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      <title>Evaluating salivary MMP-8 as a biomarker for periodontal diseases: A systematic review and meta-analysis</title>
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      <abstractText>Objective Periodontitis is the irreversible destructive process of the periodontium and is the major cause of tooth loss in adults worldwide. Diagnosis of early-stage periodontal disease is crucial for improving outcomes, and to this end, the application of indicator biomarkers is gaining interest. One such method involves measuring the level of matrix metalloproteinase-8 (MMP-8). This systematic review and meta-analysis aims to evaluate the salivary MMP-8 level of periodontitis and gingivitis cases compared to healthy controls. Data We evaluated all studies that compared different laboratory techniques for measuring salivary MMP-8 levels in periodontitis and gingivitis patients, alongside healthy controls. Sources The systematic search was performed on 10 October 2022 in three electronic databases. Study selection results Pooled mean differences (MD) were calculated with 95 % confidence intervals (CIs) between the researched groups. In addition, the correlation coefficient results between MMP-8 values and other clinical parameters were narratively summarized. Based on 20 eligible studies (n = 1725), patients with periodontitis presented significantly higher MMP-8 levels (MD = 273.26 ng/ml, CI: 194.42; 352.10). Similarly, patients with gingivitis presented significantly higher salivary MMP-8 levels than healthy individuals (MD = 122.82 ng/ml, CI: 64.19; 181.45) based on the results of 10 eligible studies (n = 704). Additionally, we found higher MMP-8 levels in periodontitis compared to gingivitis (MD = 112.04 ng/ml, CI: 56.15; 167.92). The correlation results suggest that salivary MMP-8 is associated with different clinical periodontal parameters. Conclusion Salivary MMP-8 level measurement may be a reliable method to distinguish between periodontal health and periodontal disease and also to distinguish between gingivitis and periodontitis. Clinical significance The measurement of salivary MMP-8 levels may have the potential to differentiate between periodontal health and disease reliably. Accordingly, it can be considered for integration into routine dental examinations as a quick and convenient method for the early detection and prevention of periodontitis, pending further validation.</abstractText>
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style=&quot;float: left&quot; src=&quot;/frontend/resources/grid/publication-core-icon.png&quot;&gt; &lt;div class=&quot;autype autype0&quot;&gt; &lt;span class=&quot;author-name&quot; mtid=&quot;10085881&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10085881&quot; target=&quot;_blank&quot;&gt;Domokos Zsuzsanna (&lt;span class=&quot;authorship-author-name&quot;&gt;Domokos Zsuzsanna&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Fogászat&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Fogorvostudományi Kar&quot;&gt;FOK&lt;/span&gt;/Fogászati és Szájsebészeti Oktató Intézet; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Transzlációs Medicina Központ&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10071180&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10071180&quot; target=&quot;_blank&quot;&gt;Simon Fanni (&lt;span class=&quot;authorship-author-name&quot;&gt;Simon Fanni&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Parodontológia&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Fogorvostudományi Kar&quot;&gt;FOK&lt;/span&gt;/Fogászati és Szájsebészeti Oktató Intézet&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10086477&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10086477&quot; target=&quot;_blank&quot;&gt;Uhrin Eszter (&lt;span class=&quot;authorship-author-name&quot;&gt;Uhrin Eszter&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Orvostudomány, egészségtudomány&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Fogorvostudományi Kar&quot;&gt;FOK&lt;/span&gt;/Fogászati és Szájsebészeti Oktató Intézet; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Transzlációs Medicina Központ&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10055762&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10055762&quot; target=&quot;_blank&quot;&gt;Szabó Bence (&lt;span class=&quot;authorship-author-name&quot;&gt;Szabó Bence&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Biológia, paleontológia&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Transzlációs Medicina Központ&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10071961&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10071961&quot; target=&quot;_blank&quot;&gt;Váncsa Szilárd (&lt;span class=&quot;authorship-author-name&quot;&gt;Váncsa Szilárd&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Orvostudomány, egészségtudomány&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/Pankreász Betegségek Intézete; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Transzlációs Medicina Központ; &lt;span title=&quot;Pécsi Tudományegyetem&quot;&gt;PTE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/Transzlációs Medicina Intézet&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10006652&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10006652&quot; target=&quot;_blank&quot;&gt;Varga Gábor (&lt;span class=&quot;authorship-author-name&quot;&gt;Varga Gábor&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Élettan, orálbiológia&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Fogorvostudományi Kar&quot;&gt;FOK&lt;/span&gt;/Orálbiológiai Tanszék; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Transzlációs Medicina Központ&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10002629&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10002629&quot; target=&quot;_blank&quot;&gt;Hegyi Péter (&lt;span class=&quot;authorship-author-name&quot;&gt;Hegyi Péter&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Gasztroenterológia&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/Pankreász Betegségek Intézete; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Transzlációs Medicina Központ; &lt;span title=&quot;Pécsi Tudományegyetem&quot;&gt;PTE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/Transzlációs Medicina Intézet&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10018993&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10018993&quot; target=&quot;_blank&quot;&gt;Kerémi Beáta (&lt;span class=&quot;authorship-author-name&quot;&gt;Kerémi Beáta&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Konzerváló Fogászat, Orálbiológia&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Fogorvostudományi Kar&quot;&gt;FOK&lt;/span&gt;/Helyreállító Fogászati és Endodonciai Klinika; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Transzlációs Medicina Központ&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10018900&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10018900&quot; target=&quot;_blank&quot;&gt;Németh Orsolya ✉ (&lt;span class=&quot;authorship-author-name&quot;&gt;Németh Orsolya&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Fogpótlástan&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Fogorvostudományi Kar&quot;&gt;FOK&lt;/span&gt;/Fogászati és Szájsebészeti Oktató Intézet; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Transzlációs Medicina Központ&lt;/span&gt; &lt;/div&gt; &lt;/div&gt; &lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;35591724&quot; target=&quot;_blank&quot;&gt;Evaluating salivary MMP-8 as a biomarker for periodontal diseases: A systematic review and meta-analysis&lt;/a&gt;&lt;/div&gt; &lt;div&gt; &lt;span class=&quot;journal-title&quot;&gt;HELIYON&lt;/span&gt; &lt;span class=&quot;journal-issn&quot;&gt;( &lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/2405-8440&quot;&gt;2405-8440&lt;/a&gt;)&lt;/span&gt;: &lt;span class=&quot;journal-volume&quot;&gt;10&lt;/span&gt; &lt;span class=&quot;journal-issue&quot;&gt;22&lt;/span&gt; &lt;span class=&quot;page&quot;&gt; Paper e40402. 17 p. &lt;/span&gt; &lt;span class=&quot;year&quot;&gt;(2024)&lt;/span&gt; &lt;/div&gt; &lt;div class=&quot;pub-footer&quot;&gt;  &lt;span class=&quot;language&quot; xmlns=&quot;http://www.w3.org/1999/html&quot;&gt;Nyelv: Angol | &lt;/span&gt; &lt;span class=&quot;identifiers&quot;&gt; &lt;span class=&quot;id identifier oa_GOLD&quot; title=&quot; Gold &quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;10.1016/j.heliyon.2024.e40402&quot; target=&quot;_blank&quot; href=&quot;https://doi.org/10.1016/j.heliyon.2024.e40402&quot;&gt; DOI &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:black&quot; title=&quot;MEDLINE:39641024&quot; target=&quot;_blank&quot; href=&quot;https://www.webofscience.com/wos/woscc/full-record/MEDLINE:39641024&quot;&gt; WoS &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;85209539691&quot; target=&quot;_blank&quot; href=&quot;http://www.scopus.com/record/display.url?origin=inward&amp;eid=2-s2.0-85209539691&quot;&gt; Scopus &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;39641024&quot; target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=39641024&amp;dopt=Abstract&quot;&gt; PubMed &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;https://linkinghub.elsevier.com/retrieve/pii/S240584402416433X&quot; target=&quot;_blank&quot; href=&quot;https://linkinghub.elsevier.com/retrieve/pii/S240584402416433X&quot;&gt; Egyéb URL &lt;/a&gt; &lt;/span&gt; &lt;/span&gt; &lt;OnlyViewableByAuthor&gt;&lt;div class=&quot;ratings&quot;&gt; &lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Multidisciplinary&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;Q1&lt;/div&gt; &lt;/div&gt;&lt;/OnlyViewableByAuthor&gt; &lt;div class=&quot;publication-citation&quot; style=&quot;margin-left: 0.5cm;&quot;&gt; &lt;span title=&quot;Nyilvános idézőközlemények összesen, említések nélkül&quot; class=&quot;citingPub-count&quot;&gt;Nyilvános idéző összesen: 24&lt;/span&gt; | Független: 24 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 16 | Scopus jelölt:&amp;nbsp;23 | WoS/Scopus jelölt:&amp;nbsp;24 | DOI jelölt:&amp;nbsp;24 &lt;/div&gt;   &lt;div class=&quot;mtid&quot;&gt;&lt;span class=&quot;long-pub-mtid&quot;&gt;Közlemény: 35591724&lt;/span&gt; | &lt;span class=&quot;status-data status-VALIDATED&quot;&gt; Egyeztetett &lt;/span&gt; Forrás Duplumgyanú | &lt;span class=&quot;type-subtype&quot;&gt;Folyóiratcikk ( Összefoglaló cikk ) &lt;/span&gt; | &lt;span class=&quot;pub-category&quot;&gt;Tudományos&lt;/span&gt; | &lt;span class=&quot;publication-sourceOfData&quot;&gt;RIS-Egyéb&lt;/span&gt; &lt;/div&gt; &lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2025.01.31. 12:06 Gere Tamásné (SE_KK_Admin5_GT, admin) &lt;/div&gt; &lt;/div&gt;&lt;/div&gt;</template2>
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