https://m2.mtmt.hu/ hun 2026-05-31 16:06 JournalArticle 35601054 ADMIN_APPROVED true Department of Urology, University of Duisburg-Essen, Essen, Germany Institute of Pathology, University Medicine Essen, University of Duisburg-Essen, Essen, Germany Department of Urology, University Hospitals Leuven, Leuven, Belgium Lindenhofspital, Bern, Switzerland Urology Research Laboratory, Department for BioMedical Research, University of Bern, Bern, Switzerland Department of Urology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland Department of Urology, Semmelweis University, Budapest, Hungary Research Centre for Natural Sciences, Cancer Biomarker Research Group, Institute of Enzymology, Budapest, Hungary Department of Bioinformatics, Semmelweis University, Budapest, Hungary Dr. Senckenberg Institute of Pathology, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main, Germany Cited By :1 Export Date: 21 February 2025 CODEN: PCPDF Correspondence Address: Szarvas, T.; Department of Urology, Germany; email: tibor.szarvas@uk-essen.de Funding details: American Angus Association, AAA Funding details: Deutsche Forschungsgemeinschaft, DFG Funding details: Novartis Funding details: Bristol-Myers Squibb, BMS Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, RRF-2.3.1-21-2022-00015, TKP2021-NVA-15 Funding text 1: BH: Advisory boards for Janssen, Bayer, ABX, Lightpoint, Amgen, MSD, Pfizer, Novartis. Invited speaker for Accord, Astellas, Janssen R&D. Honoraria from Uromed. Research funding from AAA/Novartis, Bristol Myers Squibb, and German Research Foundation. Leadership roles for DKG AUO and DGU. The authors declare no potential conflicts of interest with the present project and publication. Funding text 2: This project was supported by National Research, Development and Innovation Office of Hungary (PharmaLab, RRF-2.3.1-21-2022-00015 and TKP2021-NVA-15). Open access funding provided by Semmelweis University. 0 false 2026-05-28T11:02:49.340+0000 2026-05-28T11:00:59.314+0000 2024-11-26T08:29:50.002+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-02-03T13:23:00.495+0000 2026-05-28T11:00:59.549+0000 true 10025544 Lévayné Deseő Katalin /api/admin/10025544 Admin true 10025544 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2025-04-30T14:16:31.216+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Olah, Csilla Enhancing risk stratification models in localized prostate cancer by novel validated tissue biomarkers true true /api/journal/20116 REVIEWED true false 20116 false 20116 true 1365-7852 1476-5608 Journal FOREIGN 28 3 773 781 773 9 2025 BackgroundLocalized prostate cancer (PCa) is a largely heterogeneous disease regarding its clinical behavior. Current risk stratification relies on clinicopathological parameters and distinguishing between indolent and aggressive cases remains challenging. To improve risk stratification, we aimed to identify new prognostic markers for PCa.MethodsWe performed an in silico analysis on publicly available PCa transcriptome datasets. The top 20 prognostic genes were assessed in PCa tissue samples of our institutional cohort (n = 92) using the NanoString nCounter technology. The three most promising candidates were further assessed by immunohistochemistry (IHC) in an institutional (n = 121) and an independent validation cohort from the EMPACT consortium (n = 199). Cancer-specific survival (CSS) and progression-free survival (PFS) were used as endpoints.ResultsOur in silico analysis identified 113 prognostic genes. The prognostic values of seven of the top 20 genes were confirmed in our institutional radical prostatectomy (RPE) cohort. Low CENPO, P2RX5, ABCC5 as well as high ASF1B, NCAPH, UBE2C, and ZWINT gene expressions were associated with shorter CSS. IHC analysis confirmed the significant associations between NCAPH and UBE2C staining and worse CSS. In the external validation cohort, higher NCAPH and ZWINT protein expressions were associated with shorter PFS. The combination of the newly identified tissue protein markers improved standard risk stratification models, such as D'Amico, CAPRA, and Cambridge prognostic groups.ConclusionsWe identified and validated high tissue levels of NCAPH, UBE2C, and ZWINT as novel prognostic risk factors in clinically localized PCa patients. The use of these markers can improve routinely used risk estimation models. 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<span class="author-name" >Mairinger Fabian </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wessolly Michael </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Joniau Steven </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Spahn Martin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kruithof-de Julio Marianna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hadaschik Boris </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10097365"><a href="/gui2/?type=authors&mode=browse&sel=10097365" target="_blank">Soos Aron (<span class="authorship-author-name">Soós Áron Roland</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013343"><a href="/gui2/?type=authors&mode=browse&sel=10013343" target="_blank">Nyirady Peter (<span class="authorship-author-name">Nyirády Péter</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Gyorffy Balazs (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Bioinformatika Tanszék; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Onkológiai Biomarker Kutatócsoport (Lendület)</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Reis Henning<sup>**</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052466"><a href="/gui2/?type=authors&mode=browse&sel=10052466" target="_blank">Szarvas Tibor ✉ (<span class="authorship-author-name">Szarvas Tibor</span> <span class="authorAux-mtmt"> urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35601054" target="_blank">Enhancing risk stratification models in localized prostate cancer by novel validated tissue biomarkers</a></div> <div> <span class="journal-title">PROSTATE CANCER AND PROSTATIC DISEASES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1365-7852">1365-7852</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1476-5608">1476-5608</a>)</span>: <span class="journal-volume">28</span> <span class="journal-issue">3</span> <span class="page"> pp 773-781 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/s41391-024-00918-9" target="_blank" href="https://doi.org/10.1038/s41391-024-00918-9"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001354807100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001354807100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85208959350" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85208959350"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39543244" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39543244&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Urology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 7</span> | Független: 6 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 7 | Scopus jelölt:&nbsp;7 | WoS/Scopus jelölt:&nbsp;7 | DOI jelölt:&nbsp;7 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35601054&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35601054</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> Nemzeti Gyógyszerkutatási és Fejlesztési Laboratórium (PharmaLab)(RRF-2.3.1-21-2022-00015) Támogató: NKFIH, (TKP2021-NVA-15), (Open access funding provided by Semmelweis University) </div> <div class="lastModified">Utolsó módosítás: 2026.05.28. 13:00 Lévayné Deseő Katalin (MTMT Központi admin) </div> <div class="lockedBy">Központi kezelésű 2025.04.30. 16:16 Vándor Andrea (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Urology, University of Duisburg-Essen, Essen, Germany Institute of Pathology, University Medicine Essen, University of Duisburg-Essen, Essen, Germany Department of Urology, University Hospitals Leuven, Leuven, Belgium Lindenhofspital, Bern, Switzerland Urology Research Laboratory, Depar...</pre> </div></div>