This systematic review and meta-analysis protocol aims to evaluate the comparative
efficacy of different sentinel lymph node (SLN) detection techniques in the management
of vulvar cancer. Vulvar cancer, though rare, predominantly affects older women and
requires effective management strategies. The SLN technique has become a standard
approach for early-stage cases, offering reduced morbidity compared to complete lymphadenectomy.
Currently, various SLN detection methods exist, including the use of Technetium-99m
(Tc99m), Indocyanine Green (ICG), and superparamagnetic iron oxide (SPIO), but there
is a lack of comprehensive comparison of their efficacy. This review will systematically
search relevant databases, including PubMed, Scopus, Cochrane, Web of Science and
Embase following PRISMA guidelines, to gather data from clinical trials. The primary
outcome will be the detection rates of SLN techniques with secondary outcomes examining
patient characteristics and procedural factors. The analysis will utilize random-effects
models to compare detection rates across studies. The results of this study aim to
provide insights into the optimal SLN detection method with potential implications
for clinical practice guidelines in vulvar cancer management. The protocol is registered
under the PROSPERO registration number CRD42024590774.
