https://m2.mtmt.hu/ hun 2026-09-23 07:49 JournalArticle 35593131 VALIDATED true Export Date: 6 January 2025 CODEN: MOLEF Correspondence Address: Balogh, G.T.; Department of Chemical and Environmental Process Engineering, Műegyetem rakpart 3, Hungary; email: balogh.gyorgy.tibor@semmelweis.hu Correspondence Address: Volk, B.; Department of Chemical and Environmental Process Engineering, Műegyetem rakpart 3, Hungary; email: volk.balazs@egis.hu Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding text 1: This work was prepared in the framework of 2020-1.1.2-PIACI-KFI-2020-00039 project with the support of the Ministry of Culture and Innovation, from the National Research, Development and Innovation Fund, Hungary. 0 false 2026-06-04T07:41:09.481+0000 2025-01-28T14:06:04.199+0000 2024-11-21T12:28:25.513+0000 true 10015206 Áncsán Gizella /api/admin/10015206 Admin Áncsán Gizella (SE admin) true 10015206 2025-01-19T21:34:53.131+0000 2025-01-19T21:34:53.131+0000 2025-01-06T13:52:13.311+0000 true 10072271 Andódy Katalin /api/admin/10072271 Admin Andódy Katalin (BME admin4) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Várda, Ernák F. true true /api/journal/25013 REVIEWED MOLECULES 1431-5157 1420-3049 true false 25013 false 25013 true 1431-5157 1420-3049 Journal FOREIGN 29 23 5496 5496 13 2024 Benzenesulfonamides are an outstandingly important family of compounds in organic and medicinal chemistry. Herein, we report detailed studies on the electrochemical mono- and dideethylation of model compound N,N-diethylbenzenesulfonamide. In this context, all parameters of the electrosynthesis were systematically investigated, with a special emphasis on solvent screening and the effect of water on the outcome of the reaction. Beside a commercially available electrochemical reactor, a custom-made device has also successfully been designed and used in these transformations. Optimization of the reaction led to a green, scaled-up synthesis of the dealkylated products. Our experiments also render the synthesis and potential in situ use of the corresponding N-methoxyalkyl intermediate, a precursor of the reactive and versatile N-sulfonyliminium cation, possible. Funding 2048160 /api/funding/2048160 (2020-1.1.2-PIACI-KFI-2020-00039) false true true 2024 true true true false true false GOLD 2026-06-04 true https://doi.org/10.3390/molecules29235496 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Q1 false false false false 2024-12-29T10:20:45.203+0000 Egis Gyógyszergyár Zrt.; Elektronikus Eszközök Tanszéke (BME / VIK); Farmakológiai és Gyógyszerkutatás-fejlesztési K... (SE / KSZE); Gyógyszerészi Kémiai Intézet (SE / GYTK); Kémiai és Környezeti Folyamatmérnöki Tanszék (BME / VBK); Vegyészmérnöki és Biomérnöki Kar (BME) 6 21 6 6 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 121766663 /api/authorship/121766663 Várda, Ernák F. [Várda, Ernák Ferenc (Szerves kémia, sz...), szerző] Kémiai és Környezeti Folyamatmérnöki Tanszék (BME / VBK) 1 0.167 true false false Author 10089550 /api/author/10089550 Várda Ernák Ferenc (Szerves kémia, szerves elektrokémia) Várda Ernák Ferenc true true Várda Ernák F. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 121766664 /api/authorship/121766664 Gyűjtő, Imre [Gyűjtő, Imre (kémiai tudományok), szerző] Vegyészmérnöki és Biomérnöki Kar (BME); Egis Gyógyszergyár Zrt. 2 0.167 false false false Author 10061371 /api/author/10061371 Gyűjtő Imre (kémiai tudományok) Gyűjtő Imre true 10061371 true Gyűjtő Imre true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 121766665 /api/authorship/121766665 Ender, Ferenc [Ender, Ferenc (Elektronikus eszk...), szerző] Elektronikus Eszközök Tanszéke (BME / VIK) 3 0.167 false false false Author 10042119 /api/author/10042119 Ender Ferenc (Elektronikus eszközök) Ender Ferenc true 10042119 true Ender Ferenc true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 121766666 /api/authorship/121766666 Csekő, Richárd [Csekő, Richárd (Elektronikus Eszk...), szerző] Elektronikus Eszközök Tanszéke (BME / VIK) 4 0.167 false false false Author 10079325 /api/author/10079325 Csekő Richárd (Elektronikus Eszközök) Csekő Richárd true true Csekő Richárd true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 121766667 /api/authorship/121766667 Balogh, György T. ✉ [Balogh, György Tibor (Gyógyszerkémia), szerző] Kémiai és Környezeti Folyamatmérnöki Tanszék (BME / VBK); Gyógyszerészi Kémiai Intézet (SE / GYTK); Farmakológiai és Gyógyszerkutatás-fejlesztési K... (SE / KSZE) 5 0.167 false false true Author 10011949 /api/author/10011949 Balogh György Tibor (Gyógyszerkémia) Balogh György Tibor true 10011949 true Balogh György T. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 121766668 /api/authorship/121766668 Volk, Balázs ✉ [Volk, Balázs (Hatóanyag gyártóe...), szerző] Egis Gyógyszergyár Zrt. 6 0.167 false true true Author 10012714 /api/author/10012714 Volk Balázs (Hatóanyag gyártóeljárás-fejlesztés, heterociklusos vegyületek kémiája, alkaloidok szintézise) Volk Balázs true 10012714 true Volk Balázs true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 27990038 /api/publicationidentifier/27990038 DOI: 10.3390/molecules29235496 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/molecules29235496 https://doi.org/10.3390/molecules29235496 false true PublicationIdentifier 28127445 /api/publicationidentifier/28127445 WoS: 001376458600001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001376458600001 https://www.webofscience.com/wos/woscc/full-record/001376458600001 false true PublicationIdentifier 28133629 /api/publicationidentifier/28133629 Scopus: 85212705251 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85212705251 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85212705251 false true PublicationIdentifier 28127446 /api/publicationidentifier/28127446 PubMed: 39683657 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39683657 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39683657&dopt=Abstract false true Classification 12197 /api/classification/12197 Gyógyszerészet, farmakogenomika, gyógyszerkutatás és tervezés, gyógyszeres kezelés true true SjrRating 11438118 /api/sjrrating/11438118 sjr:Q1 (2024) Scopus - Analytical Chemistry MOLECULES 1431-5157 1420-3049 31 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1602 /api/classificationexternal/1602 Scopus - Analytical Chemistry true 1602 true Q1 DIRECT true true Reference 60083791 /api/reference/60083791 1. 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(2024) MOLECULES 1431-5157 1420-3049 29 23<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10089550"><a href="/gui2/?type=authors&mode=browse&sel=10089550" target="_blank">Várda Ernák F. (<span class="authorship-author-name">Várda Ernák Ferenc</span> <span class="authorAux-mtmt"> Szerves kémia, szerves elektrokémia</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Kémiai és Környezeti Folyamatmérnöki Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061371"><a href="/gui2/?type=authors&mode=browse&sel=10061371" target="_blank">Gyűjtő Imre (<span class="authorship-author-name">Gyűjtő Imre</span> <span class="authorAux-mtmt"> kémiai tudományok</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/Vegyészmérnöki és Biomérnöki Kar; Egis Gyógyszergyár Zrt.</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10042119"><a href="/gui2/?type=authors&mode=browse&sel=10042119" target="_blank">Ender Ferenc (<span class="authorship-author-name">Ender Ferenc</span> <span class="authorAux-mtmt"> Elektronikus eszközök</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Villamosmérnöki és Informatikai Kar">VIK</span>/Elektronikus Eszközök Tanszéke</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10079325"><a href="/gui2/?type=authors&mode=browse&sel=10079325" target="_blank">Csekő Richárd (<span class="authorship-author-name">Csekő Richárd</span> <span class="authorAux-mtmt"> Elektronikus Eszközök</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Villamosmérnöki és Informatikai Kar">VIK</span>/Elektronikus Eszközök Tanszéke</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011949"><a href="/gui2/?type=authors&mode=browse&sel=10011949" target="_blank">Balogh György T. ✉ (<span class="authorship-author-name">Balogh György Tibor</span> <span class="authorAux-mtmt"> Gyógyszerkémia</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Kémiai és Környezeti Folyamatmérnöki Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészi Kémiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012714"><a href="/gui2/?type=authors&mode=browse&sel=10012714" target="_blank">Volk Balázs ✉ (<span class="authorship-author-name">Volk Balázs</span> <span class="authorAux-mtmt"> Hatóanyag gyártóeljárás-fejlesztés, heterociklu...</span>) </a> </span> <span class="author-affil">Egis Gyógyszergyár Zrt.</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35593131" target="_blank">Detailed Studies on the Methoxylation and Subsequent Dealkylation of N,N-Diethylbenzenesulfonamide Using a Tailor-Made Electrosynthetic Reactor</a></div> <div> <span class="journal-title">MOLECULES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1431-5157">1431-5157</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1420-3049">1420-3049</a>)</span>: <span class="journal-volume">29</span> <span class="journal-issue">23</span> <span class="page"> Paper 5496. 13 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/molecules29235496" target="_blank" href="https://doi.org/10.3390/molecules29235496"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001376458600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001376458600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85212705251" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85212705251"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39683657" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39683657&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Analytical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Chemistry (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmaceutical Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Drug Discovery&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35593131</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (2020-1.1.2-PIACI-KFI-2020-00039) </div> <div class="lastModified">Utolsó módosítás: 2025.01.28. 15:06 Lantos Jonatán (Egis admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 6 January 2025 CODEN: MOLEF Correspondence Address: Balogh, G.T.; Department of Chemical and Environmental Process Engineering, Műegyetem rakpart 3, Hungary; email: balogh.gyorgy.tibor@semmelweis.hu Correspondence Address: Volk, B.; Department of Chemical and Environmental Process Engineering, Műegyetem rakpart...</pre> </div></div>