https://m2.mtmt.hu/ hun 2026-09-22 20:42 JournalArticle 35604855 VALIDATED true Funding Agency and Grant Number: Hungarian National Research, Development, and Innovation Fund; [NKFIH K-147107] Funding text: The present study was funded in part by the Hungarian National Research, Development, and Innovation Fund (NKFIH K-147107). 0 false 2026-09-20T19:29:01.578+0000 2026-06-18T17:18:55.945+0000 2024-11-26T19:25:18.444+0000 true 10018804 Szalóky-Siki Ágnes /api/admin/10018804 Admin Szalóky-Siki Ágnes (SE_FOK_Admin5_SIKIÁ, admin) true 10018804 2026-07-26T19:35:21.240+0000 2025-01-07T09:43:33.813+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Összefoglaló cikk (Folyóiratcikk) 102 true 1134514 true 1 /api/category/1 Category Tudományos true 1 Cavalcante, Bianca Golzio Navarro true true /api/journal/10017543 REVIEWED JOURNAL OF CLINICAL MEDICINE 2077-0383 true false 10017543 false 10017543 true 2077-0383 Journal FOREIGN 13 23 7154 7154 21 2024 Background: Molar–incisor hypomineralization (MIH) is an enamel defect affecting molars and incisors, often leading to hypersensitivity, enamel breakdown, and increased caries risk. Non-invasive treatments, such as casein phosphopeptide–amorphous calcium phosphate (CPP-ACP) and fluoride varnish, show potential in remineralizing affected enamel and reducing sensitivity, but their efficacy is still debated. This study systematically reviews and analyzes the effectiveness of CPP-ACP and other non-invasive agents in improving remineralization and reducing hypersensitivity in MIH-affected teeth. Methods: A systematic search was conducted on PubMed, Embase, and Central in July 2024, including interventional and observational studies on remineralization and hypersensitivity in pediatric MIH patients (<18 years). A total of 1566 studies were found, with 15 included in the meta-analysis. A random-effects model was applied, including subgroup analysis by lesion severity. Results: CPP-ACP showed no statistically significant advantage over fluoride in remineralization (MD −3.80, 95% CI: −8.57; 0.98), but it significantly reduced hypersensitivity compared to fluoride varnish (MD −2.36, 95% CI: −3.83; −0.89). Although this reduction in hypersensitivity may be clinically relevant, the high heterogeneity (I² = 83%) and wide confidence intervals limit the reliability of these findings. Conclusions: CPP-ACP has a moderate effect in reducing hypersensitivity but does not outperform fluoride in remineralization. Other agents, such as calcium glycerophosphate and silver diamine fluoride, showed mild benefits. The current evidence base is limited and heterogeneous, highlighting the need for high-quality, long-term studies to confirm these findings and guide MIH management. Funding 2047124 /api/funding/2047124 (K-147107) false true true 2024 true true true false false GOLD 2026-09-20 true https://doi.org/10.3390/jcm13237154 13 0 13 12 1 13 13 11 12 13 13 12 12 12 1 0 13 12 13 12 0 5 5 Folyóiratcikk Journal Article 24 13 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 4 4 4 4 2026 0 9 8 9 8 Q1 false false false false 2024-11-27T08:14:44.319+0000 Anatómiai, Szövet- és Fejlődéstani Intézet (SE / AOK / I); Fogászati és Szájsebészeti Oktató Intézet (SE / FOK); Gyermekfogászati és Fogszabályozási Klinika (SE / FOK); Helyreállító Fogászati és Endodonciai Klinika (SE / FOK); Orálbiológiai Tanszék (SE / FOK); Pankreász Betegségek Intézete (SE / AOK / K); Radiológia Tanszék (SE / AOK / K / OKK); Transzlációs Medicina Intézet (PTE / ÁOK); Transzlációs Medicina Központ (SE / KSZE) 9 64 9 9 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 121868150 /api/authorship/121868150 Cavalcante, Bianca Golzio Navarro [Golzio Navarro Cavalcante, Bianca (Clinical Medicine), szerző] Orálbiológiai Tanszék (SE / FOK); Transzlációs Medicina Központ (SE / KSZE) 1 0.111 true false false Author 10078009 /api/author/10078009 Golzio Navarro Cavalcante Bianca (Clinical Medicine) Golzio Navarro Cavalcante Bianca true true Cavalcante Bianca Golzio Navarro true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 121868151 /api/authorship/121868151 Mlinkó, Éva [Mlinkó, Éva (Fogszabályozás, G...), szerző] Gyermekfogászati és Fogszabályozási Klinika (SE / FOK) 2 0.111 false false false Author 10066989 /api/author/10066989 Mlinkó Éva (Fogszabályozás, Gyermekfogászat) Mlinkó Éva true true Mlinkó Éva true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 121868152 /api/authorship/121868152 Szabó, Bence [Szabó, Bence (Biológia, paleont...), szerző] Transzlációs Medicina Központ (SE / KSZE) 3 0.111 false false false Author 10055762 /api/author/10055762 Szabó Bence (Biológia, paleontológia) Szabó Bence true 10055762 true Szabó Bence true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 121868153 /api/authorship/121868153 Teutsch, Brigitta [Teutsch, Brigitta (Gasztroenterológia), szerző] Transzlációs Medicina Központ (SE / KSZE); Radiológia Tanszék (SE / AOK / K / OKK); Transzlációs Medicina Intézet (PTE / ÁOK) 4 0.111 false false false Author 10078049 /api/author/10078049 Teutsch Brigitta (Gasztroenterológia) Teutsch Brigitta true true Teutsch Brigitta true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 121868154 /api/authorship/121868154 Hegyi, Péter [Hegyi, Péter (Gasztroenterológia), szerző] Pankreász Betegségek Intézete (SE / AOK / K); Transzlációs Medicina Központ (SE / KSZE); Transzlációs Medicina Intézet (PTE / ÁOK) 5 0.111 false false false Author 10002629 /api/author/10002629 Hegyi Péter (Gasztroenterológia) Hegyi Péter true 10002629 true Hegyi Péter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 121868155 /api/authorship/121868155 Vág, János [Vág, János (Fogászat), szerző] Helyreállító Fogászati és Endodonciai Klinika (SE / FOK); Transzlációs Medicina Központ (SE / KSZE) 6 0.111 false false false Author 10035110 /api/author/10035110 Vág János (Fogászat) Vág János true 10035110 true Vág János true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 121868156 /api/authorship/121868156 Németh, Orsolya [Németh, Orsolya (Fogpótlástan), szerző] Fogászati és Szájsebészeti Oktató Intézet (SE / FOK); Transzlációs Medicina Központ (SE / KSZE) 7 0.111 false false false Author 10018900 /api/author/10018900 Németh Orsolya (Fogpótlástan) Németh Orsolya true 10018900 true Németh Orsolya true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 121868157 /api/authorship/121868157 Gerber, Gábor [Gerber, Gábor (Idegtudományok), szerző] Anatómiai, Szövet- és Fejlődéstani Intézet (SE / AOK / I); Transzlációs Medicina Központ (SE / KSZE) 8 0.111 false false false Author 10020686 /api/author/10020686 Gerber Gábor (Idegtudományok) Gerber Gábor true 10020686 true Gerber Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 121868158 /api/authorship/121868158 Varga, Gábor ✉ [Varga, Gábor (Élettan, orálbiol...), szerző] Orálbiológiai Tanszék (SE / FOK); Transzlációs Medicina Központ (SE / KSZE) 9 0.111 false true true Author 10006652 /api/author/10006652 Varga Gábor (Élettan, orálbiológia) Varga Gábor true 10006652 true Varga Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 28022418 /api/publicationidentifier/28022418 DOI: 10.3390/jcm13237154 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/jcm13237154 https://doi.org/10.3390/jcm13237154 false true PublicationIdentifier 28162600 /api/publicationidentifier/28162600 WoS: 001377291400001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001377291400001 https://www.webofscience.com/wos/woscc/full-record/001377291400001 true true PublicationIdentifier 29155826 /api/publicationidentifier/29155826 Scopus: 86000772269 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 86000772269 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-86000772269 false true PublicationIdentifier 28123933 /api/publicationidentifier/28123933 PubMed: 39685613 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39685613 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39685613&dopt=Abstract false true Classification 12276 /api/classification/12276 Fogászat true true Keyword 3375201 /api/keyword/3375201 [Meta-analysis] true true SjrRating 11482758 /api/sjrrating/11482758 sjr:Q1 (2024) Scopus - Medicine (miscellaneous) JOURNAL OF CLINICAL MEDICINE 2077-0383 607 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 Scopus - Medicine (miscellaneous) true 2701 true Q1 DIRECT true true Reference 60234165 /api/reference/60234165 1. 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(2024) JOURNAL OF CLINICAL MEDICINE 2077-0383 13 23<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10078009"><a href="/gui2/?type=authors&mode=browse&sel=10078009" target="_blank">Cavalcante Bianca Golzio Navarro (<span class="authorship-author-name">Golzio Navarro Cavalcante Bianca</span> <span class="authorAux-mtmt"> Clinical Medicine</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Orálbiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10066989"><a href="/gui2/?type=authors&mode=browse&sel=10066989" target="_blank">Mlinkó Éva (<span class="authorship-author-name">Mlinkó Éva</span> <span class="authorAux-mtmt"> Fogszabályozás, Gyermekfogászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Gyermekfogászati és Fogszabályozási Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055762"><a href="/gui2/?type=authors&mode=browse&sel=10055762" target="_blank">Szabó Bence (<span class="authorship-author-name">Szabó Bence</span> <span class="authorAux-mtmt"> Biológia, paleontológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10078049"><a href="/gui2/?type=authors&mode=browse&sel=10078049" target="_blank">Teutsch Brigitta (<span class="authorship-author-name">Teutsch Brigitta</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Orvosi Képalkotó Klinika">OKK</span>/Radiológia Tanszék; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Péter (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pankreász Betegségek Intézete; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035110"><a href="/gui2/?type=authors&mode=browse&sel=10035110" target="_blank">Vág János (<span class="authorship-author-name">Vág János</span> <span class="authorAux-mtmt"> Fogászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Helyreállító Fogászati és Endodonciai Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018900"><a href="/gui2/?type=authors&mode=browse&sel=10018900" target="_blank">Németh Orsolya (<span class="authorship-author-name">Németh Orsolya</span> <span class="authorAux-mtmt"> Fogpótlástan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Fogászati és Szájsebészeti Oktató Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020686"><a href="/gui2/?type=authors&mode=browse&sel=10020686" target="_blank">Gerber Gábor (<span class="authorship-author-name">Gerber Gábor</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10006652"><a href="/gui2/?type=authors&mode=browse&sel=10006652" target="_blank">Varga Gábor ✉ (<span class="authorship-author-name">Varga Gábor</span> <span class="authorAux-mtmt"> Élettan, orálbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Orálbiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35604855" target="_blank">Non-Invasive Strategies for Remineralization and Hypersensitivity Management in Molar–Incisor Hypomineralization—A Systematic Review and Meta-Analysis</a></div> <div> <span class="journal-title">JOURNAL OF CLINICAL MEDICINE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2077-0383">2077-0383</a>)</span>: <span class="journal-volume">13</span> <span class="journal-issue">23</span> <span class="page"> Paper 7154. 21 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/jcm13237154" target="_blank" href="https://doi.org/10.3390/jcm13237154"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001377291400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001377291400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="86000772269" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-86000772269"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39685613" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39685613&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 13</span> | Független: 12 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 11 | Scopus jelölt:&nbsp;12 | WoS/Scopus jelölt:&nbsp;13 | DOI jelölt:&nbsp;13 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35604855&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35604855</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (K-147107) </div> <div class="lastModified">Utolsó módosítás: 2026.06.18. 19:18 Milánkovics Róbert (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Hungarian National Research, Development, and Innovation Fund; [NKFIH K-147107] Funding text: The present study was funded in part by the Hungarian National Research, Development, and Innovation Fund (NKFIH K-147107).</pre> </div></div>