https://m2.mtmt.hu/ eng 2026-10-25 00:01 JournalArticle 35581090 VALIDATED true * Megosztott szerzőség 0 false 2026-10-21T14:12:28.135+0000 2024-12-02T10:09:34.427+0000 2024-11-19T13:30:41.522+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Róbert Milánkovics (PTE ÁOK admin 4) true 10039043 2026-08-17T11:30:58.381+0000 2024-12-02T10:09:34.597+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Ágnes Szalóky-Siki (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Ács, Márton true true /api/journal/10019966 REVIEWED SCIENTIFIC REPORTS 2045-2322 true false 10019966 false 10019966 true 2045-2322 Journal FOREIGN 14 1 28104 28104 11 2024 Orofacial clefts are among the most prevalent birth defects, with severe medical and psychosocial consequences. Cleft lip with or without cleft palate (CL ± P) and cleft palate only (CPO) affect on average nearly 1/700 births worldwide. The cause of most non-syndromic cases is unknown. Maternal factors and disorders are assumed to modify the risk of orofacial clefting. In the present study, we performed a systematic review and meta-analysis to analyze the effects of maternal underweight, obesity, hypertension, diabetes, as well as smoking, and alcohol consumption on the development of orofacial clefts. As CL ± CP and CPO have distinct pathogenetic backgrounds, these cleft subtypes were assessed separately. Altogether, 5,830 studies were identified and 64 of them met the inclusion and exclusion criteria. Obesity significantly elevated the odds of clefting (OR = 1.28, CI:1.08-1.51) (ORCL±CP = 1.23, CI:1.01-1.50; ORCPO = 1.31, CI:0.97-1.77). Maternal underweight also significantly increased the odds of clefting (OR = 1.21 CI:1.06-1.38). In mothers with type 1 diabetes, the odds of cleft development were significantly elevated (OR = 1,75, CI:1.45-2.12). Essential hypertension was also associated with higher odds of developing cleft (OR = 1.55, CI:1.18-2.03). Smoking during pregnancy significantly elevated the odds of cleft development (OR = 1.55, CI:1.34-1.79) (ORCL±CP = 1.58, CI:1.36-1.83; ORCPO = 1.50, CI:1.15-1.96). Passive smoking was even more damaging than active tobacco use, but alcohol consumption had no effect. In conclusion, this study clearly showed the importance of maintaining normal maternal body weight and emphasized the importance of hypertension and type 1 diabetes care in the first months of pregnancy. It also highlighted similarnegative effects of passive and active smoking, while alcohol consumption did not seem to be a significant risk factor for cleft development. However, there is a complete lack of available studies on the interactions of these factors, which is an essential direction for improving prevention. Funding 2046825 /api/funding/2046825 (K-147107) false true true true 2024 true true true false true false GOLD 2026-10-21 true https://doi.org/10.1038/s41598-024-79346-7 15 0 15 15 0 15 15 14 13 15 15 15 15 15 0 0 15 15 15 15 0 4 4 Folyóiratcikk Journal Article 24 15 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 7 7 7 7 2026 0 8 8 8 8 Q1 A nemzetközi false 10002007 false false false 2024-11-18T15:00:06.775+0000 Anatómiai, Szövet- és Fejlődéstani Intézet (SE / AOK / I); Biostatisztika tanszék (ÁTE / GBI); Orálbiológiai Tanszék (SE / FOK); Pankreász Betegségek Intézete (SE / AOK / K); Transzlációs Medicina Intézet (PTE / ÁOK); Transzlációs Medicina Központ (SE / KSZE) 9 67 6 9 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 121692621 /api/authorship/121692621 Ács, Márton [Ács, Márton (Szájsebészet), author] Centre for Translational Medicine (SU / KSZE); Department of Oral Biology (SU / FD) 1 0.111 true false false Author 10092848 /api/author/10092848 Márton Ács (Szájsebészet) Ács Márton true true Ács Márton true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 121692622 /api/authorship/121692622 Cavalcante, Bianca Golzio Navarro [Golzio Navarro Cavalcante, Bianca (Clinical Medicine), author] Department of Oral Biology (SU / FD); Centre for Translational Medicine (SU / KSZE) 2 0.111 false false false Author 10078009 /api/author/10078009 Bianca Golzio Navarro Cavalcante (Clinical Medicine) Golzio Navarro Cavalcante Bianca true true Cavalcante Bianca Golzio Navarro true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 121692623 /api/authorship/121692623 Bănărescu, Mădălina [Banarescu, Madalina (Oromaxillofacial ...), author] Centre for Translational Medicine (SU / KSZE) 3 0.111 false false false Author 10094669 /api/author/10094669 Madalina Banarescu (Oromaxillofacial Surgery) Banarescu Madalina true true Bănărescu Mădălina true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 121692624 /api/authorship/121692624 Wenning, Alexander Schulze [Schulze Wenning, Alexander (Orvostudomány, eg...), author] Centre for Translational Medicine (SU / KSZE) 4 0.111 false false false Author 10086439 /api/author/10086439 Alexander Schulze Wenning (Orvostudomány, egészségtudomány) Schulze Wenning Alexander true true Wenning Alexander Schulze true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 121692625 /api/authorship/121692625 Hegyi, Péter [Hegyi, Péter (Gasztroenterológia), author] Institute for Translational Medicine (UP / UPMS); Institute of Pancreatic Diseases (SU / FM / C); Centre for Translational Medicine (SU / KSZE) 5 0.111 false false false Author 10002629 /api/author/10002629 Péter Hegyi (Gasztroenterológia) Hegyi Péter true 10002629 true Hegyi Péter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 121692626 /api/authorship/121692626 Szabó, Bence [Szabó, Bence (Biológia, paleont...), author] Centre for Translational Medicine (SU / KSZE) 6 0.111 false false false Author 10055762 /api/author/10055762 Bence Szabó (Biológia, paleontológia) Szabó Bence true 10055762 true Szabó Bence true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 121692627 /api/authorship/121692627 Harnos, Andrea [Harnos, Andrea (Biostatisztika), author] Centre for Translational Medicine (SU / KSZE); Department of Biostatistics (UVMB / IEB) 7 0.111 false false false Author 10002007 /api/author/10002007 Andrea Harnos (Biostatisztika) Harnos Andrea true 10002007 true Harnos Andrea true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 121692628 /api/authorship/121692628 Gerber, Gábor** [Gerber, Gábor (Idegtudományok), author] Anatómiai, Szövet- és Fejlődéstani Intézet (SU / FM / I); Centre for Translational Medicine (SU / KSZE) 8 0.111 false true false Author 10020686 /api/author/10020686 Gábor Gerber (Idegtudományok) Gerber Gábor true 10020686 true Gerber Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 121692629 /api/authorship/121692629 Varga, Gábor ✉ [Varga, Gábor (Élettan, orálbiol...), author] Department of Oral Biology (SU / FD); Centre for Translational Medicine (SU / KSZE) 9 0.111 false true true Author 10006652 /api/author/10006652 Gábor Varga (Élettan, orálbiológia) Varga Gábor true 10006652 true Varga Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 27949433 /api/publicationidentifier/27949433 DOI: 10.1038/s41598-024-79346-7 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1038/s41598-024-79346-7 https://doi.org/10.1038/s41598-024-79346-7 false true PublicationIdentifier 28014119 /api/publicationidentifier/28014119 WoS: 001356224700007 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001356224700007 https://www.webofscience.com/wos/woscc/full-record/001356224700007 false true PublicationIdentifier 28004000 /api/publicationidentifier/28004000 Scopus: 85209154843 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85209154843 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85209154843 true true PublicationIdentifier 27949432 /api/publicationidentifier/27949432 PubMed: 39548204 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 39548204 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39548204&dopt=Abstract false true Classification 12276 /api/classification/12276 Odontology true true Keyword 3375201 /api/keyword/3375201 [Meta-analysis] true true MtaRating 519359 /api/mtarating/519359 IX. Committee on Sociology:A nemzetközi SCIENTIFIC REPORTS 2045-2322 RatingType 10007 /api/ratingtype/10007 IX. Committee on Sociology SZTB Institute 14102 /api/institute/14102 Committee on Sociology HASSELIX SZTB [1901-] 0 false true false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true A nemzetközi true 19359 true MtaRating 11551161 /api/mtarating/11551161 IX. Committee on Regional Studies:B nemzetközi SCIENTIFIC REPORTS 2045-2322 RatingType 10010 /api/ratingtype/10010 IX. Committee on Regional Studies RegTB Institute 14100 /api/institute/14100 Committee on Regional Studies HASSELIX RTB [1901-] 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true B nemzetközi true true SjrRating 11736109 /api/sjrrating/11736109 sjr:Q1 (2024) Scopus - Multidisciplinary SCIENTIFIC REPORTS 2045-2322 23 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 Scopus - Multidisciplinary true 1000 true Q1 DIRECT true true /api/publication/35581090 Ács Márton et al. Maternal factors increase risk of orofacial cleft : a meta-analysis. (2024) SCIENTIFIC REPORTS 2045-2322 14 1<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10092848"><a href="/gui2/?type=authors&mode=browse&sel=10092848" target="_blank">Ács Márton (<span class="authorship-author-name">Ács Márton</span> <span class="authorAux-mtmt"> Szájsebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Oral Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10078009"><a href="/gui2/?type=authors&mode=browse&sel=10078009" target="_blank">Cavalcante Bianca Golzio Navarro (<span class="authorship-author-name">Golzio Navarro Cavalcante Bianca</span> <span class="authorAux-mtmt"> Clinical Medicine</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Oral Biology; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10094669"><a href="/gui2/?type=authors&mode=browse&sel=10094669" target="_blank">Bănărescu Mădălina (<span class="authorship-author-name">Banarescu Madalina</span> <span class="authorAux-mtmt"> Oromaxillofacial Surgery</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10086439"><a href="/gui2/?type=authors&mode=browse&sel=10086439" target="_blank">Wenning Alexander Schulze (<span class="authorship-author-name">Schulze Wenning Alexander</span> <span class="authorAux-mtmt"> Orvostudomány, egészségtudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Péter (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Institute of Pancreatic Diseases; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055762"><a href="/gui2/?type=authors&mode=browse&sel=10055762" target="_blank">Szabó Bence (<span class="authorship-author-name">Szabó Bence</span> <span class="authorAux-mtmt"> Biológia, paleontológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002007"><a href="/gui2/?type=authors&mode=browse&sel=10002007" target="_blank">Harnos Andrea (<span class="authorship-author-name">Harnos Andrea</span> <span class="authorAux-mtmt"> Biostatisztika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine; <span title="University of Veterinary Medicine Budapest">UVMB</span>/<span title="Élelmiszerlánc-biztonsági és Járványvédelmi Intézet">ÉBJI</span>/<span title="Institute of Economics and Biostatistics">IEB</span>/Department of Biostatistics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020686"><a href="/gui2/?type=authors&mode=browse&sel=10020686" target="_blank">Gerber Gábor^** (<span class="authorship-author-name">Gerber Gábor</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10006652"><a href="/gui2/?type=authors&mode=browse&sel=10006652" target="_blank">Varga Gábor ✉ (<span class="authorship-author-name">Varga Gábor</span> <span class="authorAux-mtmt"> Élettan, orálbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Oral Biology; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35581090" target="_blank">Maternal factors increase risk of orofacial cleft : a meta-analysis</a></div> <div> <span class="journal-title">SCIENTIFIC REPORTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-2322">2045-2322</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">1</span> <span class="page"> Paper 28104. 11 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41598-024-79346-7" target="_blank" href="https://doi.org/10.1038/s41598-024-79346-7"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001356224700007" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001356224700007"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85209154843" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85209154843"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39548204" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39548204&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 15</span> | Independent citation: 15 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 14 | Number of citations in Scopus:&nbsp;13 | WoS/Scopus assigned:&nbsp;15 | Number of citations with DOI:&nbsp;15 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35581090&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 35581090</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (K-147107) </div> <div class="lastModified">Last Modified: 2024.12.02. 11:09 Ágnes Szalóky-Siki (SE_KK_Admin5_SZSA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: * Megosztott szerzőség</pre> </div></div>