 2026-08-28T08:28:47.943+0000 2026-04-27T10:16:41.613+0000 2024-12-16T09:55:30.491+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2026-08-28T08:27:21.073+0000 2026-04-27T10:16:41.927+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Angiolillo, Dominick J. International Consensus Statement on Platelet Function and Genetic Testing in Percutaneous Coronary Intervention 2024 Update true true /api/journal/10013685 REVIEWED true false 10013685 false 10013685 true 1936-8798 1876-7605 Journal FOREIGN 17 22 2639 2663 2639 25 2024 Current evidence indicates that dual antiplatelet therapy with aspirin plus a P2Y12 inhibitor is essential for the prevention of thrombotic events after percutaneous coronary interventions. However, dual antiplatelet therapy is associated with increased bleeding which may outweigh the benefits. This has set the foundations for customizing antiplatelet treatments to the individual patient. However, bleeding and ischemic risks are often present in the same patient, making it difficult to achieve this balance. The fact that oral P2Y12 inhibitors (clopidogrel, prasugrel, and ticagrelor) have diverse pharmacodynamic profiles that affect clinical outcomes supports the rationale for using platelet function and genetic testing to individualize antiplatelet treatment regimens. Indeed, up to one-third of patients treated with clopidogrel, but a minority of those treated with prasugrel or ticagrelor, exhibit high residual platelet reactivity resulting in an increased thrombotic risk. On the other hand, prasugrel and ticagrelor are frequently associated with low platelet reactivity and increased bleeding risk compared with clopidogrel without providing any additional reduction in ischemic events compared with patients who adequately respond to clopidogrel. The use of platelet function and genetic testing may allow for a guided selection of oral P2Y12 inhibitors. However, the nonuniform results of randomized controlled trials have led guidelines to provide limited recommendations on the implementation of these tests in patients undergoing percutaneous coronary intervention. In light of recent advancements in the field, this consensus document by a panel of international experts fills in the guideline gap by providing updates on the latest evidence in the field as well as recommendations for clinical practice. 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class="autype autype0"> <span class="author-name" >Angiolillo Dominick J. ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028344"><a href="/gui2/?type=authors&mode=browse&sel=10028344" target="_blank">Aradi Daniel (<span class="authorship-author-name">Aradi Dániel</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; et al. (33) </div> <div><a target="_blank" href="/api/publication/35639578?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35639578" target="_blank">International Consensus Statement on Platelet Function and Genetic Testing in Percutaneous Coronary Intervention 2024 Update</a></div> <div> <span class="journal-title">JACC-CARDIOVASCULAR INTERVENTIONS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1936-8798">1936-8798</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1876-7605">1876-7605</a>)</span>: <span class="journal-volume">17</span> <span class="journal-issue">22</span> <span class="page"> pp 2639-2663 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1016/j.jcin.2024.08.027" target="_blank" href="https://doi.org/10.1016/j.jcin.2024.08.027"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001367443500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001367443500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85205897891" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85205897891"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39603778" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39603778&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 71</span> | Független: 33 | Függő: 38 | Nem jelölt: 0 | WoS jelölt: 70 | Scopus jelölt:&nbsp;60 | WoS/Scopus jelölt:&nbsp;71 | DOI jelölt:&nbsp;71 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35639578&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 12 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35639578</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2026.04.27. 12:16 Molnár-Taga Márta (SE 4-es admin) </div> </div></div>