https://m2.mtmt.hu/ hun 2026-09-20 23:45 JournalArticle 35596201 VALIDATED true 0 false 2026-05-24T11:51:46.366+0000 2025-07-02T12:46:18.864+0000 2024-11-22T18:57:30.436+0000 true 10071667 Stepanova Ganna /api/author/10071667 Author Stepanova Ganna (Theoretical and Translational Medicine) true 2025-07-02T12:46:19.175+0000 2025-07-02T12:46:19.175+0000 2024-12-31T07:41:24.812+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Stepanova, Ganna true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 25 23 12551 12551 24 2024 Kidney fibrosis is a hallmark of chronic kidney diseases. Evidence shows that genetic variability and complement component 3 (C3) might influence tubulointerstitial fibrosis. Still, the role of renal C3 production in the epithelial-to-mesenchymal transition (EMT) and genetically determined fibrosis progression remains undiscovered. The kidneys of fibrosis-resistant C57Bl/6J (B6) and fibrosis-prone CBA/J (CBA) and BALB/cJ (BalbC) mice (n = 4–8/group) were subjected to unilateral ureteral obstruction (UUO) and analyzed after 1, 3, and 7 days, along with human focal glomerular sclerotic (FSGS) and healthy kidneys. Mouse primary tubular epithelial cells (PTECs) were investigated after 24 h of treatment with transforming growth factor β (TGFβ) or complement anaphylatoxin 3a (C3a) agonist (n = 4/group). UUO resulted in delayed kidney injury in fibrosis-resistant B6 mice, but very early renal C3 messenger RNA (mRNA) induction in fibrosis-prone CBA and BalbC mice, along with collagen I (Col1a1) and collagen III (Col3a1). CBA depicted the fastest fibrosis progression with the highest C3, lipocalin-2 (Lcn2), Tgfb1, and chemokine (C-C motif) ligand 2 (Ccl2) expression. Human FSGS kidneys depicted C3 mRNA over-expression and strong tubular C3 immunostaining. In PTECs, C3a agonist treatment induced pro-fibrotic early growth response protein 1 (EGR1) expression and the EMT, independent of TGFβ signaling. We conclude that de novo renal tubular C3 synthesis is associated with the genetically determined kidney fibrosis progression rate in mice and the pathogenesis of FSGS in humans. This tubular C3 overproduction can, through local pro-fibrotic effects, influence the progression of chronic kidney disease. Funding 2048201 /api/funding/2048201 (BO/00304/20/5) false true Funding 2048202 /api/funding/2048202 (ÚNKP-22-5-SE-202206201434) false true Funding 2048203 /api/funding/2048203 (KP2024) false true Funding 2048204 /api/funding/2048204 (KFP2024) false true true true 2024 true true true false true false GOLD 2026-05-24 false http://www.mdpi.com/journal/ijms 5 0 5 5 0 5 5 5 2 5 5 5 5 5 0 0 5 5 5 5 0 5 5 Folyóiratcikk Journal Article 24 5 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 3 3 3 3 2026 0 2 2 2 2 D1 false 10014641 false false false 2024-12-30T07:41:24.624+0000 Transzlációs Medicina Intézet (SE / AOK / I) 4 20 1 4 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 121785424 /api/authorship/121785424 Stepanova, Ganna [Stepanova, Ganna (Theoretical and T...), szerző] Transzlációs Medicina Intézet (SE / AOK / I) 1 0.25 true false false Author 10071667 /api/author/10071667 Stepanova Ganna (Theoretical and Translational Medicine) Stepanova Ganna true true Stepanova Ganna true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 121785425 /api/authorship/121785425 Manzéger, Anna [Manzéger, Anna (molekuláris genetika), szerző] Transzlációs Medicina Intézet (SE / AOK / I) 2 0.25 false false false Author 10055151 /api/author/10055151 Manzéger Anna (molekuláris genetika) Manzéger Anna true 10055151 true Manzéger Anna true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 121785426 /api/authorship/121785426 Mózes, Miklós M. [Mózes, Miklós (Nephrologia), szerző] Transzlációs Medicina Intézet (SE / AOK / I) 3 0.25 false false false Author 10015693 /api/author/10015693 Mózes Miklós (Nephrologia) Mózes Miklós true 10015693 true Mózes Miklós M. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 121785427 /api/authorship/121785427 Kökény, Gábor ✉ [Kökény, Gábor (Nefrológia), szerző] Transzlációs Medicina Intézet (SE / AOK / I) 4 0.25 false true true Author 10014641 /api/author/10014641 Kökény Gábor (Nefrológia) Kökény Gábor true 10014641 true Kökény Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 27998312 /api/publicationidentifier/27998312 DOI: 10.3390/ijms252312551 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/ijms252312551 https://doi.org/10.3390/ijms252312551 false true PublicationIdentifier 28137762 /api/publicationidentifier/28137762 WoS: 001376368700001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001376368700001 https://www.webofscience.com/wos/woscc/full-record/001376368700001 true true PublicationIdentifier 28137763 /api/publicationidentifier/28137763 Scopus: 85211910854 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85211910854 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85211910854 true true PublicationIdentifier 28137764 /api/publicationidentifier/28137764 PubMed: 39684261 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39684261 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39684261&dopt=Abstract true true Classification 12304 /api/classification/12304 Nefrológia true true SjrRating 11489344 /api/sjrrating/11489344 sjr:D1 (2024) Scopus - Organic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 18 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1605 /api/classificationexternal/1605 Scopus - Organic Chemistry true 1605 true D1 DIRECT true true Reference 60138543 /api/reference/60138543 1. Centers for Disease Control and Prevention (2023). Chronic Kidney Disease in the United States, 2023. 1 false true Reference 60138544 /api/reference/60138544 2. Mayo Clinic (2020, December 03). Chronic Kidney Disease—Symptoms and Causes—Mayo Clinic. Mayo Foundation for Medical Education and Research (MFMER). Available online: https://www.mayoclinic.org/diseases-conditions/chronic-kidney-disease/symptoms-causes/syc-20354521. 2 false true Reference 60138545 /api/reference/60138545 3. Zeisberg 2010: Mechanisms of Tubulointerstitial Fibrosis., J. Am. Soc. Nephrol., 21, p. 1819, DOI: 10.1681/ASN.2010080793 3 10.1681/ASN.2010080793 false true Reference 60138546 /api/reference/60138546 4. McDowall, C. (2020, December 03). Novel Mechanisms of Tubulointerstitial Fibrosis. Available online: https://e-space.mmu.ac.uk/620511/. 4 false true Reference 60138547 /api/reference/60138547 5. Liu, B.-C., Lan, H.-Y., and Lv, L.-L. (2019). Renal Fibrosis: Mechanisms and Therapies, Springer. Advances in Experimental Medicine and Biology., DOI: 10.1007/978-981-13-8871-2 5 10.1007/978-981-13-8871-2 false true Reference 60138548 /api/reference/60138548 6. Gewin 2018: Renal Fibrosis: Primacy of the Proximal Tubule., Matrix Biol., 68–69, p. 248, DOI: 10.1016/j.matbio.2018.02.006 6 10.1016/j.matbio.2018.02.006 false true Reference 60138549 /api/reference/60138549 7. Keith 2004: Longitudinal Follow-Up and Outcomes Among a Population With Chronic Kidney Disease in a Large Managed Care Organization., Arch. Intern. Med., 164, p. 659, DOI: 10.1001/archinte.164.6.659 7 10.1001/archinte.164.6.659 false true Reference 60138550 /api/reference/60138550 8. Kopp 2022: Susceptibility to Kidney Fibrosis in Mice Is Associated with Early Growth Response-2 Protein and Tissue Inhibitor of Metalloproteinase-1 Expression., Kidney Int., 102, p. 337, DOI: 10.1016/j.kint.2022.03.029 8 10.1016/j.kint.2022.03.029 false true Reference 60138551 /api/reference/60138551 9. Kokeny 2010: The Rowett Rat Strain Is Resistant to Renal Fibrosis., Nephrol. Dial. Transplant., 25, p. 1458, DOI: 10.1093/ndt/gfp689 9 10.1093/ndt/gfp689 false true Reference 60138552 /api/reference/60138552 10. Haroun 2003: Risk Factors for Chronic Kidney Disease: A Prospective Study of 23,534 Men and Women in Washington County, Maryland., J. Am. Soc. Nephrol., 14, p. 2934, DOI: 10.1097/01.ASN.0000095249.99803.85 10 10.1097/01.ASN.0000095249.99803.85 false true Reference 60138553 /api/reference/60138553 11. Migeon 2008: X Inactivation, Female Mosaicism, and Sex Differences in Renal Diseases., J. Am. Soc. Nephrol., 19, p. 2052, DOI: 10.1681/ASN.2008020198 11 10.1681/ASN.2008020198 false true Reference 60138554 /api/reference/60138554 12. Choi 2007: Age Affects Outcomes in Chronic Kidney Disease., J. Am. Soc. Nephrol., 18, p. 2758, DOI: 10.1681/ASN.2007040422 12 10.1681/ASN.2007040422 false true Reference 60138555 /api/reference/60138555 13. Mack 2015: Origin of Myofibroblasts and Cellular Events Triggering Fibrosis., Kidney Int., 87, p. 297, DOI: 10.1038/ki.2014.287 13 10.1038/ki.2014.287 false true Reference 60138556 /api/reference/60138556 14. Ricklin 2016: Complement in Disease: A Defence System Turning Offensive., Nat. Rev. Nephrol., 12, p. 383, DOI: 10.1038/nrneph.2016.70 14 10.1038/nrneph.2016.70 false true Reference 60138557 /api/reference/60138557 15. Noris 2013: Overview of Complement Activation and Regulation., Semin. Nephrol., 33, p. 479, DOI: 10.1016/j.semnephrol.2013.08.001 15 10.1016/j.semnephrol.2013.08.001 false true Reference 60138558 /api/reference/60138558 16. Ricklin 2013: Complement in Immune and Inflammatory Disorders: Therapeutic Interventions., J. Immunol., 190, p. 3839, DOI: 10.4049/jimmunol.1203200 16 10.4049/jimmunol.1203200 false true Reference 60138559 /api/reference/60138559 17. Chen, S.-F., and Chen, M. (2019). Complement Activation in Progression of Chronic Kidney Disease. Advances in Experimental Medicine and Biology, Springer LLC., DOI: 10.1007/978-981-13-8871-2_20 17 10.1007/978-981-13-8871-2_20 false true Reference 60138560 /api/reference/60138560 18. Bartoszek 2014: The Complement Cascade and Renal Disease., Arch. Immunol. Ther. Exp., 62, p. 47, DOI: 10.1007/s00005-013-0254-x 18 10.1007/s00005-013-0254-x false true Reference 60138561 /api/reference/60138561 19. Fearn 2015: Complement Activation in Progressive Renal Disease., World J. Nephrol., 4, p. 31, DOI: 10.5527/wjn.v4.i1.31 19 10.5527/wjn.v4.i1.31 false true Reference 60138562 /api/reference/60138562 20. Gao, S., Cui, Z., and Zhao, M. (2020). The Complement C3a and C3a Receptor Pathway in Kidney Diseases. Front. Immunol., 11., DOI: 10.3389/fimmu.2020.01875 20 10.3389/fimmu.2020.01875 false true Reference 60138563 /api/reference/60138563 21. Morigi, M., Locatelli, M., Rota, C., Buelli, S., Corna, D., Rizzo, P., Abbate, M., Conti, D., Perico, L., and Longaretti, L. (2016). A Previously Unrecognized Role of C3a in Proteinuric Progressive Nephropathy. Sci. Rep., 6., DOI: 10.1038/srep28445 21 10.1038/srep28445 false true Reference 60138564 /api/reference/60138564 22. Bao 2011: Distinct Roles for C3a and C5a in Complement-Induced Tubulointerstitial Injury., Kidney Int., 80, p. 524, DOI: 10.1038/ki.2011.158 22 10.1038/ki.2011.158 false true Reference 60138565 /api/reference/60138565 23. Xavier 2017: Pericytes and Immune Cells Contribute to Complement Activation in Tubulointerstitial Fibrosis., Am. J. Physiol. Ren. Physiol., 312, p. F516, DOI: 10.1152/ajprenal.00604.2016 23 10.1152/ajprenal.00604.2016 false true Reference 60138566 /api/reference/60138566 24. Zhou 2013: Complement 3 Activates the Renal Renin-Angiotensin System by Induction of Epithelial-to-Mesenchymal Transition of the Nephrotubulus in Mice., Am. J. Physiol. Physiol., 305, p. F957, DOI: 10.1152/ajprenal.00344.2013 24 10.1152/ajprenal.00344.2013 false true Reference 60138567 /api/reference/60138567 25. Kim, S.J., Koo, H.M., Lim, B.J., Oh, H.J., Yoo, D.E., Shin, D.H., Lee, M.J., Doh, F.M., Park, J.T., and Yoo, T.-H. (2012). Decreased Circulating C3 Levels and Mesangial C3 Deposition Predict Renal Outcome in Patients with IgA Nephropathy. PLoS ONE, 7., DOI: 10.1371/journal.pone.0040495 25 10.1371/journal.pone.0040495 false true Reference 60138568 /api/reference/60138568 26. Han, R., Hu, S., Qin, W., Shi, J., Zeng, C., Bao, H., and Liu, Z. (2019). Upregulated Long Noncoding RNA LOC105375913 Induces Tubulointerstitial Fibrosis in Focal Segmental Glomerulosclerosis. Sci. Rep., 9., DOI: 10.1038/s41598-018-36902-2 26 10.1038/s41598-018-36902-2 false true Reference 60138569 /api/reference/60138569 27. Huang, J., Cui, Z., Gu, Q.-H., Zhang, Y.-M., Qu, Z., Wang, X., Wang, F., Cheng, X.-Y., Meng, L.-Q., and Liu, G. (2020). Complement Activation Profile of Patients with Primary Focal Segmental Glomerulosclerosis. PLoS ONE, 15., DOI: 10.1371/journal.pone.0234934 27 10.1371/journal.pone.0234934 false true Reference 60138570 /api/reference/60138570 28. Sacks 1993: Complement C3 Gene Expression and Regulation in Human Glomerular Epithelial Cells., Immunology, 79, p. 348 28 false true Reference 60138571 /api/reference/60138571 29. Tang 2001: Transferrin but Not Albumin Mediates Stimulation of Complement C3 Biosynthesis in Human Proximal Tubular Epithelial Cells., Am. J. Kidney Dis., 37, p. 94, DOI: 10.1053/ajkd.2001.20593 29 10.1053/ajkd.2001.20593 false true Reference 60138572 /api/reference/60138572 30. Sheerin 1997: TNF-α Regulation of C3 Gene Expression and Protein Biosynthesis in Rat Glomerular Endothelial Cells., Kidney Int., 51, p. 703, DOI: 10.1038/ki.1997.101 30 10.1038/ki.1997.101 false true Reference 60138573 /api/reference/60138573 31. Gerritsma 1996: Interleukin-1 Alpha Enhances the Biosynthesis of Complement C3 and Factor B by Human Kidney Proximal Tubular Epithelial Cells In Vitro., Mol. Immunol., 33, p. 847, DOI: 10.1016/0161-5890(96)84610-4 31 10.1016/0161-5890(96)84610-4 false true Reference 60138574 /api/reference/60138574 32. Portilla 2021: Role of Intracellular Complement Activation in Kidney Fibrosis., Br. J. Pharmacol., 178, p. 2880, DOI: 10.1111/bph.15408 32 10.1111/bph.15408 false true Reference 60138575 /api/reference/60138575 33. Hinz 2012: Recent Developments in Myofibroblast Biology: Paradigms for Connective Tissue Remodeling., Am. J. Pathol., 180, p. 1340, DOI: 10.1016/j.ajpath.2012.02.004 33 10.1016/j.ajpath.2012.02.004 false true Reference 60138576 /api/reference/60138576 34. Yang, S., and Plotnikov, S.V. (2021). Mechanosensitive Regulation of Fibrosis. Cells, 10., DOI: 10.3390/cells10050994 34 10.3390/cells10050994 false true Reference 60138577 /api/reference/60138577 35. Gewin 2017: Progression of Chronic Kidney Disease: Too Much Cellular Talk Causes Damage., Kidney Int., 91, p. 552, DOI: 10.1016/j.kint.2016.08.025 35 10.1016/j.kint.2016.08.025 false true Reference 60138578 /api/reference/60138578 36. Zhou, S., Yin, X., Mayr, M., Noor, M., Hylands, P.J., and Xu, Q. (2020). Proteomic Landscape of TGF-Β1-Induced Fibrogenesis in Renal Fibroblasts. Sci. Rep., 10., DOI: 10.1038/s41598-020-75989-4 36 10.1038/s41598-020-75989-4 false true Reference 60138579 /api/reference/60138579 37. Vallée, A., and Lecarpentier, Y. (2019). TGF-β in Fibrosis by Acting as a Conductor for Contractile Properties of Myofibroblasts. Cell Biosci., 9., DOI: 10.1186/s13578-019-0362-3 37 10.1186/s13578-019-0362-3 false true Reference 60138580 /api/reference/60138580 38. Ma 2003: Model of Robust Induction of Glomerulosclerosis in Mice: Importance of Genetic Background., Kidney Int., 64, p. 350, DOI: 10.1046/j.1523-1755.2003.00058.x 38 10.1046/j.1523-1755.2003.00058.x false true Reference 60138581 /api/reference/60138581 39. Sheerm 2008: Synthesis of Complement Protein C3 in the Kidney Is an Important Mediator of Local Tissue Injury., FASEB J., 22, p. 1065, DOI: 10.1096/fj.07-8719com 39 10.1096/fj.07-8719com false true Reference 60138582 /api/reference/60138582 40. Phanish 2010: Connective Tissue Growth Factor-(CTGF, CCN2)—A Marker, Mediator and Therapeutic Target for Renal Fibrosis., Nephron Exp. Nephrol., 114, p. e83, DOI: 10.1159/000262316 40 10.1159/000262316 false true Reference 60138583 /api/reference/60138583 41. Rebolledo 2019: Denervation-Induced Skeletal Muscle Fibrosis Is Mediated by CTGF/CCN2 Independently of TGF-β., Matrix Biol., 82, p. 20, DOI: 10.1016/j.matbio.2019.01.002 41 10.1016/j.matbio.2019.01.002 false true Reference 60138584 /api/reference/60138584 42. Weston 2005: Modulation of the TGFβ/Smad Signaling Pathway in Mesangial Cells by CTGF/CCN2., Exp. Cell Res., 307, p. 305, DOI: 10.1016/j.yexcr.2005.03.022 42 10.1016/j.yexcr.2005.03.022 false true Reference 60138585 /api/reference/60138585 43. Zakiyanov 2019: Matrix Metalloproteinases in Renal Diseases: A Critical Appraisal., Kidney Blood Press. Res., 44, p. 298, DOI: 10.1159/000499876 43 10.1159/000499876 false true Reference 60138586 /api/reference/60138586 44. Hawksworth 2017: Complement in the Fundamental Processes of the Cell., Mol. Immunol., 84, p. 17, DOI: 10.1016/j.molimm.2016.11.010 44 10.1016/j.molimm.2016.11.010 false true Reference 60138587 /api/reference/60138587 45. Clark 2008: Evidence for Non-Traditional Activation of Complement Factor C3 during Murine Liver Regeneration., Mol. Immunol., 45, p. 3125, DOI: 10.1016/j.molimm.2008.03.008 45 10.1016/j.molimm.2008.03.008 false true Reference 60138588 /api/reference/60138588 46. Brooimans 1991: Interleukin 2 Mediates Stimulation of Complement C3 Biosynthesis in Human Proximal Tubular Epithelial Cells., J. Clin. Investig., 88, p. 379, DOI: 10.1172/JCI115314 46 10.1172/JCI115314 false true Reference 60138589 /api/reference/60138589 47. Tang 1999: Apical Proteins Stimulate Complement Synthesis by Cultured Human Proximal Tubular Epithelial Cells., J. Am. Soc. Nephrol., 10, p. 69, DOI: 10.1681/ASN.V10169 47 10.1681/ASN.V10169 false true Reference 60138590 /api/reference/60138590 48. Kremlitzka, M., Nowacka, A.A., Mohlin, F.C., Bompada, P., De Marinis, Y., and Blom, A.M. (2019). Interaction of Serum-Derived and Internalized C3 With DNA in Human B Cells—A Potential Involvement in Regulation of Gene Transcription. Front. Immunol., 10., DOI: 10.3389/fimmu.2019.00493 48 10.3389/fimmu.2019.00493 false true Reference 60138591 /api/reference/60138591 49. Cui 2019: Complement C3 Exacerbates Renal Interstitial Fibrosis by Facilitating the M1 Macrophage Phenotype in a Mouse Model of Unilateral Ureteral Obstruction., Am. J. Physiol. Ren. Physiol., 317, p. F1171, DOI: 10.1152/ajprenal.00165.2019 49 10.1152/ajprenal.00165.2019 false true Reference 60138592 /api/reference/60138592 50. Kiafard 2007: Use of Monoclonal Antibodies to Assess Expression of Anaphylatoxin Receptors in Tubular Epithelial Cells of Human, Murine and Rat Kidneys., Immunobiology, 212, p. 129, DOI: 10.1016/j.imbio.2006.11.003 50 10.1016/j.imbio.2006.11.003 false true Reference 60138593 /api/reference/60138593 51. Li, L., Yin, Q., Tang, X., Bai, L., Zhang, J., Gou, S., Zhu, H., Cheng, J., Fu, P., and Liu, F. (2014). C3a Receptor Antagonist Ameliorates Inflammatory and Fibrotic Signals in Type 2 Diabetic Nephropathy by Suppressing the Activation of TGF-β/Smad3 and IKBα Pathway. PLoS ONE, 9., DOI: 10.1371/journal.pone.0113639 51 10.1371/journal.pone.0113639 false true Reference 60138594 /api/reference/60138594 52. Muorah 2016: Stat3 Controls Tubulointerstitial Communication during CKD., J. Am. Soc. Nephrol., 27, p. 3690, DOI: 10.1681/ASN.2015091014 52 10.1681/ASN.2015091014 false true Reference 60138595 /api/reference/60138595 53. Németh, Á., Mózes, M.M., Calvier, L., Hansmann, G., and Kökény, G. (2019). The PPARγ Agonist Pioglitazone Prevents TGF-β Induced Renal Fibrosis by Repressing EGR-1 and STAT3. BMC Nephrol., 20., DOI: 10.1186/s12882-019-1431-x 53 10.1186/s12882-019-1431-x false true Reference 60138596 /api/reference/60138596 54. Booth 2010: Connective Tissue Growth Factor Promotes Fibrosis Downstream of TGFbeta and IL-6 in Chronic Cardiac Allograft Rejection., Am. J. Transpl., 10, p. 220, DOI: 10.1111/j.1600-6143.2009.02826.x 54 10.1111/j.1600-6143.2009.02826.x false true Reference 60138597 /api/reference/60138597 55. Chen 2019: Blocking Interleukin-6 Trans-Signaling Protects Against Renal Fibrosis by Suppressing STAT3 Activation., Theranostics, 9, p. 3980, DOI: 10.7150/thno.32352 55 10.7150/thno.32352 false true Reference 60138598 /api/reference/60138598 56. Panizo, S., Martínez-Arias, L., Alonso-Montes, C., Cannata, P., Martín-Carro, B., Fernández-Martín, J.L., Naves-Díaz, M., Carrillo-López, N., and Cannata-Andía, J.B. (2021). Fibrosis in Chronic Kidney Disease: Pathogenesis and Consequences. Int. J. Mol. Sci., 22., DOI: 10.3390/ijms22010408 56 10.3390/ijms22010408 false true Reference 60138599 /api/reference/60138599 57. Docherty 2009: Increased E-Cadherin Expression in the Ligated Kidney Following Unilateral Ureteric Obstruction., Kidney Int., 75, p. 205, DOI: 10.1038/ki.2008.482 57 10.1038/ki.2008.482 false true Reference 60138600 /api/reference/60138600 58. Kriz 2011: Epithelial-Mesenchymal Transition (EMT) in Kidney Fibrosis: Fact or Fantasy?., J. Clin. Investig., 121, p. 468, DOI: 10.1172/JCI44595 58 10.1172/JCI44595 false true Reference 60138601 /api/reference/60138601 59. Liu 2011: Effect of Anaphylatoxin C3a, C5a on the Tubular Epithelial-Myofibroblast Transdifferentiation in Vitro., Chin. Med. J., 124, p. 4039 59 false true Reference 60138602 /api/reference/60138602 60. Bagnasco 2009: Proteinuria and Epithelial-to-Mesenchymal Transition: The Role of Complement., J. Am. Soc. Nephrol., 20, p. 459, DOI: 10.1681/ASN.2009010063 60 10.1681/ASN.2009010063 false true Reference 60138603 /api/reference/60138603 61. Wu 2020: Proximal Tubule Translational Profiling during Kidney Fibrosis Reveals Proinflammatory and Long Noncoding RNA Expression Patterns with Sexual Dimorphism., J. Am. Soc. Nephrol., 31, p. 23, DOI: 10.1681/ASN.2019040337 61 10.1681/ASN.2019040337 false true Reference 60138604 /api/reference/60138604 62. Arvaniti, E., Moulos, P., Vakrakou, A., Chatziantoniou, C., Chadjichristos, C., Kavvadas, P., Charonis, A., and Politis, P.K. (2016). Whole-Transcriptome Analysis of UUO Mouse Model of Renal Fibrosis Reveals New Molecular Players in Kidney Diseases. Sci. Rep., 6., DOI: 10.1038/srep26235 62 10.1038/srep26235 false true Reference 60138605 /api/reference/60138605 63. Kuppe 2021: Decoding Myofibroblast Origins in Human Kidney Fibrosis., Nature, 589, p. 281, DOI: 10.1038/s41586-020-2941-1 63 10.1038/s41586-020-2941-1 false true Reference 60138606 /api/reference/60138606 64. Stamellou 2024: Long-Term Outcomes of Adults with FSGS in the German Chronic Kidney Disease Cohort., Clin. Kidney J., 17, p. sfae131, DOI: 10.1093/ckj/sfae131 64 10.1093/ckj/sfae131 false true Reference 60138607 /api/reference/60138607 65. Fischer 2021: Complement in Renal Disease as a Potential Contributor to Arterial Hypertension., Kidney Blood Press. Res., 46, p. 362, DOI: 10.1159/000515823 65 10.1159/000515823 false true Reference 60138608 /api/reference/60138608 66. Campbell 2022: Efficacy and Safety of ACE Inhibitor and Angiotensin Receptor Blocker Therapies in Primary Focal Segmental Glomerulosclerosis Treatment: A Systematic Review and Meta-Analysis., Kidney Med., 4, p. 100457, DOI: 10.1016/j.xkme.2022.100457 66 10.1016/j.xkme.2022.100457 false true Reference 60138609 /api/reference/60138609 67. Caster 2022: Efficacy and Safety of Immunosuppressive Therapy in Primary Focal Segmental Glomerulosclerosis: A Systematic Review and Meta-Analysis., Kidney Med., 4, p. 100501, DOI: 10.1016/j.xkme.2022.100501 67 10.1016/j.xkme.2022.100501 false true Reference 60138610 /api/reference/60138610 68. Ng 2024: Drug Repurposing for Glomerular Diseases: An Underutilized Resource., Nat. Rev. Nephrol., 20, p. 707, DOI: 10.1038/s41581-024-00864-8 68 10.1038/s41581-024-00864-8 false true Reference 60138611 /api/reference/60138611 69. Manzéger, A., Garmaa, G., Mózes, M.M., Hansmann, G., and Kökény, G. (2023). Pioglitazone Protects Tubular Epithelial Cells during Kidney Fibrosis by Attenuating MiRNA Dysregulation and Autophagy Dysfunction Induced by TGF-β. Int. J. Mol. Sci., 24., DOI: 10.3390/ijms242115520 69 10.3390/ijms242115520 false true Reference 60138612 /api/reference/60138612 70. Piecha 2008: Calcimimetic R-568 or Calcitriol: Equally Beneficial on Progression of Renal Damage in Subtotally Nephrectomized Rats., Am. J. Physiol. Physiol., 294, p. F748, DOI: 10.1152/ajprenal.00220.2007 70 10.1152/ajprenal.00220.2007 false true Reference 60138613 /api/reference/60138613 71. Festing 2002: Guidelines for the Design and Statistical Analysis of Experiments Using Laboratory Animals., ILAR J., 43, p. 244, DOI: 10.1093/ilar.43.4.244 71 10.1093/ilar.43.4.244 false true /api/publication/35596201 Stepanova Ganna et al. Renal Epithelial Complement C3 Expression Affects Kidney Fibrosis Progression. (2024) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 25 23<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10071667"><a href="/gui2/?type=authors&mode=browse&sel=10071667" target="_blank">Stepanova Ganna (<span class="authorship-author-name">Stepanova Ganna</span> <span class="authorAux-mtmt"> Theoretical and Translational Medicine</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055151"><a href="/gui2/?type=authors&mode=browse&sel=10055151" target="_blank">Manzéger Anna (<span class="authorship-author-name">Manzéger Anna</span> <span class="authorAux-mtmt"> molekuláris genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015693"><a href="/gui2/?type=authors&mode=browse&sel=10015693" target="_blank">Mózes Miklós M. (<span class="authorship-author-name">Mózes Miklós</span> <span class="authorAux-mtmt"> Nephrologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014641"><a href="/gui2/?type=authors&mode=browse&sel=10014641" target="_blank">Kökény Gábor ✉ (<span class="authorship-author-name">Kökény Gábor</span> <span class="authorAux-mtmt"> Nefrológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35596201" target="_blank">Renal Epithelial Complement C3 Expression Affects Kidney Fibrosis Progression</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">25</span> <span class="journal-issue">23</span> <span class="page"> Paper 12551. 24 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/ijms252312551" target="_blank" href="https://doi.org/10.3390/ijms252312551"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001376368700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001376368700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85211910854" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85211910854"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39684261" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39684261&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 5</span> | Független: 5 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 5 | Scopus jelölt:&nbsp;2 | WoS/Scopus jelölt:&nbsp;5 | DOI jelölt:&nbsp;5 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35596201&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35596201</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (BO/00304/20/5), (ÚNKP-22-5-SE-202206201434), (KP2024), (KFP2024) </div> <div class="lastModified">Utolsó módosítás: 2025.07.02. 14:46 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> </div></div>