https://m2.mtmt.hu/ hun 2026-09-20 23:13 JournalArticle 35610852 APPROVED true Export Date: 06 February 2026; Cited By: 7; Correspondence Address: J.T. Varga; Department of Pulmonology, Semmelweis University, Budapest, 1083, Hungary; email: varga.janos.tamas@semmelweis.hu; 0 false 2026-09-20T08:42:11.112+0000 2026-07-20T13:22:39.372+0000 2024-11-28T20:57:33.744+0000 true 10028758 Varga János Tamás /api/author/10028758 Author true 10028758 2026-09-16T15:48:37.489+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Fekete, Mónika The Role of Trace Elements in COPD: Pathogenetic Mechanisms and Therapeutic Potential of Zinc, Iron, Magnesium, Selenium, Manganese, Copper, and Calcium true true /api/journal/10016563 REVIEWED true false 10016563 false 10016563 true 2072-6643 Journal FOREIGN 16 23 4118 4118 27 2024 Background: Chronic obstructive pulmonary disease (COPD) is a progressive, inflammatory airway disorder characterized by a gradual decline in lung function and increased oxidative stress. Both oxidative stress and inflammation are central to its pathophysiology, with trace elements such as zinc, copper, iron, manganese, magnesium, selenium, and calcium playing key roles in various cellular processes. Objective: This article reviews the role of trace elements in COPD, focusing on their involvement in disease pathogenesis and their therapeutic potential. Specifically, we examine the effects of zinc, copper, iron, magnesium, manganese, selenium, and calcium in COPD. Methods: We performed a comprehensive narrative review of the literature across databases including PubMed, Web of Science, Cochrane Library, and Google Scholar, identifying studies that explore the therapeutic effects of trace elements in COPD. The studies included in the review consisted of cohort analyses, randomized controlled trials, and clinical investigations. Results: Zinc, copper, iron, magnesium, manganese, selenium, and calcium are critical to both the pathophysiology and management of COPD. These trace elements contribute to the regulation of inflammation, the modulation of oxidative stress, and the maintenance of lung function. Zinc and copper, for instance, reduce oxidative stress and modulate immune responses, while iron is essential for oxygen transport. Magnesium, manganese, selenium, and calcium are vital for muscle function, respiratory performance, reducing inflammation, and improving pulmonary function. Conclusions: The minerals zinc, copper, iron, magnesium, manganese, selenium, and calcium may contribute to beneficial effects as part of the standard therapeutic management of COPD. Maintaining optimal levels of these trace elements may support the regulation of inflammatory processes, a reduction in oxidative stress, and an improvement in the pulmonary function. However, further clinical research is necessary to confirm their efficacy and establish safe dosage recommendations in COPD treatment. Funding 2047240 /api/funding/2047240 false true Funding 2047241 /api/funding/2047241 false true Funding 2047242 /api/funding/2047242 false true Funding 2047243 /api/funding/2047243 false true Funding 2047244 /api/funding/2047244 false true true true 2024 true true true false true false GOLD 2026-09-20 true https://doi.org/10.3390/nu16234118 48 0 47 34 14 45 33 25 25 28 28 27 27 35 13 0 48 35 47 34 0 32 32 Folyóiratcikk Journal Article 24 34 Könyvrészlet Chapter in Book 25 13 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 1 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 19 12 19 12 2026 0 29 23 29 23 D1 false false false false 2024-11-27T22:50:02.757+0000 Doktori Iskola (SE); Megelőző Orvostani és Népegészségtani Intézet (SE / AOK / I); Pulmonológiai Klinika (SE / AOK / K); Reumatológiai és Klinikai Immunológiai Tanszék (SE / AOK / K / BOK); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 9 45 5 9 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 121926268 /api/authorship/121926268 1 0.111 true false false Author 10058020 /api/author/10058020 Fekete Mónika true 10058020 true Fekete Mónika true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121926269 /api/authorship/121926269 2 0.111 true false false Author 10089009 /api/author/10089009 Lehoczki Andrea Marianna true true Lehoczki Andrea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121926270 /api/authorship/121926270 3 0.111 true false false Author 10055259 /api/author/10055259 Csípő Tamás true 10055259 true Csípő Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121926271 /api/authorship/121926271 4 0.111 true false false Author 10035785 /api/author/10035785 Fazekas-Pongor Vince true 10035785 true Fazekas-Pongor Vince true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121926272 /api/authorship/121926272 5 0.111 false false false Author 10048535 /api/author/10048535 Szappanos Ágnes true 10048535 true Szappanos Ágnes true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121926273 /api/authorship/121926273 6 0.111 false false false Author 10080371 /api/author/10080371 Major Dávid true true Major Dávid true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121926274 /api/authorship/121926274 7 0.111 false false false Author 10078731 /api/author/10078731 Mózes Noémi true true Mózes Noémi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121926275 /api/authorship/121926275 8 0.111 false false false Author 10079892 /api/author/10079892 Dósa Norbert Sándor true true Dósa Norbert true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 121926276 /api/authorship/121926276 9 0.111 false true true Author 10028758 /api/author/10028758 Varga János Tamás true 10028758 true Varga János Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 28036987 /api/publicationidentifier/28036987 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/nu16234118 https://doi.org/10.3390/nu16234118 false true PublicationIdentifier 28137920 /api/publicationidentifier/28137920 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001376481900001 https://www.webofscience.com/wos/woscc/full-record/001376481900001 true true PublicationIdentifier 28137923 /api/publicationidentifier/28137923 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85212204498 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85212204498 true true PublicationIdentifier 28127817 /api/publicationidentifier/28127817 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39683514 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39683514&dopt=Abstract true true Classification 12141 /api/classification/12141 true true SjrRating 11464918 /api/sjrrating/11464918 23 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1106 /api/classificationexternal/1106 true 1106 true D1 DIRECT true true /api/publication/35610852 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10058020"><a href="/gui2/?type=authors&mode=browse&sel=10058020" target="_blank">Fekete Mónika (<span class="authorship-author-name">Fekete Mónika</span> <span class="authorAux-mtmt"> Népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/Doktori Iskola; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10089009"><a href="/gui2/?type=authors&mode=browse&sel=10089009" target="_blank">Lehoczki Andrea<sup>*</sup> (<span class="authorship-author-name">Lehoczki Andrea Marianna</span> <span class="authorAux-mtmt"> hematológia, belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/Doktori Iskola; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055259"><a href="/gui2/?type=authors&mode=browse&sel=10055259" target="_blank">Csípő Tamás<sup>*</sup> (<span class="authorship-author-name">Csípő Tamás</span> <span class="authorAux-mtmt"> kardiológia, vaszkuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/Doktori Iskola; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035785"><a href="/gui2/?type=authors&mode=browse&sel=10035785" target="_blank">Fazekas-Pongor Vince<sup>*</sup> (<span class="authorship-author-name">Fazekas-Pongor Vince</span> <span class="authorAux-mtmt"> népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/Doktori Iskola; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048535"><a href="/gui2/?type=authors&mode=browse&sel=10048535" target="_blank">Szappanos Ágnes (<span class="authorship-author-name">Szappanos Ágnes</span> <span class="authorAux-mtmt"> reumatológia és immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Onkológiai Klinika">BOK</span>/Reumatológiai és Klinikai Immunológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10080371"><a href="/gui2/?type=authors&mode=browse&sel=10080371" target="_blank">Major Dávid (<span class="authorship-author-name">Major Dávid</span> <span class="authorAux-mtmt"> Megelőző orvostan, társadalomegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10078731"><a href="/gui2/?type=authors&mode=browse&sel=10078731" target="_blank">Mózes Noémi (<span class="authorship-author-name">Mózes Noémi</span> <span class="authorAux-mtmt"> egészségtudomány/táplálkozástudomány/epidemiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10079892"><a href="/gui2/?type=authors&mode=browse&sel=10079892" target="_blank">Dósa Norbert (<span class="authorship-author-name">Dósa Norbert Sándor</span> <span class="authorAux-mtmt"> orvos</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028758"><a href="/gui2/?type=authors&mode=browse&sel=10028758" target="_blank">Varga János Tamás ✉ (<span class="authorship-author-name">Varga János Tamás</span> <span class="authorAux-mtmt"> pulmonológia, pulm. rehabilitáció</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pulmonológiai Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35610852" target="_blank">The Role of Trace Elements in COPD: Pathogenetic Mechanisms and Therapeutic Potential of Zinc, Iron, Magnesium, Selenium, Manganese, Copper, and Calcium</a></div> <div> <span class="journal-title">NUTRIENTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2072-6643">2072-6643</a>)</span>: <span class="journal-volume">16</span> <span class="journal-issue">23</span> <span class="page"> Paper 4118. 27 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/nu16234118" target="_blank" href="https://doi.org/10.3390/nu16234118"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001376481900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001376481900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85212204498" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85212204498"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39683514" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39683514&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Food Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Nutrition and Dietetics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 48</span> | Független: 35 | Függő: 13 | Nem jelölt: 0 | WoS jelölt: 25 | Scopus jelölt:&nbsp;25 | WoS/Scopus jelölt:&nbsp;28 | DOI jelölt:&nbsp;33 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35610852&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 32 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35610852</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (TKP2021-NKTA-47), Nemzeti Kardiovaszkuláris Laboratórium(RRF-2.3.1-21-2022-00003) Támogató: NKFIH, Nemzeti Gyógyszerkutatási és Fejlesztési Laboratórium (PharmaLab)(RRF-2.3.1-21-2022-00015) Támogató: NKFIH, (135784) Támogató: NKFIH, (101004093/EUniWell/EAC-A02- 2019/EAC-A02-2019-1) </div> <div class="lastModified">Utolsó módosítás: 2026.07.20. 15:22 Kósáné Holecz Anna Mária (SE_KK_Reumatológia_Admin5_KHAM, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 06 February 2026; Cited By: 7; Correspondence Address: J.T. Varga; Department of Pulmonology, Semmelweis University, Budapest, 1083, Hungary; email: varga.janos.tamas@semmelweis.hu;</pre> </div></div>