https://m2.mtmt.hu/ hun 2026-04-30 12:19 JournalArticle 35630711 ADMIN_APPROVED true Barts Cancer Centre, Barts Health NHS Trust Biomedical Research Center, Queen Mary University of London, London, United Kingdom County Oncology Centre, Hetényi Géza Hospital, Szolnok, Hungary Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France National Cancer Center Hospital East, Kashiwa, Japan Medical Oncology Center, National Institute of Oncology, Budapest, Hungary Sunnybrook Health Sciences Centre‒Odette Cancer Centre, Toronto, ON, Canada CHU de Québec-Université Laval, Quebec City, QC, Canada Department of Internal Medicine-Hematology/Oncology, University of Michigan Health System, Ann Arbor, MI, United States Georges Pompidou European Hospital, University Paris Cité, Paris, France Department of Medical Oncology, Maria Middelares Hospital, Gent, Belgium Center for Oncological Research (CORE), University of Antwerp, Antwerp, Belgium Vall d'Hebron Institute of Oncology, Vall d'Hebron University Hospital, Barcelona, Spain Centre Léon Bérard, Lyon, France Department of Medical Oncology, Koc University Hospital, Istanbul, Turkey Merck & Co., Inc., Rahway, NJ, United States Division of Medical Oncology, Department of Internal Medicine, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Turkey Export Date: 15 January 2025 Correspondence Address: Powles, T.; Barts Cancer Centre, Charterhouse Square, EC, United Kingdom; email: thomas.powles1@nhs.net Chemicals/CAS: carboplatin, 41575-94-4; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; gemcitabine, 103882-84-4, 95058-81-4; pembrolizumab, 1374853-91-4 0 false 2026-01-12T13:16:35.128+0000 2026-01-12T13:13:14.811+0000 2024-12-10T13:48:42.596+0000 true 10070075 Nádas Orsolya /api/admin/10070075 Admin true 2026-01-12T13:13:06.798+0000 2026-01-12T13:13:06.798+0000 2026-01-12T13:13:14.966+0000 true 10101957 Pirmann Tamás /api/admin/10101957 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Powles, Thomas Cisplatin- or Carboplatin-Based Chemotherapy Plus Pembrolizumab in Advanced Urothelial Cancer Exploratory Analysis From the Phase 3 KEYNOTE-361 Study. true true /api/journal/10009549 REVIEWED true false 10009549 false 10009549 true 1558-7673 1938-0682 Journal FOREIGN 23 1 102261 102261 2025 KEYNOTE-361 evaluated first-line pembrolizumab with and without platinum-based chemotherapy versus chemotherapy alone in advanced or metastatic urothelial carcinoma. The primary end points of progression-free survival (PFS) or overall survival (OS) were not met. Exploratory analysis of efficacy by platinum agent (cisplatin or carboplatin) is reported.Eligible patients were randomly assigned 1:1:1 to receive pembrolizumab 200 mg intravenously every 3 weeks for ≤35 cycles with or without chemotherapy (gemcitabine with investigator's choice of either cisplatin or carboplatin) or chemotherapy alone. This exploratory subset analysis evaluated PFS and objective response rate (ORR) per RECIST v1.1 by blinded independent central review and OS for cisplatin- or carboplatin-based chemotherapy with versus without pembrolizumab for patients assigned to chemotherapy-containing arms of KEYNOTE-361.Of 1010 patients enrolled, 703 were assigned to receive a chemotherapy-containing regimen (n = 312 cisplatin based; n = 391 carboplatin based). Median follow-up was 31.3 months. For cisplatin-based arms, with versus without pembrolizumab, median OS was 20.1 versus 16.4 months (HR 0.88, 95% CI, 0.67-1.15) and median PFS was 8.5 versus 7.1 months (HR 0.67, 0.51-0.89). ORR was 64.1% versus 48.7%, respectively. For carboplatin-based arms, with versus without pembrolizumab, median OS was 15.5 versus 12.3 months (HR 0.84, 95% CI, 0.67-1.06) and median PFS was 8.0 versus 6.7 months (HR 0.86, 0.68-1.09). ORR was 47.2% versus 41.8%, respectively. Among patients in the cisplatin-based versus carboplatin-based chemotherapy alone arms, 55.8% versus 41.8% received a subsequent antiprogrammed cell death protein 1/ligand 1 therapy. The addition of pembrolizumab did not significantly increase the incidence of adverse events reported.Results suggest trends toward OS and PFS improvements with the addition of pembrolizumab to gemcitabine-platinum doublet over gemcitabine-platinum alone regardless of whether cisplatin or carboplatin was the chosen platinum agent. 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/api/sjrrating/11627644 14 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2748 /api/classificationexternal/2748 true 2748 true Q1 FROM_LAST_YEAR true true /api/publication/35630711 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Powles Thomas </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Csőszi Tibor </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Loriot Yohann </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Matsubara Nobuaki </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034949"><a href="/gui2/?type=authors&mode=browse&sel=10034949" target="_blank">Geczi Lajos (<span class="authorship-author-name">Géczi Lajos</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Cheng Susanna Y-S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Fradet Yves </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Alva Ajjai </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Oudard Stéphane </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Vulsteke Christof </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Morales-Barrera Rafael </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Fléchon Aude </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gunduz Seyda </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Liu Chih-Chin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Moreno Blanca Homet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bavle Abhishek </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Özgüroğlu Mustafa </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35630711" target="_blank">Cisplatin- or Carboplatin-Based Chemotherapy Plus Pembrolizumab in Advanced Urothelial Cancer : Exploratory Analysis From the Phase 3 KEYNOTE-361 Study..</a></div> <div> <span class="journal-title">CLINICAL GENITOURINARY CANCER</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1558-7673">1558-7673</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1938-0682">1938-0682</a>)</span>: <span class="journal-volume">23</span> <span class="journal-issue">1</span> <span class="page"> p. 102261. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.clgc.2024.102261" target="_blank" href="https://doi.org/10.1016/j.clgc.2024.102261"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001377361300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001377361300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85211021499" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85211021499"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39642775" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39642775&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Urology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 1 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35630711&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35630711</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2026.01.12. 14:13 Pirmann Tamás (OOI admin4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Barts Cancer Centre, Barts Health NHS Trust Biomedical Research Center, Queen Mary University of London, London, United Kingdom County Oncology Centre, Hetényi Géza Hospital, Szolnok, Hungary Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France National Cancer Center Hospital East, Kashiwa, Japan ...</pre> </div></div>