https://m2.mtmt.hu/ hun 2026-09-21 22:46 JournalArticle 35581552 VALIDATED true Department of Pharmacodynamics, Semmelweis University, 4 Nagyvárad Tér, Budapest, H-1089, Hungary Center for Pharmacology and Drug Research & Development, Semmelweis University, 26 Üllői Út, Budapest, H-1085, Hungary Export Date: 09 July 2026; Cited By: 5; Correspondence Address: T. Tábi; Department of Pharmacodynamics, Semmelweis University, Budapest, 4 Nagyvárad Tér, H-1089, Hungary; email: tabi.tamas@semmelweis.hu 0 false 2026-09-18T07:17:47.559+0000 2026-07-09T09:22:50.354+0000 2024-11-19T14:09:38.262+0000 true 10030040 Ruzsits Ágnes /api/admin/10030040 Admin true 10030040 2026-09-18T07:16:28.895+0000 2024-12-16T10:57:14.490+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Sikur, Noémi Resveratrol and Its Derivatives Diminish Lipid Accumulation in Adipocytes In Vitro—Mechanism of Action and Structure–Activity Relationship true true /api/journal/10016563 REVIEWED true false 10016563 false 10016563 true 2072-6643 Journal FOREIGN 16 22 3869 3869 15 2024 Background and Objectives: Expansion of white adipose tissue causes systemic inflammation and increased risk of metabolic diseases due to its endocrine function. Resveratrol was suggested to be able to prevent obesity-related disorders by mimicking caloric restriction; however, its structure–activity relationships and molecular targets are still unknown. We aimed to compare the effects of resveratrol and its analogues on adipocyte metabolism and lipid accumulation in vitro. Methods: Mouse embryonic fibroblasts were differentiated to adipocytes in the absence or presence of resveratrol or its derivatives (oxyresveratrol, monomethylated resveratrol, or trimethylated resveratrol). Intracellular lipid content was assessed by Oil Red O staining. Glucose uptake and its response to insulin were estimated by 2-NBDG, and mitochondrial activity was assayed via resazurin reduction. Involvement of potential molecular pathways was investigated by concurrent treatment with their inhibitors. Results: Although lipid accumulation was significantly reduced by all analogues without altering protein content, oxyresveratrol was the most potent (IC50 = 4.2 μM), while the lowest potency was observed with trimethylated resveratrol (IC50 = 27.4 μM). Increased insulin-stimulated glucose uptake was restored by each analogue with comparable efficiency. The enhanced mitochondrial activity was normalized by resveratrol and its methylated derivatives, while oxyresveratrol had a minor impact on it. Among the examined pathways, inhibition of SIRT1, PGC-1α, and JNK diminished the lipid-reducing effect of the compounds. Autophagy appeared to play a key role in the effect of all compounds but oxyresveratrol. Conclusions: Resveratrol and its analogues can mimic caloric restriction with complex mechanisms, including activation of SIRT1, PGC-1α, and JNK, making them possible drug candidates to treat obesity-related diseases. 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59967476 /api/reference/59967476 32 10.3892/etm.2015.2895 false true Reference 59967477 /api/reference/59967477 33 10.1007/s00280-010-1525-4 false true Reference 59967478 /api/reference/59967478 34 10.1002/jps.22588 false true Reference 59967479 /api/reference/59967479 35 10.1101/pdb.prot4398 false true Reference 59967480 /api/reference/59967480 36 10.1152/ajpcell.00379.2020 false true Reference 59967481 /api/reference/59967481 37 false true Reference 59967482 /api/reference/59967482 38 10.1024/0300-9831/a000784 false true Reference 59967483 /api/reference/59967483 39 false true Reference 59967484 /api/reference/59967484 40 10.1002/ptr.2503 false true Reference 59967485 /api/reference/59967485 41 10.3390/ijms222413446 false true Reference 59967486 /api/reference/59967486 42 false true Reference 59967487 /api/reference/59967487 43 10.1016/j.jnutbio.2018.02.007 false true Reference 59967488 /api/reference/59967488 44 10.1096/fj.201902222R false true Reference 59967489 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src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10098480"><a href="/gui2/?type=authors&mode=browse&sel=10098480" target="_blank">Sikur Noémi (<span class="authorship-author-name">Sikur Noémi Blanka</span> <span class="authorAux-mtmt"> Gyógyszerészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10101371"><a href="/gui2/?type=authors&mode=browse&sel=10101371" target="_blank">Böröczky Csenge (<span class="authorship-author-name">Böröczky Csenge</span> <span class="authorAux-mtmt"> Gyógyszerészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10094028"><a href="/gui2/?type=authors&mode=browse&sel=10094028" target="_blank">Paszternák Alexandra (<span class="authorship-author-name">Paszternák Alexandra</span> <span class="authorAux-mtmt"> Gyógyszerésztudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gyöngyössy Ramá </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003174"><a href="/gui2/?type=authors&mode=browse&sel=10003174" target="_blank">Szökő Éva (<span class="authorship-author-name">Szökő Éva</span> <span class="authorAux-mtmt"> Farmakológia, gyógyszeranalitika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077053"><a href="/gui2/?type=authors&mode=browse&sel=10077053" target="_blank">Varga Kamilla<sup>**</sup> (<span class="authorship-author-name">Varga Kamilla</span> <span class="authorAux-mtmt"> Gyógyszerészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012548"><a href="/gui2/?type=authors&mode=browse&sel=10012548" target="_blank">Tábi Tamás ✉ (<span class="authorship-author-name">Tábi Tamás</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35581552" target="_blank">Resveratrol and Its Derivatives Diminish Lipid Accumulation in Adipocytes In Vitro—Mechanism of Action and Structure–Activity Relationship</a></div> <div> <span class="journal-title">NUTRIENTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2072-6643">2072-6643</a>)</span>: <span class="journal-volume">16</span> <span class="journal-issue">22</span> <span class="page"> Paper 3869. 15 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/nu16223869" target="_blank" href="https://doi.org/10.3390/nu16223869"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001365859200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001365859200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85210922640" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85210922640"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39599655" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39599655&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Food Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Nutrition and Dietetics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 7</span> | Független: 7 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 6 | Scopus jelölt:&nbsp;6 | WoS/Scopus jelölt:&nbsp;6 | DOI jelölt:&nbsp;6 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35581552&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35581552</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (2024-2.1.1-EKÖP-2024-00004-259), (EKÖP-2024-203) </div> <div class="lastModified">Utolsó módosítás: 2026.07.09. 11:22 Ruzsits Ágnes (SE_GYTK_Gyhatástan_Admin5_RÁ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Pharmacodynamics, Semmelweis University, 4 Nagyvárad Tér, Budapest, H-1089, Hungary Center for Pharmacology and Drug Research & Development, Semmelweis University, 26 Üllői Út, Budapest, H-1085, Hungary Export Date: 09 July 2026; Cited By: 5; Correspondence Address: T. Tábi; Department of Pharmacodynamics, Semmelweis University, Buda...</pre> </div></div>